Smarcd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Smarcd1
Entrez Gene ID	83797
Full Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms	AA407987,Baf60a,D15Kz1
General protein information	Preferred Names SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Names SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 60 kDa BRG-1/Brm-associated factor subunit A BRG1-associated factor 60A SWI/SNF complex 60 kDa subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F1\|15 56.13 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_031842.2	NP_114030.2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Smarcd1	NP_001102222.1
Gallus gallus (chicken)	SMARCD1	XP_424488.3
Drosophila melanogaster (fruit fly)	Bap60	NP_511143.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000923	XP_309104.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005336	XP_315349.3
Arabidopsis thaliana (thale cress)	CHC1	NP_196921.1
Arabidopsis thaliana (thale cress)	AT3G01890	NP_566154.2
Xenopus tropicalis (tropical clawed frog)	smarcd1	NP_001004862.1
Homo sapiens (human)	SMARCD1	NP_003067.3
Canis lupus familiaris (dog)	SMARCD1	XP_543674.3
Bos taurus (cattle)	SMARCD1	NP_001033648.1
Caenorhabditis elegans (roundworm)	swsn-2.2	NP_491329.2
Pan troglodytes (chimpanzee)	SMARCD1	XP_509054.3
Mus musculus (house mouse)	Smarcd1	NP_114030.2
Oryza sativa (rice)	Os04g0382100	NP_001052605.1
	LOC712130	XP_001111275.2
Danio rerio (zebrafish)	smarcd1	NP_938172.1
Caenorhabditis elegans (roundworm)	swsn-2.1	NP_499250.1

Gene Ontology
Bibliography

Related articles in PubMed

Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle.
Meng ZX, Tao W, Sun J, Wang Q, Mi L, Lin JD
Diabetes67(1)85-97(2018 Jan)

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.
Witzel M, Petersheim D, Fan Y, Bahrami E, Racek T, Rohlfs M, Pucha?ka J, Mertes C, Gagneur J, Ziegenhain C, Enard W, Stray-Pedersen A, Arkwright PD, Abboud MR, Pazhakh V, Lieschke GJ, Krawitz PM, Dahlhoff M, Schneider MR, Wolf E, Horny HP, Schmidt H, Sch?ffer AA, Klein C
Nature genetics49(5)742-752(2017 May)

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.
He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A
Development (Cambridge, England)143(11)1937-47(2016 06)

Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.
Nguyen H, Sokpor G, Pham L, Rosenbusch J, Stoykova A, Staiger JF, Tuoc T
Cell cycle (Georgetown, Tex.)15(10)1317-24(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

work revealed functional redundancy between Baf60a and Baf60c in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance. Unexpectedly, mice lacking these two factors in skeletal muscle were protected from diet-induced and age-associated metabolic disorders. Transcriptional profiling analysis identified the muscle thermogenic gene program and myokine secretion as key pathways that inte
Title: Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle.

Hepatocyte-specific inactivation of Baf60a reduced bile acid production.
Title: A Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and Atherosclerosis.

propose a role for SMARCD1 in restricting pluripotency and activating lineage pathways by regulating H3K27 methylation
Title: Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation.

hypermethylation-mediated silencing of miR-490-3p reactivates SMARCD1 to confer malignant phenotypes, mechanistically linking H. pylori, chromatin remodeling, and gastric carcinogenesis
Title: Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.

Tbx1 expression increases Baf60a occupation of the Wnt5a gene and enhances its H3K4 monomethylation status, while Baf60a knockdown abolishes the ability of Tbx1 to regulate Wnt5a and other target genes.
Title: Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a.

The following Smarcd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Smarcd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15150	NM_031842.2 Latest version!	Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (Smarcd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Smarcd1 ( NM_031842.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_114030.2 Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (Smarcd1), mRNA.

