Pomk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pomk
Entrez Gene ID	74653
Full Name	protein-O-mannose kinase
Synonyms	4930444A02Rik,Sgk196
General protein information	Preferred Names protein-O-mannose kinase Names protein O-mannose kinase probable inactive protein kinase-like protein SgK196 protein kinase-like protein SgK196 sugen kinase 196
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_029037.4	NP_083313.1	protein O-mannose kinase

Pathways from BioSystems

Homologies

Homo sapiens (human)	POMK	NP_001264900.1
Pan troglodytes (chimpanzee)	SGK196	XP_519740.2
Mus musculus (house mouse)	Pomk	NP_083313.1
Xenopus tropicalis (tropical clawed frog)	LOC100497421	XP_004911106.1
Canis lupus familiaris (dog)	SGK196	XP_005629839.1
Rattus norvegicus (Norway rat)	Pomk	NP_001020054.1
Danio rerio (zebrafish)	pomk	NP_001007415.1
Gallus gallus (chicken)	SGK196	NP_001026303.1
	LOC706318	XP_001099665.1
Bos taurus (cattle)	LOC514490	NP_001091496.1

Gene Ontology
Bibliography

Related articles in PubMed

3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.
Nagae M, Mishra SK, Neyazaki M, Oi R, Ikeda A, Matsugaki N, Akashi S, Manya H, Mizuno M, Yagi H, Kato K, Senda T, Endo T, Nogi T, Yamaguchi Y
Genes to cells : devoted to molecular & cellular mechanisms22(4)348-359(2017 Apr)

POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations.
Di Costanzo S, Balasubramanian A, Pond HL, Rozkalne A, Pantaleoni C, Saredi S, Gupta VA, Sunu CM, Yu TW, Kang PB, Salih MA, Mora M, Gussoni E, Walsh CA, Manzini MC
Human molecular genetics23(21)5781-92(2014 Nov)

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
Science (New York, N.Y.)341(6148)896-9(2013 Aug)

Congenital hydrocephalus in genetically engineered mice.
Vogel P, Read RW, Hansen GM, Payne BJ, Small D, Sands AT, Zambrowicz BP
Veterinary pathology49(1)166-81(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study elucidated the atomic structure of mouse POMK catalytic domain in both the absence and presence of donor and acceptor substrates.
Title: 3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.

Congenital hydrocephalus and defective neuronal migration in cerebellar development in 4930444A02Rik mice
Title: Congenital hydrocephalus in genetically engineered mice.

The following Pomk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pomk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15592	NM_029037.4 Latest version!	Mus musculus protein-O-mannose kinase (Pomk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pomk ( NM_029037.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083313.1 Mus musculus protein-O-mannose kinase (Pomk), mRNA.

Price & Availability↑

CloneID	OMu15592
Clone ID Related Accession (Same CDS sequence)	NM_029037.4
Accession Version	NM_029037.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Mus musculus(house mouse)
Product	protein O-mannose kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093366.9. On Apr 30, 2007 this sequence version replaced NM_029037.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK043620.1, SRR1660813.130893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGACAGC AACATGGAAC CAGGAATGGT CTCACGCATA GAGAGCTCCC CCGGGGCGTG 
GGGCTGCTGC TCGCCATGGC CCTTATGAAC GTGGCGCTCT ACCTCTGCCT TGATCAGCTT 
TTCATCTCCC CTGGACGATC CACCGCGGAC TCTAGGCGCT GTCCTCCGGG CTACTTCAGA 
ATGGGGCGGA TGAGAAACTG CTCACGCTGG CTGTCCTGTG AAGAGCTGAG GACAGAAGTC 
AGGCAGCTGA AGCGCGTTGG GGAGGGAGCC GTGAAGAGAG TCTTTCTGTC TGAATGGAAG 
GAACACAAAG TCGCTCTCTC CCGGCTCACC AGGCTGGAGA TGAAGGAGGA CTTCCTGCAT 
GGGCTGCAGA TGCTGAAGTC TCTACAGAGT GAGCACGTGG TCACGCTGGT GGGCTACTGT 
GAGGAAGATG GCACTATTCT CACCGAATAT CACCCCTTAG GTTCCTTGAG CAACCTGGAA 
GAAACACTAA ACCTTTCAAA GTACCAAGAC GTGAACACTT GGCAGCACAG GCTGCAGCTG 
GCCATGGAGT ACGTCAGCAT CATTAACTAT CTGCATCACA GCCCCCTGGG CACGAGGGTC 
ATGTGTGACT CTAACGACCT GCCCAAAACA TTGTCCCAGT ACCTGCTAAC AAGTAACTTC 
AGCATTGTGG CAAACGACCT GGACGCTCTG CCCCTGGTAG ACCATGACTC TGGGGTACTT 
ATAAAGTGTG GCCACAGAGA GCTCCATGGG GATTTTGTGG CTCCAGAGCA GCTGTGGCCC 
TACGGAGAAG ACACGCCCTT CCAAGACGAT CTCATGCCTT CCTACAATGA GAAGGTTGAC 
ATCTGGAAGA TTCCAGATGT CTCCAGTTTC CTCTTGGGGC ACGTGGAAGG GAGTGATATG 
GTTAGATTCC ATTTGTTTGA TATCCATAAG GCGTGCAAGA GCCAGATCCC GGCAGAAAGA 
CCCACTGCTC AGAACGTGCT AGACGCTTAC CAGAGGGTTT TCCATTCACT CCGAGACACT 
GTGATGTCGC AGACGAAAGA AATGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083313.1
CDS	282..1331
Translation	MGQQHGTRNGLTHRELPRGVGLLLAMALMNVALYLCLDQLFISPGRSTADSRRCPPGYFRMGRMRNCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPLGSLSNLEETLNLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAYQRVFHSLRDTVMSQTKEML

Target ORF information:

RefSeq Version	NM_029037.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein-O-mannose kinase (Pomk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029037.4

ORF Insert Sequence:

ATGGGACAGC AACATGGAAC CAGGAATGGT CTCACGCATA GAGAGCTCCC CCGGGGCGTG 
GGGCTGCTGC TCGCCATGGC CCTTATGAAC GTGGCGCTCT ACCTCTGCCT TGATCAGCTT 
TTCATCTCCC CTGGACGATC CACCGCGGAC TCTAGGCGCT GTCCTCCGGG CTACTTCAGA 
ATGGGGCGGA TGAGAAACTG CTCACGCTGG CTGTCCTGTG AAGAGCTGAG GACAGAAGTC 
AGGCAGCTGA AGCGCGTTGG GGAGGGAGCC GTGAAGAGAG TCTTTCTGTC TGAATGGAAG 
GAACACAAAG TCGCTCTCTC CCGGCTCACC AGGCTGGAGA TGAAGGAGGA CTTCCTGCAT 
GGGCTGCAGA TGCTGAAGTC TCTACAGAGT GAGCACGTGG TCACGCTGGT GGGCTACTGT 
GAGGAAGATG GCACTATTCT CACCGAATAT CACCCCTTAG GTTCCTTGAG CAACCTGGAA 
GAAACACTAA ACCTTTCAAA GTACCAAGAC GTGAACACTT GGCAGCACAG GCTGCAGCTG 
GCCATGGAGT ACGTCAGCAT CATTAACTAT CTGCATCACA GCCCCCTGGG CACGAGGGTC 
ATGTGTGACT CTAACGACCT GCCCAAAACA TTGTCCCAGT ACCTGCTAAC AAGTAACTTC 
AGCATTGTGG CAAACGACCT GGACGCTCTG CCCCTGGTAG ACCATGACTC TGGGGTACTT 
ATAAAGTGTG GCCACAGAGA GCTCCATGGG GATTTTGTGG CTCCAGAGCA GCTGTGGCCC 
TACGGAGAAG ACACGCCCTT CCAAGACGAT CTCATGCCTT CCTACAATGA GAAGGTTGAC 
ATCTGGAAGA TTCCAGATGT CTCCAGTTTC CTCTTGGGGC ACGTGGAAGG GAGTGATATG 
GTTAGATTCC ATTTGTTTGA TATCCATAAG GCGTGCAAGA GCCAGATCCC GGCAGAAAGA 
CCCACTGCTC AGAACGTGCT AGACGCTTAC CAGAGGGTTT TCCATTCACT CCGAGACACT 
GTGATGTCGC AGACGAAAGA AATGCTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.
Genes to cells : devoted to molecular & cellular mechanisms22(4)348-359(2017 Apr)
Nagae M,Mishra SK,Neyazaki M,Oi R,Ikeda A,Matsugaki N,Akashi S,Manya H,Mizuno M,Yagi H,Kato K,Senda T,Endo T,Nogi T,Yamaguchi Y

POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations.
Human molecular genetics23(21)5781-92(2014 Nov)
Di Costanzo S,Balasubramanian A,Pond HL,Rozkalne A,Pantaleoni C,Saredi S,Gupta VA,Sunu CM,Yu TW,Kang PB,Salih MA,Mora M,Gussoni E,Walsh CA,Manzini MC

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
Science (New York, N.Y.)341(6148)896-9(2013 Aug)
Yoshida-Moriguchi T,Willer T,Anderson ME,Venzke D,Whyte T,Muntoni F,Lee H,Nelson SF,Yu L,Campbell KP

Congenital hydrocephalus in genetically engineered mice.
Veterinary pathology49(1)166-81(2012 Jan)
Vogel P,Read RW,Hansen GM,Payne BJ,Small D,Sands AT,Zambrowicz BP

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Pomk cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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