Sohlh2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sohlh2
Entrez Gene ID	74434
Full Name	spermatogenesis and oogenesis specific basic helix-loop-helix 2
Synonyms	4933406N12Rik,AI413378,Sosf2
General protein information	Preferred Names spermatogenesis and oogenesis specific basic helix-loop-helix 2 Names spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_028937.3	NP_083213.2	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SOHLH2	XP_543134.3
Pan troglodytes (chimpanzee)	SOHLH2	XP_003314166.1
	SOHLH2	XP_002800767.1
Mus musculus (house mouse)	Sohlh2	NP_083213.2
Rattus norvegicus (Norway rat)	Sohlh2	NP_001030133.1
Homo sapiens (human)	CCDC169-SOHLH2	NP_001185839.1
Bos taurus (cattle)	SOHLH2	XP_002691848.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.
Shin YH, Ren Y, Suzuki H, Golnoski KJ, Ahn HW, Mico V, Rajkovic A
The Journal of clinical investigation127(6)2106-2117(2017 Jun)

BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Zhao ZA, Gao Z, Ma H, Duan E, Gao F, Gao S, Yi Z, Li L
Nature communications814182(2017 Jan)

Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells.
Kato Y, Katsuki T, Kokubo H, Masuda A, Saga Y
Nature communications711272(2016 Apr)

SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes.
Park M, Lee Y, Jang H, Lee OH, Park SW, Kim JH, Hong K, Song H, Park SP, Park YY, Ko JJ, Choi Y
Scientific reports620980(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sohlh1 and Sohlh2 are essential regulators of oocyte differentiation but do not affect meiosis I.
Title: Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.

SOHLH2 is critical for the formation of synaptonemal complexes.
Title: SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes.

Sohlh2 may inhibit oocyte apoptosis via c-kit/PI3K/Akt/Foxo3a signalling pathway
Title: Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway.

SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter.
Title: SOHLH1 and SOHLH2 directly down-regulate STIMULATED BY RETINOIC ACID 8 (STRA8) expression.

Our findings suggest that an SOHLH2/SOHLH1/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis.
Title: Auto-regulation of the Sohlh1 gene by the SOHLH2/SOHLH1/SP1 complex: implications for early spermatogenesis and oogenesis.

The following Sohlh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sohlh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22016	NM_028937.3 Latest version!	Mus musculus spermatogenesis and oogenesis specific basic helix-loop-helix 2 (Sohlh2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sohlh2 ( NM_028937.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083213.2 Mus musculus spermatogenesis and oogenesis specific basic helix-loop-helix 2 (Sohlh2), mRNA.

Price & Availability↑

CloneID	OMu22016
Clone ID Related Accession (Same CDS sequence)	NM_028937.3
Accession Version	NM_028937.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Mus musculus(house mouse)
Product	spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ086115.1 and AI413378.1. On Oct 10, 2007 this sequence version replaced NM_028937.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ086115.1, AK016704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGACC GGATCAGCAC TGGGGAGCTA GGCCGGAGGC CTGGGCAGGG CAGAGTAAAT 
CTTTTGCTGG TTGGAGATGC CACAAGATAC TTCCTGGCTG GCTCTATGCA GAAATTCTTT 
CCTAGCACAG CACAGATCAC CCTGACCATC AGCAATGTGA AGAAGGTCGC CGTGCTTTTG 
GCTGCTAACT CGTTTGACAT AATTTTCTTG AAGGTGACTT CCACTCTAAC TGCAGAGGAG 
CAGGAGGCTG CCAAGTTAAT TAGATCTGGC AAGAAGAAAA ACACACATTT GCTGTTTGCT 
TTTGTAATAC CTGAAAGACT TAAAGGCTAT GTTTCAGAAT ATGGAGCTGA CATTAGTTTC 
AGTGAGCCGC TGACCTTGGA AAAAGTGAAC ACGGTGATAC ACTACTGGAA AACGTATTTC 
ACAAATACGG ATATGGAAAA CACTGAGTTG CCTCCAGAAT GCCGGCTGTA CTTTCAGACG 
TCCCGCAGTG AACTCGGAGG GCGTTTTTCT ACAGATATGT TTCTTTGCTC TGAACTGCTG 
AAGAATGACG CTAGACTTGG ATTAAAGGCC CCGTTGTCGA GTCTAGACAA AAGCAAACAG 
GCGTCTTTTC TTCACTCAAC CAAAGAAAAG CTGAGACGAG AACGCATCAA GTCTTGCTGT 
GAGCAGCTGC GCACGCTCCT GCCATACGTC AAGGGGAGGA AGAGCGATGT GGCATCAGTT 
ATCGAGGCCA CAGTTGATTA TGTGAAGCAG GTCCGGGAGT CTCTCTCTCC AGCCATTATG 
GCCCAGGTTA CAGAAGCCAT TCAGAACAAT AGAAGGTTTT CTAAGAGACA GATGCCCATC 
GAGCTGTTCC TTCCATTCTC AGCCACATCA CAGAGGGAAG ATGCCATGCT GACCAGCGCT 
TTCTCACCTG TGCAAGAGAT TCAGCTCCTG GCTGATCGGG GCCTGAACGT GTATTCCATG 
ACTGCTGCAG GAGGAGCTTT GGAGGGAGCA GTGAGAGGTC AGCCAGGCTC TGTTTCCGAG 
AGCTCTATTG AGGATCTGTA TAAGACTCGC GTCCCCAGCA CAGCCCGATC TCTGAATTCC 
TTCCACTCTG TCAAATACAC TTCTGGAACT GTCTCTCCCC ATGAGGCAGC TGCCAGGACA 
AATCAGAACA TTTCCACTTA TTTGCCACCC ACTGCACCCA GTGTGTCCAA CTTTATTCCT 
CAGCACTGCA ATGCCATGCT TTGCCCAGCA CGCCCAACCA GTCCCAACTG CCTGTGCACT 
CCGGGCCATG AGCTTGCAGC CAGTTCTCGC GCTGCCTCAG CCAGCATCTT TCGTGGATTC 
CGTGCGGCGT CAGCTTCGGA TCACCAGGCC TCTCAGCCAC CTGCTCTGCC ATCTCCACAG 
CCTCACGACA GTAGTTACTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083213.2
CDS	24..1427
Translation	MADRISTGELGRRPGQGRVNLLLVGDATRYFLAGSMQKFFPSTAQITLTISNVKKVAVLLAANSFDIIFLKVTSTLTAEEQEAAKLIRSGKKKNTHLLFAFVIPERLKGYVSEYGADISFSEPLTLEKVNTVIHYWKTYFTNTDMENTELPPECRLYFQTSRSELGGRFSTDMFLCSELLKNDARLGLKAPLSSLDKSKQASFLHSTKEKLRRERIKSCCEQLRTLLPYVKGRKSDVASVIEATVDYVKQVRESLSPAIMAQVTEAIQNNRRFSKRQMPIELFLPFSATSQREDAMLTSAFSPVQEIQLLADRGLNVYSMTAAGGALEGAVRGQPGSVSESSIEDLYKTRVPSTARSLNSFHSVKYTSGTVSPHEAAARTNQNISTYLPPTAPSVSNFIPQHCNAMLCPARPTSPNCLCTPGHELAASSRAASASIFRGFRAASASDHQASQPPALPSPQPHDSSYF

Target ORF information:

RefSeq Version	NM_028937.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus spermatogenesis and oogenesis specific basic helix-loop-helix 2 (Sohlh2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028937.3

ORF Insert Sequence:

ATGGCCGACC GGATCAGCAC TGGGGAGCTA GGCCGGAGGC CTGGGCAGGG CAGAGTAAAT 
CTTTTGCTGG TTGGAGATGC CACAAGATAC TTCCTGGCTG GCTCTATGCA GAAATTCTTT 
CCTAGCACAG CACAGATCAC CCTGACCATC AGCAATGTGA AGAAGGTCGC CGTGCTTTTG 
GCTGCTAACT CGTTTGACAT AATTTTCTTG AAGGTGACTT CCACTCTAAC TGCAGAGGAG 
CAGGAGGCTG CCAAGTTAAT TAGATCTGGC AAGAAGAAAA ACACACATTT GCTGTTTGCT 
TTTGTAATAC CTGAAAGACT TAAAGGCTAT GTTTCAGAAT ATGGAGCTGA CATTAGTTTC 
AGTGAGCCGC TGACCTTGGA AAAAGTGAAC ACGGTGATAC ACTACTGGAA AACGTATTTC 
ACAAATACGG ATATGGAAAA CACTGAGTTG CCTCCAGAAT GCCGGCTGTA CTTTCAGACG 
TCCCGCAGTG AACTCGGAGG GCGTTTTTCT ACAGATATGT TTCTTTGCTC TGAACTGCTG 
AAGAATGACG CTAGACTTGG ATTAAAGGCC CCGTTGTCGA GTCTAGACAA AAGCAAACAG 
GCGTCTTTTC TTCACTCAAC CAAAGAAAAG CTGAGACGAG AACGCATCAA GTCTTGCTGT 
GAGCAGCTGC GCACGCTCCT GCCATACGTC AAGGGGAGGA AGAGCGATGT GGCATCAGTT 
ATCGAGGCCA CAGTTGATTA TGTGAAGCAG GTCCGGGAGT CTCTCTCTCC AGCCATTATG 
GCCCAGGTTA CAGAAGCCAT TCAGAACAAT AGAAGGTTTT CTAAGAGACA GATGCCCATC 
GAGCTGTTCC TTCCATTCTC AGCCACATCA CAGAGGGAAG ATGCCATGCT GACCAGCGCT 
TTCTCACCTG TGCAAGAGAT TCAGCTCCTG GCTGATCGGG GCCTGAACGT GTATTCCATG 
ACTGCTGCAG GAGGAGCTTT GGAGGGAGCA GTGAGAGGTC AGCCAGGCTC TGTTTCCGAG 
AGCTCTATTG AGGATCTGTA TAAGACTCGC GTCCCCAGCA CAGCCCGATC TCTGAATTCC 
TTCCACTCTG TCAAATACAC TTCTGGAACT GTCTCTCCCC ATGAGGCAGC TGCCAGGACA 
AATCAGAACA TTTCCACTTA TTTGCCACCC ACTGCACCCA GTGTGTCCAA CTTTATTCCT 
CAGCACTGCA ATGCCATGCT TTGCCCAGCA CGCCCAACCA GTCCCAACTG CCTGTGCACT 
CCGGGCCATG AGCTTGCAGC CAGTTCTCGC GCTGCCTCAG CCAGCATCTT TCGTGGATTC 
CGTGCGGCGT CAGCTTCGGA TCACCAGGCC TCTCAGCCAC CTGCTCTGCC ATCTCCACAG 
CCTCACGACA GTAGTTACTT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.
The Journal of clinical investigation127(6)2106-2117(2017 Jun)
Shin YH,Ren Y,Suzuki H,Golnoski KJ,Ahn HW,Mico V,Rajkovic A

BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
Nature communications814182(2017 Jan)
Liu W,Wang F,Xu Q,Shi J,Zhang X,Lu X,Zhao ZA,Gao Z,Ma H,Duan E,Gao F,Gao S,Yi Z,Li L

Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells.
Nature communications711272(2016 Apr)
Kato Y,Katsuki T,Kokubo H,Masuda A,Saga Y

SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes.
Scientific reports620980(2016 Feb)
Park M,Lee Y,Jang H,Lee OH,Park SW,Kim JH,Hong K,Song H,Park SP,Park YY,Ko JJ,Choi Y

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Sohlh2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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