Clec4g cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clec4g
Entrez Gene ID	75863
Full Name	C-type lectin domain family 4, member g
Synonyms	4930572L20Rik
General protein information	Preferred Names C-type lectin domain family 4, member g Names C-type lectin domain family 4 member G
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A1.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_029465.3	NP_083741.1	C-type lectin domain family 4 member G

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CLEC4G	XP_005633000.1
Mus musculus (house mouse)	Clec4g	NP_083741.1
Homo sapiens (human)	CLEC4G	NP_940894.1
Rattus norvegicus (Norway rat)	Clec4g	XP_006248857.1
Pan troglodytes (chimpanzee)	CLEC4G	XP_001154312.3
Bos taurus (cattle)	CLEC4G	NP_001192535.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

Involvement of LSECtin in the hepatic natural killer cell response.
Yang J, Wang H, Wang M, Liu B, Xu H, Xu F, Zhao D, Hu B, Zhao N, Wang J, Liu D, Tang L, He F
Biochemical and biophysical research communications476(1)49-55(2016 07)

Clec4g (LSECtin) interacts with BACE1 and suppresses A? generation.
Kizuka Y, Kitazume S, Sato K, Taniguchi N
FEBS letters589(13)1418-22(2015 Jun)

LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
Xu F, Liu J, Liu D, Liu B, Wang M, Hu Z, Du X, Tang L, He F
Cancer research74(13)3418-28(2014 Jul)

Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Liu B, Wang M, Wang X, Zhao D, Liu D, Liu J, Chen PJ, Yang D, He F, Tang L
Journal of immunology (Baltimore, Md. : 1950)190(8)4185-95(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study shows that C-type lectin LSECtin, a member of the DC-SIGN family, is a novel liver regulator for natural killer cells (NK cells). LSECtin could bind to NK cells in a carbohydrate-dependent manner and could regulate the number of hepatic NK cells.
Title: Involvement of LSECtin in the hepatic natural killer cell response.

Data show that C-type lectin-like domain family 4, member g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving enzyme-1 (BACE1)-mediated amyloid-beta (Abeta) peptides generation.
Title: Clec4g (LSECtin) interacts with BACE1 and suppresses A? generation.

When expressed in B16 melanoma cells, LSECtin promoted tumor growth, whereas its blockade slowed tumor growth in either wild-type or LSECtin-deficient mice.
Title: LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.

LSECtin may facilitate the reduction of liver inflammation at the cost of delaying virus clearance, an effect that might be hijacked by the virus as an escape mechanism.
Title: Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.

LSECtin-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of Cbl-b.
Title: Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets.

The following Clec4g gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec4g cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07031	NM_029465.3 Latest version!	Mus musculus C-type lectin domain family 4, member g (Clec4g), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clec4g ( NM_029465.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083741.1 Mus musculus C-type lectin domain family 4, member g (Clec4g), mRNA.

Price & Availability↑

CloneID	OMu07031
Clone ID Related Accession (Same CDS sequence)	NM_029465.3
Accession Version	NM_029465.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	C-type lectin domain family 4 member G
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK079992.1 and AI449163.1. On Apr 28, 2009 this sequence version replaced NM_029465.2. ##Evidence-Data-START## Transcript exon combination :: BC087963.1, AK079992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGAACACTG GTGAATACAA CAAGCTGGGC AGTGCAATTG AAGAGGTCTC CAGAGGGCAA 
TTGGGACGTT GGGAGTGCTA CAAACAAAGA CTTTTCTTCC TGGTCTTGGC TCTGCTGGTG 
GCCACAGTTC TATGGGCTCT CATTCTGAGC ACCCTACTGT CCAGTGCCTC CAGCAAGCTC 
AGGGTGCTGC TCAGCCACCA GGACCTGCTG AGGACAAATG CCTCAGAGCA GAAGATGACG 
TTGAGTTCCC TGAAGGATGA TATCGGAGCC TGCAGGAATT GCTGCTCCGT GACAAAAGCG 
CAGTTGCAAA CCACACTGGC GGAGTTTAAG GACATACAAG CAAAGTTGAT GGAGCAGGAG 
AGCATCCTGA AAGAACTGCA AGAGCGTGTG ACCCAGGACT TGGCTAAAGC AAGCAGAGAC 
CGTGAGAACA TCCGCAGTGA GCTGTTCCAG GCACTGGAAG CTGTCAAGCG CCAGAACAGC 
TCCTGTGAGC AGTGCCCACC ATCATGGCTA CCCTTCCAAG GTTCCTGCTA CTATTTCTCT 
GAGACACAGG CCACATGGGA TACAGCACAA AGCTACTGTG GAGGCCAGGG TGCCCATCTG 
GTGATTGTCA GAGGCCTGAA CGAGCAGGGC TTCCTGAGTC AGCACACACG TGGCCGGGGC 
TATTGGTTGG GTCTGAGGGC AGTTCGCCAC CTCAACAAGA TTCAAGGCTA CCGGTGGGTA 
GATGGAGCCT CACTCAACTT CAGCCACTGG AACTCTGGAG AGCCCAATGA TTCCAGAGGA 
CATGAGGACT GTATCATGAT GCTGCACTCG GGGCTGTGGA ATGATGCACC ATGTACCAAT 
GAGAGAGATG GCTGGATCTG TGAGAAGAGG AGCAGTTGCT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083741.1
CDS	7..891
Translation	MNTGEYNKLGSAIEEVSRGQLGRWECYKQRLFFLVLALLVATVLWALILSTLLSSASSKLRVLLSHQDLLRTNASEQKMTLSSLKDDIGACRNCCSVTKAQLQTTLAEFKDIQAKLMEQESILKELQERVTQDLAKASRDRENIRSELFQALEAVKRQNSSCEQCPPSWLPFQGSCYYFSETQATWDTAQSYCGGQGAHLVIVRGLNEQGFLSQHTRGRGYWLGLRAVRHLNKIQGYRWVDGASLNFSHWNSGEPNDSRGHEDCIMMLHSGLWNDAPCTNERDGWICEKRSSCY

