Hrg cDNA ORF clone, Mus musculus(house mouse)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with ?2 integrin.
Roche F, Sipil? K, Honjo S, Johansson S, Tugues S, Heino J, Claesson-Welsh L
Matrix biology : journal of the International Society for Matrix Biology4889-99(2015 Oct)

The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perovi?-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C
International journal of cancer136(11)2693-704(2015 Jun)

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.
Vu TT, Zhou J, Leslie BA, Stafford AR, Fredenburgh JC, Ni R, Qiao S, Vaezzadeh N, Jahnen-Dechent W, Monia BP, Gross PL, Weitz JI
Blood125(17)2712-9(2015 Apr)

Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes.
Tugues S, Roche F, Noguer O, Orlova A, Bhoi S, Padhan N, Akerud P, Honjo S, Selvaraju RK, Mazzone M, Tolmachev V, Claesson-Welsh L
PloS one9(9)e107483(2014)

HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.
Title: Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with ?2 integrin.

Results show that HRG is a novel transcriptional target gene of FXR in human hepatoma cells, human upcyteVR primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo.
Title: The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.

Mice deficient in HRG have normal hemostasis, but demonstrate accelerated thrombosis via the contact system.
Title: Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.

mononuclear phagocytes have specific binding sites for HRG and that these cells are essential for uptake of HRG from blood and distribution of HRG in tissues. Thus, inflammatory cells mediate the effect of HRG on tumor growth and metastatic spread.
Title: Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes.

HRG-deficiency promotes tumor progression via enhanced platelet activity. HRG is a potent tumor suppressor, with capacity to attenuate the angiogenic switch, tumor growth, EMT and subsequent metastatic spread, by regulating platelet activity.
Title: HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment.