S1pr5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	S1pr5
Entrez Gene ID	94226
Full Name	sphingosine-1-phosphate receptor 5
Synonyms	Edg8,S1P5,lpB4
General protein information	Preferred Names sphingosine-1-phosphate receptor 5 Names sphingosine 1-phosphate receptor 5 S1P receptor 5 S1P receptor Edg-8 endothelial differentiation G-protein-coupled receptor 8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 lysophospholipid receptor B4 sphingosine 1-phosphate receptor Edg-8 sphingosine-1-phosphate receptor LPB4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_053190.2	NP_444420.1	sphingosine 1-phosphate receptor 5

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	S1PR5	XP_003316134.1
Bos taurus (cattle)	S1PR5	NP_001179404.1
	S1PR5	XP_001101585.2
Canis lupus familiaris (dog)	S1PR5	XP_005632952.1
Mus musculus (house mouse)	S1pr5	NP_444420.1
Danio rerio (zebrafish)	s1pr5b	NP_001073124.1
Homo sapiens (human)	S1PR5	NP_001159687.1
Rattus norvegicus (Norway rat)	S1pr5	NP_068543.2

Gene Ontology
Bibliography

Related articles in PubMed

Sphingosine 1-phosphate signaling through its receptor S1P
Andrieu G, Ledoux A, Branka S, Bocquet M, Gilhodes J, Walzer T, Kasahara K, Inagaki M, Sabbadini RA, Cuvillier O, Hatzoglou A
Science signaling10(472)(2017 Mar)

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-? response.
Fang V, Chaluvadi VS, Ramos-Perez WD, Mendoza A, Baeyens A, Rivera R, Chun J, Cammer M, Schwab SR
Nature immunology18(1)15-25(2017 Jan)

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Phillips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD
Cell reports16(10)2666-2685(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reduced frequency of patrolling monocytes in bone marrow of KO mice
Title: S1PR5 is pivotal for the homeostasis of patrolling monocytes.

Coordinated changes in CXCR4 and S1P5 responsiveness govern NK-cell trafficking.
Title: Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.

Fndings suggest that S1P(5) may mediate the effects of S1P in terms of regulating ERK-1/2 signaling in ES cells.
Title: Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.

These findings identify S1P5 as a T-bet-induced gene that is required for natural killer cell egress from lymph nodes and bone marrow.
Title: T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.

KLF2 regulates T cell homeostasis at least partly by controlling CD62L and S1P1 expression, and therefore T cell egress from the thymus and circulation in the periphery.
Title: Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription.

The following S1pr5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1pr5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09329	NM_053190.2 Latest version!	Mus musculus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S1pr5 ( NM_053190.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444420.1 Mus musculus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA.

Price & Availability↑

CloneID	OMu09329
Clone ID Related Accession (Same CDS sequence)	NM_053190.2
Accession Version	NM_053190.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	sphingosine 1-phosphate receptor 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY736639.1, AK081126.1, AI848371.1 and AI852113.1. On Nov 15, 2007 this sequence version replaced NM_053190.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY736639.1, BI329992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCG GGCTGCTGCG GCCGGCGCCG GTGAGTGAGG TTATTGTCCT TCACTACAAC 
TACACCGGCA AGCTCCGCGG GGCGCGCTAC CAGCCCGGCG CCGGCCTGCG CGCAGACGCC 
GCAGTGTGTC TGGCTGTGTG TGCCTTCATT GTGCTGGAGA ACTTGGCTGT GCTCTTGGTG 
CTGGTCCGCC ACCCTCGCTT CCATGCGCCC ATGTTTCTGC TCCTTGGCAG CCTCACTTTG 
TCGGACCTGC TCGCCGGGGC GGCCTACGCC ACCAACATCC TACTGTCCGG GCCGCTCACG 
CTGCGCCTGT CGCCTGCGCT TTGGTTTGCG CGTGAGGGGG GCGTCTTCGT GGCGCTCGCC 
GCGTCGGTGC TGAGCCTCTT GGCCATTGCT TTAGAGCGCC ACCTTACCAT GGCCCGTCGT 
GGACCCGCAC CCGCCGCCAG TCGCGCTCGC ACGCTGGCGA TGGCGGTGGC CGCCTGGGGC 
GCGTCGCTAT TGCTCGGGCT GCTACCCGCG CTGGGCTGGA ACTGCTTAGG ACGCCTGGAA 
ACCTGCTCCA CCGTGCTGCC GCTCTACGCC AAGGCCTATG TGCTCTTCTG CGTGCTGGCC 
TTCCTGGGCA TCCTGGCTGC CATCTGTGCG CTCTATGCAA GGATTTACTG TCAGGTGCGG 
GCCAACGCGC GTCGCCTGCG GGCGGGTCCT GGGTCCCGCA GGGCCACCTC GTCCTCGCGA 
TCCCGGCACA CGCCGCGGTC GCTGGCCCTG CTTCGTACCC TTAGCGTGGT GCTCCTGGCC 
TTCGTGGCCT GCTGGGGACC GCTGTTTCTC TTGCTATTAC TGGATGTCGC GTGCCCAGCC 
CGCGCGTGTC CCGTGCTCCT GCAGGCCGAT CCCTTCCTGG GTCTAGCCAT GGCTAACTCG 
CTGCTGAATC CCATCATCTA CACCTTCACC AACCGAGATC TGCGCCACGC GCTCCTGCGG 
CTGCTCTGCT GTGGCCGCGG ACCCTGCAAC CAAGACTCCT CCAACAGCTT GCAGCGATCC 
CCCAGTGCTG CCGGGCCTTC CGGTGGTGGC CTGCGACGCT GCCTGCCACC AACCTTGGAT 
CGCAGCTCTA GCCCATCAGA ACACTTGTCT CCCCAGCAGG ACGGGGTGGA CACCAGCTGC 
TCCACCGGCA GTCCTGGAGT AGCAACCGCC AACCGGAGCC TGGTGCCTAC TGCTACAGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444420.1
CDS	284..1486
Translation	MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLVLVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALAASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWGASLLLGLLPALGWNCLGRLETCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAAGPSGGGLRRCLPPTLDRSSSPSEHLSPQQDGVDTSCSTGSPGVATANRSLVPTATD

