Ifi27l2a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ifi27l2a
Entrez Gene ID	76933
Full Name	interferon, alpha-inducible protein 27 like 2A
Synonyms	2310061N23Rik,Ifi27,Isg12,Isg12(b1)
General protein information	Preferred Names interferon, alpha-inducible protein 27 like 2A Names interferon alpha-inducible protein 27-like protein 2A interferon stimulated gene 12(b1) interferon-stimulated gene 12 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 E

mRNA and Protein(s)

mRNA	Protein	Name
NM_029803.3	NP_084079.1	interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor
NM_001281830.1	NP_001268759.1	interferon alpha-inducible protein 27-like protein 2A isoform 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ifi27l2a	NP_084079.1
Mus musculus (house mouse)	Ifi27l2b	NP_663424.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.
Lucas TM, Richner JM, Diamond MS
Journal of virology90(5)2600-15(2015 Dec)

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, Nell?ker C, Vesely C, Ponting CP, McLaughlin PJ, Jantsch MF, Dorin J, Adams IR, Scadden AD, Ohman M, Keegan LP, O'Connell MA
Cell reports9(4)1482-94(2014 Nov)

The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.
Tantawy MA, Hatesuer B, Wilk E, Dengler L, Kasnitz N, Wei? S, Schughart K
PloS one9(9)e106392(2014)

ISG12 is a critical modulator of innate immune responses in murine models of sepsis.
Uhrin P, Perkmann T, Binder B, Schabbauer G
Immunobiology218(9)1207-16(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection.
Title: The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.

up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections
Title: The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.

modulator of innate immune responses in sepsis models
Title: ISG12 is a critical modulator of innate immune responses in murine models of sepsis.

Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors.
Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.

Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function.
Title: Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells.

The following Ifi27l2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifi27l2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13708	NM_001281830.1 Latest version!	Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu14020	NM_029803.3 Latest version!	Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ifi27l2a ( NM_001281830.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001268759.1 Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13708
Clone ID Related Accession (Same CDS sequence)	NM_001281830.1
Accession Version	NM_001281830.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	interferon alpha-inducible protein 27-like protein 2A isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154347.2 and AK040279.1. Transcript Variant: This variant (2) lacks an exon and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK040279.1, BB207553.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGGAA CACTGTTTGG CTCTGCCATA GGAGGAGCTC TGGCTGTGGC AGGGGCACCT 
GTGGCCCTGG CTGCCATGGG CTTCACTGGG ACAGGCATTG CAGCTGCCTC CATAGCAGCC 
AAGATGATGT CTGCTGCAGC AATTGCCAAT GGAGGTGGAG TTGCAGCAGG AAGCCTGGTA 
GCCACACTCC AATCAGCAGG CCCGTCAAGT CCACTGTGCA GGAAGACACA CCCAGTGACT 
GAAGACAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268759.1
CDS	48..302
Translation	MLGTLFGSAIGGALAVAGAPVALAAMGFTGTGIAAASIAAKMMSAAAIANGGGVAAGSLVATLQSAGPSSPLCRKTHPVTEDSC

Target ORF information:

RefSeq Version	NM_001281830.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281830.1

ORF Insert Sequence:

ATGTTGGGAA CACTGTTTGG CTCTGCCATA GGAGGAGCTC TGGCTGTGGC AGGGGCACCT 
GTGGCCCTGG CTGCCATGGG CTTCACTGGG ACAGGCATTG CAGCTGCCTC CATAGCAGCC 
AAGATGATGT CTGCTGCAGC AATTGCCAAT GGAGGTGGAG TTGCAGCAGG AAGCCTGGTA 
GCCACACTCC AATCAGCAGG CCCGTCAAGT CCACTGTGCA GGAAGACACA CCCAGTGACT 
GAAGACAGCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ifi27l2a ( NM_029803.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084079.1 Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14020
Clone ID Related Accession (Same CDS sequence)	NM_029803.3
Accession Version	NM_029803.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154347.2 and AK160503.1. On Aug 8, 2013 this sequence version replaced NM_029803.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC100588.1, BC086889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGGAA CACTGTTTGG CTCTGCCATA GGAGGAGCTC TGGCTGTGGC AGGGGCACCT 
GTGGCCCTGG CTGCCATGGG CTTCACTGGG ACAGGCATTG CAGCTGCCTC CATAGCAGCC 
AAGATGATGT CTGCTGCAGC AATTGCCAAT GGAGGTGGAG TTGCAGCAGG AAGCCTGGTA 
GCCACACTCC AATCAGCAGG GGTCCTTGGA CTCTCCACAT CAACAAATGC CATCCTAGGG 
GCTGCTGGGG CAGCTGTTGG AGCCTTGCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084079.1
CDS	48..320
Translation	MLGTLFGSAIGGALAVAGAPVALAAMGFTGTGIAAASIAAKMMSAAAIANGGGVAAGSLVATLQSAGVLGLSTSTNAILGAAGAAVGALL

Target ORF information:

RefSeq Version	NM_029803.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon, alpha-inducible protein 27 like 2A (Ifi27l2a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029803.3

ORF Insert Sequence:

ATGTTGGGAA CACTGTTTGG CTCTGCCATA GGAGGAGCTC TGGCTGTGGC AGGGGCACCT 
GTGGCCCTGG CTGCCATGGG CTTCACTGGG ACAGGCATTG CAGCTGCCTC CATAGCAGCC 
AAGATGATGT CTGCTGCAGC AATTGCCAAT GGAGGTGGAG TTGCAGCAGG AAGCCTGGTA 
GCCACACTCC AATCAGCAGG GGTCCTTGGA CTCTCCACAT CAACAAATGC CATCCTAGGG 
GCTGCTGGGG CAGCTGTTGG AGCCTTGCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.
Journal of virology90(5)2600-15(2015 Dec)
Lucas TM,Richner JM,Diamond MS

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Cell reports9(4)1482-94(2014 Nov)
Mannion NM,Greenwood SM,Young R,Cox S,Brindle J,Read D,Nell?ker C,Vesely C,Ponting CP,McLaughlin PJ,Jantsch MF,Dorin J,Adams IR,Scadden AD,Ohman M,Keegan LP,O'Connell MA

The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.
PloS one9(9)e106392(2014)
Tantawy MA,Hatesuer B,Wilk E,Dengler L,Kasnitz N,Wei? S,Schughart K

ISG12 is a critical modulator of innate immune responses in murine models of sepsis.
Immunobiology218(9)1207-16(2013 Sep)
Uhrin P,Perkmann T,Binder B,Schabbauer G

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Ifi27l2a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報