Tprn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tprn
Entrez Gene ID	97031
Full Name	taperin
Synonyms	C430004E15Rik,C87750
General protein information	Preferred Names taperin Names taperin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_175286.4	NP_780495.2	taperin

Pathways from BioSystems

Homologies

	LOC721581	XP_001117763.1
Bos taurus (cattle)	TPRN	NP_001096820.2
Rattus norvegicus (Norway rat)	Tprn	NP_001019480.2
Xenopus tropicalis (tropical clawed frog)	LOC101731408	XP_004917615.1
Homo sapiens (human)	TPRN	NP_001121700.2
Gallus gallus (chicken)	TPRN	XP_415534.4
Mus musculus (house mouse)	Tprn	NP_780495.2

Gene Ontology
Bibliography

Related articles in PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.
Chen M, Wang Q, Zhu GH, Hu P, Zhou Y, Wang T, Lai RS, Xiao ZA, Xie DH
Biochemical and biophysical research communications479(4)703-707(2016 Oct)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
Zhao B, Wu Z, M?ller U
eLife5(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

taperin plays an important role in maintenance of hair cell stereocilia.
Title: Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.

The following Tprn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tprn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21494	NM_175286.4 Latest version!	Mus musculus taperin (Tprn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tprn ( NM_175286.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780495.2 Mus musculus taperin (Tprn), mRNA.

Price & Availability↑

CloneID	OMu21494
Clone ID Related Accession (Same CDS sequence)	NM_175286.4
Accession Version	NM_175286.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-14
Organism	Mus musculus(house mouse)
Product	taperin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL732309.9, AK082888.1 and AI842038.1. On Jun 11, 2008 this sequence version replaced NM_175286.3. Sequence Note: The RefSeq transcript and protein were derived from genomic and transcript sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC089508.1, AK171799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGCC TGGGGCGGCT CGACCCGGGG CCGCGAACCG TGATGCCCGC CTGGAAACGG 
GAGATCCTTG AGCGGAGGCG AGCTAAACTG GCCGCCCTGA GCGGAGGCCA GGGATCTGGA 
GCGGCGCCGG ATGGGCCTAA CGAGCGGCTG GTGCTGGCCG AGAGTCTGGG TCCACTAAGC 
CAGAACCCGT TCATGCGACT TGAGTCGGAG CGGCGGCGCG GGACGCGGCC CGCTCAGCAG 
CTGCTGGAGC TGTACTGTCG CGTGCCCGGC GTGCGGACCA TTCGAGCGGA CAACATCCTC 
ATCATCGAGT CAGCGCCAGG CTTCCCACCC GCTGTGCCGC CCGCTGCGGG CATCCGCGCT 
GCCGAGGTAG TAGTGTACGA GGCGCCACAG CCCGGCCGTG TCAGCCGCCT GCTGGAAAAG 
TTCGACTCGC CTGCTGCGCC CTGCCGCCGC GGGAGCCCAG AGCGCTTCCG CCCTGCGCTC 
CCGCAGCTTC CCGTGGCGTC TGCATCTGCT GCCACGCGCA CTCCTACCAA TCGGTCGTTG 
GCTCCTGCCT CACCGGTGCG CCTCAGCCAG CCCGCACCCC CTATTTCGCC TGTCCCCGTT 
GCCCAGCGCG CGGGTCAGCG CTCTGCCTGT TGCGAGCCCG CGCACCCCGA CGGCACTGCC 
GGCCCCGGGG CCCGGCGCAG CGACTTTTTA CAGAAGACCG GCAGCAACTC TTTCACTGTT 
CACCCCCGGG GCCTGCCCCG CAGTGCGGTC AATCGCTCGC TTTCTAATGG ACCCATGACT 
CAGGAATCCC CTACCGGCCC TGCCAATGGG TTGTCAGGCT CTCCGCCTGT ACCGGGAAAG 
TGGAAGCCAA AGGTGGAGTC AAAGGAACCC TCTCTCCACC CGCCCCCAAG CCCTGGGACT 
CCAAGTGCCA CTTCAGTTGG GCCCCCTGCC TTCCCAGCGC CCAGCCCAGC CAGTGCCACT 
CCCAGTCAGC GCCAGTGGGT CTCCTCTGCC ACCAGCGCCA ATGATTCCTT TGAAATAAGG 
CCATCCTCCA AGCCAGACAT GGAAACTATC CCAATCGGGG ACCTTCAGGC CAGGGCCCTG 
GCCAACCTCC GAGTGAACTC CCGCAACTCC TTCGTGTTGA TCCCCAAGCG CAAAGCCCCT 
GGGAACTATC CTTTGGCGGG GAGGCAATTT GAGGAGCCAA AGGGGGAGGT GGGCTGGGCC 
TCTCAGAGCC AGGGGCTCGG ATCCCAGCTG GTGTCTACAG TGGATGGTGC ACCTGCCCTA 
GAGAAGAGTC CCTTGGCTGC TGAGATGCAG TGGGCAGTTA GGAAGGGGGC CTGCCCCAGG 
CCAGCAATTT CTGACACAGA CAAGTGTGTT AGGTGGCAGA GACCAGCCTC GCCACCTCCA 
TTTCTACCAG CCACAGCTGA AGCTGAGCCG GCTGAAGGCT TGGGGGTTCC TGGCTTGGCC 
AAGAATGGCC AGGAGCCTGT GAGGCCAGGA CTTCCAGTCA CCTTCATTGA TGAAGTAGAC 
TCAGAGGAGG AGGCCTTTCA AGAAGCCAAA CTGCCCTCCT CAGCAGTTGG TGTGCCTTCC 
CAGTACCACC TGCACCCTGC CAGGCCTGGA CACACCTCAG AACTCCTGAA CCGAGGTAGC 
AACACTTTCA CAGTAGTGCC CAAGAGAAAG CCAGGGACCC TTCAGGAGCC ACACTTAAGT 
CAGACCAATG GTCAGTCCCA GCAAGGGGCA GAGGAACAGG ATGCTGAGAG CCTCTCAGGA 
CCCCATACTA CCCTGGAGAA CACCCTAAAG AAACGATACC CCACTGTGCA CGAGATTGAG 
GTGATTGGTG GTTACCTGGC CCTGCAGAAG TCCTGCCTCA TCAAAGCTGG CTCCTCGAGA 
AAAAAGATGA AGATCTCCTT CAATGACAAG AGCCTGCATA CAACATTTGA GTACCCTTCT 
GAGAGCTCTC TGGCACAGGA AGAGGCGGAG GAGGAGGAGG AGGAGGAAGG AGAGGAAGAT 
GGTGAAGAGG AGGAAGTGGG GCCTGACTCA GAGAAACCCT TCACAGTTTT CTTGCCCCGG 
GCCACATTTG TAAGCAGTGT GGGACCTGAG AGCAGCTCAG GTCTGTCCAG CTACACTCCA 
AAGCATTCCA TGGCCTTCAG CAAGTGGCAG GAACAGACAC TGGTGCAGAC TCCAACTGAT 
GTGGAGCTCC CACCGAAGGA GGTCATGCTC ACACCTGCCA GTCAGAACGA CCTCTCGGAC 
TTCCGCAGCG AGCCAGCCCT CTATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780495.2
CDS	91..2340
Translation	MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF

Target ORF information:

RefSeq Version	NM_175286.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus taperin (Tprn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175286.4

ORF Insert Sequence:

ATGGCCGGCC TGGGGCGGCT CGACCCGGGG CCGCGAACCG TGATGCCCGC CTGGAAACGG 
GAGATCCTTG AGCGGAGGCG AGCTAAACTG GCCGCCCTGA GCGGAGGCCA GGGATCTGGA 
GCGGCGCCGG ATGGGCCTAA CGAGCGGCTG GTGCTGGCCG AGAGTCTGGG TCCACTAAGC 
CAGAACCCGT TCATGCGACT TGAGTCGGAG CGGCGGCGCG GGACGCGGCC CGCTCAGCAG 
CTGCTGGAGC TGTACTGTCG CGTGCCCGGC GTGCGGACCA TTCGAGCGGA CAACATCCTC 
ATCATCGAGT CAGCGCCAGG CTTCCCACCC GCTGTGCCGC CCGCTGCGGG CATCCGCGCT 
GCCGAGGTAG TAGTGTACGA GGCGCCACAG CCCGGCCGTG TCAGCCGCCT GCTGGAAAAG 
TTCGACTCGC CTGCTGCGCC CTGCCGCCGC GGGAGCCCAG AGCGCTTCCG CCCTGCGCTC 
CCGCAGCTTC CCGTGGCGTC TGCATCTGCT GCCACGCGCA CTCCTACCAA TCGGTCGTTG 
GCTCCTGCCT CACCGGTGCG CCTCAGCCAG CCCGCACCCC CTATTTCGCC TGTCCCCGTT 
GCCCAGCGCG CGGGTCAGCG CTCTGCCTGT TGCGAGCCCG CGCACCCCGA CGGCACTGCC 
GGCCCCGGGG CCCGGCGCAG CGACTTTTTA CAGAAGACCG GCAGCAACTC TTTCACTGTT 
CACCCCCGGG GCCTGCCCCG CAGTGCGGTC AATCGCTCGC TTTCTAATGG ACCCATGACT 
CAGGAATCCC CTACCGGCCC TGCCAATGGG TTGTCAGGCT CTCCGCCTGT ACCGGGAAAG 
TGGAAGCCAA AGGTGGAGTC AAAGGAACCC TCTCTCCACC CGCCCCCAAG CCCTGGGACT 
CCAAGTGCCA CTTCAGTTGG GCCCCCTGCC TTCCCAGCGC CCAGCCCAGC CAGTGCCACT 
CCCAGTCAGC GCCAGTGGGT CTCCTCTGCC ACCAGCGCCA ATGATTCCTT TGAAATAAGG 
CCATCCTCCA AGCCAGACAT GGAAACTATC CCAATCGGGG ACCTTCAGGC CAGGGCCCTG 
GCCAACCTCC GAGTGAACTC CCGCAACTCC TTCGTGTTGA TCCCCAAGCG CAAAGCCCCT 
GGGAACTATC CTTTGGCGGG GAGGCAATTT GAGGAGCCAA AGGGGGAGGT GGGCTGGGCC 
TCTCAGAGCC AGGGGCTCGG ATCCCAGCTG GTGTCTACAG TGGATGGTGC ACCTGCCCTA 
GAGAAGAGTC CCTTGGCTGC TGAGATGCAG TGGGCAGTTA GGAAGGGGGC CTGCCCCAGG 
CCAGCAATTT CTGACACAGA CAAGTGTGTT AGGTGGCAGA GACCAGCCTC GCCACCTCCA 
TTTCTACCAG CCACAGCTGA AGCTGAGCCG GCTGAAGGCT TGGGGGTTCC TGGCTTGGCC 
AAGAATGGCC AGGAGCCTGT GAGGCCAGGA CTTCCAGTCA CCTTCATTGA TGAAGTAGAC 
TCAGAGGAGG AGGCCTTTCA AGAAGCCAAA CTGCCCTCCT CAGCAGTTGG TGTGCCTTCC 
CAGTACCACC TGCACCCTGC CAGGCCTGGA CACACCTCAG AACTCCTGAA CCGAGGTAGC 
AACACTTTCA CAGTAGTGCC CAAGAGAAAG CCAGGGACCC TTCAGGAGCC ACACTTAAGT 
CAGACCAATG GTCAGTCCCA GCAAGGGGCA GAGGAACAGG ATGCTGAGAG CCTCTCAGGA 
CCCCATACTA CCCTGGAGAA CACCCTAAAG AAACGATACC CCACTGTGCA CGAGATTGAG 
GTGATTGGTG GTTACCTGGC CCTGCAGAAG TCCTGCCTCA TCAAAGCTGG CTCCTCGAGA 
AAAAAGATGA AGATCTCCTT CAATGACAAG AGCCTGCATA CAACATTTGA GTACCCTTCT 
GAGAGCTCTC TGGCACAGGA AGAGGCGGAG GAGGAGGAGG AGGAGGAAGG AGAGGAAGAT 
GGTGAAGAGG AGGAAGTGGG GCCTGACTCA GAGAAACCCT TCACAGTTTT CTTGCCCCGG 
GCCACATTTG TAAGCAGTGT GGGACCTGAG AGCAGCTCAG GTCTGTCCAG CTACACTCCA 
AAGCATTCCA TGGCCTTCAG CAAGTGGCAG GAACAGACAC TGGTGCAGAC TCCAACTGAT 
GTGGAGCTCC CACCGAAGGA GGTCATGCTC ACACCTGCCA GTCAGAACGA CCTCTCGGAC 
TTCCGCAGCG AGCCAGCCCT CTATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.
Biochemical and biophysical research communications479(4)703-707(2016 Oct)
Chen M,Wang Q,Zhu GH,Hu P,Zhou Y,Wang T,Lai RS,Xiao ZA,Xie DH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
eLife5(2016 06)
Zhao B,Wu Z,M?ller U

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Tprn cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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