Target ORF information:

RefSeq Version	NM_053190.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053190.2

ORF Insert Sequence:

ATGGAGCCCG GGCTGCTGCG GCCGGCGCCG GTGAGTGAGG TTATTGTCCT TCACTACAAC 
TACACCGGCA AGCTCCGCGG GGCGCGCTAC CAGCCCGGCG CCGGCCTGCG CGCAGACGCC 
GCAGTGTGTC TGGCTGTGTG TGCCTTCATT GTGCTGGAGA ACTTGGCTGT GCTCTTGGTG 
CTGGTCCGCC ACCCTCGCTT CCATGCGCCC ATGTTTCTGC TCCTTGGCAG CCTCACTTTG 
TCGGACCTGC TCGCCGGGGC GGCCTACGCC ACCAACATCC TACTGTCCGG GCCGCTCACG 
CTGCGCCTGT CGCCTGCGCT TTGGTTTGCG CGTGAGGGGG GCGTCTTCGT GGCGCTCGCC 
GCGTCGGTGC TGAGCCTCTT GGCCATTGCT TTAGAGCGCC ACCTTACCAT GGCCCGTCGT 
GGACCCGCAC CCGCCGCCAG TCGCGCTCGC ACGCTGGCGA TGGCGGTGGC CGCCTGGGGC 
GCGTCGCTAT TGCTCGGGCT GCTACCCGCG CTGGGCTGGA ACTGCTTAGG ACGCCTGGAA 
ACCTGCTCCA CCGTGCTGCC GCTCTACGCC AAGGCCTATG TGCTCTTCTG CGTGCTGGCC 
TTCCTGGGCA TCCTGGCTGC CATCTGTGCG CTCTATGCAA GGATTTACTG TCAGGTGCGG 
GCCAACGCGC GTCGCCTGCG GGCGGGTCCT GGGTCCCGCA GGGCCACCTC GTCCTCGCGA 
TCCCGGCACA CGCCGCGGTC GCTGGCCCTG CTTCGTACCC TTAGCGTGGT GCTCCTGGCC 
TTCGTGGCCT GCTGGGGACC GCTGTTTCTC TTGCTATTAC TGGATGTCGC GTGCCCAGCC 
CGCGCGTGTC CCGTGCTCCT GCAGGCCGAT CCCTTCCTGG GTCTAGCCAT GGCTAACTCG 
CTGCTGAATC CCATCATCTA CACCTTCACC AACCGAGATC TGCGCCACGC GCTCCTGCGG 
CTGCTCTGCT GTGGCCGCGG ACCCTGCAAC CAAGACTCCT CCAACAGCTT GCAGCGATCC 
CCCAGTGCTG CCGGGCCTTC CGGTGGTGGC CTGCGACGCT GCCTGCCACC AACCTTGGAT 
CGCAGCTCTA GCCCATCAGA ACACTTGTCT CCCCAGCAGG ACGGGGTGGA CACCAGCTGC 
TCCACCGGCA GTCCTGGAGT AGCAACCGCC AACCGGAGCC TGGTGCCTAC TGCTACAGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sphingosine 1-phosphate signaling through its receptor S1P
Science signaling10(472)(2017 Mar)
Andrieu G,Ledoux A,Branka S,Bocquet M,Gilhodes J,Walzer T,Kasahara K,Inagaki M,Sabbadini RA,Cuvillier O,Hatzoglou A

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-? response.
Nature immunology18(1)15-25(2017 Jan)
Fang V,Chaluvadi VS,Ramos-Perez WD,Mendoza A,Baeyens A,Rivera R,Chun J,Cammer M,Schwab SR

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Cell reports16(10)2666-2685(2016 09)
Kennedy AJ,Rahn EJ,Paulukaitis BS,Savell KE,Kordasiewicz HB,Wang J,Lewis JW,Posey J,Strange SK,Guzman-Karlsson MC,Phillips SE,Decker K,Motley ST,Swayze EE,Ecker DJ,Michael TP,Day JJ,Sweatt JD

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S1pr5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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