Ankrd23 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ankrd23
Entrez Gene ID	78321
Full Name	ankyrin repeat domain 23
Synonyms	1110058D09Rik,2310041C05Rik,AI853437,Darp,MARP3
General protein information	Preferred Names ankyrin repeat domain 23 Names ankyrin repeat domain-containing protein 23 diabetes-realted ankyrin repeat protein diabetes-related ankyrin repeat protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_153502.4	NP_705722.2	ankyrin repeat domain-containing protein 23 isoform 1
NM_001310521.1	NP_001297450.1	ankyrin repeat domain-containing protein 23 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ankrd23	NP_001101681.1
Pan troglodytes (chimpanzee)	ANKRD23	XP_001151487.1
Canis lupus familiaris (dog)	ANKRD23	XP_538465.2
Homo sapiens (human)	ANKRD23	NP_659431.5
Bos taurus (cattle)	ANKRD23	XP_005212450.1
Mus musculus (house mouse)	Ankrd23	NP_705722.2

Gene Ontology
Bibliography

Related articles in PubMed

The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation.
Wang X, Zeng R, Xu H, Xu Z, Zuo B
Gene62968-75(2017 Sep)

Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees.
Laughlin MH, Yang HT, Tharp DL, Rector RS, Padilla J, Bowles DK
Microcirculation (New York, N.Y. : 1994)24(2)(2017 Feb)

MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy.
Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E
Nature communications712120(2016 Jun)

Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle.
Shimoda Y, Matsuo K, Kitamura Y, Ono K, Ueyama T, Matoba S, Yamada H, Wu T, Chen J, Emoto N, Ikeda K
PloS one10(9)e0138624(2015)

The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.
Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J
PloS one9(4)e93638(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed expression of myoblast differentiation marker genes were increased by interference and reduced by ANKRD23 overexpression, indicating that ANKRD23 played a negative role in the myoblast differentiation; discovered a long non-coding RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene. Thus, AK004293 had no significant effect on the expression of myoblast differentiation maker genes and ANKRD23.
Title: The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation.

DARP regulates glucose disposal in skeletal muscle and thus modifies the glucose homeostasis by modulating AMPK activity.
Title: Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle.

CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload.
Title: The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.

Dapr is involved in the PI3K signaling cascade, potentially acting as a scaffold protein for PKB and coordinating its compartmentalization during differentiation.
Title: Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.

DARP plays important structural and gene regulatory roles in skeletal muscle.
Title: Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.

The following Ankrd23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ankrd23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02468	NM_153502.4 Latest version!	Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu71700	NM_001310521.1 Latest version!	Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ankrd23 ( NM_153502.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_705722.2 Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02468
Clone ID Related Accession (Same CDS sequence)	NM_153502.4
Accession Version	NM_153502.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	ankyrin repeat domain-containing protein 23 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC132370.1, AF492400.1 and BC022973.1. On Jul 15, 2015 this sequence version replaced NM_153502.3. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC132370.1, AF492400.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTTCA TCAGCATTGA GCAGTTGGTA AGTGGAGAAA GAGTTGATAG GAAAGCGTTG 
GAGTTTGGAC GTGGAGTTCC TGATCCTGGA GGCTGGCCTA GTGGCTGGAC GCTGGGACCC 
CAAGAGGCTG TGGCCCGGGA GAAACTAAAG TTGGAGGAAG AGAAAAGGAA GAAACTGGAA 
AGATTTAACA GCTCCAGACT GACTCTGGAC AATCTGACAG ACTTGGAAAA CTTGGTTCAA 
AGACGAAGAA AAAAACGACA GAGACACAAA GTCCCCCCCA GGGAACCTGA GTCTGGGGCT 
GAGCCTCAGC CCCAGGTCCC ACTGGAGCCC GTGGGCCTGG AAATGTTCCT GAAGGCAGCT 
GCTGAGAACC AGGAGGCCCT GATTGACAAG TACCTGGCGG ACGGAGGGGA CCCCAATGCC 
CATGACAAGC TCCACCGCAC AGCCTTGCAC TGGGCCTGTC TGAAGGGCCA CAGACAGCTG 
GTGAACAAGC TGCTGGCGGC AGGAGCTGCT ATAGAAGTAC GGGATTTGCT GGACAGGACG 
CCCGTGTTCT GGGCCTGCCG CGGAGGACAC CTGGACATTC TCAAACGGCT GCTTAACCAG 
GGAGCTCAGG TCAACGCACA AGACAAGATC TGGAGCACCC CTCTCCATGT GGCAGTGCGC 
ATGGGCCACT CCGACTGCCT AGAGCACCTT ATCGAGTGTG GCGCCCACAT CAACGCACAG 
GATAAGGAAG GGGACACAGC ACTCCACGAG GCCGTGCGCT ATGGGCACCA CAAAGCAACG 
AAACTGCTGC TGCTCTATGG AGCCAAGCTG GGTGTGAAGA ATGTGGCTTC CCAGACACCA 
GTGCAGCTGG CTCGAGACTG GCAGCGGGGC ATCCGGGACG CACTCCAGGC CCACGTGGGC 
CATCCCCGTA CCCGGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_705722.2
CDS	32..952
Translation	MDFISIEQLVSGERVDRKALEFGRGVPDPGGWPSGWTLGPQEAVAREKLKLEEEKRKKLERFNSSRLTLDNLTDLENLVQRRRKKRQRHKVPPREPESGAEPQPQVPLEPVGLEMFLKAAAENQEALIDKYLADGGDPNAHDKLHRTALHWACLKGHRQLVNKLLAAGAAIEVRDLLDRTPVFWACRGGHLDILKRLLNQGAQVNAQDKIWSTPLHVAVRMGHSDCLEHLIECGAHINAQDKEGDTALHEAVRYGHHKATKLLLLYGAKLGVKNVASQTPVQLARDWQRGIRDALQAHVGHPRTRC

Target ORF information:

RefSeq Version	NM_153502.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153502.4

ORF Insert Sequence:

ATGGACTTCA TCAGCATTGA GCAGTTGGTA AGTGGAGAAA GAGTTGATAG GAAAGCGTTG 
GAGTTTGGAC GTGGAGTTCC TGATCCTGGA GGCTGGCCTA GTGGCTGGAC GCTGGGACCC 
CAAGAGGCTG TGGCCCGGGA GAAACTAAAG TTGGAGGAAG AGAAAAGGAA GAAACTGGAA 
AGATTTAACA GCTCCAGACT GACTCTGGAC AATCTGACAG ACTTGGAAAA CTTGGTTCAA 
AGACGAAGAA AAAAACGACA GAGACACAAA GTCCCCCCCA GGGAACCTGA GTCTGGGGCT 
GAGCCTCAGC CCCAGGTCCC ACTGGAGCCC GTGGGCCTGG AAATGTTCCT GAAGGCAGCT 
GCTGAGAACC AGGAGGCCCT GATTGACAAG TACCTGGCGG ACGGAGGGGA CCCCAATGCC 
CATGACAAGC TCCACCGCAC AGCCTTGCAC TGGGCCTGTC TGAAGGGCCA CAGACAGCTG 
GTGAACAAGC TGCTGGCGGC AGGAGCTGCT ATAGAAGTAC GGGATTTGCT GGACAGGACG 
CCCGTGTTCT GGGCCTGCCG CGGAGGACAC CTGGACATTC TCAAACGGCT GCTTAACCAG 
GGAGCTCAGG TCAACGCACA AGACAAGATC TGGAGCACCC CTCTCCATGT GGCAGTGCGC 
ATGGGCCACT CCGACTGCCT AGAGCACCTT ATCGAGTGTG GCGCCCACAT CAACGCACAG 
GATAAGGAAG GGGACACAGC ACTCCACGAG GCCGTGCGCT ATGGGCACCA CAAAGCAACG 
AAACTGCTGC TGCTCTATGG AGCCAAGCTG GGTGTGAAGA ATGTGGCTTC CCAGACACCA 
GTGCAGCTGG CTCGAGACTG GCAGCGGGGC ATCCGGGACG CACTCCAGGC CCACGTGGGC 
CATCCCCGTA CCCGGTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ankrd23 ( NM_001310521.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297450.1 Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu71700
Clone ID Related Accession (Same CDS sequence)	NM_001310521.1
Accession Version	NM_001310521.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Mus musculus(house mouse)
Product	ankyrin repeat domain-containing protein 23 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX224440.1, AF492400.1 and BC022973.1. On Jul 15, 2015 this sequence version replaced XM_006496342.1. Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1, which results in translation initiation from a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.248689.1, SRR1660819.8481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCTGA AGGCAGCTGC TGAGAACCAG GAGGCCCTGA TTGACAAGTA CCTGGCGGAC 
GGAGGGGACC CCAATGCCCA TGACAAGCTC CACCGCACAG CCTTGCACTG GGCCTGTCTG 
AAGGGCCACA GACAGCTGGT GAACAAGCTG CTGGCGGCAG GAGCTGCTAT AGAAGTACGG 
GATTTGCTGG ACAGGACGCC CGTGTTCTGG GCCTGCCGCG GAGGACACCT GGACATTCTC 
AAACGGCTGC TTAACCAGGG AGCTCAGGTC AACGCACAAG ACAAGATCTG GAGCACCCCT 
CTCCATGTGG CAGTGCGCAT GGGCCACTCC GACTGCCTAG AGCACCTTAT CGAGTGTGGC 
GCCCACATCA ACGCACAGGA TAAGGAAGGG GACACAGCAC TCCACGAGGC CGTGCGCTAT 
GGGCACCACA AAGCAACGAA ACTGCTGCTG CTCTATGGAG CCAAGCTGGG TGTGAAGAAT 
GTGGCTTCCC AGACACCAGT GCAGCTGGCT CGAGACTGGC AGCGGGGCAT CCGGGACGCA 
CTCCAGGCCC ACGTGGGCCA TCCCCGTACC CGGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297450.1
CDS	376..954
Translation	MFLKAAAENQEALIDKYLADGGDPNAHDKLHRTALHWACLKGHRQLVNKLLAAGAAIEVRDLLDRTPVFWACRGGHLDILKRLLNQGAQVNAQDKIWSTPLHVAVRMGHSDCLEHLIECGAHINAQDKEGDTALHEAVRYGHHKATKLLLLYGAKLGVKNVASQTPVQLARDWQRGIRDALQAHVGHPRTRC

Target ORF information:

RefSeq Version	NM_001310521.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310521.1

ORF Insert Sequence:

ATGTTCCTGA AGGCAGCTGC TGAGAACCAG GAGGCCCTGA TTGACAAGTA CCTGGCGGAC 
GGAGGGGACC CCAATGCCCA TGACAAGCTC CACCGCACAG CCTTGCACTG GGCCTGTCTG 
AAGGGCCACA GACAGCTGGT GAACAAGCTG CTGGCGGCAG GAGCTGCTAT AGAAGTACGG 
GATTTGCTGG ACAGGACGCC CGTGTTCTGG GCCTGCCGCG GAGGACACCT GGACATTCTC 
AAACGGCTGC TTAACCAGGG AGCTCAGGTC AACGCACAAG ACAAGATCTG GAGCACCCCT 
CTCCATGTGG CAGTGCGCAT GGGCCACTCC GACTGCCTAG AGCACCTTAT CGAGTGTGGC 
GCCCACATCA ACGCACAGGA TAAGGAAGGG GACACAGCAC TCCACGAGGC CGTGCGCTAT 
GGGCACCACA AAGCAACGAA ACTGCTGCTG CTCTATGGAG CCAAGCTGGG TGTGAAGAAT 
GTGGCTTCCC AGACACCAGT GCAGCTGGCT CGAGACTGGC AGCGGGGCAT CCGGGACGCA 
CTCCAGGCCC ACGTGGGCCA TCCCCGTACC CGGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation.
Gene62968-75(2017 Sep)
Wang X,Zeng R,Xu H,Xu Z,Zuo B

Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees.
Microcirculation (New York, N.Y. : 1994)24(2)(2017 Feb)
Laughlin MH,Yang HT,Tharp DL,Rector RS,Padilla J,Bowles DK

MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy.
Nature communications712120(2016 Jun)
Lange S,Gehmlich K,Lun AS,Blondelle J,Hooper C,Dalton ND,Alvarez EA,Zhang X,Bang ML,Abassi YA,Dos Remedios CG,Peterson KL,Chen J,Ehler E

Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle.
PloS one10(9)e0138624(2015)
Shimoda Y,Matsuo K,Kitamura Y,Ono K,Ueyama T,Matoba S,Yamada H,Wu T,Chen J,Emoto N,Ikeda K

The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.
PloS one9(4)e93638(2014)
Bang ML,Gu Y,Dalton ND,Peterson KL,Chien KR,Chen J

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Ankrd23 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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