Clec2d cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clec2d
Entrez Gene ID	93694
Full Name	C-type lectin domain family 2, member d
Synonyms	Clr-b,Clrb,Ocil
General protein information	Preferred Names C-type lectin domain family 2, member d Names C-type lectin domain family 2 member D C-type lectin-domain family 2 member D C-type lectin-related protein B lectin-like transmembrane protein osteoclast inhibitory lectin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_053109.3	NP_444339.1	C-type lectin domain family 2 member D
XM_006506805.3	XP_006506868.1	C-type lectin domain family 2 member D isoform X1
XM_006506805.4	XP_006506868.1	C-type lectin domain family 2 member D isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Clec2i	NP_064653.1
Mus musculus (house mouse)	Clec2g	NP_001161695.1
Mus musculus (house mouse)	Clec2d	NP_444339.1

Gene Ontology
Bibliography

Related articles in PubMed

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popovi? B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpoti? A, Allan DSJ, Makrigiannis AP, Jonji? S, Rossjohn J, Carlyle JR
Cell169(1)58-71.e14(2017 Mar)

Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.
Kirkham CL, Aguilar OA, Yu T, Tanaka M, Mesci A, Chu KL, Fine JH, Mossman KL, Bremner R, Allan DSJ, Carlyle JR
Journal of innate immunity9(4)343-358(2017)

The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.
Rahim MM, Chen P, Mottashed AN, Mahmoud AB, Thomas MJ, Zhu Q, Brooks CG, Kartsogiannis V, Gillespie MT, Carlyle JR, Makrigiannis AP
Blood125(14)2217-27(2015 Apr)

Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.
Chen P, Aguilar OA, Rahim MM, Allan DS, Fine JH, Kirkham CL, Ma J, Tanaka M, Tu MM, Wight A, Kartsogiannis V, Gillespie MT, Makrigiannis AP, Carlyle JR
Journal of immunology (Baltimore, Md. : 1950)194(6)2909-18(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that killer cell lectin-like receptors NKR-P1B:Clr-b (Klrb1:Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Title: Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.

Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
Title: Poxvirus infection-associated downregulation of C-type lectin-related-b prevents NK cell inhibition by NK receptor protein-1B.

LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma contributes to modulate immune responses
Title: Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses.

PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2+)/CaMK II, and MAPK signaling pathways.
Title: Parathyroid hormone-related protein regulates osteoclast inhibitory lectin expression via multiple signaling pathways in osteoblast-like cells.

OCIL is a physiological negative regulator of bone.
Title: Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo.

The following Clec2d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec2d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09111	NM_053109.3 Latest version!	Mus musculus C-type lectin domain family 2, member d (Clec2d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu37696	XM_006506805.4 Latest version!	Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu37696	XM_006506805.3	Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clec2d ( XM_006506805.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506868.1 Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37696
Clone ID Related Accession (Same CDS sequence)	XM_006506805.3 , XM_006506805.4
Accession Version	XM_006506805.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 2 member D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006506805.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCTCA CTGTAGCTGT AATTGCTCTT TCTGTTGCTT TGTCAGCAAC AAAGACAGAA 
CAGATCCCAG TCAACAAGAC CTATGCTGCT TGCCCGCAAA ACTGGATTGG AGTTGAAAAT 
AAATGTTTTT ATTTTTCTGA ATACCCAAGT AACTGGACAT TCGCCCAGGC CTTCTGCATG 
GCACAAGAGG CCCAACTAGC TCGGTTTGAC AACCAGGATG AGCTGAATTT CCTAATGAGA 
TACAAGGCGA ATTTTGATTC CTGGATTGGC CTGCACAGAG AGTCGTCAGA GCACCCTTGG 
AAGTGGACAG ACAACACTGA GTATAACAAC ACGATTCCCA TCCGGGGAGA GGAAAGATTT 
GCCTACCTGA ACAACAACGG GATCAGCAGT ACCAGGATCT ATTCACTTCG GATGTGGATC 
TGTAGCAAGC TCAACAGCTA TAGCCTCCAC TGCCAAACTC CTTTTTTTCC TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506868.1
CDS	380..856
Translation	MVLTVAVIALSVALSATKTEQIPVNKTYAACPQNWIGVENKCFYFSEYPSNWTFAQAFCMAQEAQLARFDNQDELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNTIPIRGEERFAYLNNNGISSTRIYSLRMWICSKLNSYSLHCQTPFFPS

Target ORF information:

RefSeq Version	XM_006506805.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506805.3

ORF Insert Sequence:

ATGGTCCTCA CTGTAGCTGT AATTGCTCTT TCTGTTGCTT TGTCAGCAAC AAAGACAGAA 
CAGATCCCAG TCAACAAGAC CTATGCTGCT TGCCCGCAAA ACTGGATTGG AGTTGAAAAT 
AAATGTTTTT ATTTTTCTGA ATACCCAAGT AACTGGACAT TCGCCCAGGC CTTCTGCATG 
GCACAAGAGG CCCAACTAGC TCGGTTTGAC AACCAGGATG AGCTGAATTT CCTAATGAGA 
TACAAGGCGA ATTTTGATTC CTGGATTGGC CTGCACAGAG AGTCGTCAGA GCACCCTTGG 
AAGTGGACAG ACAACACTGA GTATAACAAC ACGATTCCCA TCCGGGGAGA GGAAAGATTT 
GCCTACCTGA ACAACAACGG GATCAGCAGT ACCAGGATCT ATTCACTTCG GATGTGGATC 
TGTAGCAAGC TCAACAGCTA TAGCCTCCAC TGCCAAACTC CTTTTTTTCC TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec2d ( NM_053109.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444339.1 Mus musculus C-type lectin domain family 2, member d (Clec2d), mRNA.

Price & Availability↑

CloneID	OMu09111
Clone ID Related Accession (Same CDS sequence)	NM_053109.3
Accession Version	NM_053109.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 2 member D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY320031.1 and AW987086.1. On Feb 18, 2011 this sequence version replaced NM_053109.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY320031.1, AF321553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTGTGTCA CAAAGGCTTC CCTACCTATG CTTAGTCCCA CAGGCAGCCC GCAGGAGGTA 
GAAGTGGGTA AAATTCTCCA AGGAAAAAGG CACGGAACCA TCTCCCCTGA GTCTTGTGCT 
AAGCTTTACT GCTACTATGG AGTGATCATG GTCCTCACTG TAGCTGTAAT TGCTCTTTCT 
GTTGCTTTGT CAGCAACAAA GACAGAACAG ATCCCAGTCA ACAAGACCTA TGCTGCTTGC 
CCGCAAAACT GGATTGGAGT TGAAAATAAA TGTTTTTATT TTTCTGAATA CCCAAGTAAC 
TGGACATTCG CCCAGGCCTT CTGCATGGCA CAAGAGGCCC AACTAGCTCG GTTTGACAAC 
CAGGATGAGC TGAATTTCCT AATGAGATAC AAGGCGAATT TTGATTCCTG GATTGGCCTG 
CACAGAGAGT CGTCAGAGCA CCCTTGGAAG TGGACAGACA ACACTGAGTA TAACAACACG 
ATTCCCATCC GGGGAGAGGA AAGATTTGCC TACCTGAACA ACAACGGGAT CAGCAGTACC 
AGGATCTATT CACTTCGGAT GTGGATCTGT AGCAAGCTCA ACAGCTATAG CCTCCACTGC 
CAAACTCCTT TTTTTCCTTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444339.1
CDS	67..690
Translation	MCVTKASLPMLSPTGSPQEVEVGKILQGKRHGTISPESCAKLYCYYGVIMVLTVAVIALSVALSATKTEQIPVNKTYAACPQNWIGVENKCFYFSEYPSNWTFAQAFCMAQEAQLARFDNQDELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNTIPIRGEERFAYLNNNGISSTRIYSLRMWICSKLNSYSLHCQTPFFPS

Target ORF information:

RefSeq Version	NM_053109.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 2, member d (Clec2d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053109.3

ORF Insert Sequence:

ATGTGTGTCA CAAAGGCTTC CCTACCTATG CTTAGTCCCA CAGGCAGCCC GCAGGAGGTA 
GAAGTGGGTA AAATTCTCCA AGGAAAAAGG CACGGAACCA TCTCCCCTGA GTCTTGTGCT 
AAGCTTTACT GCTACTATGG AGTGATCATG GTCCTCACTG TAGCTGTAAT TGCTCTTTCT 
GTTGCTTTGT CAGCAACAAA GACAGAACAG ATCCCAGTCA ACAAGACCTA TGCTGCTTGC 
CCGCAAAACT GGATTGGAGT TGAAAATAAA TGTTTTTATT TTTCTGAATA CCCAAGTAAC 
TGGACATTCG CCCAGGCCTT CTGCATGGCA CAAGAGGCCC AACTAGCTCG GTTTGACAAC 
CAGGATGAGC TGAATTTCCT AATGAGATAC AAGGCGAATT TTGATTCCTG GATTGGCCTG 
CACAGAGAGT CGTCAGAGCA CCCTTGGAAG TGGACAGACA ACACTGAGTA TAACAACACG 
ATTCCCATCC GGGGAGAGGA AAGATTTGCC TACCTGAACA ACAACGGGAT CAGCAGTACC 
AGGATCTATT CACTTCGGAT GTGGATCTGT AGCAAGCTCA ACAGCTATAG CCTCCACTGC 
CAAACTCCTT TTTTTCCTTC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec2d ( XM_006506805.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506868.1 Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37696
Clone ID Related Accession (Same CDS sequence)	XM_006506805.3 , XM_006506805.4
Accession Version	XM_006506805.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 2 member D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006506805.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCTCA CTGTAGCTGT AATTGCTCTT TCTGTTGCTT TGTCAGCAAC AAAGACAGAA 
CAGATCCCAG TCAACAAGAC CTATGCTGCT TGCCCGCAAA ACTGGATTGG AGTTGAAAAT 
AAATGTTTTT ATTTTTCTGA ATACCCAAGT AACTGGACAT TCGCCCAGGC CTTCTGCATG 
GCACAAGAGG CCCAACTAGC TCGGTTTGAC AACCAGGATG AGCTGAATTT CCTAATGAGA 
TACAAGGCGA ATTTTGATTC CTGGATTGGC CTGCACAGAG AGTCGTCAGA GCACCCTTGG 
AAGTGGACAG ACAACACTGA GTATAACAAC ACGATTCCCA TCCGGGGAGA GGAAAGATTT 
GCCTACCTGA ACAACAACGG GATCAGCAGT ACCAGGATCT ATTCACTTCG GATGTGGATC 
TGTAGCAAGC TCAACAGCTA TAGCCTCCAC TGCCAAACTC CTTTTTTTCC TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506868.1
CDS	377..853
Translation	MVLTVAVIALSVALSATKTEQIPVNKTYAACPQNWIGVENKCFYFSEYPSNWTFAQAFCMAQEAQLARFDNQDELNFLMRYKANFDSWIGLHRESSEHPWKWTDNTEYNNTIPIRGEERFAYLNNNGISSTRIYSLRMWICSKLNSYSLHCQTPFFPS

Target ORF information:

RefSeq Version	XM_006506805.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 2, member d (Clec2d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506805.4

ORF Insert Sequence:

ATGGTCCTCA CTGTAGCTGT AATTGCTCTT TCTGTTGCTT TGTCAGCAAC AAAGACAGAA 
CAGATCCCAG TCAACAAGAC CTATGCTGCT TGCCCGCAAA ACTGGATTGG AGTTGAAAAT 
AAATGTTTTT ATTTTTCTGA ATACCCAAGT AACTGGACAT TCGCCCAGGC CTTCTGCATG 
GCACAAGAGG CCCAACTAGC TCGGTTTGAC AACCAGGATG AGCTGAATTT CCTAATGAGA 
TACAAGGCGA ATTTTGATTC CTGGATTGGC CTGCACAGAG AGTCGTCAGA GCACCCTTGG 
AAGTGGACAG ACAACACTGA GTATAACAAC ACGATTCCCA TCCGGGGAGA GGAAAGATTT 
GCCTACCTGA ACAACAACGG GATCAGCAGT ACCAGGATCT ATTCACTTCG GATGTGGATC 
TGTAGCAAGC TCAACAGCTA TAGCCTCCAC TGCCAAACTC CTTTTTTTCC TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.
Cell169(1)58-71.e14(2017 Mar)
Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popovi? B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpoti? A,Allan DSJ,Makrigiannis AP,Jonji? S,Rossjohn J,Carlyle JR

Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.
Journal of innate immunity9(4)343-358(2017)
Kirkham CL,Aguilar OA,Yu T,Tanaka M,Mesci A,Chu KL,Fine JH,Mossman KL,Bremner R,Allan DSJ,Carlyle JR

The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.
Blood125(14)2217-27(2015 Apr)
Rahim MM,Chen P,Mottashed AN,Mahmoud AB,Thomas MJ,Zhu Q,Brooks CG,Kartsogiannis V,Gillespie MT,Carlyle JR,Makrigiannis AP

Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.
Journal of immunology (Baltimore, Md. : 1950)194(6)2909-18(2015 Mar)
Chen P,Aguilar OA,Rahim MM,Allan DS,Fine JH,Kirkham CL,Ma J,Tanaka M,Tu MM,Wight A,Kartsogiannis V,Gillespie MT,Makrigiannis AP,Carlyle JR

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Clec2d cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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