Gene Symbol | Kdm5b |
Entrez Gene ID | 75605 |
Full Name | lysine (K)-specific demethylase 5B |
Synonyms | 2010009J12Rik,2210016I17Rik,AW556288,D1Ertd202e,Jarid1b,PLU-1,PUT1,Plu1,RBBP2H1A,Rb-Bp2,mKIAA4034 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]. |