Atl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atl1
Entrez Gene ID	73991
Full Name	atlastin GTPase 1
Synonyms	4930435M24Rik,Adfsp,Fsp1,Spg3,Spg3a
General protein information	Preferred Names atlastin GTPase 1 Names atlastin-1 spastic paraplegia 3A homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 C2
Summary	This gene encodes a member of the dynamin family of GTPases. The encoded protein interacts with tubule-shaping proteins of the endoplasmic reticulum. Mutations in the homologous human gene can cause hereditary spastic paraplegia. [provided by RefSeq, Feb 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178628.5	NP_848743.1	atlastin-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATL1	XP_005623439.1
	ATL1	XP_001101240.1
Gallus gallus (chicken)	ATL1	XP_421466.4
Pan troglodytes (chimpanzee)	ATL1	XP_001156076.1
Mus musculus (house mouse)	Atl1	NP_848743.1
Danio rerio (zebrafish)	atl1	NP_001139172.1
Xenopus tropicalis (tropical clawed frog)	atl1	NP_001072222.1
Homo sapiens (human)	ATL1	NP_056999.2
Bos taurus (cattle)	ATL1	NP_001029803.1
Rattus norvegicus (Norway rat)	Atl1	NP_001009831.1

Gene Ontology
Bibliography

Related articles in PubMed

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.
Zhao G, Zhu PP, Renvois? B, Maldonado-B?ez L, Park SH, Blackstone C
Experimental cell research349(1)32-44(2016 Nov)

VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation.
Shih YT, Hsueh YP
Nature communications711020(2016 Mar)

Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia.
Rinaldi C, Schmidt T, Situ AJ, Johnson JO, Lee PR, Chen KL, Bott LC, Fad? R, Harmison GH, Parodi S, Grunseich C, Renvois? B, Biesecker LG, De Michele G, Santorelli FM, Filla A, Stevanin G, D?rr A, Brice A, Casals N, Traynor BJ, Blackstone C, Ulmer TS, Fischbeck KH
JAMA neurology72(5)561-70(2015 May)

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.
Hashimoto Y, Shirane M, Matsuzaki F, Saita S, Ohnishi T, Nakayama KI
The Journal of biological chemistry289(19)12946-61(2014 May)

Atlastin-1 regulates dendritic morphogenesis in mouse cerebral cortex.
Gao Y, Jiang T, Qu C, Tao H, Cao H, Zhao Y, Wang Y, Qu J, Chen JG
Neuroscience research77(3)137-42(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells.
Title: Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.

VCP (valosin-containing protein), together with its cofactor P47 and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1), regulates tubular ER formation
Title: VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation.

This publication discusses functional and mutational aspects of atlastin GTPase 1 in humans.
Title: Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A.

The following Atl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15858	NM_178628.5 Latest version!	Mus musculus atlastin GTPase 1 (Atl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$328.30 $469.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atl1 ( NM_178628.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848743.1 Mus musculus atlastin GTPase 1 (Atl1), mRNA.

Price & Availability↑

CloneID	OMu15858
Clone ID Related Accession (Same CDS sequence)	NM_178628.5
Accession Version	NM_178628.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	atlastin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX236218.1, AK050339.1, AK046919.1 and AC166827.2. On Feb 18, 2010 this sequence version replaced NM_178628.4. ##Evidence-Data-START## Transcript exon combination :: AK050339.1, SRR1660815.49663.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTAAGA GCCGCAGGGA CAGAAACAGT TGGGGTGGGT TTTCAGAGAA GTCAAGTGAC 
TGGAGCTCAG AAGAGGAGGA GCCAGTGAGA AAGGCAGGGC CTGTCCAGGT CCTCATCGTC 
AAGGACGACC ATTCCTTTGA GTTAGACGAG GCTGCGCTGA ACCGCATCCT TCTGTCCCAG 
GCCGTCAGAG ACAAGGAGGT GGTTGCTGTG TCTGTTGCTG GAGCCTTTAG AAAAGGGAAA 
TCCTTCCTGA TGGACTTCAT GTTGCGGTAC ATGTACAACC AGGAATCTGT TGATTGGGTT 
GGAGATTACA ATGAACCATT GACTGGATTT TCATGGAGGG GTGGATCGGA ACGAGAAACC 
ACAGGAATCC AGATATGGAG TGAAGTTTTC CTCATCAATA AGCTTGATGG TAAAAAGGTT 
GCAGTGTTAC TGATGGATAC TCAGGGAACC TTTGACAGTC AGTCAACTTT GAGAGATTCG 
GCCACAGTAT TTGCGCTTAG CACAATGATA AGCTCAATAC AGGTCTACAA CTTGTCCCAG 
AATGTCCAGG AGGATGATCT CCAGCACCTG CAGCTTTTCA CTGAGTATGG CAGGTTGGCA 
ATGGAAGAAA CATTCCTGAA GCCTTTTCAG AGTCTGATAT TTCTTGTTCG AGACTGGAGT 
TTCCCATACG AATTTTCATA TGGAGCTGAT GGTGGCGCCA AGTTCTTGGA AAAACGCCTC 
AAGGTCTCAG GGAACCAGCA TGAAGAGCTG CAGAACGTCA GGAAGCACAT CCACTCCTGC 
TTCACCAACA TTTCCTGCTT TCTCCTACCT CATCCTGGCT TAAAAGTCGC TACCAACCCA 
AACTTTGATG GGAAACTAAA AGAAATAGAT GATGAATTCA TCAAAAACTT GAAAATACTG 
ATTCCATGGC TCCTGAGTCC TGAGCGTCTA GATATTAAAG AGATCAATGG GAATAAAATC 
ACCTGCCGAG GCCTGCTGGA GTACTTCAAG GCATACATAA AGATATACCA AGGTGAAGAA 
TTGCCGCATC CCAAGTCCAT GTTACAGGCC ACAGCAGAAG CTAACAATTT AGCAGCTGTT 
GCAACTGCCA AGGACACATA CAACAAGAAG ATGGAAGAGG TTTGTGGTGG TGATAAACCA 
TTTTTGGCCC CTAACGACCT GCAAAGCAAG CACCTGCAGC TAAAAGAAGA ATCTGTGAAG 
TTATTCCGAG GCGTGAAGAA GATGGGCGGG GAAGAGTTCA GCCGGCGTTA CCTGCAGCAG 
CTGGAGAGTG AAATAGATGA ACTCTACATC CAGTATATTA AGCACAATGA CAGCAAAAAT 
ATCTTCCATG CTGCTCGAAC CCCAGCCACA CTGTTCGTTG TCATCTTTAT CACATACGTG 
ATTGCTGGTG TGACTGGATT CATTGGTTTG GACATCATAG CTAGCCTGTG CAACATGATC 
ATGGGACTGA CGCTTATCAC CCTCTGCACC TGGGCATATA TCCGCTACTC TGGCGAATAT 
CGAGAGCTGG GTGCTGTAAT CGACCAGGTA GCTGCAGCTT TGTGGGACCA GGGAAGCACA 
AATGAGGCGT TATACAAGCT TTACAGTGCA GCAGCAACCC ACAGACACCT GTGTCACCAA 
GCTTTCCCTG CACCCAAGTC AGAGCCTACT CAACAACCGG AAAAGAAGAA AATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848743.1
CDS	395..2071
Translation	MAKSRRDRNSWGGFSEKSSDWSSEEEEPVRKAGPVQVLIVKDDHSFELDEAALNRILLSQAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEVFLINKLDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILIPWLLSPERLDIKEINGNKITCRGLLEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEVCGGDKPFLAPNDLQSKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLCHQAFPAPKSEPTQQPEKKKI

Target ORF information:

RefSeq Version	NM_178628.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus atlastin GTPase 1 (Atl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178628.5

ORF Insert Sequence:

ATGGCTAAGA GCCGCAGGGA CAGAAACAGT TGGGGTGGGT TTTCAGAGAA GTCAAGTGAC 
TGGAGCTCAG AAGAGGAGGA GCCAGTGAGA AAGGCAGGGC CTGTCCAGGT CCTCATCGTC 
AAGGACGACC ATTCCTTTGA GTTAGACGAG GCTGCGCTGA ACCGCATCCT TCTGTCCCAG 
GCCGTCAGAG ACAAGGAGGT GGTTGCTGTG TCTGTTGCTG GAGCCTTTAG AAAAGGGAAA 
TCCTTCCTGA TGGACTTCAT GTTGCGGTAC ATGTACAACC AGGAATCTGT TGATTGGGTT 
GGAGATTACA ATGAACCATT GACTGGATTT TCATGGAGGG GTGGATCGGA ACGAGAAACC 
ACAGGAATCC AGATATGGAG TGAAGTTTTC CTCATCAATA AGCTTGATGG TAAAAAGGTT 
GCAGTGTTAC TGATGGATAC TCAGGGAACC TTTGACAGTC AGTCAACTTT GAGAGATTCG 
GCCACAGTAT TTGCGCTTAG CACAATGATA AGCTCAATAC AGGTCTACAA CTTGTCCCAG 
AATGTCCAGG AGGATGATCT CCAGCACCTG CAGCTTTTCA CTGAGTATGG CAGGTTGGCA 
ATGGAAGAAA CATTCCTGAA GCCTTTTCAG AGTCTGATAT TTCTTGTTCG AGACTGGAGT 
TTCCCATACG AATTTTCATA TGGAGCTGAT GGTGGCGCCA AGTTCTTGGA AAAACGCCTC 
AAGGTCTCAG GGAACCAGCA TGAAGAGCTG CAGAACGTCA GGAAGCACAT CCACTCCTGC 
TTCACCAACA TTTCCTGCTT TCTCCTACCT CATCCTGGCT TAAAAGTCGC TACCAACCCA 
AACTTTGATG GGAAACTAAA AGAAATAGAT GATGAATTCA TCAAAAACTT GAAAATACTG 
ATTCCATGGC TCCTGAGTCC TGAGCGTCTA GATATTAAAG AGATCAATGG GAATAAAATC 
ACCTGCCGAG GCCTGCTGGA GTACTTCAAG GCATACATAA AGATATACCA AGGTGAAGAA 
TTGCCGCATC CCAAGTCCAT GTTACAGGCC ACAGCAGAAG CTAACAATTT AGCAGCTGTT 
GCAACTGCCA AGGACACATA CAACAAGAAG ATGGAAGAGG TTTGTGGTGG TGATAAACCA 
TTTTTGGCCC CTAACGACCT GCAAAGCAAG CACCTGCAGC TAAAAGAAGA ATCTGTGAAG 
TTATTCCGAG GCGTGAAGAA GATGGGCGGG GAAGAGTTCA GCCGGCGTTA CCTGCAGCAG 
CTGGAGAGTG AAATAGATGA ACTCTACATC CAGTATATTA AGCACAATGA CAGCAAAAAT 
ATCTTCCATG CTGCTCGAAC CCCAGCCACA CTGTTCGTTG TCATCTTTAT CACATACGTG 
ATTGCTGGTG TGACTGGATT CATTGGTTTG GACATCATAG CTAGCCTGTG CAACATGATC 
ATGGGACTGA CGCTTATCAC CCTCTGCACC TGGGCATATA TCCGCTACTC TGGCGAATAT 
CGAGAGCTGG GTGCTGTAAT CGACCAGGTA GCTGCAGCTT TGTGGGACCA GGGAAGCACA 
AATGAGGCGT TATACAAGCT TTACAGTGCA GCAGCAACCC ACAGACACCT GTGTCACCAA 
GCTTTCCCTG CACCCAAGTC AGAGCCTACT CAACAACCGG AAAAGAAGAA AATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.
Experimental cell research349(1)32-44(2016 Nov)
Zhao G,Zhu PP,Renvois? B,Maldonado-B?ez L,Park SH,Blackstone C

VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation.
Nature communications711020(2016 Mar)
Shih YT,Hsueh YP

Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia.
JAMA neurology72(5)561-70(2015 May)
Rinaldi C,Schmidt T,Situ AJ,Johnson JO,Lee PR,Chen KL,Bott LC,Fad? R,Harmison GH,Parodi S,Grunseich C,Renvois? B,Biesecker LG,De Michele G,Santorelli FM,Filla A,Stevanin G,D?rr A,Brice A,Casals N,Traynor BJ,Blackstone C,Ulmer TS,Fischbeck KH

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia.
The Journal of biological chemistry289(19)12946-61(2014 May)
Hashimoto Y,Shirane M,Matsuzaki F,Saita S,Ohnishi T,Nakayama KI

Atlastin-1 regulates dendritic morphogenesis in mouse cerebral cortex.
Neuroscience research77(3)137-42(2013 Nov)
Gao Y,Jiang T,Qu C,Tao H,Cao H,Zhao Y,Wang Y,Qu J,Chen JG

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Atl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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