Rnd3 cDNA ORF clone, Mus musculus(house mouse)

Genetic deletion of
Dong H, Lin X, Li Y, Hu R, Xu Y, Guo X, La Q, Wang S, Fang C, Guo J, Li Q, Mao S, Liu B
Oncotarget8(53)91112-91122(2017 Oct)

Rnd3 in Cancer: A Review of the Evidence for Tumor Promoter or Suppressor.
Paysan L, Piquet L, Saltel F, Moreau V
Molecular cancer research : MCR14(11)1033-1044(2016 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Rnd3 acted as a novel proangiogenic factor involved in cardiac responsive angiogenesis through HIF1alpha-VEGFA signaling promotion.
Title: Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1?/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1? and Regulates Responsive Cardiac Angiogenesis.

These results indicate that RhoE plays a role in suppressing tumor initiation and progression.
Title: RhoE is required for contact inhibition and negatively regulates tumor initiation and progression.

Rnd3 is a novel factor involved in intracellular calcium homeostasis regulation in the heart.
Title: Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.

Animals with Rnd3 haploinsufficiency are predisposed to hemodynamic stress. Hyperactivation of Rho kinase activity is responsible in part for the apoptotic cardiomyopathy development.
Title: Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.

Data show that the Plexin B2 receptor interacts physically and functionally with Rnd3 and stimulates RhoA activity in migrating cortical neurons.
Title: An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.