Nhej1 cDNA ORF clone, Mus musculus(house mouse)

PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.
Abramowski V, Etienne O, Elsaid R, Yang J, Berland A, Kermasson L, Roch B, Musilli S, Moussu JP, Lipson-Ruffert K, Revy P, Cumano A, Boussin FD, de Villartay JP
Cell death and differentiation25(2)444-452(2018 Feb)

Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
Title: Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.

PAXX and XLF proteins may have redundant functions during Non-homologous end joining.
Title: Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.

Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis
Title: Synthetic lethality between PAXX and XLF in mammalian development.

XLF has an important role during V(D)J recombination.
Title: XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination.

These results reveal an unanticipated functional interplay between the RAG complex and XLF in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly.
Title: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.