Deptor cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Deptor
Entrez Gene ID	97998
Full Name	DEP domain containing MTOR-interacting protein
Synonyms	Depdc6
General protein information	Preferred Names DEP domain containing MTOR-interacting protein Names DEP domain-containing mTOR-interacting protein DEP domain-containing protein 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 D1\|15 21.96 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_145470.3	NP_663445.2	DEP domain-containing mTOR-interacting protein isoform a
NM_001037937.3	NP_001033026.1	DEP domain-containing mTOR-interacting protein isoform b

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100493830	XP_004915116.1
Homo sapiens (human)	DEPTOR	NP_073620.2
Canis lupus familiaris (dog)	DEPTOR	XP_539149.2
Gallus gallus (chicken)	DEPDC6	NP_001186431.1
Danio rerio (zebrafish)	deptor	NP_001070788.2
Pan troglodytes (chimpanzee)	DEPTOR	XP_519926.2
Rattus norvegicus (Norway rat)	Deptor	XP_006241722.1
	DEPTOR	XP_001097652.1
Bos taurus (cattle)	DEPTOR	NP_001095782.1
Mus musculus (house mouse)	Deptor	NP_663445.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of hepatic DEPTOR alters the metabolic transition to fasting.
Caron A, Mouchiroud M, Gautier N, Labb? SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, G?linas Y, Marette A, Richard D, Sabatini DM, Laplante M
Molecular metabolism6(5)447-458(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65.
Title: p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes.

Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Title: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation.

These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC neurons. Taken together, these results show that DEPTOR overexpression in POMC neurons does not affect energy balance regulation but could modu
Title: DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance.

The present study indicates that regulation of DEPTOR/mTOR signaling may be an important mechanism for glutamine in prevention against the development of colitis-associated colorectal cancer (CAC): the chemopreventive effect of dietary glutamine on CAC is, at least in part, associated with the induction of autophagy.
Title: Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway.

p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
Title: p38? and ? promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.

The following Deptor gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Deptor cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00164	NM_001037937.3 Latest version!	Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu11633	NM_145470.3 Latest version!	Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Deptor ( NM_001037937.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001033026.1 Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00164
Clone ID Related Accession (Same CDS sequence)	NM_001037937.3
Accession Version	NM_001037937.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-09
Organism	Mus musculus(house mouse)
Product	DEP domain-containing mTOR-interacting protein isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK139888.1, AK220300.1 and AC124659.10. On Oct 18, 2013 this sequence version replaced NM_001037937.2. Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK139888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACAAG CCTTCCTGGT GGTTCTCAGG CATTCTATCT CTGAGGATCG ACTTCCTCCT 
CTGAGTGTAA TAACCTCAGG CTGCAGGCTG CGGCTCCATG AAGAAAAGGT TATTAAAGAT 
AGACGGCACC ATCTCAAAAC CTACCCAAAC TGCTTTGTTG CAAAAGAGCT GATTGACTGG 
CTCATTGAAC ATAAGGAGGC CTCTGACCGA GAGACGGCGA TAAAACTCAT GCAGAAATTA 
GCCGACCGGG GCATCATTCA TCACGTGTGT GATGAGCACA AGGAATTCAA GGATGTAAAA 
CTCTTCTACC GCTTTAGGAA GGATGATGGG ACCTTTGCAC TGGACAGTGA GGTGAAGGCC 
TTCATGAGAG GACAGAGGCT CTATGAAAAA CTGATGAGCC CTGAAACTAC ACTCCTCCAG 
CCTAGAGAGG AGGAGGGGGT GAAGTATGAG CGGACCTTCA TGGCATCCGA ATTCCTGGAC 
TGGTTGGTTC AGGAAGGTGA AGCCACAACA AGGAAAGAGG CAGAGCAGCT TTGCCACCGG 
CTTATGGACC ATGGGATCAT CCAGCATGTG TCTAACAAGC ACCCGTTTGT GGACAGCAAC 
CTCCTCTACC AGTTCAGAAT GAACTTCCGT CGGAGGCGGA GGCTGATGGA GCTGCTCAAT 
GAGACGTCCC CGTCCTCTCA GGAGACGCAT GACAGTCCCT TCTGTCTGAG GAAGCAGAGC 
CACGACAGTC GGAAATCTAC CAGCTTTATG TCAGTCAGCC CCAGCAAGGA GATCAAGATC 
GTGTCTGCCG TGCGGAGGAG CAGCATGAGC AGCTGCGGCA GCAGTGGCTA CTTCAGCAGC 
AGCCCCACAC TCAGCAGCAG CCCCCCTGTG CTCTGCAACC CCAAATCTGT GCTGAAGAGA 
CCTGTCACTT CTGAGGAACT CTTGACTCCG GGGGCTCCGT ACGCAAGGAA GACATTCACG 
ATTGTTGGTG ACGCAGTTGG CTGGGGCTTT GTGGTACGAG GAAGTAAACC ATGCCACATC 
CAGGCTGTGG ACCCCAGTGG ACCTGCAGCC GCTGCAGGGA TGAAGGTCTG TCAGTTTGTC 
GTCTCTGTCA ATGGCCTCAA CGTGCTGAAT GTAGACTACC GCACCGTGAG CAATCTGATT 
CTGACAGGCC CAAGGACAAT TGTCATGGAA GTCATGGAGG AGTTGGACTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033026.1
CDS	40..1233
Translation	MKQAFLVVLRHSISEDRLPPLSVITSGCRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFALDSEVKAFMRGQRLYEKLMSPETTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMDHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNETSPSSQETHDSPFCLRKQSHDSRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLNVDYRTVSNLILTGPRTIVMEVMEELDC

