Clec4g cDNA ORF clone, Mus musculus(house mouse)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

Involvement of LSECtin in the hepatic natural killer cell response.
Yang J, Wang H, Wang M, Liu B, Xu H, Xu F, Zhao D, Hu B, Zhao N, Wang J, Liu D, Tang L, He F
Biochemical and biophysical research communications476(1)49-55(2016 07)

Clec4g (LSECtin) interacts with BACE1 and suppresses A? generation.
Kizuka Y, Kitazume S, Sato K, Taniguchi N
FEBS letters589(13)1418-22(2015 Jun)

LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
Xu F, Liu J, Liu D, Liu B, Wang M, Hu Z, Du X, Tang L, He F
Cancer research74(13)3418-28(2014 Jul)

Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Liu B, Wang M, Wang X, Zhao D, Liu D, Liu J, Chen PJ, Yang D, He F, Tang L
Journal of immunology (Baltimore, Md. : 1950)190(8)4185-95(2013 Apr)

This study shows that C-type lectin LSECtin, a member of the DC-SIGN family, is a novel liver regulator for natural killer cells (NK cells). LSECtin could bind to NK cells in a carbohydrate-dependent manner and could regulate the number of hepatic NK cells.
Title: Involvement of LSECtin in the hepatic natural killer cell response.

Data show that C-type lectin-like domain family 4, member g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving enzyme-1 (BACE1)-mediated amyloid-beta (Abeta) peptides generation.
Title: Clec4g (LSECtin) interacts with BACE1 and suppresses A? generation.

When expressed in B16 melanoma cells, LSECtin promoted tumor growth, whereas its blockade slowed tumor growth in either wild-type or LSECtin-deficient mice.
Title: LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.

LSECtin may facilitate the reduction of liver inflammation at the cost of delaying virus clearance, an effect that might be hijacked by the virus as an escape mechanism.
Title: Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.

LSECtin-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of Cbl-b.
Title: Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets.