Cstf2t cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cstf2t
Entrez Gene ID	83410
Full Name	cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms	64kDa,C77975,tCstF-64,tauCstF-64
General protein information	Preferred Names cleavage stimulation factor, 3' pre-RNA subunit 2, tau Names cleavage stimulation factor subunit 2 tau variant CF-1 64 kDa subunit, tau CSTF 64 kDa subunit, tau cleavage stimulation factor 64 kDa subunit, tau cleavage stimulation factor subunit 2 tau cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_031249.2	NP_112539.2	cleavage stimulation factor subunit 2 tau variant

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CSTF2T	XP_005636710.1
Rattus norvegicus (Norway rat)	Cstf2t	NP_001101056.1
Bos taurus (cattle)	CSTF2T	NP_001229511.1
Mus musculus (house mouse)	Cstf2t	NP_112539.2
Pan troglodytes (chimpanzee)	CSTF2T	XP_001163035.2
Homo sapiens (human)	CSTF2T	NP_056050.1
	CSTF2T	XP_001099871.1

Gene Ontology
Bibliography

Related articles in PubMed

TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
Grozdanov PN, Amatullah A, Graber JH, MacDonald CC
Biology of reproduction94(2)34(2016 Feb)

The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice.
Harris JC, Martinez JM, Grozdanov PN, Bergeson SE, Grammas P, MacDonald CC
PloS one11(11)e0165976(2016)

The ?CstF-64 polyadenylation protein controls genome expression in testis.
Li W, Yeh HJ, Shankarling GS, Ji Z, Tian B, MacDonald CC
PloS one7(10)e48373(2012)

Spermatogenetic but not immunological defects in mice lacking the ?CstF-64 polyadenylation protein.
Hockert KJ, Martincic K, Mendis-Handagama SM, Borghesi LA, Milcarek C, Dass B, MacDonald CC
Journal of reproductive immunology89(1)26-37(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice.
Title: TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.

Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice
Title: The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice.

The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes.
Title: The ?CstF-64 polyadenylation protein controls genome expression in testis.

primarily supports spermatogenesis, but only incidently supports immune cell function
Title: Spermatogenetic but not immunological defects in mice lacking the ?CstF-64 polyadenylation protein.

tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
Title: Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64.

The following Cstf2t gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cstf2t cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58358	NM_031249.2 Latest version!	Mus musculus cleavage stimulation factor, 3' pre-RNA subunit 2, tau (Cstf2t), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cstf2t ( NM_031249.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_112539.2 Mus musculus cleavage stimulation factor, 3' pre-RNA subunit 2, tau (Cstf2t), mRNA.

Price & Availability↑

CloneID	OMu58358
Clone ID Related Accession (Same CDS sequence)	NM_031249.2
Accession Version	NM_031249.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1899bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	cleavage stimulation factor subunit 2 tau variant
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ182579.1, AK082910.1 and BY637182.1. On May 23, 2007 this sequence version replaced NM_031249.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGTCGAGTT TGGCGGTCAG AGACCCAGCC ATGGATCGAT CGCTGCGTTC GGTGTTCGTG 
GGGAACATTC CGTATGAGGC GACGGAGGAG CAGTTAAAGG ACATTTTCTC AGAGGTTGGT 
TCAGTTGTCA GTTTCCGTCT CGTCTACGAT AGAGAGACTG GGAAGCCCAA GGGTTATGGC 
TTCTGCGAGT ACCAAGACCA GGAGACTGCG CTCAGTGCCA TGCGAAACCT CAATGGGCGA 
GAGTTTAGTG GGAGAGCGCT TCGGGTGGAC AATGCCGCCA GCGAAAAGAA CAAGGAGGAG 
TTAAAGAGCT TAGGCCCGGC GGCCCCCATC ATTGACTCCC CCTATGGGGA CCCTATCGAC 
CCAGAAGATG CTCCAGAATC GATTACTAGA GCAGTCGCCA GCTTGCCCCC AGAGCAGATG 
TTTGAGCTCA TGAAGCAGAT GAAGTTGTGT GTCCAGAACA GTCACCAGGA AGCTCGAAAC 
ATGCTACTTC AGAACCCACA GTTGGCGTAT GCTTTGCTGC AGGCACAAGT GGTGATGAGA 
ATCATGGATC CAGAGATTGC ACTGAAAATT TTGCATCGTA AGATACATGT CACACCACTG 
ATCCCAGGCA AATCTCAGCC GGTCTCTGGG CCTGGCCCTG GTGGGCCTGG GCCTAGTGGG 
CCTGGCGGCC CTGGCCCCGG CCCTGCCCCT GGCCTCTGCC CGGGACCTAA CGTCATGTTG 
AACCAACAGA ATCCTCCTGC CCCTCAGCCT CAGCATCTGC CAAGAAGACC TGTGAAGGAC 
ATTCCACCTC TGATGCAGAC CTCTATCCAG GGAGGAATTC CAGCTCCGGG GCCAATACCA 
GCTGCAGTTC CTGGACCTGG ACCTGGTTCC TTAACTCCAG GAGGAGCAAT GCAGCCACAA 
GTTGGCATGC CAGTGGTTGG TCCAGTGCCC CTGGAGCGAG GACAGATGCA GATATCAGAT 
CCTAGACCTC CGATGCCTCG TGGACCCATG CCTTCTGGTG GCATACCTCC TCGAGGACTA 
CTGGGAGATG CTCCAAATGA CCCACGTGGA GGGACTTTGC TCTCAGTGAC TGGAGAAGTA 
GAGCCCAGGG GCTATATGGG ACCACCCCAT CAGGGTCCTC CAATGCATCA TGGTCATGAC 
AACCGTGGCC CTGCCTCACA TGATATGAGA GGAGGACCAT TGGCAGCAGA TCCCAGAATG 
CTAATTGGAG AGCCCAGAGG TCCCATGATA GATCAGAGAG GTCTACCTAT GGATGGTAGA 
GGAGGTAGAG AATCTCGAGG GATGGAGACT CGGCCCATGG AAACTGAGGT CTTGGAGCCA 
CGAGGAATGG AGAGAAGGAT GGAGACCTGC GCGATGGAAA CCAGAGGCAT GGATGCAAGA 
GGACTAGAGA TGAGGGGCCC TGGCCCTAGT TCCAGAGGTC CGATGACTGG TGGAATCCAG 
GGTCCTGGCC CTATTAATAT GGGGGCAGGT GGCCCTCAGG GACCTAGACA GGTTCCAAAT 
ATTGCAGGAG TGGGAAATCC TGGAGGTACC ATGCAGGGGG CAGGTATACA AGGAGGAGGG 
ATGCAGGGAG CAGGTATGCA AGGAGGAGGG ATGCAAGGAG CAGGCATGCA AGGAGGAGGG 
ATGCAGGGAG CTGGCATGCA AGCAGGGATG CAGGGAGCTA GCATGCAAGG AGGGATGCAG 
GGAGCTGGCA TGCAAGGAGC CAGTAAGCAA GGTGGAGGCC AGCCTAGCAG TTTTAGCCCT 
GGGCAAAGCC AGGTAACTCC ACAAGATCAA GAAAAAGCAG CTTTGATCAT GCAGGTTCTC 
CAGCTGACTG CGGATCAGAT TGCCATGCTG CCTCCCGAAC AAAGGCAGAG CATTTTGATT 
TTAAAGGAAC AAATCCAGAA ATCCACTGGG GCTTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112539.2
CDS	226..2124
Translation	MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQPVSGPGPGGPGPSGPGGPGPGPAPGLCPGPNVMLNQQNPPAPQPQHLPRRPVKDIPPLMQTSIQGGIPAPGPIPAAVPGPGPGSLTPGGAMQPQVGMPVVGPVPLERGQMQISDPRPPMPRGPMPSGGIPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYMGPPHQGPPMHHGHDNRGPASHDMRGGPLAADPRMLIGEPRGPMIDQRGLPMDGRGGRESRGMETRPMETEVLEPRGMERRMETCAMETRGMDARGLEMRGPGPSSRGPMTGGIQGPGPINMGAGGPQGPRQVPNIAGVGNPGGTMQGAGIQGGGMQGAGMQGGGMQGAGMQGGGMQGAGMQAGMQGASMQGGMQGAGMQGASKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS

Target ORF information:

RefSeq Version	NM_031249.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cleavage stimulation factor, 3' pre-RNA subunit 2, tau (Cstf2t), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031249.2

ORF Insert Sequence:

ATGTCGAGTT TGGCGGTCAG AGACCCAGCC ATGGATCGAT CGCTGCGTTC GGTGTTCGTG 
GGGAACATTC CGTATGAGGC GACGGAGGAG CAGTTAAAGG ACATTTTCTC AGAGGTTGGT 
TCAGTTGTCA GTTTCCGTCT CGTCTACGAT AGAGAGACTG GGAAGCCCAA GGGTTATGGC 
TTCTGCGAGT ACCAAGACCA GGAGACTGCG CTCAGTGCCA TGCGAAACCT CAATGGGCGA 
GAGTTTAGTG GGAGAGCGCT TCGGGTGGAC AATGCCGCCA GCGAAAAGAA CAAGGAGGAG 
TTAAAGAGCT TAGGCCCGGC GGCCCCCATC ATTGACTCCC CCTATGGGGA CCCTATCGAC 
CCAGAAGATG CTCCAGAATC GATTACTAGA GCAGTCGCCA GCTTGCCCCC AGAGCAGATG 
TTTGAGCTCA TGAAGCAGAT GAAGTTGTGT GTCCAGAACA GTCACCAGGA AGCTCGAAAC 
ATGCTACTTC AGAACCCACA GTTGGCGTAT GCTTTGCTGC AGGCACAAGT GGTGATGAGA 
ATCATGGATC CAGAGATTGC ACTGAAAATT TTGCATCGTA AGATACATGT CACACCACTG 
ATCCCAGGCA AATCTCAGCC GGTCTCTGGG CCTGGCCCTG GTGGGCCTGG GCCTAGTGGG 
CCTGGCGGCC CTGGCCCCGG CCCTGCCCCT GGCCTCTGCC CGGGACCTAA CGTCATGTTG 
AACCAACAGA ATCCTCCTGC CCCTCAGCCT CAGCATCTGC CAAGAAGACC TGTGAAGGAC 
ATTCCACCTC TGATGCAGAC CTCTATCCAG GGAGGAATTC CAGCTCCGGG GCCAATACCA 
GCTGCAGTTC CTGGACCTGG ACCTGGTTCC TTAACTCCAG GAGGAGCAAT GCAGCCACAA 
GTTGGCATGC CAGTGGTTGG TCCAGTGCCC CTGGAGCGAG GACAGATGCA GATATCAGAT 
CCTAGACCTC CGATGCCTCG TGGACCCATG CCTTCTGGTG GCATACCTCC TCGAGGACTA 
CTGGGAGATG CTCCAAATGA CCCACGTGGA GGGACTTTGC TCTCAGTGAC TGGAGAAGTA 
GAGCCCAGGG GCTATATGGG ACCACCCCAT CAGGGTCCTC CAATGCATCA TGGTCATGAC 
AACCGTGGCC CTGCCTCACA TGATATGAGA GGAGGACCAT TGGCAGCAGA TCCCAGAATG 
CTAATTGGAG AGCCCAGAGG TCCCATGATA GATCAGAGAG GTCTACCTAT GGATGGTAGA 
GGAGGTAGAG AATCTCGAGG GATGGAGACT CGGCCCATGG AAACTGAGGT CTTGGAGCCA 
CGAGGAATGG AGAGAAGGAT GGAGACCTGC GCGATGGAAA CCAGAGGCAT GGATGCAAGA 
GGACTAGAGA TGAGGGGCCC TGGCCCTAGT TCCAGAGGTC CGATGACTGG TGGAATCCAG 
GGTCCTGGCC CTATTAATAT GGGGGCAGGT GGCCCTCAGG GACCTAGACA GGTTCCAAAT 
ATTGCAGGAG TGGGAAATCC TGGAGGTACC ATGCAGGGGG CAGGTATACA AGGAGGAGGG 
ATGCAGGGAG CAGGTATGCA AGGAGGAGGG ATGCAAGGAG CAGGCATGCA AGGAGGAGGG 
ATGCAGGGAG CTGGCATGCA AGCAGGGATG CAGGGAGCTA GCATGCAAGG AGGGATGCAG 
GGAGCTGGCA TGCAAGGAGC CAGTAAGCAA GGTGGAGGCC AGCCTAGCAG TTTTAGCCCT 
GGGCAAAGCC AGGTAACTCC ACAAGATCAA GAAAAAGCAG CTTTGATCAT GCAGGTTCTC 
CAGCTGACTG CGGATCAGAT TGCCATGCTG CCTCCCGAAC AAAGGCAGAG CATTTTGATT 
TTAAAGGAAC AAATCCAGAA ATCCACTGGG GCTTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
Biology of reproduction94(2)34(2016 Feb)
Grozdanov PN,Amatullah A,Graber JH,MacDonald CC

The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice.
PloS one11(11)e0165976(2016)
Harris JC,Martinez JM,Grozdanov PN,Bergeson SE,Grammas P,MacDonald CC

The ?CstF-64 polyadenylation protein controls genome expression in testis.
PloS one7(10)e48373(2012)
Li W,Yeh HJ,Shankarling GS,Ji Z,Tian B,MacDonald CC

Spermatogenetic but not immunological defects in mice lacking the ?CstF-64 polyadenylation protein.
Journal of reproductive immunology89(1)26-37(2011 Apr)
Hockert KJ,Martincic K,Mendis-Handagama SM,Borghesi LA,Milcarek C,Dass B,MacDonald CC

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Cstf2t cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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