Lrat cDNA ORF clone, Mus musculus(house mouse)

Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT.
Ajat M, Molenaar M, Brouwers JFHM, Vaandrager AB, Houweling M, Helms JB
Biochimica et biophysica acta1862(2)176-187(2017 02)

Dimerization of visual pigments in vivo.
Zhang T, Cao LH, Kumar S, Enemchukwu NO, Zhang N, Lambert A, Zhao X, Jones A, Wang S, Dennis EM, Fnu A, Ham S, Rainier J, Yau KW, Fu Y
Proceedings of the National Academy of Sciences of the United States of America113(32)9093-8(2016 08)

Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores.
Asson-Batres MA, Ryzhov S, Tikhomirov O, Duarte CW, Congdon CB, Lessard CR, McFarland S, Rochette-Egly C, Tran TL, Galindo CL, Favreau-Lessard AJ, Sawyer DB
American journal of physiology. Heart and circulatory physiology310(11)H1773-89(2016 Jun)

Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium.
Wen B, Li S, Li H, Chen Y, Ma X, Wang J, Lu F, Qu J, Hou L
Scientific reports621208(2016 Feb)

examined LRAT regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs
Title: Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes.

LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma
Title: LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma B16F10 cell line.

Mislocalized M-opsin was degraded whereas mislocalized S-opsin accumulated in Lrat(-/-) cones before the onset of massive ventral/central cone degeneration.
Title: Pathophysilogical mechanism and treatment strategies for Leber congenital amaurosis.

Studies provide mechanistic insights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LRAT as a critical component of this process.
Title: Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein.

Lrat KO mice exhibited increased levels of retinoic acid-responsive genes, including p21.
Title: Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration.