Hapln2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hapln2
Entrez Gene ID	73940
Full Name	hyaluronan and proteoglycan link protein 2
Synonyms	4930401E20Rik,Bral1
General protein information	Preferred Names hyaluronan and proteoglycan link protein 2 Names hyaluronan and proteoglycan link protein 2 brain link protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 38.78 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006502148.2	XP_006502211.1	hyaluronan and proteoglycan link protein 2 isoform X1
NM_022031.2	NP_071314.1	hyaluronan and proteoglycan link protein 2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HAPLN2	NP_001069152.1
Danio rerio (zebrafish)	hapln2	NP_001076285.2
Pan troglodytes (chimpanzee)	HAPLN2	XP_003949671.1
Rattus norvegicus (Norway rat)	Hapln2	NP_071621.1
Gallus gallus (chicken)	HAPLN2	XP_423654.4
Canis lupus familiaris (dog)	HAPLN2	XP_547532.4
Mus musculus (house mouse)	Hapln2	NP_071314.1
Homo sapiens (human)	HAPLN2	NP_068589.1
	HAPLN2	XP_001116614.1
Xenopus tropicalis (tropical clawed frog)	hapln2	XP_002941550.2

Gene Ontology
Bibliography

Related articles in PubMed

Three mechanisms assemble central nervous system nodes of Ranvier.
Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN
Neuron78(3)469-82(2013 May)

Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.
Bekku Y, Vargov? L, Goto Y, Vor?sek I, Dmytrenko L, Narasaki M, Ohtsuka A, F?ssler R, Ninomiya Y, Sykov? E, Oohashi T
The Journal of neuroscience : the official journal of the Society for Neuroscience30(8)3113-23(2010 Feb)

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Human molecular genetics15(8)1329-41(2006 Apr)

A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation.
Karim SA, Johnson KJ, Griffiths IR, Vouyiouklis DA
Genomics83(2)225-30(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings provide an understanding of the mechanisms underlying the accumulation of cations due to diffusion barriers around the nodes during saltatory conduction, emphasizing the importance of the Bral1-based extramilieu for neuronal conductivity.
Title: Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.

colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems.
Title: Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems.

The following Hapln2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hapln2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21085	NM_022031.2 Latest version!	Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
OMu21085	XM_006502148.2 Latest version!	Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hapln2 ( NM_022031.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_071314.1 Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), mRNA.

