Syce1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syce1
Entrez Gene ID	74075
Full Name	synaptonemal complex central element protein 1
Synonyms	4933406J07Rik
General protein information	Preferred Names synaptonemal complex central element protein 1 Names synaptonemal complex central element protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F4\|7

mRNA and Protein(s)

mRNA	Protein	Name
NM_001143765.1	NP_001137237.1	synaptonemal complex central element protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SYCE1	NP_001137236.1
Mus musculus (house mouse)	Syce1	NP_001137237.1
Pan troglodytes (chimpanzee)	SYCE1	XP_001146521.1
	SYCE1	XP_002805923.1
Bos taurus (cattle)	SYCE1	NP_001033238.2
Canis lupus familiaris (dog)	LOC480826	XP_005637983.1
Rattus norvegicus (Norway rat)	Syce1	NP_001020229.2

Gene Ontology
Bibliography

Related articles in PubMed

Exome sequencing reveals SYCE1 mutation associated with autosomal recessive primary ovarian insufficiency.
de Vries L, Behar DM, Smirin-Yosef P, Lagovsky I, Tzur S, Basel-Vanagaite L
The Journal of clinical endocrinology and metabolism99(10)E2129-32(2014 Oct)

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
Fukuda T, Fukuda N, Agostinho A, Hern?ndez-Hern?ndez A, Kouznetsova A, H??g C
The EMBO journal33(11)1243-55(2014 Jun)

Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components.
Fraune J, Brochier-Armanet C, Alsheimer M, Benavente R
Genetics195(3)781-93(2013 Nov)

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
Shi YQ, Zhuang XJ, Xu B, Hua J, Liao SY, Shi Q, Cooke HJ, Han C
Gene527(1)352-9(2013 Sep)

Meiosis in mice without a synaptonemal complex.
Kouznetsova A, Benavente R, Pastink A, H??g C
PloS one6(12)e28255(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genes involved in essential steps in chromosome synapsis and recombination during meiosis, such as synaptonemal complex central element 1 (SYCE1), have been shown to cause POI in animal models.
Title: Exome sequencing reveals SYCE1 mutation associated with autosomal recessive primary ovarian insufficiency.

Mutation in the Syce1 results in disruption of synapsis.
Title: Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair.

Transcripts highly enriched in ovary; gene expressed in female germline in addition to male germline.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1.
Title: Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.

The following Syce1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syce1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22558	NM_001143765.1 Latest version!	Mus musculus synaptonemal complex central element protein 1 (Syce1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syce1 ( NM_001143765.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001137237.1 Mus musculus synaptonemal complex central element protein 1 (Syce1), mRNA.

Price & Availability↑

CloneID	OMu22558
Clone ID Related Accession (Same CDS sequence)	NM_001143765.1
Accession Version	NM_001143765.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-08
Organism	Mus musculus(house mouse)
Product	synaptonemal complex central element protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY081845.1, AK016694.1 and AC107815.11. On or before Jan 7, 2009 this sequence version replaced XM_001479666.1, XM_001472886.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK016694.1, BY716381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCA GACCGCAGCC GTTGGGTATG GAGCCCGAGG GCTCAGCAGA CCTGCTCCAC 
GGGCCTGAGG GGGCCAGAGG GCAGTATGGG TCCACACAGA AAATTGAAGA CTTAATGGAC 
ATGGTGAAAA AGTTGCAGAA AGTGGGAAGC CTAGAGCCCC GGATTGAGGT CCTGATTAAC 
CGTATTAATG AGGTTCAGCA AGCAAAAAAG AAAGCCAGTG AGGAGCTTGG AGAGGCCCAG 
ACTGTCTGGG ACAACCTGCA GAAGGAACTG GACTTACTAC GTGAAGAGAA AGTACGTCTG 
AAGGATATTT TGAACAGAAA GGAAGAGACC CTGAGGATTA TGCAGCTGCA CTGCCAGGAG 
AAGGAAAGTG AGGCACAGAG GAAGCACAGC ATGTTGCAGG AGTGTAAAGA GAGAATTTCT 
TTCCTGAACT CCCAGATCGA CAAAGAGAAG GCCAAACTAA GAAAACTGAG GTTGGATTTT 
GAAGAACATC TGGAGACTTT GATGAGTCAA CATAAGGACA CCTTGGAATT TCATAAGCCT 
GAACATCTGA CAAAGGAGAT GTGTGTTTTG GACAGCAGCA AGGAGCAGCT GCTCAAGGAA 
GAGAAACTGA TGAAAGTAAA GCTGGAGGAT GTGAGACAGC GGCTGTGTGC CCTGGGCGGG 
CCTGAGGGTT CTTCCAGCCT CATTGAGGGA CTCTTCCTCC GAAGCCATGA GGCAGCTGCA 
GCAATGCAGA TGTTCAAGGA TGAGAACAAG AAAGCTGAGG AGTTCCTAGA GGCTGCAGCT 
CAGCAGCACG AGCAGCTGCA GCAGAGGTGC CACCAGCTAC AGCAGAAACG GCAGAGGCTG 
AAGGAAGAAC TGGAAAAGCA TGGGGTACAG ATCCTTGCTC ATAGTACGCA AAACGAAGAA 
GACAGCTCAT GGAGGATGGC CAGTCCTAAA CCTGTAGAAG TCCACGAGGA GACAGCCCAA 
GACCAAGAGC GCCCATCAAG CAGGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137237.1
CDS	41..1030
Translation	MATRPQPLGMEPEGSADLLHGPEGARGQYGSTQKIEDLMDMVKKLQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDNLQKELDLLREEKVRLKDILNRKEETLRIMQLHCQEKESEAQRKHSMLQECKERISFLNSQIDKEKAKLRKLRLDFEEHLETLMSQHKDTLEFHKPEHLTKEMCVLDSSKEQLLKEEKLMKVKLEDVRQRLCALGGPEGSSSLIEGLFLRSHEAAAAMQMFKDENKKAEEFLEAAAQQHEQLQQRCHQLQQKRQRLKEELEKHGVQILAHSTQNEEDSSWRMASPKPVEVHEETAQDQERPSSRT

Target ORF information:

RefSeq Version	NM_001143765.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus synaptonemal complex central element protein 1 (Syce1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001143765.1

ORF Insert Sequence:

ATGGCCACCA GACCGCAGCC GTTGGGTATG GAGCCCGAGG GCTCAGCAGA CCTGCTCCAC 
GGGCCTGAGG GGGCCAGAGG GCAGTATGGG TCCACACAGA AAATTGAAGA CTTAATGGAC 
ATGGTGAAAA AGTTGCAGAA AGTGGGAAGC CTAGAGCCCC GGATTGAGGT CCTGATTAAC 
CGTATTAATG AGGTTCAGCA AGCAAAAAAG AAAGCCAGTG AGGAGCTTGG AGAGGCCCAG 
ACTGTCTGGG ACAACCTGCA GAAGGAACTG GACTTACTAC GTGAAGAGAA AGTACGTCTG 
AAGGATATTT TGAACAGAAA GGAAGAGACC CTGAGGATTA TGCAGCTGCA CTGCCAGGAG 
AAGGAAAGTG AGGCACAGAG GAAGCACAGC ATGTTGCAGG AGTGTAAAGA GAGAATTTCT 
TTCCTGAACT CCCAGATCGA CAAAGAGAAG GCCAAACTAA GAAAACTGAG GTTGGATTTT 
GAAGAACATC TGGAGACTTT GATGAGTCAA CATAAGGACA CCTTGGAATT TCATAAGCCT 
GAACATCTGA CAAAGGAGAT GTGTGTTTTG GACAGCAGCA AGGAGCAGCT GCTCAAGGAA 
GAGAAACTGA TGAAAGTAAA GCTGGAGGAT GTGAGACAGC GGCTGTGTGC CCTGGGCGGG 
CCTGAGGGTT CTTCCAGCCT CATTGAGGGA CTCTTCCTCC GAAGCCATGA GGCAGCTGCA 
GCAATGCAGA TGTTCAAGGA TGAGAACAAG AAAGCTGAGG AGTTCCTAGA GGCTGCAGCT 
CAGCAGCACG AGCAGCTGCA GCAGAGGTGC CACCAGCTAC AGCAGAAACG GCAGAGGCTG 
AAGGAAGAAC TGGAAAAGCA TGGGGTACAG ATCCTTGCTC ATAGTACGCA AAACGAAGAA 
GACAGCTCAT GGAGGATGGC CAGTCCTAAA CCTGTAGAAG TCCACGAGGA GACAGCCCAA 
GACCAAGAGC GCCCATCAAG CAGGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exome sequencing reveals SYCE1 mutation associated with autosomal recessive primary ovarian insufficiency.
The Journal of clinical endocrinology and metabolism99(10)E2129-32(2014 Oct)
de Vries L,Behar DM,Smirin-Yosef P,Lagovsky I,Tzur S,Basel-Vanagaite L

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
The EMBO journal33(11)1243-55(2014 Jun)
Fukuda T,Fukuda N,Agostinho A,Hern?ndez-Hern?ndez A,Kouznetsova A,H??g C

Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components.
Genetics195(3)781-93(2013 Nov)
Fraune J,Brochier-Armanet C,Alsheimer M,Benavente R

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
Gene527(1)352-9(2013 Sep)
Shi YQ,Zhuang XJ,Xu B,Hua J,Liao SY,Shi Q,Cooke HJ,Han C

Meiosis in mice without a synaptonemal complex.
PloS one6(12)e28255(2011)
Kouznetsova A,Benavente R,Pastink A,H??g C

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Syce1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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