P2ry13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2ry13
Entrez Gene ID	74191
Full Name	purinergic receptor P2Y, G-protein coupled 13
Synonyms	2010001L06Rik,GPCR1,GPR94,Gpr86,P2Y13,P2yr13,SP174
General protein information	Preferred Names purinergic receptor P2Y, G-protein coupled 13 Names P2Y purinoceptor 13 G protein-coupled receptor 68 G protein-coupled receptor 86 Vpurinergic receptor P2Y, G-protein coupled 13 purinergic receptor P2Y13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_028808.3	NP_083084.2	P2Y purinoceptor 13

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	P2ry13	NP_001002853.1
Homo sapiens (human)	P2RY13	NP_795713.2
Danio rerio (zebrafish)	LOC100329592	XP_002664563.1
Pan troglodytes (chimpanzee)	P2RY13	XP_001145323.1
Mus musculus (house mouse)	P2ry13	NP_083084.2
Xenopus tropicalis (tropical clawed frog)	p2ry13	NP_001015696.1
Canis lupus familiaris (dog)	P2RY13	XP_005634626.1
Gallus gallus (chicken)	LOC101749756	XP_004943638.1
Bos taurus (cattle)	P2RY13	NP_001091621.1

Gene Ontology
Bibliography

Related articles in PubMed

Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia.
Jiang P, Xing F, Guo B, Yang J, Li Z, Wei W, Hu F, Lee I, Zhang X, Pan L, Xu J
PloS one12(8)e0183114(2017)

Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Ru? L, Ba?ez-Coronel M, Creus-Muncunill J, Giralt A, Alcal?-Vida R, Mentxaka G, Kagerbauer B, Zome?o-Abell?n MT, Aranda Z, Venturi V, P?rez-Navarro E, Estivill X, Mart? E
The Journal of clinical investigation126(11)4319-4330(2016 Nov)

P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.
Guarracino JF, Cinalli AR, Fern?ndez V, Roquel LI, Losavio AS
Neuroscience32631-44(2016 06)

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.
Lichtenstein L, Serhan N, Espinosa-Delgado S, Fabre A, Annema W, Tietge UJ, Robaye B, Boeynaems JM, Laffargue M, Perret B, Martinez LO
Cardiovascular research106(2)314-23(2015 May)

P2Y13 receptor regulates HDL metabolism and atherosclerosis in vivo.
Goffinet M, Tardy C, Boubekeur N, Cholez G, Bluteau A, Oniciu DC, Lalwani ND, Dasseux JL, Barbaras R, Baron R
PloS one9(4)e95807(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 receptors among BV-2 microglia.
Title: Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia.

Conclude that, at motor nerve terminals, the Gi/o protein-coupled P2Y receptors implicated in presynaptic inhibition of spontaneous and evoked acetylcholine release are of the subtype P2Y13. This study provides new insights into the types of purinergic receptors that contribute to the fine-tuning of cholinergic transmission at mammalian neuromuscular junction.
Title: P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.

The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary reverse cholesterol transport
Title: Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.

P2Y13 receptor activation is crucial in mediating the high-fat-diet and palmitic acid-induced myenteric neuronal loss.
Title: The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.

Up-regulation of HDL-cholesterol metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice.
Title: P2Y13 receptor regulates HDL metabolism and atherosclerosis in vivo.

The following P2ry13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2ry13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18921	NM_028808.3 Latest version!	Mus musculus purinergic receptor P2Y, G-protein coupled 13 (P2ry13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2ry13 ( NM_028808.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083084.2 Mus musculus purinergic receptor P2Y, G-protein coupled 13 (P2ry13), mRNA.

Price & Availability↑

CloneID	OMu18921
Clone ID Related Accession (Same CDS sequence)	NM_028808.3
Accession Version	NM_028808.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	P2Y purinoceptor 13
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK083264.1 and AW489196.1. On Jun 20, 2009 this sequence version replaced NM_028808.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038560.1, AK008013.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCGGGA CAATCAACAC CACTGGGATG CAGGGCTTCA ACAAGTCTGA GCGGTGCCCC 
AGGGACACTC GGATGACACA GCTGCTGTTC CCGGTTCTCT ATACTGTGGT CTTCCTGGCA 
GGCATCCTGC TGAACACCGT GGCCCTCTGG GTGTTCGTCC ACATCCCCAG CAATTCCACC 
TTTATCGTCT ACCTCAAGAA CACTCTGGTG GCAGACTTGA TAATGGCACT CATGCTGCCT 
TTCAAAATCC TTTCCGACTC ACACCTTGCG CCCTGGCAGC TCCGAGGATT TGTGTGCACG 
CTCTCCTCCG TGGTCTTCTA TGAGACGATG TATGTGGGTA TCATGATGCT GGGCCTCATC 
GCTTTCGACA GGTTCCTCAA GATCATCATG CCGTTCAGGA AAACCTTTGT CAAAAAGACG 
GCTTTCGCAA AAACAGTCTC CATTTCCGTC TGGTCCCTGA TGTTCTTCAT CTCCCTGCCA 
AACATGATCT TGAACAAGGA GGCAACGCCA TCATCCGTGA AGAAGTGTGC ATCTTTGAAG 
AGTCCCCTTG GGCTGTGGTG GCATCAGGTG GTCAGTCACA CCTGCCAGTT CATTTTCTGG 
GCTGTGTTTA TTCTGATGCT TCTGTTTTAT GCGGTGATTA CCAAAAAGGT GTACAACTCC 
TATAGGAAGT TTAGGAGTAA GGACAGCAGG CACAAGCGGC TGGAGGTGAA GGTATTTATC 
GTCATGGCTG TCTTCTTTGT CTGCTTTGCC CCACTGCATT TTGTCAGAAT ACCATACACT 
TACAGTCAAA CCACCAATAA GACTGACTGT AGGTTAGAAA ACCAGCTGTT TATTGCTAAA 
GAAGCAACTC TCTTTCTGGC AACAACTAAC ATTTGTATGG ACCCCTTAAT ATACATAATT 
TTATGCAAGA AGTTCACACA AAAGGTGCCA TGTGTGAGAT GGGGAAAGGC AAGAACAGCA 
GGATCAAGCG AAGACCACCA CAGTAGTCAG ACAGACAACA TCACCCTAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083084.2
CDS	65..1078
Translation	MLGTINTTGMQGFNKSERCPRDTRMTQLLFPVLYTVVFLAGILLNTVALWVFVHIPSNSTFIVYLKNTLVADLIMALMLPFKILSDSHLAPWQLRGFVCTLSSVVFYETMYVGIMMLGLIAFDRFLKIIMPFRKTFVKKTAFAKTVSISVWSLMFFISLPNMILNKEATPSSVKKCASLKSPLGLWWHQVVSHTCQFIFWAVFILMLLFYAVITKKVYNSYRKFRSKDSRHKRLEVKVFIVMAVFFVCFAPLHFVRIPYTYSQTTNKTDCRLENQLFIAKEATLFLATTNICMDPLIYIILCKKFTQKVPCVRWGKARTAGSSEDHHSSQTDNITLA