Price & Availability↑

CloneID	OMu21085
Clone ID Related Accession (Same CDS sequence)	XM_006502148.2 , NM_022031.2
Accession Version	NM_022031.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	hyaluronan and proteoglycan link protein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY122070.1, AB049055.1, AK081264.1 and BE651789.1. On Oct 26, 2007 this sequence version replaced NM_022031.1. ##Evidence-Data-START## Transcript exon combination :: AB049055.1, BC138584.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAAGCA GGATCCCTCT CCCTGCGTTC TGCTGCTTCC TTCTCCCCTG GGCCTTCACC 
AGCTTTCACA AAGCCCTGGG GAATCCGGCC CCCCATCCGG GTCCCCACTA CCTCCTGCCC 
CCCATCCACG AGGTCATTCA CTCTCGTCGT GGGGCCACGG CCACACTGCC CTGCGTCCTG 
GGCACCTCGC CTCCCAGCTA CAAAGTACGC TGGAGCAAAG TGGAGCCCGG TGAGCTGCGG 
GAAACGCTAA TCCTCATTAC CAACGGACTG CACGCCCGGG ACTACGGGCT CCTGGGAGGG 
CGCGCCAGCT TGCGGAGAGG GCATCGGCTG GACGCCTCCC TGATCATCAA GAACGTGCGT 
CTGGAGGATG AGGGTCGGTA CCGCTGCGAG CTCATCAATG GCATTGAGGA CGAGAGCGTG 
GCACTGACCC TGCGCCTGGA GGGTGTGGTG TTTCCGTACC AACCCAGCCG AGGCCGCTAC 
CAGTTCAATT ACTTCGAAGC GAAGCGGGCG TGTGAAGAGC AGGACGGACG CCTGGCCACT 
TACGGCCAAC TCTACCAGGC GTGGACCGAG GGGCTGGACT GGTGCAACGC CGGCTGGTTG 
CTCGAGGGCT CCGTGCGTTA CCCTGTGCTC ACCGCGCGGG CTCCGTGCGG CGGCCACGGG 
CGGCCAGGCA TCCGCAGCTA CGGGCCCCGC GACCGCAGCC GCGACCGCTA TGACGCCTTC 
TGCTTCACCT CGGCCCTGGC AGGCCAGGTG TTCTTCGTGC CGGGGCGGCT GACGCTGTCA 
GAAGCCCACG CGGCTTGCCG GAGGCGCGGA GCCGTAGTAG CCAAGGTCGG GCACCTCTAC 
GCCGCCTGGA AGTTCTCCGG CCTGGATCAA TGCGACGGAG GCTGGCTGGC GGACGGCAGC 
GTTCGCTTCC CCATCACGAC GCCGCGGCCG CGCTGTGGGG GTCTCCCTGA CCCAGGGGTG 
CGCAGCTTCG GCTTCCCCCG ACCCCAGCAG GCGTCCTACG GGACCTACTG CTATGCCGAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071314.1
CDS	238..1263
Translation	MPSRIPLPAFCCFLLPWAFTSFHKALGNPAPHPGPHYLLPPIHEVIHSRRGATATLPCVLGTSPPSYKVRWSKVEPGELRETLILITNGLHARDYGLLGGRASLRRGHRLDASLIIKNVRLEDEGRYRCELINGIEDESVALTLRLEGVVFPYQPSRGRYQFNYFEAKRACEEQDGRLATYGQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGHGRPGIRSYGPRDRSRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQASYGTYCYAEK

Target ORF information:

RefSeq Version	NM_022031.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022031.2

ORF Insert Sequence:

