Ptges2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptges2
Entrez Gene ID	96979
Full Name	prostaglandin E synthase 2
Synonyms	0610038H10Rik,C79137,Gbf1,Mpges2,Pges2
General protein information	Preferred Names prostaglandin E synthase 2 Names prostaglandin E synthase 2 GATE-binding factor 1 mPGES-2 microsomal prostaglandin E synthase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 B
Summary	The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133783.2	NP_598544.2	prostaglandin E synthase 2

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004992	XP_315097.4
Pan troglodytes (chimpanzee)	PTGES2	NP_001233456.1
	PTGES2	XP_001091842.2
Canis lupus familiaris (dog)	PTGES2	NP_001124522.1
Caenorhabditis elegans (roundworm)	R11A8.5	NP_501913.1
Mus musculus (house mouse)	Ptges2	NP_598544.2
Rattus norvegicus (Norway rat)	Ptges2	NP_001101302.1
Gallus gallus (chicken)	PTGES2	XP_415498.1
Arabidopsis thaliana (thale cress)	AT5G42150	NP_199030.1
Danio rerio (zebrafish)	ptgesl	NP_956574.1
Drosophila melanogaster (fruit fly)	Su(P)	NP_524116.2
Oryza sativa (rice)	Os04g0244400	NP_001052302.1
Xenopus tropicalis (tropical clawed frog)	ptges2	XP_002935550.1
Homo sapiens (human)	PTGES2	NP_079348.1
Bos taurus (cattle)	PTGES2	NP_001160026.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.
Zhang MZ, Yao B, Wang Y, Yang S, Wang S, Fan X, Harris RC
The Journal of clinical investigation125(11)4281-94(2015 Nov)

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.
Ma X, Aoki T, Tsuruyama T, Narumiya S
Cancer research75(14)2822-32(2015 Jul)

mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2.
Sun Y, Jia Z, Yang G, Kakizoe Y, Liu M, Yang KT, Liu Y, Yang B, Yang T
Journal of hepatology61(6)1328-1336(2014 Dec)

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M
Nature immunology14(6)554-63(2013 Jun)

MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2.
Matysiak M, Fortak-Michalska M, Szymanska B, Orlowski W, Jurewicz A, Selmaj K
Journal of immunology (Baltimore, Md. : 1950)190(10)5102-9(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mPGES-2 deletion enhanced streptozotocin (STZ)-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus in mice.
Title: mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2.

increased expression of miR-146a in bone marrow-derived mesenchymal stem cells correlated with inhibition of prostaglandin E2 synthase-2 and inhibition of prostaglandin E2 release.
Title: MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2.

PGE(2) protects the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation
Title: Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.

This article reviews the involvement of the PGE(2), Wnt, and BMP pathways in the development of gastric cancer.
Title: Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models.

Analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase.
Title: Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.

The following Ptges2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptges2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10215	NM_133783.2 Latest version!	Mus musculus prostaglandin E synthase 2 (Ptges2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptges2 ( NM_133783.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598544.2 Mus musculus prostaglandin E synthase 2 (Ptges2), mRNA.

Price & Availability↑

CloneID	OMu10215
Clone ID Related Accession (Same CDS sequence)	NM_133783.2
Accession Version	NM_133783.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	prostaglandin E synthase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX221758.1, AK050616.1 and BE956255.1. On Oct 8, 2009 this sequence version replaced NM_133783.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004846.1, AK050616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGG CGGCGCGCCT TTCGTGGGTG CTTGTCTCTA GCCGGTGCGC CCTGACTGAG 
GGGCTGCTCA CACGACCCTG GCAGCCGCTC TCGGCACAGA GCCGGGCTGG CTTCACCAGG 
GTGGCTGCCG GAAGCCGGGG CGCCGCGGTC CGCAAGGGGA GCCCGCGGTT GCTGGGGGCG 
GCGGCGCTGG CCCTGGGCGG CGCGCTGGGG CTGTACCACA CCGTGCGGTG GCACCAGCGT 
TCCCAGGACC TCCGCGCGGA GCGCTCGGCT GCGCAGCTGC CCCTGTCGAA CAGCCTGCAG 
CTGACCCTGT ACCAGTACAA GACATGTCCC TTCTGCAGCA AAGTCCGTGC CTTCCTCGAC 
TTCCACTCCC TGCCCTATCA GGTGGTGGAG GTGAATCCCG TGAGAAGGAC TGAGATCAAA 
TTCTCCTCCT ACAGGAAAGT GCCCATCTTG GTGGCCCAGG AAGGAGACAG CTTGCAACAG 
CTCAATGACT CCTCTGTCAT CATTAGTGCC CTCAAGACCT ACCTGGTTTC AGGGCAGCCC 
CTGGAAGAGG TCATCACTTA TTACCCACCC ATGAAGGCCA TGAATGACCA GGGCAAGGAG 
GTGACCGAGT TTTGCAACAA GTACTGGCTC ATGCTGGACG AGAAGGAGGC CCAGCAGATG 
TATGGCGGGA AGGAAGCCAG GACGGAGGAG ATGAAGTGGC GGCAGTGGGC GGATGACTGG 
CTGGTGCATC TCATCTCTCC CAACGTGTAC CGAACACCCG CTGAGGCCTT GGCTTCCTTC 
GACTACATTG TCCGTGAGGG CAAGTTTGGG GCTGTGGAGG CTGCCATGGC CAAGTATGTG 
GGCGCGGCTG CCATGTACCT CATCAGCAAG CGCCTCAAAA GCAGGCACCA CCTGCAGGAT 
GATGTACGGG TAGACCTCTA TGAAGCAGCC AACAAGTGGG TGACAGCCGT GGGTAAAGAC 
CGGCCATTCA TGGGGGGTCA GAAGCCTAAC CTTGCTGACC TGGCAGTGTA TGGTGTGCTG 
CGAGTGATGG AGGGTCTGGA GGCCTTCGAC GACCTGATGC GACACTCACA CATCCAGCCT 
TGGTACCTGC GGATGGAGCG GGCCATTGAA GAAGCCCCCT CGGTGCATCA TGTCAACCCT 
AGCTGCAAAG ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598544.2
CDS	386..1540
Translation	MAQAARLSWVLVSSRCALTEGLLTRPWQPLSAQSRAGFTRVAAGSRGAAVRKGSPRLLGAAALALGGALGLYHTVRWHQRSQDLRAERSAAQLPLSNSLQLTLYQYKTCPFCSKVRAFLDFHSLPYQVVEVNPVRRTEIKFSSYRKVPILVAQEGDSLQQLNDSSVIISALKTYLVSGQPLEEVITYYPPMKAMNDQGKEVTEFCNKYWLMLDEKEAQQMYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPAEALASFDYIVREGKFGAVEAAMAKYVGAAAMYLISKRLKSRHHLQDDVRVDLYEAANKWVTAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLEAFDDLMRHSHIQPWYLRMERAIEEAPSVHHVNPSCKD

Target ORF information:

RefSeq Version	NM_133783.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus prostaglandin E synthase 2 (Ptges2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133783.2

ORF Insert Sequence:

ATGGCCCAGG CGGCGCGCCT TTCGTGGGTG CTTGTCTCTA GCCGGTGCGC CCTGACTGAG 
GGGCTGCTCA CACGACCCTG GCAGCCGCTC TCGGCACAGA GCCGGGCTGG CTTCACCAGG 
GTGGCTGCCG GAAGCCGGGG CGCCGCGGTC CGCAAGGGGA GCCCGCGGTT GCTGGGGGCG 
GCGGCGCTGG CCCTGGGCGG CGCGCTGGGG CTGTACCACA CCGTGCGGTG GCACCAGCGT 
TCCCAGGACC TCCGCGCGGA GCGCTCGGCT GCGCAGCTGC CCCTGTCGAA CAGCCTGCAG 
CTGACCCTGT ACCAGTACAA GACATGTCCC TTCTGCAGCA AAGTCCGTGC CTTCCTCGAC 
TTCCACTCCC TGCCCTATCA GGTGGTGGAG GTGAATCCCG TGAGAAGGAC TGAGATCAAA 
TTCTCCTCCT ACAGGAAAGT GCCCATCTTG GTGGCCCAGG AAGGAGACAG CTTGCAACAG 
CTCAATGACT CCTCTGTCAT CATTAGTGCC CTCAAGACCT ACCTGGTTTC AGGGCAGCCC 
CTGGAAGAGG TCATCACTTA TTACCCACCC ATGAAGGCCA TGAATGACCA GGGCAAGGAG 
GTGACCGAGT TTTGCAACAA GTACTGGCTC ATGCTGGACG AGAAGGAGGC CCAGCAGATG 
TATGGCGGGA AGGAAGCCAG GACGGAGGAG ATGAAGTGGC GGCAGTGGGC GGATGACTGG 
CTGGTGCATC TCATCTCTCC CAACGTGTAC CGAACACCCG CTGAGGCCTT GGCTTCCTTC 
GACTACATTG TCCGTGAGGG CAAGTTTGGG GCTGTGGAGG CTGCCATGGC CAAGTATGTG 
GGCGCGGCTG CCATGTACCT CATCAGCAAG CGCCTCAAAA GCAGGCACCA CCTGCAGGAT 
GATGTACGGG TAGACCTCTA TGAAGCAGCC AACAAGTGGG TGACAGCCGT GGGTAAAGAC 
CGGCCATTCA TGGGGGGTCA GAAGCCTAAC CTTGCTGACC TGGCAGTGTA TGGTGTGCTG 
CGAGTGATGG AGGGTCTGGA GGCCTTCGAC GACCTGATGC GACACTCACA CATCCAGCCT 
TGGTACCTGC GGATGGAGCG GGCCATTGAA GAAGCCCCCT CGGTGCATCA TGTCAACCCT 
AGCTGCAAAG ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension.
The Journal of clinical investigation125(11)4281-94(2015 Nov)
Zhang MZ,Yao B,Wang Y,Yang S,Wang S,Fan X,Harris RC

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.
Cancer research75(14)2822-32(2015 Jul)
Ma X,Aoki T,Tsuruyama T,Narumiya S

mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2.
Journal of hepatology61(6)1328-1336(2014 Dec)
Sun Y,Jia Z,Yang G,Kakizoe Y,Liu M,Yang KT,Liu Y,Yang B,Yang T

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nature immunology14(6)554-63(2013 Jun)
Taketomi Y,Ueno N,Kojima T,Sato H,Murase R,Yamamoto K,Tanaka S,Sakanaka M,Nakamura M,Nishito Y,Kawana M,Kambe N,Ikeda K,Taguchi R,Nakamizo S,Kabashima K,Gelb MH,Arita M,Yokomizo T,Nakamura M,Watanabe K,Hirai H,Nakamura M,Okayama Y,Ra C,Aritake K,Urade Y,Morimoto K,Sugimoto Y,Shimizu T,Narumiya S,Hara S,Murakami M

MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2.
Journal of immunology (Baltimore, Md. : 1950)190(10)5102-9(2013 May)
Matysiak M,Fortak-Michalska M,Szymanska B,Orlowski W,Jurewicz A,Selmaj K

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Ptges2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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