Target ORF information:

RefSeq Version	NM_029465.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-type lectin domain family 4, member g (Clec4g), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029465.3

ORF Insert Sequence:

ATGAACACTG GTGAATACAA CAAGCTGGGC AGTGCAATTG AAGAGGTCTC CAGAGGGCAA 
TTGGGACGTT GGGAGTGCTA CAAACAAAGA CTTTTCTTCC TGGTCTTGGC TCTGCTGGTG 
GCCACAGTTC TATGGGCTCT CATTCTGAGC ACCCTACTGT CCAGTGCCTC CAGCAAGCTC 
AGGGTGCTGC TCAGCCACCA GGACCTGCTG AGGACAAATG CCTCAGAGCA GAAGATGACG 
TTGAGTTCCC TGAAGGATGA TATCGGAGCC TGCAGGAATT GCTGCTCCGT GACAAAAGCG 
CAGTTGCAAA CCACACTGGC GGAGTTTAAG GACATACAAG CAAAGTTGAT GGAGCAGGAG 
AGCATCCTGA AAGAACTGCA AGAGCGTGTG ACCCAGGACT TGGCTAAAGC AAGCAGAGAC 
CGTGAGAACA TCCGCAGTGA GCTGTTCCAG GCACTGGAAG CTGTCAAGCG CCAGAACAGC 
TCCTGTGAGC AGTGCCCACC ATCATGGCTA CCCTTCCAAG GTTCCTGCTA CTATTTCTCT 
GAGACACAGG CCACATGGGA TACAGCACAA AGCTACTGTG GAGGCCAGGG TGCCCATCTG 
GTGATTGTCA GAGGCCTGAA CGAGCAGGGC TTCCTGAGTC AGCACACACG TGGCCGGGGC 
TATTGGTTGG GTCTGAGGGC AGTTCGCCAC CTCAACAAGA TTCAAGGCTA CCGGTGGGTA 
GATGGAGCCT CACTCAACTT CAGCCACTGG AACTCTGGAG AGCCCAATGA TTCCAGAGGA 
CATGAGGACT GTATCATGAT GCTGCACTCG GGGCTGTGGA ATGATGCACC ATGTACCAAT 
GAGAGAGATG GCTGGATCTG TGAGAAGAGG AGCAGTTGCT ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

Involvement of LSECtin in the hepatic natural killer cell response.
Biochemical and biophysical research communications476(1)49-55(2016 07)
Yang J,Wang H,Wang M,Liu B,Xu H,Xu F,Zhao D,Hu B,Zhao N,Wang J,Liu D,Tang L,He F

Clec4g (LSECtin) interacts with BACE1 and suppresses A? generation.
FEBS letters589(13)1418-22(2015 Jun)
Kizuka Y,Kitazume S,Sato K,Taniguchi N

LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
Cancer research74(13)3418-28(2014 Jul)
Xu F,Liu J,Liu D,Liu B,Wang M,Hu Z,Du X,Tang L,He F

Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)190(8)4185-95(2013 Apr)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L

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Clec4g cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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