Price & Availability↑

CloneID	OMu15150
Clone ID Related Accession (Same CDS sequence)	NM_031842.2
Accession Version	NM_031842.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1548bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CV562378.1, BC079839.1, BC059921.1 and CX221058.1. On Feb 8, 2007 this sequence version replaced NM_031842.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059921.1, U66620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCC GGGCGGGTTT CCAGTCTGTG GCTCCGAGCG GCGGCGCGGG AGCCTCAGGA 
GGAGCGGGCG TGGCGGCTGC TCTGGGCCCG GGCGGAACTC CCGGGCCTCC CGTGCGAATG 
GGCCCGGCGC CGGGTCAAGG GCTGTACCGC TCTCCGATGC CCGGGGCGGC CTATCCGAGA 
CCAGGTATGC TGCCAGGTAG CCGAATGACA CCTCAGGGAC CTTCCATGGG ACCTCCTGGC 
TATGGGGGGA ACCCTTCAGT CCGACCTGGT CTGGCCCAGT CAGGGATGGA CCAGTCCCGC 
AAGAGACCTG CACCTCAACA GATCCAGCAG GTCCAGCAGC AGGCGGTCCA AAATCGAAAT 
CACAATGCAA AGAAAAAGAA GATGGCTGAC AAAATCCTAC CTCAAAGGAT TCGGGAACTG 
GTCCCAGAAT CACAGGCCTA CATGGATCTC CTGGCTTTTG AAAGGAAACT GGACCAGACT 
ATTATGAGGA AGCGGCTAGA TATCCAGGAG GCCTTGAAAC GTCCCATCAA GCAAAAACGG 
AAGCTGCGAA TTTTCATTTC TAACACGTTC AATCCGGCTA AGTCGGACGC GGAGGATGGG 
GAAGGGACGG TGGCTTCCTG GGAGCTCCGG GTAGAAGGCC GGCTCCTGGA GGACGCGGCC 
TTGTCCAAAT ATGACGCCAC CAAGCAAAAG AGAAAGTTCT CTTCCTTTTT TAAGTCCTTG 
GTGATCGAAC TGGACAAAGA CCTCTATGGC CCAGACAACC ATCTGGTAGA ATGGCACAGG 
ACCGCCACTA CCCAGGAGAC CGATGGCTTC CAGGTGAAGC GGCCAGGAGA TGTGAATGTA 
CGGTGTACTG TCCTGCTGAT GCTGGACTAC CAGCCCCCCC AGTTTAAATT AGACCCTCGC 
CTGGCTCGGC TCTTGGGCAT CCATACCCAG ACACGTCCAG TGATCATCCA AGCACTGTGG 
CAGTATATTA AAACACACAA GCTCCAGGAC CCTCACGAGC GAGAGTTTGT TCTCTGTGAC 
AAGTACCTCC AGCAGATCTT TGAATCTCAG CGGATGAAGT TCTCAGAGAT CCCTCAGCGG 
CTCCACGCCT TGCTTATGCC ACCAGAGCCC ATCATCATCA ATCATGTCAT CAGTGTGGAC 
CCAAATGACC AGAAAAAGAC CGCGTGCTAT GACATTGACG TGGAGGTGGA TGACACTCTG 
AAGACCCAGA TGAACTCTTT CCTGTTGTCC ACTGCCAGCC AGCAGGAGAT CGCCACTCTA 
GACAACAAGA TCCATGAGAC GATAGAGACC ATCAACCAGC TGAAGACCCA GCGAGAGTTC 
ATGTTGAGCT TTGCCCGAGA CCCTCAGGGT TTCATCAATG ATTGGCTTCA GTCCCAGTGC 
AGGGACCTCA AGACGATGAC TGATGTGGTG GGTAACCCGG AAGAGGAGCG TCGTGCTGAG 
TTCTACTTCC AGCCCTGGGC TCAGGAGGCT GTGTGCCGAT ACTTCTACTC CAAGGTGCAG 
CAGAGGCGGC AAGAGTTAGA GCAAGCCCTG GGAATCCGAA ACACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114030.2
CDS	36..1583
Translation	MAARAGFQSVAPSGGAGASGGAGVAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDAALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVLCDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT

Target ORF information:

RefSeq Version	NM_031842.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (Smarcd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031842.2

ORF Insert Sequence:

ATGGCGGCCC GGGCGGGTTT CCAGTCTGTG GCTCCGAGCG GCGGCGCGGG AGCCTCAGGA 
GGAGCGGGCG TGGCGGCTGC TCTGGGCCCG GGCGGAACTC CCGGGCCTCC CGTGCGAATG 
GGCCCGGCGC CGGGTCAAGG GCTGTACCGC TCTCCGATGC CCGGGGCGGC CTATCCGAGA 
CCAGGTATGC TGCCAGGTAG CCGAATGACA CCTCAGGGAC CTTCCATGGG ACCTCCTGGC 
TATGGGGGGA ACCCTTCAGT CCGACCTGGT CTGGCCCAGT CAGGGATGGA CCAGTCCCGC 
AAGAGACCTG CACCTCAACA GATCCAGCAG GTCCAGCAGC AGGCGGTCCA AAATCGAAAT 
CACAATGCAA AGAAAAAGAA GATGGCTGAC AAAATCCTAC CTCAAAGGAT TCGGGAACTG 
GTCCCAGAAT CACAGGCCTA CATGGATCTC CTGGCTTTTG AAAGGAAACT GGACCAGACT 
ATTATGAGGA AGCGGCTAGA TATCCAGGAG GCCTTGAAAC GTCCCATCAA GCAAAAACGG 
AAGCTGCGAA TTTTCATTTC TAACACGTTC AATCCGGCTA AGTCGGACGC GGAGGATGGG 
GAAGGGACGG TGGCTTCCTG GGAGCTCCGG GTAGAAGGCC GGCTCCTGGA GGACGCGGCC 
TTGTCCAAAT ATGACGCCAC CAAGCAAAAG AGAAAGTTCT CTTCCTTTTT TAAGTCCTTG 
GTGATCGAAC TGGACAAAGA CCTCTATGGC CCAGACAACC ATCTGGTAGA ATGGCACAGG 
ACCGCCACTA CCCAGGAGAC CGATGGCTTC CAGGTGAAGC GGCCAGGAGA TGTGAATGTA 
CGGTGTACTG TCCTGCTGAT GCTGGACTAC CAGCCCCCCC AGTTTAAATT AGACCCTCGC 
CTGGCTCGGC TCTTGGGCAT CCATACCCAG ACACGTCCAG TGATCATCCA AGCACTGTGG 
CAGTATATTA AAACACACAA GCTCCAGGAC CCTCACGAGC GAGAGTTTGT TCTCTGTGAC 
AAGTACCTCC AGCAGATCTT TGAATCTCAG CGGATGAAGT TCTCAGAGAT CCCTCAGCGG 
CTCCACGCCT TGCTTATGCC ACCAGAGCCC ATCATCATCA ATCATGTCAT CAGTGTGGAC 
CCAAATGACC AGAAAAAGAC CGCGTGCTAT GACATTGACG TGGAGGTGGA TGACACTCTG 
AAGACCCAGA TGAACTCTTT CCTGTTGTCC ACTGCCAGCC AGCAGGAGAT CGCCACTCTA 
GACAACAAGA TCCATGAGAC GATAGAGACC ATCAACCAGC TGAAGACCCA GCGAGAGTTC 
ATGTTGAGCT TTGCCCGAGA CCCTCAGGGT TTCATCAATG ATTGGCTTCA GTCCCAGTGC 
AGGGACCTCA AGACGATGAC TGATGTGGTG GGTAACCCGG AAGAGGAGCG TCGTGCTGAG 
TTCTACTTCC AGCCCTGGGC TCAGGAGGCT GTGTGCCGAT ACTTCTACTC CAAGGTGCAG 
CAGAGGCGGC AAGAGTTAGA GCAAGCCCTG GGAATCCGAA ACACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle.
Diabetes67(1)85-97(2018 Jan)
Meng ZX,Tao W,Sun J,Wang Q,Mi L,Lin JD

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.
Nature genetics49(5)742-752(2017 May)
Witzel M,Petersheim D,Fan Y,Bahrami E,Racek T,Rohlfs M,Pucha?ka J,Mertes C,Gagneur J,Ziegenhain C,Enard W,Stray-Pedersen A,Arkwright PD,Abboud MR,Pazhakh V,Lieschke GJ,Krawitz PM,Dahlhoff M,Schneider MR,Wolf E,Horny HP,Schmidt H,Sch?ffer AA,Klein C

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.
Development (Cambridge, England)143(11)1937-47(2016 06)
He S,Limi S,McGreal RS,Xie Q,Brennan LA,Kantorow WL,Kokavec J,Majumdar R,Hou H Jr,Edelmann W,Liu W,Ashery-Padan R,Zavadil J,Kantorow M,Skoultchi AI,Stopka T,Cvekl A

Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.
Cell cycle (Georgetown, Tex.)15(10)1317-24(2016 May)
Nguyen H,Sokpor G,Pham L,Rosenbusch J,Stoykova A,Staiger JF,Tuoc T

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Smarcd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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