Hyal4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hyal4
Entrez Gene ID	77042
Full Name	hyaluronoglucosaminidase 4
Synonyms	4632428M18Rik,CSHY
General protein information	Preferred Names hyaluronoglucosaminidase 4 Names hyaluronidase-4 chondroitin sulfate endo-beta-N-acetylgalactosaminidase chondroitin sulfate hydrolase hyal-4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A3.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_029848.1	NP_084124.1	hyaluronidase-4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HYAL4	XP_003586042.1
Mus musculus (house mouse)	Hyal4	NP_084124.1
Danio rerio (zebrafish)	LOC100149853	XP_001922123.1
Homo sapiens (human)	HYAL4	NP_036401.2
Canis lupus familiaris (dog)	HYAL4	XP_532444.2
	HYAL4	XP_001086758.1
Rattus norvegicus (Norway rat)	Hyal4	NP_001094250.1
Pan troglodytes (chimpanzee)	HYAL4	XP_003318799.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
Kaneiwa T, Miyazaki A, Kogawa R, Mizumoto S, Sugahara K, Yamada S
The Journal of biological chemistry287(50)42119-28(2012 Dec)

Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Kim E, Baba D, Kimura M, Yamashita M, Kashiwabara S, Baba T
Proceedings of the National Academy of Sciences of the United States of America102(50)18028-33(2005 Dec)

Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5.
Zhang H, Shertok S, Miller K, Taylor L, Martin-Deleon PA
Molecular reproduction and development72(3)404-10(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
Title: Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).

The following Hyal4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hyal4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58113	NM_029848.1 Latest version!	Mus musculus hyaluronoglucosaminidase 4 (Hyal4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hyal4 ( NM_029848.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084124.1 Mus musculus hyaluronoglucosaminidase 4 (Hyal4), mRNA.

Price & Availability↑

CloneID	OMu58113
Clone ID Related Accession (Same CDS sequence)	NM_029848.1
Accession Version	NM_029848.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Mus musculus(house mouse)
Product	hyaluronidase-4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125402.1. On or before Oct 30, 2006 this sequence version replaced XM_132998.3, XM_912735.2, XM_990875.1. ##Evidence-Data-START## Transcript exon combination :: BC125402.1, AK014599.1 [ECO:0000332] ##Evidence-Data-END##

ATGCAACTAT TGCCTGAAGG ACAATTAAGA CTCTGTGTTT TTCAACCAGT ACATCTTACA 
TCGGGGCTGC TCATACTTTT TATCCTGAAG TCTATCTCAT CCCTAAAACC TGCCCGACTT 
CCAGTTTATC AAAGGAAACC TTTTATTGCT GCTTGGAATG CTCCAACAGA CCTGTGTTTG 
ATAAAATATA ATTTAACACT GAACTTAAAA GTGTTTCAGA TGGTTGGAAG CCCTCGGCTC 
AAAGACAGGG GGCAAAATGT TGTTATATTT TATGCCAACA GATTGGGATA TTACCCATGG 
TATACATCAG AAGGGGTACC CATCAATGGT GGTCTTCCCC AAAACACAAG CTTACAAGTA 
CACCTGAAAA AAGCTGCCCA GGATATTAAT TATTACATCC CTTCTGAAAA TTTCAGTGGA 
CTTGCTGTTA TAGACTGGGA ATATTGGCGC CCACAGTGGG CCCGGAACTG GAACACAAAG 
GATATCTACA GACAGAAGTC AAGAACTCTT ATTTCTGATA TGAAAGAGAA CATATCTGCT 
GCTGATATTG AATATTCAGC CAAGGCAACT TTTGAGAAAA GTGCAAAAGC TTTCATGGAG 
GAAACTATCA AATTGGGAAG TAAGAGCAGA CCCAAGGGCC TTTGGGGTTA TTATTTATAT 
CCTGATTGCC ACAATTATAA TGTTTATGCC ACAAACTATA CTGGGTCATG CCCAGAAGAG 
GAAGTTTTGA GGAACAATGA CCTCTCTTGG CTCTGGAACA GCAGTACAGC CCTGTATCCT 
GCTGTCAGTA TTAGGAAATC CTTTGCAGAC AGTGAAAACA CTTTGCACTT CTCACGATTT 
CGGGTGCGTG AATCACTGAG GATTTCCACC ATGACATCAC AGGATTATGC TCTGCCTGTA 
TTTGTCTACA CACAGCTGGG CTACAAAGAG GAACCTTTAC TTTTCCTTTC TAAGCAAGAT 
CTAATTAGTA CCATAGGAGA AAGTGCTGCG TTGGGAGCGG CAGGCATTGT TGTTTGGGGA 
GACATGAATT TAACTTCATC TGAGGAGAAC TGTACGAAAG TGAACCGCTT TGTGAATTCT 
GATTTTGGCA GCTACATAAT CAATGTGACC AGAGCAGCTG AGGTGTGCAG TCGTCACCTT 
TGCAAGAATA ATGGGAGGTG TGTACGGAAG ACATGGAAAG CAGCTCATTA CCTCCATTTG 
AACCCTGCAA GTTACCACAT AGAGGCCTCT GAGGATGGAG AATTCATAGT GAGGGGAAGA 
GCATCAGACA CTGACCTAGC TGTGATGGCA GAGAATTTCC TATGTCACTG TTATGAGGGA 
TATGAGGGGG CTGACTGTAG AGAAATGACA GAGGCCAGTG GCCCCTCGGG GCTTTCCCTT 
TCCTCTAGCT CTGTAATAAC ACTGTGTCTG CTAGTTCTAG CAGGTTATCA AAGCATTCAG 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084124.1
CDS	218..1663
Translation	MQLLPEGQLRLCVFQPVHLTSGLLILFILKSISSLKPARLPVYQRKPFIAAWNAPTDLCLIKYNLTLNLKVFQMVGSPRLKDRGQNVVIFYANRLGYYPWYTSEGVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTKDIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGLWGYYLYPDCHNYNVYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLHFSRFRVRESLRISTMTSQDYALPVFVYTQLGYKEEPLLFLSKQDLISTIGESAALGAAGIVVWGDMNLTSSEENCTKVNRFVNSDFGSYIINVTRAAEVCSRHLCKNNGRCVRKTWKAAHYLHLNPASYHIEASEDGEFIVRGRASDTDLAVMAENFLCHCYEGYEGADCREMTEASGPSGLSLSSSSVITLCLLVLAGYQSIQL

Target ORF information:

RefSeq Version	NM_029848.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus hyaluronoglucosaminidase 4 (Hyal4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029848.1

ORF Insert Sequence:

ATGCAACTAT TGCCTGAAGG ACAATTAAGA CTCTGTGTTT TTCAACCAGT ACATCTTACA 
TCGGGGCTGC TCATACTTTT TATCCTGAAG TCTATCTCAT CCCTAAAACC TGCCCGACTT 
CCAGTTTATC AAAGGAAACC TTTTATTGCT GCTTGGAATG CTCCAACAGA CCTGTGTTTG 
ATAAAATATA ATTTAACACT GAACTTAAAA GTGTTTCAGA TGGTTGGAAG CCCTCGGCTC 
AAAGACAGGG GGCAAAATGT TGTTATATTT TATGCCAACA GATTGGGATA TTACCCATGG 
TATACATCAG AAGGGGTACC CATCAATGGT GGTCTTCCCC AAAACACAAG CTTACAAGTA 
CACCTGAAAA AAGCTGCCCA GGATATTAAT TATTACATCC CTTCTGAAAA TTTCAGTGGA 
CTTGCTGTTA TAGACTGGGA ATATTGGCGC CCACAGTGGG CCCGGAACTG GAACACAAAG 
GATATCTACA GACAGAAGTC AAGAACTCTT ATTTCTGATA TGAAAGAGAA CATATCTGCT 
GCTGATATTG AATATTCAGC CAAGGCAACT TTTGAGAAAA GTGCAAAAGC TTTCATGGAG 
GAAACTATCA AATTGGGAAG TAAGAGCAGA CCCAAGGGCC TTTGGGGTTA TTATTTATAT 
CCTGATTGCC ACAATTATAA TGTTTATGCC ACAAACTATA CTGGGTCATG CCCAGAAGAG 
GAAGTTTTGA GGAACAATGA CCTCTCTTGG CTCTGGAACA GCAGTACAGC CCTGTATCCT 
GCTGTCAGTA TTAGGAAATC CTTTGCAGAC AGTGAAAACA CTTTGCACTT CTCACGATTT 
CGGGTGCGTG AATCACTGAG GATTTCCACC ATGACATCAC AGGATTATGC TCTGCCTGTA 
TTTGTCTACA CACAGCTGGG CTACAAAGAG GAACCTTTAC TTTTCCTTTC TAAGCAAGAT 
CTAATTAGTA CCATAGGAGA AAGTGCTGCG TTGGGAGCGG CAGGCATTGT TGTTTGGGGA 
GACATGAATT TAACTTCATC TGAGGAGAAC TGTACGAAAG TGAACCGCTT TGTGAATTCT 
GATTTTGGCA GCTACATAAT CAATGTGACC AGAGCAGCTG AGGTGTGCAG TCGTCACCTT 
TGCAAGAATA ATGGGAGGTG TGTACGGAAG ACATGGAAAG CAGCTCATTA CCTCCATTTG 
AACCCTGCAA GTTACCACAT AGAGGCCTCT GAGGATGGAG AATTCATAGT GAGGGGAAGA 
GCATCAGACA CTGACCTAGC TGTGATGGCA GAGAATTTCC TATGTCACTG TTATGAGGGA 
TATGAGGGGG CTGACTGTAG AGAAATGACA GAGGCCAGTG GCCCCTCGGG GCTTTCCCTT 
TCCTCTAGCT CTGTAATAAC ACTGTGTCTG CTAGTTCTAG CAGGTTATCA AAGCATTCAG 
TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).
The Journal of biological chemistry287(50)42119-28(2012 Dec)
Kaneiwa T,Miyazaki A,Kogawa R,Mizumoto S,Sugahara K,Yamada S

Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.
Proceedings of the National Academy of Sciences of the United States of America102(50)18028-33(2005 Dec)
Kim E,Baba D,Kimura M,Yamashita M,Kashiwabara S,Baba T

Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5.
Molecular reproduction and development72(3)404-10(2005 Nov)
Zhang H,Shertok S,Miller K,Taylor L,Martin-Deleon PA

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Hyal4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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