Target ORF information:

RefSeq Version	NM_028808.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus purinergic receptor P2Y, G-protein coupled 13 (P2ry13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028808.3

ORF Insert Sequence:

ATGCTCGGGA CAATCAACAC CACTGGGATG CAGGGCTTCA ACAAGTCTGA GCGGTGCCCC 
AGGGACACTC GGATGACACA GCTGCTGTTC CCGGTTCTCT ATACTGTGGT CTTCCTGGCA 
GGCATCCTGC TGAACACCGT GGCCCTCTGG GTGTTCGTCC ACATCCCCAG CAATTCCACC 
TTTATCGTCT ACCTCAAGAA CACTCTGGTG GCAGACTTGA TAATGGCACT CATGCTGCCT 
TTCAAAATCC TTTCCGACTC ACACCTTGCG CCCTGGCAGC TCCGAGGATT TGTGTGCACG 
CTCTCCTCCG TGGTCTTCTA TGAGACGATG TATGTGGGTA TCATGATGCT GGGCCTCATC 
GCTTTCGACA GGTTCCTCAA GATCATCATG CCGTTCAGGA AAACCTTTGT CAAAAAGACG 
GCTTTCGCAA AAACAGTCTC CATTTCCGTC TGGTCCCTGA TGTTCTTCAT CTCCCTGCCA 
AACATGATCT TGAACAAGGA GGCAACGCCA TCATCCGTGA AGAAGTGTGC ATCTTTGAAG 
AGTCCCCTTG GGCTGTGGTG GCATCAGGTG GTCAGTCACA CCTGCCAGTT CATTTTCTGG 
GCTGTGTTTA TTCTGATGCT TCTGTTTTAT GCGGTGATTA CCAAAAAGGT GTACAACTCC 
TATAGGAAGT TTAGGAGTAA GGACAGCAGG CACAAGCGGC TGGAGGTGAA GGTATTTATC 
GTCATGGCTG TCTTCTTTGT CTGCTTTGCC CCACTGCATT TTGTCAGAAT ACCATACACT 
TACAGTCAAA CCACCAATAA GACTGACTGT AGGTTAGAAA ACCAGCTGTT TATTGCTAAA 
GAAGCAACTC TCTTTCTGGC AACAACTAAC ATTTGTATGG ACCCCTTAAT ATACATAATT 
TTATGCAAGA AGTTCACACA AAAGGTGCCA TGTGTGAGAT GGGGAAAGGC AAGAACAGCA 
GGATCAAGCG AAGACCACCA CAGTAGTCAG ACAGACAACA TCACCCTAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia.
PloS one12(8)e0183114(2017)
Jiang P,Xing F,Guo B,Yang J,Li Z,Wei W,Hu F,Lee I,Zhang X,Pan L,Xu J

Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
The Journal of clinical investigation126(11)4319-4330(2016 Nov)
Ru? L,Ba?ez-Coronel M,Creus-Muncunill J,Giralt A,Alcal?-Vida R,Mentxaka G,Kagerbauer B,Zome?o-Abell?n MT,Aranda Z,Venturi V,P?rez-Navarro E,Estivill X,Mart? E

P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.
Neuroscience32631-44(2016 06)
Guarracino JF,Cinalli AR,Fern?ndez V,Roquel LI,Losavio AS

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.
Cardiovascular research106(2)314-23(2015 May)
Lichtenstein L,Serhan N,Espinosa-Delgado S,Fabre A,Annema W,Tietge UJ,Robaye B,Boeynaems JM,Laffargue M,Perret B,Martinez LO

P2Y13 receptor regulates HDL metabolism and atherosclerosis in vivo.
PloS one9(4)e95807(2014)
Goffinet M,Tardy C,Boubekeur N,Cholez G,Bluteau A,Oniciu DC,Lalwani ND,Dasseux JL,Barbaras R,Baron R

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P2ry13 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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