Target ORF information:

RefSeq Version	NM_001037937.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037937.3

ORF Insert Sequence:

ATGAAACAAG CCTTCCTGGT GGTTCTCAGG CATTCTATCT CTGAGGATCG ACTTCCTCCT 
CTGAGTGTAA TAACCTCAGG CTGCAGGCTG CGGCTCCATG AAGAAAAGGT TATTAAAGAT 
AGACGGCACC ATCTCAAAAC CTACCCAAAC TGCTTTGTTG CAAAAGAGCT GATTGACTGG 
CTCATTGAAC ATAAGGAGGC CTCTGACCGA GAGACGGCGA TAAAACTCAT GCAGAAATTA 
GCCGACCGGG GCATCATTCA TCACGTGTGT GATGAGCACA AGGAATTCAA GGATGTAAAA 
CTCTTCTACC GCTTTAGGAA GGATGATGGG ACCTTTGCAC TGGACAGTGA GGTGAAGGCC 
TTCATGAGAG GACAGAGGCT CTATGAAAAA CTGATGAGCC CTGAAACTAC ACTCCTCCAG 
CCTAGAGAGG AGGAGGGGGT GAAGTATGAG CGGACCTTCA TGGCATCCGA ATTCCTGGAC 
TGGTTGGTTC AGGAAGGTGA AGCCACAACA AGGAAAGAGG CAGAGCAGCT TTGCCACCGG 
CTTATGGACC ATGGGATCAT CCAGCATGTG TCTAACAAGC ACCCGTTTGT GGACAGCAAC 
CTCCTCTACC AGTTCAGAAT GAACTTCCGT CGGAGGCGGA GGCTGATGGA GCTGCTCAAT 
GAGACGTCCC CGTCCTCTCA GGAGACGCAT GACAGTCCCT TCTGTCTGAG GAAGCAGAGC 
CACGACAGTC GGAAATCTAC CAGCTTTATG TCAGTCAGCC CCAGCAAGGA GATCAAGATC 
GTGTCTGCCG TGCGGAGGAG CAGCATGAGC AGCTGCGGCA GCAGTGGCTA CTTCAGCAGC 
AGCCCCACAC TCAGCAGCAG CCCCCCTGTG CTCTGCAACC CCAAATCTGT GCTGAAGAGA 
CCTGTCACTT CTGAGGAACT CTTGACTCCG GGGGCTCCGT ACGCAAGGAA GACATTCACG 
ATTGTTGGTG ACGCAGTTGG CTGGGGCTTT GTGGTACGAG GAAGTAAACC ATGCCACATC 
CAGGCTGTGG ACCCCAGTGG ACCTGCAGCC GCTGCAGGGA TGAAGGTCTG TCAGTTTGTC 
GTCTCTGTCA ATGGCCTCAA CGTGCTGAAT GTAGACTACC GCACCGTGAG CAATCTGATT 
CTGACAGGCC CAAGGACAAT TGTCATGGAA GTCATGGAGG AGTTGGACTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Deptor ( NM_145470.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663445.2 Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu11633
Clone ID Related Accession (Same CDS sequence)	NM_145470.3
Accession Version	NM_145470.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-09
Organism	Mus musculus(house mouse)
