Rd3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rd3
Entrez Gene ID	74023
Full Name	retinal degeneration 3
Synonyms	3322402L07Rik,rd-3,rd3
General protein information	Preferred Names retinal degeneration 3 Names protein RD3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H6\|1 97.09 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303132.1	NP_001290061.1	protein RD3 isoform 2
XM_006497206.4	XP_006497269.1	protein RD3 isoform X1
NM_023727.4	NP_076216.3	protein RD3 isoform 1
XM_006497205.2	XP_006497268.1	protein RD3 isoform X1
XM_006497205.3	XP_006497268.1	protein RD3 isoform X1
NM_001177900.2	NP_001171371.2	protein RD3 isoform 2
XM_006497206.3	XP_006497269.1	protein RD3 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rd3	XP_006250558.1
Homo sapiens (human)	RD3	NP_001158160.1
Pan troglodytes (chimpanzee)	RD3	XP_001170072.1
Bos taurus (cattle)	RD3	XP_002694338.1
Mus musculus (house mouse)	Rd3	NP_076216.2
	LOC716885	XP_001107911.1
Xenopus tropicalis (tropical clawed frog)	rd3	XP_004914138.1
Canis lupus familiaris (dog)	RD3	XP_852309.1
Gallus gallus (chicken)	RD3	XP_419438.1
Danio rerio (zebrafish)	rd3	NP_001074100.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.
Peshenko IV, Olshevskaya EV, Dizhoor AM
The Journal of biological chemistry291(37)19713-23(2016 09)

Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.
Chang B
Methods in molecular biology (Clifton, N.J.)1438417-30(2016)

Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1.
Zulliger R, Naash MI, Rajala RV, Molday RS, Azadi S
The Journal of biological chemistry290(6)3488-99(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region.
Title: Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.

Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106.
Title: Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.

Direct association between RD3 and GCAP1 is important for GC1 targeting.
Title: Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1.

Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments.
Title: RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of Leber congenital amaurosis 12.

Changes in gene expression associated with photoreceptor degeneration in the rd3 mouse model of Leber congenital amaurosis (LCA) type 12, are characterized.
Title: Changes in gene expression associated with retinal degeneration in the rd3 mouse.

The following Rd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu71084	NM_001177900.2 Latest version!	Mus musculus retinal degeneration 3 (Rd3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OMu71084	NM_001303132.1 Latest version!	Mus musculus retinal degeneration 3 (Rd3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu28987	NM_023727.4 Latest version!	Mus musculus retinal degeneration 3 (Rd3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu28987	XM_006497205.3 Latest version!	Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu28987	XM_006497206.4 Latest version!	Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu28987	XM_006497205.2	Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu28987	XM_006497206.3	Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rd3 ( NM_001177900.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001171371.2 Mus musculus retinal degeneration 3 (Rd3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu71084
Clone ID Related Accession (Same CDS sequence)	NM_001303132.1 , NM_001177900.2
Accession Version	NM_001177900.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC182412.2, BC017602.1, AK014383.2 and BB009603.2. On Dec 18, 2014 this sequence version replaced NM_001177900.1. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Both variants 2 and 3 encode isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017602.1, BG293251.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTTC AGGCAGCTGC 
TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC GTGTTGCAGG 
AGGCCCTGGA GAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171371.2
CDS	354..671
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGSGSCWLNESPRCRRWRGCSAPCCRRPWRR

Target ORF information:

RefSeq Version	NM_001177900.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001177900.2

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTTC AGGCAGCTGC 
TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC GTGTTGCAGG 
AGGCCCTGGA GAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( NM_001303132.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001290061.1 Mus musculus retinal degeneration 3 (Rd3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu71084
Clone ID Related Accession (Same CDS sequence)	NM_001303132.1 , NM_001177900.2
Accession Version	NM_001303132.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC089516.1, AK014383.2 and BB009603.2. Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Both variants 2 and 3 encode isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089516.1, FO715091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTTC AGGCAGCTGC 
TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC GTGTTGCAGG 
AGGCCCTGGA GAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290061.1
CDS	561..878
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGSGSCWLNESPRCRRWRGCSAPCCRRPWRR

Target ORF information:

RefSeq Version	NM_001303132.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303132.1