ATGCCAAGCA GGATCCCTCT CCCTGCGTTC TGCTGCTTCC TTCTCCCCTG GGCCTTCACC 
AGCTTTCACA AAGCCCTGGG GAATCCGGCC CCCCATCCGG GTCCCCACTA CCTCCTGCCC 
CCCATCCACG AGGTCATTCA CTCTCGTCGT GGGGCCACGG CCACACTGCC CTGCGTCCTG 
GGCACCTCGC CTCCCAGCTA CAAAGTACGC TGGAGCAAAG TGGAGCCCGG TGAGCTGCGG 
GAAACGCTAA TCCTCATTAC CAACGGACTG CACGCCCGGG ACTACGGGCT CCTGGGAGGG 
CGCGCCAGCT TGCGGAGAGG GCATCGGCTG GACGCCTCCC TGATCATCAA GAACGTGCGT 
CTGGAGGATG AGGGTCGGTA CCGCTGCGAG CTCATCAATG GCATTGAGGA CGAGAGCGTG 
GCACTGACCC TGCGCCTGGA GGGTGTGGTG TTTCCGTACC AACCCAGCCG AGGCCGCTAC 
CAGTTCAATT ACTTCGAAGC GAAGCGGGCG TGTGAAGAGC AGGACGGACG CCTGGCCACT 
TACGGCCAAC TCTACCAGGC GTGGACCGAG GGGCTGGACT GGTGCAACGC CGGCTGGTTG 
CTCGAGGGCT CCGTGCGTTA CCCTGTGCTC ACCGCGCGGG CTCCGTGCGG CGGCCACGGG 
CGGCCAGGCA TCCGCAGCTA CGGGCCCCGC GACCGCAGCC GCGACCGCTA TGACGCCTTC 
TGCTTCACCT CGGCCCTGGC AGGCCAGGTG TTCTTCGTGC CGGGGCGGCT GACGCTGTCA 
GAAGCCCACG CGGCTTGCCG GAGGCGCGGA GCCGTAGTAG CCAAGGTCGG GCACCTCTAC 
GCCGCCTGGA AGTTCTCCGG CCTGGATCAA TGCGACGGAG GCTGGCTGGC GGACGGCAGC 
GTTCGCTTCC CCATCACGAC GCCGCGGCCG CGCTGTGGGG GTCTCCCTGA CCCAGGGGTG 
CGCAGCTTCG GCTTCCCCCG ACCCCAGCAG GCGTCCTACG GGACCTACTG CTATGCCGAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hapln2 ( XM_006502148.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006502211.1 Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu21085
Clone ID Related Accession (Same CDS sequence)	XM_006502148.2 , NM_022031.2
Accession Version	XM_006502148.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	hyaluronan and proteoglycan link protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006502148.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAGCA GGATCCCTCT CCCTGCGTTC TGCTGCTTCC TTCTCCCCTG GGCCTTCACC 
AGCTTTCACA AAGCCCTGGG GAATCCGGCC CCCCATCCGG GTCCCCACTA CCTCCTGCCC 
CCCATCCACG AGGTCATTCA CTCTCGTCGT GGGGCCACGG CCACACTGCC CTGCGTCCTG 
GGCACCTCGC CTCCCAGCTA CAAAGTACGC TGGAGCAAAG TGGAGCCCGG TGAGCTGCGG 
GAAACGCTAA TCCTCATTAC CAACGGACTG CACGCCCGGG ACTACGGGCT CCTGGGAGGG 
CGCGCCAGCT TGCGGAGAGG GCATCGGCTG GACGCCTCCC TGATCATCAA GAACGTGCGT 
CTGGAGGATG AGGGTCGGTA CCGCTGCGAG CTCATCAATG GCATTGAGGA CGAGAGCGTG 
GCACTGACCC TGCGCCTGGA GGGTGTGGTG TTTCCGTACC AACCCAGCCG AGGCCGCTAC 
CAGTTCAATT ACTTCGAAGC GAAGCGGGCG TGTGAAGAGC AGGACGGACG CCTGGCCACT 
TACGGCCAAC TCTACCAGGC GTGGACCGAG GGGCTGGACT GGTGCAACGC CGGCTGGTTG 
CTCGAGGGCT CCGTGCGTTA CCCTGTGCTC ACCGCGCGGG CTCCGTGCGG CGGCCACGGG 
CGGCCAGGCA TCCGCAGCTA CGGGCCCCGC GACCGCAGCC GCGACCGCTA TGACGCCTTC 
TGCTTCACCT CGGCCCTGGC AGGCCAGGTG TTCTTCGTGC CGGGGCGGCT GACGCTGTCA 
GAAGCCCACG CGGCTTGCCG GAGGCGCGGA GCCGTAGTAG CCAAGGTCGG GCACCTCTAC 
GCCGCCTGGA AGTTCTCCGG CCTGGATCAA TGCGACGGAG GCTGGCTGGC GGACGGCAGC 
GTTCGCTTCC CCATCACGAC GCCGCGGCCG CGCTGTGGGG GTCTCCCTGA CCCAGGGGTG 
CGCAGCTTCG GCTTCCCCCG ACCCCAGCAG GCGTCCTACG GGACCTACTG CTATGCCGAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006502211.1
CDS	215..1240
Translation	MPSRIPLPAFCCFLLPWAFTSFHKALGNPAPHPGPHYLLPPIHEVIHSRRGATATLPCVLGTSPPSYKVRWSKVEPGELRETLILITNGLHARDYGLLGGRASLRRGHRLDASLIIKNVRLEDEGRYRCELINGIEDESVALTLRLEGVVFPYQPSRGRYQFNYFEAKRACEEQDGRLATYGQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGHGRPGIRSYGPRDRSRDRYDAFCFTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSVRFPITTPRPRCGGLPDPGVRSFGFPRPQQASYGTYCYAEK

