Hmgb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hmgb2
Entrez Gene ID	97165
Full Name	high mobility group box 2
Synonyms	C80539,HMG-2,Hmg2
General protein information	Preferred Names high mobility group box 2 Names high mobility group protein B2 high mobility group protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B2\|8 29.9 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008252.3	NP_032278.1	high mobility group protein B2
NM_001363445.1	NP_001350374.1	high mobility group protein B2
XM_006509524.2	XP_006509587.1	high mobility group protein B2 isoform X1
NM_001363444.1	NP_001350373.1	high mobility group protein B2
NM_001363443.1	NP_001350372.1	high mobility group protein B2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hmgb2	NP_032278.1
Danio rerio (zebrafish)	hmgb2a	NP_001032501.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000005	XP_311155.4
Caenorhabditis elegans (roundworm)	hmg-1.2	NP_001022600.1
Bos taurus (cattle)	HMGB2	NP_001032705.1
Gallus gallus (chicken)	HMGB2	NP_990817.1
Drosophila melanogaster (fruit fly)	Dsp1	NP_001138203.1
Canis lupus familiaris (dog)	HMGB2	XP_543194.2
Homo sapiens (human)	HMGB2	NP_002120.1
Pan troglodytes (chimpanzee)	HMGB2	XP_517538.3
	LOC697057	XP_001085665.1

Gene Ontology
Bibliography

Related articles in PubMed

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells.
Kimura A, Matsuda T, Sakai A, Murao N, Nakashima K
Developmental dynamics : an official publication of the American Association of Anatomists247(1)229-238(2018 Jan)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.
He YH, Wang XQ, Zhang J, Liu ZH, Pan WQ, Shen Y, Zhu ZB, Wang LJ, Yan XX, Yang K, Zhang RY, Shen WF, Ding FH, Lu L
Arteriosclerosis, thrombosis, and vascular biology37(4)717-729(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation.
Title: Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.

these results highlight the previously undiscovered and crucial role of the HMGB2-IGF2BP2 axis in myogenesis and muscle regeneration.
Title: HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2.

data demonstrate a reciprocal relationship between Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression.
Title: Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.

Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1.
Title: Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.

HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation.
Title: Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2.

The following Hmgb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hmgb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18217	NM_001363443.1 Latest version!	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu18217	NM_001363445.1 Latest version!	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu18217	NM_008252.3 Latest version!	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu18217	NM_001363444.1 Latest version!	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu18217	XM_006509524.2 Latest version!	Mus musculus high mobility group box 2 (Hmgb2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hmgb2 ( NM_008252.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032278.1 Mus musculus high mobility group box 2 (Hmgb2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18217
Clone ID Related Accession (Same CDS sequence)	NM_008252.3 , NM_001363445.1 , XM_006509524.2 , NM_001363444.1 , NM_001363443.1
Accession Version	NM_008252.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	high mobility group protein B2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY009449.1, AK012568.1, AK135297.1 and BX516410.1. On May 7, 2009 this sequence version replaced NM_008252.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 4 variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK135296.1, AK012568.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032278.1
CDS	188..820
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE

Target ORF information:

RefSeq Version	NM_008252.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008252.3

ORF Insert Sequence:

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hmgb2 ( NM_001363445.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350374.1 Mus musculus high mobility group box 2 (Hmgb2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18217
Clone ID Related Accession (Same CDS sequence)	NM_008252.3 , NM_001363445.1 , XM_006509524.2 , NM_001363444.1 , NM_001363443.1
Accession Version	NM_001363445.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	high mobility group protein B2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC130841.4. Transcript Variant: This variant (1) represents the longest transcript. All 4 variants encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK135296.1, AK008443.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350374.1
CDS	248..880
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE

Target ORF information:

RefSeq Version	NM_001363445.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363445.1

ORF Insert Sequence:

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hmgb2 ( NM_001363444.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350373.1 Mus musculus high mobility group box 2 (Hmgb2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu18217
Clone ID Related Accession (Same CDS sequence)	NM_008252.3 , NM_001363445.1 , XM_006509524.2 , NM_001363444.1 , NM_001363443.1
Accession Version	NM_001363444.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	high mobility group protein B2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC130841.4 and CN455823.1. On May 18, 2018 this sequence version replaced XM_006509524.2. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 4 variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU514342.1, CA979920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350373.1
CDS	184..816
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE

Target ORF information:

RefSeq Version	NM_001363444.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363444.1

ORF Insert Sequence:

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hmgb2 ( NM_001363443.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350372.1 Mus musculus high mobility group box 2 (Hmgb2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu18217
Clone ID Related Accession (Same CDS sequence)	NM_008252.3 , NM_001363445.1 , XM_006509524.2 , NM_001363444.1 , NM_001363443.1
Accession Version	NM_001363443.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	high mobility group protein B2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC130841.4. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 4 variants encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI111842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350372.1
CDS	189..821
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE

Target ORF information:

RefSeq Version	NM_001363443.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group box 2 (Hmgb2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363443.1

ORF Insert Sequence:

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hmgb2 ( XM_006509524.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006509587.1 Mus musculus high mobility group box 2 (Hmgb2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu18217
Clone ID Related Accession (Same CDS sequence)	NM_008252.3 , NM_001363445.1 , XM_006509524.2 , NM_001363444.1 , NM_001363443.1
Accession Version	XM_006509524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	high mobility group protein B2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006509524.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006509587.1
CDS	179..811
Translation	MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE

Target ORF information:

RefSeq Version	XM_006509524.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus high mobility group box 2 (Hmgb2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509524.2

ORF Insert Sequence:

ATGGGCAAGG GTGACCCCAA CAAGCCGCGG GGCAAAATGT CCTCGTACGC CTTCTTCGTG 
CAGACCTGCC GCGAGGAGCA CAAGAAGAAG CATCCCGACT CGTCGGTGAA CTTCGCCGAG 
TTCTCCAAGA AATGCTCCGA GAGATGGAAG ACCATGTCTG CAAAGGAAAA GTCCAAGTTT 
GAAGATTTGG CCAAGAGCGA CAAAGCTCGT TATGACAGGG AGATGAAGAA CTATGTTCCT 
CCCAAAGGGG ATAAGAAAGG AAAGAAAAAA GACCCCAATG CTCCGAAGAG ACCACCGTCT 
GCCTTCTTCC TGTTTTGCTC TGAAAATCGC CCAAAGATCA AAATTGAACA CCCAGGCCTG 
TCTATTGGAG ATACTGCGAA GAAACTGGGT GAGATGTGGT CTGAGCAATC TGCCAAAGAT 
AAACAACCGT ATGAGCAGAA AGCAGCTAAA CTAAAGGAGA AGTATGAAAA GGATATTGCT 
GCATACCGTG CCAAGGGCAA AAGTGAAGCA GGAAAGAAGG GTCCTGGTAG GCCAACAGGC 
TCAAAGAAGA AGAACGAACC AGAAGATGAG GAGGAGGAAG AAGAGGAGGA AGAGGAGGAA 
GATGACGAGG AAGAAGAGGA GGATGAAGAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells.
Developmental dynamics : an official publication of the American Association of Anatomists247(1)229-238(2018 Jan)
Kimura A,Matsuda T,Sakai A,Murao N,Nakashima K

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.
Arteriosclerosis, thrombosis, and vascular biology37(4)717-729(2017 Apr)
He YH,Wang XQ,Zhang J,Liu ZH,Pan WQ,Shen Y,Zhu ZB,Wang LJ,Yan XX,Yang K,Zhang RY,Shen WF,Ding FH,Lu L

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Hmgb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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