Product	DEP domain-containing mTOR-interacting protein isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124659.10, DV649395.1 and AK220300.1. On Oct 18, 2013 this sequence version replaced NM_145470.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004774.1, AK220300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGAGG GCAGCAGCGG CGGCAGTGGT AGCAGCGACA GCAACGCCGG CGGGAGCGGC 
GGGGTGCAGC AGAGAGAGCT GGAACGCATG GCTGAAGTCC TAGTTACGGG AGAGCAGCTC 
CGGCTGCGGC TCCATGAAGA AAAGGTTATT AAAGATAGAC GGCACCATCT CAAAACCTAC 
CCAAACTGCT TTGTTGCAAA AGAGCTGATT GACTGGCTCA TTGAACATAA GGAGGCCTCT 
GACCGAGAGA CGGCGATAAA ACTCATGCAG AAATTAGCCG ACCGGGGCAT CATTCATCAC 
GTGTGTGATG AGCACAAGGA ATTCAAGGAT GTAAAACTCT TCTACCGCTT TAGGAAGGAT 
GATGGGACCT TTGCACTGGA CAGTGAGGTG AAGGCCTTCA TGAGAGGACA GAGGCTCTAT 
GAAAAACTGA TGAGCCCTGA AACTACACTC CTCCAGCCTA GAGAGGAGGA GGGGGTGAAG 
TATGAGCGGA CCTTCATGGC ATCCGAATTC CTGGACTGGT TGGTTCAGGA AGGTGAAGCC 
ACAACAAGGA AAGAGGCAGA GCAGCTTTGC CACCGGCTTA TGGACCATGG GATCATCCAG 
CATGTGTCTA ACAAGCACCC GTTTGTGGAC AGCAACCTCC TCTACCAGTT CAGAATGAAC 
TTCCGTCGGA GGCGGAGGCT GATGGAGCTG CTCAATGAGA CGTCCCCGTC CTCTCAGGAG 
ACGCATGACA GTCCCTTCTG TCTGAGGAAG CAGAGCCACG ACAGTCGGAA ATCTACCAGC 
TTTATGTCAG TCAGCCCCAG CAAGGAGATC AAGATCGTGT CTGCCGTGCG GAGGAGCAGC 
ATGAGCAGCT GCGGCAGCAG TGGCTACTTC AGCAGCAGCC CCACACTCAG CAGCAGCCCC 
CCTGTGCTCT GCAACCCCAA ATCTGTGCTG AAGAGACCTG TCACTTCTGA GGAACTCTTG 
ACTCCGGGGG CTCCGTACGC AAGGAAGACA TTCACGATTG TTGGTGACGC AGTTGGCTGG 
GGCTTTGTGG TACGAGGAAG TAAACCATGC CACATCCAGG CTGTGGACCC CAGTGGACCT 
GCAGCCGCTG CAGGGATGAA GGTCTGTCAG TTTGTCGTCT CTGTCAATGG CCTCAACGTG 
CTGAATGTAG ACTACCGCAC CGTGAGCAAT CTGATTCTGA CAGGCCCAAG GACAATTGTC 
ATGGAAGTCA TGGAGGAGTT GGACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663445.2
CDS	182..1411
Translation	MEEGSSGGSGSSDSNAGGSGGVQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFALDSEVKAFMRGQRLYEKLMSPETTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMDHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNETSPSSQETHDSPFCLRKQSHDSRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLNVDYRTVSNLILTGPRTIVMEVMEELDC

Target ORF information:

RefSeq Version	NM_145470.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus DEP domain containing MTOR-interacting protein (Deptor), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145470.3

ORF Insert Sequence:

ATGGAAGAGG GCAGCAGCGG CGGCAGTGGT AGCAGCGACA GCAACGCCGG CGGGAGCGGC 
GGGGTGCAGC AGAGAGAGCT GGAACGCATG GCTGAAGTCC TAGTTACGGG AGAGCAGCTC 
CGGCTGCGGC TCCATGAAGA AAAGGTTATT AAAGATAGAC GGCACCATCT CAAAACCTAC 
CCAAACTGCT TTGTTGCAAA AGAGCTGATT GACTGGCTCA TTGAACATAA GGAGGCCTCT 
GACCGAGAGA CGGCGATAAA ACTCATGCAG AAATTAGCCG ACCGGGGCAT CATTCATCAC 
GTGTGTGATG AGCACAAGGA ATTCAAGGAT GTAAAACTCT TCTACCGCTT TAGGAAGGAT 
GATGGGACCT TTGCACTGGA CAGTGAGGTG AAGGCCTTCA TGAGAGGACA GAGGCTCTAT 
GAAAAACTGA TGAGCCCTGA AACTACACTC CTCCAGCCTA GAGAGGAGGA GGGGGTGAAG 
TATGAGCGGA CCTTCATGGC ATCCGAATTC CTGGACTGGT TGGTTCAGGA AGGTGAAGCC 
ACAACAAGGA AAGAGGCAGA GCAGCTTTGC CACCGGCTTA TGGACCATGG GATCATCCAG 
CATGTGTCTA ACAAGCACCC GTTTGTGGAC AGCAACCTCC TCTACCAGTT CAGAATGAAC 
TTCCGTCGGA GGCGGAGGCT GATGGAGCTG CTCAATGAGA CGTCCCCGTC CTCTCAGGAG 
ACGCATGACA GTCCCTTCTG TCTGAGGAAG CAGAGCCACG ACAGTCGGAA ATCTACCAGC 
TTTATGTCAG TCAGCCCCAG CAAGGAGATC AAGATCGTGT CTGCCGTGCG GAGGAGCAGC 
ATGAGCAGCT GCGGCAGCAG TGGCTACTTC AGCAGCAGCC CCACACTCAG CAGCAGCCCC 
CCTGTGCTCT GCAACCCCAA ATCTGTGCTG AAGAGACCTG TCACTTCTGA GGAACTCTTG 
ACTCCGGGGG CTCCGTACGC AAGGAAGACA TTCACGATTG TTGGTGACGC AGTTGGCTGG 
GGCTTTGTGG TACGAGGAAG TAAACCATGC CACATCCAGG CTGTGGACCC CAGTGGACCT 
GCAGCCGCTG CAGGGATGAA GGTCTGTCAG TTTGTCGTCT CTGTCAATGG CCTCAACGTG 
CTGAATGTAG ACTACCGCAC CGTGAGCAAT CTGATTCTGA CAGGCCCAAG GACAATTGTC 
ATGGAAGTCA TGGAGGAGTT GGACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of hepatic DEPTOR alters the metabolic transition to fasting.
Molecular metabolism6(5)447-458(2017 May)
Caron A,Mouchiroud M,Gautier N,Labb? SM,Villot R,Turcotte L,Secco B,Lamoureux G,Shum M,G?linas Y,Marette A,Richard D,Sabatini DM,Laplante M

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Deptor cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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