Target ORF information:

RefSeq Version	XM_006502148.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus hyaluronan and proteoglycan link protein 2 (Hapln2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006502148.2

ORF Insert Sequence:

ATGCCAAGCA GGATCCCTCT CCCTGCGTTC TGCTGCTTCC TTCTCCCCTG GGCCTTCACC 
AGCTTTCACA AAGCCCTGGG GAATCCGGCC CCCCATCCGG GTCCCCACTA CCTCCTGCCC 
CCCATCCACG AGGTCATTCA CTCTCGTCGT GGGGCCACGG CCACACTGCC CTGCGTCCTG 
GGCACCTCGC CTCCCAGCTA CAAAGTACGC TGGAGCAAAG TGGAGCCCGG TGAGCTGCGG 
GAAACGCTAA TCCTCATTAC CAACGGACTG CACGCCCGGG ACTACGGGCT CCTGGGAGGG 
CGCGCCAGCT TGCGGAGAGG GCATCGGCTG GACGCCTCCC TGATCATCAA GAACGTGCGT 
CTGGAGGATG AGGGTCGGTA CCGCTGCGAG CTCATCAATG GCATTGAGGA CGAGAGCGTG 
GCACTGACCC TGCGCCTGGA GGGTGTGGTG TTTCCGTACC AACCCAGCCG AGGCCGCTAC 
CAGTTCAATT ACTTCGAAGC GAAGCGGGCG TGTGAAGAGC AGGACGGACG CCTGGCCACT 
TACGGCCAAC TCTACCAGGC GTGGACCGAG GGGCTGGACT GGTGCAACGC CGGCTGGTTG 
CTCGAGGGCT CCGTGCGTTA CCCTGTGCTC ACCGCGCGGG CTCCGTGCGG CGGCCACGGG 
CGGCCAGGCA TCCGCAGCTA CGGGCCCCGC GACCGCAGCC GCGACCGCTA TGACGCCTTC 
TGCTTCACCT CGGCCCTGGC AGGCCAGGTG TTCTTCGTGC CGGGGCGGCT GACGCTGTCA 
GAAGCCCACG CGGCTTGCCG GAGGCGCGGA GCCGTAGTAG CCAAGGTCGG GCACCTCTAC 
GCCGCCTGGA AGTTCTCCGG CCTGGATCAA TGCGACGGAG GCTGGCTGGC GGACGGCAGC 
GTTCGCTTCC CCATCACGAC GCCGCGGCCG CGCTGTGGGG GTCTCCCTGA CCCAGGGGTG 
CGCAGCTTCG GCTTCCCCCG ACCCCAGCAG GCGTCCTACG GGACCTACTG CTATGCCGAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Three mechanisms assemble central nervous system nodes of Ranvier.
Neuron78(3)469-82(2013 May)
Susuki K,Chang KJ,Zollinger DR,Liu Y,Ogawa Y,Eshed-Eisenbach Y,Dours-Zimmermann MT,Oses-Prieto JA,Burlingame AL,Seidenbecher CI,Zimmermann DR,Oohashi T,Peles E,Rasband MN

Bral1: its role in diffusion barrier formation and conduction velocity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(8)3113-23(2010 Feb)
Bekku Y,Vargov? L,Goto Y,Vor?sek I,Dmytrenko L,Narasaki M,Ohtsuka A,F?ssler R,Ninomiya Y,Sykov? E,Oohashi T

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Human molecular genetics15(8)1329-41(2006 Apr)
Desai J,Shannon ME,Johnson MD,Ruff DW,Hughes LA,Kerley MK,Carpenter DA,Johnson DK,Rinchik EM,Culiat CT

A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation.
Genomics83(2)225-30(2004 Feb)
Karim SA,Johnson KJ,Griffiths IR,Vouyiouklis DA

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Hapln2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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