Elovl4 cDNA ORF clone, Mus musculus(house mouse)

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse.
Schori C, Agbaga MP, Brush RS, Ayyagari R, Grimm C, Samardzija M
PloS one13(1)e0190514(2018)

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.
Hopiavuori BR, De?k F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP
Molecular neurobiology(2017 Nov)

Studies indicate that Knock-IN and Knock-OUT strains of ELOVL4 (STGD3) model development has been to unveil the causal connection between the genotype and early-onset progressive cone degeneration in humans.
Title: Mouse Models of Stargardt 3 Dominant Macular Degeneration.

ELOVL4 was strongly expressed within the holocrine meibomian and sebaceous glands but no ELOVL4 was detected within the central meibomian duct.
Title: A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biology.

expression and outer segment mislocalization of the disease-linked 5-base-pair deletion mutant ELOVL4 protein alters photoreceptor structure and function
Title: Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks.

To elucidate the role of VLC-PUFAs in photoreceptor terminals, we conditionally deleted Elovl4 in rod and cone photoreceptors of mice and measured inner retina function, synaptic connectivity, and ultrastructure of rod terminals with reduced VLC-PUFAs.
Title: Examination of VLC-PUFA-deficient photoreceptor terminals.

The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of very long chain-PUFA in the retinal phosphatidylcholine (PC) fraction compared to retinas from wild-type mice.
Title: Very long chain polyunsaturated fatty acids and rod cell structure and function.