Glrx cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Glrx
Entrez Gene ID	93692
Full Name	glutaredoxin
Synonyms	C86710,D13Wsu156e,Glrx1,Grx1,TTase
General protein information	Preferred Names glutaredoxin Names glutaredoxin-1 TTase-1 glutaredoxin (thioltransferase) glutaredoxin 1 (thioltransferase) thioltransferase-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 C1\|13 40.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006517477.1	XP_006517540.1	glutaredoxin-1 isoform X1
NM_053108.4	NP_444338.2	glutaredoxin-1
NM_001360151.1	NP_001347080.1	glutaredoxin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GLRX	XP_851559.1
	GLRX	XP_001093482.1
Bos taurus (cattle)	LOC101902340	XP_005217293.1
Rattus norvegicus (Norway rat)	Glrx	NP_071614.1
Homo sapiens (human)	GLRX	NP_001230588.1
Pan troglodytes (chimpanzee)	GLRX	NP_001182153.1
Bos taurus (cattle)	LOC101904049	XP_005219631.1
Danio rerio (zebrafish)	glrx	NP_001005942.1
Xenopus tropicalis (tropical clawed frog)	glrx	NP_001016597.1
Bos taurus (cattle)	GLRX	NP_001032693.1
Bos taurus (cattle)	LOC101904371	XP_005219633.1
Mus musculus (house mouse)	Glrx	NP_444338.2
Gallus gallus (chicken)	GLRX	NP_990491.1
Caenorhabditis elegans (roundworm)	glrx-10	NP_490812.1

Gene Ontology
Bibliography

Related articles in PubMed

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation.
Stojkov D, Amini P, Oberson K, Sokollik C, Duppenthaler A, Simon HU, Yousefi S
The Journal of cell biology216(12)4073-4090(2017 Dec)

Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.
Li Y, Ren M, Wang X, Cui X, Zhao H, Zhao C, Zhou J, Guo Y, Hu Y, Yan C, Berk B, Wang J
Scientific reports7(1)15539(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Grx1 deficiency leads to eNOS dysfunction through oxidative modification of S-glutathionylation of eNOS (eNOS-SSG) and inactivation of NO production, enhancing the endothelial TLR4 activation, and ultimately exacerbating necrotizing enterocolitis severity.
Title: Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis.

Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin secretion, increase of reactive oxygen species (ROS) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.
Title: Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.

Our results indicate that Grx1 upregulation promotes neuroinflammation and consequent neuronal cell death in vitro, and synergizes with proinflammatory insults to promote DA loss in vivo.
Title: Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.

the Glrx1-Protein S-glutathionylation axis plays a pivotal role in house dust mite-induced allergic airways disease.
Title: Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

Glrx ablation stabilizes HIF-1alpha by increasing GSH adducts on Cys(520) promoting in vivo HIF-1alpha stabilization, VEGF-A production, and revascularization in the ischemic muscles.
Title: Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1? and improve limb revascularization.

The following Glrx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Glrx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19017	NM_001360151.1 Latest version!	Mus musculus glutaredoxin (Glrx), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu19017	NM_053108.4 Latest version!	Mus musculus glutaredoxin (Glrx), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu19017	XM_006517477.1 Latest version!	Mus musculus glutaredoxin (Glrx), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Glrx ( NM_053108.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444338.2 Mus musculus glutaredoxin (Glrx), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19017
Clone ID Related Accession (Same CDS sequence)	XM_006517477.1 , NM_053108.4 , NM_001360151.1
Accession Version	NM_053108.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	glutaredoxin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY272278.1, AK153086.1 and CO796000.1. On Apr 4, 2008 this sequence version replaced NM_053108.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054418.1, AF109314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444338.2
CDS	84..407
Translation	MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLEFVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQIGALQL

Target ORF information:

RefSeq Version	NM_053108.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin (Glrx), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053108.4

ORF Insert Sequence:

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx ( NM_001360151.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001347080.1 Mus musculus glutaredoxin (Glrx), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19017
Clone ID Related Accession (Same CDS sequence)	XM_006517477.1 , NM_053108.4 , NM_001360151.1
Accession Version	NM_001360151.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-26
Organism	Mus musculus(house mouse)
Product	glutaredoxin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT025556.12 and AC158356.2. On Jan 27, 2018 this sequence version replaced XM_006517477.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI659019.1, CA490095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347080.1
CDS	85..408
Translation	MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLEFVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQIGALQL

Target ORF information:

RefSeq Version	NM_001360151.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin (Glrx), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360151.1

ORF Insert Sequence:

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx ( XM_006517477.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006517540.1 Mus musculus glutaredoxin (Glrx), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19017
Clone ID Related Accession (Same CDS sequence)	XM_006517477.1 , NM_053108.4 , NM_001360151.1
Accession Version	XM_006517477.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	glutaredoxin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006517540.1
CDS	97..420
Translation	MAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLEFVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQIGALQL

Target ORF information:

RefSeq Version	XM_006517477.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin (Glrx), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006517477.1

ORF Insert Sequence:

ATGGCTCAGG AGTTTGTGAA CTGCAAGATC CAGTCTGGGA AGGTGGTCGT GTTCATCAAG 
CCCACCTGCC CCTACTGCAG AAAGACCCAA GAAATCCTCA GTCAACTGCC TTTCAAACAA 
GGTCTTCTGG AGTTTGTGGA CATCACAGCC ACTAACAACA CCAGTGCGAT TCAAGATTAT 
TTACAACAGC TCACCGGAGC GAGAACAGTT CCTCGGGTCT TCATAGGTAA AGACTGCATA 
GGCGGATGCA GTGATCTAAT CTCCATGCAA CAGACTGGGG AGCTGATGAC TCGGCTGAAG 
CAGATTGGAG CTCTGCAGTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation.
The Journal of cell biology216(12)4073-4090(2017 Dec)
Stojkov D,Amini P,Oberson K,Sokollik C,Duppenthaler A,Simon HU,Yousefi S

Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.
Scientific reports7(1)15539(2017 Nov)
Li Y,Ren M,Wang X,Cui X,Zhao H,Zhao C,Zhou J,Guo Y,Hu Y,Yan C,Berk B,Wang J

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Glrx cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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