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTTC AGGCAGCTGC 
TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC GTGTTGCAGG 
AGGCCCTGGA GAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( NM_023727.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076216.3 Mus musculus retinal degeneration 3 (Rd3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu28987
Clone ID Related Accession (Same CDS sequence)	XM_006497206.4 , NM_023727.4 , XM_006497205.2 , XM_006497205.3 , XM_006497206.3
Accession Version	NM_023727.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC182412.2, AK045045.1, AK014383.2 and BB009603.2. On Dec 18, 2014 this sequence version replaced NM_023727.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014383.2, AB030195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076216.3
CDS	357..944
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD

Target ORF information:

RefSeq Version	NM_023727.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023727.4

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( XM_006497205.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497268.1 Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28987
Clone ID Related Accession (Same CDS sequence)	XM_006497206.4 , NM_023727.4 , XM_006497205.2 , XM_006497205.3 , XM_006497206.3
Accession Version	XM_006497205.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006497205.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497268.1
CDS	559..1146
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD

Target ORF information:

RefSeq Version	XM_006497205.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497205.2

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( XM_006497206.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497269.1 Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu28987
Clone ID Related Accession (Same CDS sequence)	XM_006497206.4 , NM_023727.4 , XM_006497205.2 , XM_006497205.3 , XM_006497206.3
Accession Version	XM_006497206.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497206.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497269.1
CDS	2465..3052
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD

Target ORF information:

RefSeq Version	XM_006497206.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497206.3

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( XM_006497206.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497269.1 Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.

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CloneID	OMu28987
Clone ID Related Accession (Same CDS sequence)	XM_006497206.4 , NM_023727.4 , XM_006497205.2 , XM_006497205.3 , XM_006497206.3
Accession Version	XM_006497206.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497206.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497269.1
CDS	171..758
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD

Target ORF information:

RefSeq Version	XM_006497206.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497206.4

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rd3 ( XM_006497205.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006497268.1 Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28987
Clone ID Related Accession (Same CDS sequence)	XM_006497206.4 , NM_023727.4 , XM_006497205.2 , XM_006497205.3 , XM_006497206.3
Accession Version	XM_006497205.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein RD3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497205.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497268.1
CDS	583..1170
Translation	MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD

Target ORF information:

RefSeq Version	XM_006497205.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus retinal degeneration 3 (Rd3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497205.3

ORF Insert Sequence:

ATGTCCCTCA TCCCGTGGCT CCGGTGGAAC GACACCCCTC CCCGGCTCTC GGCCCGGACC 
CCGGCCGAGA TGGTGCTGGA GACGCTCATG ATGGAGCTGG CTGGGCAGAT GAGAGAGGTG 
GAGCGACAAC AGAGGGAGCG TCGCAGCGCA GTCAGGAAGA TCTGCACTGG TGTGGACTAC 
AGCTGGTTGG CAAACACGCC CAGGCCCACC TATGACATCA GCCCTGGTGA GCGGCTGCAG 
TTGGAGGATG TATGTGCCAA GATCCACCCA TCCTACTGTG GGCCTGCCAT CCTCAGGTTC 
AGGCAGCTGC TGGCTGAACG AGAGCCCGAG GTGCAGGAGG TGGCGCGGCT GTTCCGCTCC 
GTGTTGCAGG AGGCCCTGGA GAAGATGAAG CAGGAGGAGG AGGCCCATAA GCTGACACGT 
CAGTGGAGCT TGAGGCCCCG CGGCAGCCTG TCGTCCTTCA AGACCCGCGC TCGCATCGCA 
CCCTTTGCCA GTGACATCCG AACCATCTCG GAGGATGTGG AGCGCGATGC GCCACCCCCG 
CCGCGCACCT GGAGCATGCC GGAGTTCAGG GCGCCCCAGG CCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.
The Journal of biological chemistry291(37)19713-23(2016 09)
Peshenko IV,Olshevskaya EV,Dizhoor AM

Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis.
Methods in molecular biology (Clifton, N.J.)1438417-30(2016)
Chang B

Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1.
The Journal of biological chemistry290(6)3488-99(2015 Feb)
Zulliger R,Naash MI,Rajala RV,Molday RS,Azadi S

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Rd3 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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