Gabarapl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabarapl2
Entrez Gene ID	93739
Full Name	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
Synonyms	0610012F20Rik,2900019O08Rik,AI173605,GATE-16,Gef2
General protein information	Preferred Names gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 Names gamma-aminobutyric acid receptor-associated protein-like 2 GABA(A) receptor-associated protein like 2 ganglioside expression factor 2 golgi-associated ATPase enhancer of 16 kDa
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_026693.5	NP_080969.2	gamma-aminobutyric acid receptor-associated protein-like 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	GABARAPL2	NP_009216.1
Pan troglodytes (chimpanzee)	GABARAPL2	XP_511114.4
Gallus gallus (chicken)	GABARAPL2	XP_001232689.1
Xenopus tropicalis (tropical clawed frog)	gabarapl2	NP_001096511.1
Canis lupus familiaris (dog)	GABARAPL2	XP_005620731.1
Bos taurus (cattle)	GABARAPL2	NP_777100.1
Rattus norvegicus (Norway rat)	Gabarapl2	NP_073197.1
Arabidopsis thaliana (thale cress)	APG8A	NP_001078424.1
Danio rerio (zebrafish)	gabarapl2	NP_991286.1
Arabidopsis thaliana (thale cress)	ATG8B	NP_849298.1
	GABARAPL2	XP_001104154.2
Mus musculus (house mouse)	Gabarapl2	NP_080969.2

Gene Ontology
Bibliography

Related articles in PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M
Nature immunology18(8)899-910(2017 Aug)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
Itoh T, Kanno E, Uemura T, Waguri S, Fukuda M
The Journal of cell biology192(5)839-53(2011 Mar)

Autophagy is essential for mouse sense of balance.
Mari?o G, Fern?ndez AF, Cabrera S, Lundberg YW, Cabanillas R, Rodr?guez F, Salvador-Montoliu N, Vega JA, German? A, Fueyo A, Freije JM, L?pez-Ot?n C
The Journal of clinical investigation120(7)2331-44(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. Gate-16 specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform distribution of interferon-inducible GTPases. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases.
Title: Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

The following Gabarapl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabarapl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02842	NM_026693.5 Latest version!	Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 (Gabarapl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabarapl2 ( NM_026693.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080969.2 Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 (Gabarapl2), mRNA.

Price & Availability↑

CloneID	OMu02842
Clone ID Related Accession (Same CDS sequence)	NM_026693.5
Accession Version	NM_026693.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Mus musculus(house mouse)
Product	gamma-aminobutyric acid receptor-associated protein-like 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK134873.1, BC081436.1 and AI845404.1. On Nov 30, 2011 this sequence version replaced NM_026693.4. ##Evidence-Data-START## Transcript exon combination :: AF190644.1, AK134873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGTGGA TGTTTAAGGA GGACCACTCT CTGGAACACA GATGCGTGGA ATCCGCGAAG 
ATCAGAGCGA AGTACCCCGA CCGAGTTCCG GTGATCGTGG AAAAAGTCTC GGGCTCTCAG 
ATTGTTGACA TAGACAAGAG GAAGTACTTG GTCCCCTCGG ACATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCCTCCGAGA AGGCCATCTT CCTGTTTGTG 
GACAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTGTATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080969.2
CDS	117..470
Translation	MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF

Target ORF information:

RefSeq Version	NM_026693.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 (Gabarapl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026693.5

ORF Insert Sequence:

ATGAAGTGGA TGTTTAAGGA GGACCACTCT CTGGAACACA GATGCGTGGA ATCCGCGAAG 
ATCAGAGCGA AGTACCCCGA CCGAGTTCCG GTGATCGTGG AAAAAGTCTC GGGCTCTCAG 
ATTGTTGACA TAGACAAGAG GAAGTACTTG GTCCCCTCGG ACATCACTGT GGCTCAGTTC 
ATGTGGATCA TCAGGAAAAG GATCCAGCTT CCCTCCGAGA AGGCCATCTT CCTGTTTGTG 
GACAAGACAG TCCCACAGTC CAGCCTAACT ATGGGACAGC TTTACGAGAA GGAAAAAGAT 
GAAGATGGAT TCTTGTATGT GGCCTACAGC GGAGAGAACA CTTTTGGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Nature immunology18(8)899-910(2017 Aug)
Sasai M,Sakaguchi N,Ma JS,Nakamura S,Kawabata T,Bando H,Lee Y,Saitoh T,Akira S,Iwasaki A,Standley DM,Yoshimori T,Yamamoto M

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
The Journal of cell biology192(5)839-53(2011 Mar)
Itoh T,Kanno E,Uemura T,Waguri S,Fukuda M

Autophagy is essential for mouse sense of balance.
The Journal of clinical investigation120(7)2331-44(2010 Jul)
Mari?o G,Fern?ndez AF,Cabrera S,Lundberg YW,Cabanillas R,Rodr?guez F,Salvador-Montoliu N,Vega JA,German? A,Fueyo A,Freije JM,L?pez-Ot?n C

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Gabarapl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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