Lrg1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrg1
Entrez Gene ID	76905
Full Name	leucine-rich alpha-2-glycoprotein 1
Synonyms	1300008B03Rik,2310031E04Rik,Lrg,Lrhg
General protein information	Preferred Names leucine-rich alpha-2-glycoprotein 1 Names leucine-rich alpha-2-glycoprotein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 29.17 cM\|17 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_029796.2	NP_084072.1	leucine-rich alpha-2-glycoprotein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LRG1	XP_001139381.1
Mus musculus (house mouse)	Lrg1	NP_084072.1
Rattus norvegicus (Norway rat)	Lrg1	NP_001009717.1
Danio rerio (zebrafish)	si:dkey-90m5.4	XP_686282.3
	LRG1	XP_001082565.1
Canis lupus familiaris (dog)	LRG1	XP_854692.2
Gallus gallus (chicken)	LOC100858066	XP_003642913.1
Xenopus tropicalis (tropical clawed frog)	lrg1	XP_004911101.1
Homo sapiens (human)	LRG1	NP_443204.1
Bos taurus (cattle)	LRG1	NP_001039642.1

Gene Ontology
Bibliography

Related articles in PubMed

Leucine-rich ?2-glycoprotein overexpression in the brain contributes to memory impairment.
Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H
Neurobiology of aging6011-19(2017 Dec)

Leucine-rich
Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T
Physiological reports5(24)(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age.
Title: Leucine-rich ?2-glycoprotein overexpression in the brain contributes to memory impairment.

This study shows that TNF-alpha is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.
Title: TNF-?-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.

findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF during brain development
Title: Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling.

Leucine-rich alpha2-glycoprotein signalling could be a therapeutic target against cardiovascular diseases
Title: Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction.

Loss of LRG is associated with Lewis lung carcinoma.
Title: Leucine-rich ?-2-glycoprotein promotes TGF?1-mediated growth suppression in the Lewis lung carcinoma cell lines.

The following Lrg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07493	NM_029796.2 Latest version!	Mus musculus leucine-rich alpha-2-glycoprotein 1 (Lrg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrg1 ( NM_029796.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084072.1 Mus musculus leucine-rich alpha-2-glycoprotein 1 (Lrg1), mRNA.

Price & Availability↑

CloneID	OMu07493
Clone ID Related Accession (Same CDS sequence)	NM_029796.2
Accession Version	NM_029796.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Mus musculus(house mouse)
Product	leucine-rich alpha-2-glycoprotein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC030733.1. On Jun 19, 2003 this sequence version replaced NM_029796.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030733.1, BC092077.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGGTCTCTT GGCAGCATCA AGGAAGCCTC CAGGATCTCA AGACCTGCCT TGCCAGAACC 
CTGTTTCTCC TGGCCCTCTT GGGCAGGGTG TCCAGCCTCA AGGAATGCCT GATACTGCAG 
TCGGCTGAGG GTAGCACCGT CTCCTGCCAT GGTCCCACCG AGTTTCCGAG CTCCCTCCCT 
GCCGACACTG TCCATCTGTC GGTGGAATTC TCCAACCTGA CGCAGCTGCC CGCCGCCGCC 
CTGCAAGGGT GTCCGGGTCT GCGGGAGCTG CACCTCTCGA GCAATCGCCT GCAGGCGCTG 
TCTCCCGAGT TGCTGGCGCC CGTGCCCCGG CTGCGCGCCC TGGATCTGAC CCGCAATGCT 
CTCCGCAGCC TGCCCCCCGG GTTGTTCAGC ACCTCGGCCA ACCTGAGCAC CCTGGTCCTG 
AGGGAGAACC AGCTGCGGGA GGTGAGCGCG CAATGGCTTC AGGGCCTGGA CGCCCTGGGC 
CACTTGGACC TGGCGGAGAA CCAGCTGAGT TCGCTGCCCT CCGGGCTCCT CGCCAGCCTC 
GGCGCCCTGC ACACCCTCGA CCTTGGGTAC AACCTGCTGG AGTCGCTGCC CGAGGGACTC 
CTGCGGGGCC CAAGGCGGCT GCAGCGCCTG CACCTGGAAG GGAACCGACT GCAGAGGCTG 
GAGGATAGCC TGCTTGCGCC CCAACCGTTC CTGCGCGTCC TGTTCCTGAA TGACAACCAG 
TTGGTCGGGG TGGCGACCGG CTCCTTCCAG GGCCTACAGC ACCTGGATAT GTTGGATCTG 
TCCAATAACT CTCTGTCCAG CACGCCCCCG GGCCTGTGGG CGTTCCTGGG GAGGCCGACC 
CGCGACATGC AGGACGGCTT CGACATCTCC CACAACCCCT GGATCTGTGA CAAGAACCTG 
GCGGACCTTT GCCGCTGGCT GGTCGCCAAC CGAAACAAGA TGTTCTCACA GAACGACACG 
CGCTGTGCGG GGCCCGAGGC CATGAAGGGT CAGCGGCTGC TGGACGTGGC AGAGCTGGGG 
TCCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084072.1
CDS	61..1089
Translation	MVSWQHQGSLQDLKTCLARTLFLLALLGRVSSLKECLILQSAEGSTVSCHGPTEFPSSLPADTVHLSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSPELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWLQGLDALGHLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQRLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFLGRPTRDMQDGFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLLDVAELGSL

Target ORF information:

RefSeq Version	NM_029796.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine-rich alpha-2-glycoprotein 1 (Lrg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029796.2

ORF Insert Sequence:

ATGGTCTCTT GGCAGCATCA AGGAAGCCTC CAGGATCTCA AGACCTGCCT TGCCAGAACC 
CTGTTTCTCC TGGCCCTCTT GGGCAGGGTG TCCAGCCTCA AGGAATGCCT GATACTGCAG 
TCGGCTGAGG GTAGCACCGT CTCCTGCCAT GGTCCCACCG AGTTTCCGAG CTCCCTCCCT 
GCCGACACTG TCCATCTGTC GGTGGAATTC TCCAACCTGA CGCAGCTGCC CGCCGCCGCC 
CTGCAAGGGT GTCCGGGTCT GCGGGAGCTG CACCTCTCGA GCAATCGCCT GCAGGCGCTG 
TCTCCCGAGT TGCTGGCGCC CGTGCCCCGG CTGCGCGCCC TGGATCTGAC CCGCAATGCT 
CTCCGCAGCC TGCCCCCCGG GTTGTTCAGC ACCTCGGCCA ACCTGAGCAC CCTGGTCCTG 
AGGGAGAACC AGCTGCGGGA GGTGAGCGCG CAATGGCTTC AGGGCCTGGA CGCCCTGGGC 
CACTTGGACC TGGCGGAGAA CCAGCTGAGT TCGCTGCCCT CCGGGCTCCT CGCCAGCCTC 
GGCGCCCTGC ACACCCTCGA CCTTGGGTAC AACCTGCTGG AGTCGCTGCC CGAGGGACTC 
CTGCGGGGCC CAAGGCGGCT GCAGCGCCTG CACCTGGAAG GGAACCGACT GCAGAGGCTG 
GAGGATAGCC TGCTTGCGCC CCAACCGTTC CTGCGCGTCC TGTTCCTGAA TGACAACCAG 
TTGGTCGGGG TGGCGACCGG CTCCTTCCAG GGCCTACAGC ACCTGGATAT GTTGGATCTG 
TCCAATAACT CTCTGTCCAG CACGCCCCCG GGCCTGTGGG CGTTCCTGGG GAGGCCGACC 
CGCGACATGC AGGACGGCTT CGACATCTCC CACAACCCCT GGATCTGTGA CAAGAACCTG 
GCGGACCTTT GCCGCTGGCT GGTCGCCAAC CGAAACAAGA TGTTCTCACA GAACGACACG 
CGCTGTGCGG GGCCCGAGGC CATGAAGGGT CAGCGGCTGC TGGACGTGGC AGAGCTGGGG 
TCCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Leucine-rich ?2-glycoprotein overexpression in the brain contributes to memory impairment.
Neurobiology of aging6011-19(2017 Dec)
Akiba C,Nakajima M,Miyajima M,Ogino I,Miura M,Inoue R,Nakamura E,Kanai F,Tada N,Kunichika M,Yoshida M,Nishimura K,Kondo A,Sugano H,Arai H

Leucine-rich
Physiological reports5(24)(2017 12)
Honda H,Fujimoto M,Serada S,Urushima H,Mishima T,Lee H,Ohkawara T,Kohno N,Hattori N,Yokoyama A,Naka T

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Lrg1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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