Arhgap18 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arhgap18
Entrez Gene ID	73910
Full Name	Rho GTPase activating protein 18
Synonyms	4833419J07Rik,AI314906,AI843501
General protein information	Preferred Names Rho GTPase activating protein 18 Names rho GTPase-activating protein 18 arhgap18 rho-type GTPase-activating protein 18
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 A4

mRNA and Protein(s)

mRNA	Protein	Name
XM_006512885.3	XP_006512948.1	rho GTPase-activating protein 18 isoform X1
NM_176837.2	NP_789807.1	rho GTPase-activating protein 18
XM_006512885.4	XP_006512948.1	rho GTPase-activating protein 18 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ARHGAP18	NP_001104242.1
Mus musculus (house mouse)	Arhgap18	NP_789807.1
	ARHGAP18	XP_001105288.1
Canis lupus familiaris (dog)	ARHGAP18	XP_533497.3
Gallus gallus (chicken)	ARHGAP18	XP_419743.3
Xenopus tropicalis (tropical clawed frog)	arhgap18	NP_001072336.1
Rattus norvegicus (Norway rat)	Arhgap18	NP_001164046.1
Homo sapiens (human)	ARHGAP18	NP_277050.2
Danio rerio (zebrafish)	LOC100004252	XP_001343601.5
Pan troglodytes (chimpanzee)	ARHGAP18	XP_001168191.2
Xenopus tropicalis (tropical clawed frog)	LOC101734415	XP_004920294.1

Gene Ontology
Bibliography

Related articles in PubMed

LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage.
Thompson WR, Yen SS, Uzer G, Xie Z, Sen B, Styner M, Burridge K, Rubin J
Bone107172-180(2018 Feb)

ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.
Liu R, Lo L, Lay AJ, Zhao Y, Ting KK, Robertson EN, Sherrah AG, Jarrah S, Li H, Zhou Z, Hambly BD, Richmond DR, Jeremy RW, Bannon PG, Vadas MA, Gamble JR
Circulation research121(5)512-524(2017 Aug)

The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.
Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang GH, Lay AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, McCaughan G, Kavallaris M, Vadas MA, Gamble JR
Molecular biology of the cell28(8)1066-1078(2017 Apr)

Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.
Yeung CY, Taylor SH, Garva R, Holmes DF, Zeef LA, Soininen R, Boot-Handford RP, Kadler KE
PloS one9(9)e107036(2014)

ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.
Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR
Small GTPases5(3)1-15(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ARHGAP 18 was identified as a novel protective gene against thoracic aortic aneurysm formation.
Title: ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.

In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis.
Title: The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.

Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity.
Title: ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

The following Arhgap18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arhgap18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06244	NM_176837.2 Latest version!	Mus musculus Rho GTPase activating protein 18 (Arhgap18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OMu43980	XM_006512885.4 Latest version!	Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu43980	XM_006512885.3	Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arhgap18 ( XM_006512885.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512948.1 Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu43980
Clone ID Related Accession (Same CDS sequence)	XM_006512885.3 , XM_006512885.4
Accession Version	XM_006512885.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	rho GTPase-activating protein 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512885.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTTGGGGTT GCCCAGACAC TCAAGAAAGG 
AGAAGTTTTC CTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512948.1
CDS	440..2197
Translation	MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGWGCPDTQERRSFPV

Target ORF information:

RefSeq Version	XM_006512885.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512885.3

ORF Insert Sequence:

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTTGGGGTT GCCCAGACAC TCAAGAAAGG 
AGAAGTTTTC CTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Arhgap18 ( NM_176837.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_789807.1 Mus musculus Rho GTPase activating protein 18 (Arhgap18), mRNA.

Price & Availability↑

CloneID	OMu06244
Clone ID Related Accession (Same CDS sequence)	NM_176837.2
Accession Version	NM_176837.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	rho GTPase-activating protein 18
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC158631.6 and AC101709.11. On Nov 17, 2006 this sequence version replaced NM_176837.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC030858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTGCTGATG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC AAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGCGATG TGCTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACACTCAAG 
AAAGGAGAAG TTTTCCTGTA TGAGATTGGA GGAAATATTG GGGAACGTTG CCTCGATGAC 
GACACACACA TGAAGGACTT GTACCAACTG AACCCGAATG CCGAGTGGGT CATAAAATCC 
AAGCCAGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789807.1
CDS	73..2064
Translation	MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKSKPV

Target ORF information:

RefSeq Version	NM_176837.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rho GTPase activating protein 18 (Arhgap18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176837.2

ORF Insert Sequence:

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTGCTGATG TTCCTCAGGG AGTGATTCGA 
GTGCAAGCTC CCCATCTTTC AAAAGTTTCC ATGGCAATAC AGCTAACTGA AGAACTAAAA 
GCCAGCGATG TGCTTGCCAG GTTTCTCAGC CAAGAAAGTG GGGTTGCCCA GACACTCAAG 
AAAGGAGAAG TTTTCCTGTA TGAGATTGGA GGAAATATTG GGGAACGTTG CCTCGATGAC 
GACACACACA TGAAGGACTT GTACCAACTG AACCCGAATG CCGAGTGGGT CATAAAATCC 
AAGCCAGTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Arhgap18 ( XM_006512885.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512948.1 Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu43980
Clone ID Related Accession (Same CDS sequence)	XM_006512885.3 , XM_006512885.4
Accession Version	XM_006512885.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	rho GTPase-activating protein 18 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512885.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTTGGGGTT GCCCAGACAC TCAAGAAAGG 
AGAAGTTTTC CTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512948.1
CDS	177..1934
Translation	MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGWGCPDTQERRSFPV

Target ORF information:

RefSeq Version	XM_006512885.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rho GTPase activating protein 18 (Arhgap18), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512885.4

ORF Insert Sequence:

ATGAACTGGC TATCGAGTTC CTCGGGAGTT GTGCTAACTG CTTACCACCC CAGCGGCAAG 
GACCAGGTCG CTGGGGACAG CCATGTAAAG GGAGGCGACG AAGCCACCTC CAGTCGCAGA 
TATGGCCAAT ACACCATAAA CCAAGAAGGC TCCACCAAAG TTCCCGAGAG GCCTCCATTT 
GATCGATCGA GTTCTCAGGA TTCCTTGGAT GAATCAATGG AAGCCTATTG GACAGAACTA 
GAAAACATCA AGAGGTCGAA TGAAAATCGC CAAGAAGGTC AAGAGGCCAT AGTTGTCAAA 
GAACCTGATG AGGGAGAACT GGAAGAAGAA TGGCTCAAAG AAGCAGGTCT ATCCAATCTT 
TTTGGAGAGT CTATTGATGA CCCGCAGGAA AGCATTCTGT TTTTATCTAC ACTGACCCGG 
ACTCAGGCAG CAGCTGTTCA GAAACGGGTG GAAACGGTCT CCCAGACCTT GAGGAAGAAA 
AACAAACAGC ACCACATTCG TGACGTCAGA GACATATTTG CTCAACAGAG AGAGGCACAA 
GAAAAACCTC CAGATGACTC AGACTTGCGG TCAGTCAGAA CAAACGAAAA CAAAGGCCAA 
GGAAAAGATG ATCAGCCATC TAGTGGGGCT GTCGATAGCA AGGAGCAGAT CTCACGGGTG 
CCTGAGGACA CACCTGCCTC TGAAACAGAC ATCAATCTGG AGGTGTCATT TGCGGAGCAA 
GCTGTCAATC AGAAAGAGTT CAGTAAGGAG AGGACGCAGA AGATCAGCAG CAACGACTCT 
TTGCCCAGTT TCAGACTGCC AAAAGATAAA ACAGGTACGA CAAGGATTGG AGACTTGGCA 
CCCCAAGACA TGAAGAAAGT TTGCTCTCTA TCCCTGATTG AACTCACTGC CCTGTATGAT 
GTGTTGGGCT TGGAATTCAA ACAACAGAAA GCTGTGAAAA TCAAAACCAG AGACTCTGGT 
CTTTTTGGTA TTCCTTTAAC GATATTGTTA GAACAAGATC AAAGAAAAGT GCCTGGAACA 
CGAATACCCT TGATCTTTCA AAAACTGATT TCTCGAATTG AAGAAGGCAG TCTGGAAACC 
GAGGGCCTCC TACGGATACC AGGAGCAGCC ATGAGAATCA AGAATCTTTG CCAAGAACTA 
GAAGCGAAAT TTTACGAGGG GACTTTCAAT TGGGAAAGTG TCAAACAGCA CGATGCGGCC 
AGCCTGCTGA AGCTCTTTCT GAGAGAATTG CCCCAGCCAC TGCTGAGCAT GGAGTATCTC 
AAAGCCTTCC AAGCTGTCCA GAATCTTCCA ACCAGAAAGG AACAGTTGCA GGCTTTGAAC 
CTCCTTGTCA TTCTTCTACC TGACGCAAAC AGAGACACAC TGAAGGCCTT GCTTGAATTT 
CTCCAAAGAG TCATAGATAA CAAAGAGAAG AACAAGATGA CAGCTGGGAA TGTAGCAATG 
GTCATGGCCC CAAATCTCTT CATGTGCCAC ACGCTGGGCT TGAAGTCCAG TGAACAGCGA 
GAATTTGAAA TGGCAGCTGG GACAGCAAAT GTCATGCACT TATTGATTAG GTACCAGAAA 
ATTCTATGGA CAATCCCTAA ATTTATTGTA ATCCAAGTGA GGAAACAGAA TATTGAGAAT 
CAAAAGAAGG AAAGGAAAGC CATGAAGAAA TTGCTGAAGA AAATGGCTTA TGACCGGGAA 
AAACATGAAA AGCAAGATAA AACTGCAAAT GGTTGGGGTT GCCCAGACAC TCAAGAAAGG 
AGAAGTTTTC CTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage.
Bone107172-180(2018 Feb)
Thompson WR,Yen SS,Uzer G,Xie Z,Sen B,Styner M,Burridge K,Rubin J

ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.
Circulation research121(5)512-524(2017 Aug)
Liu R,Lo L,Lay AJ,Zhao Y,Ting KK,Robertson EN,Sherrah AG,Jarrah S,Li H,Zhou Z,Hambly BD,Richmond DR,Jeremy RW,Bannon PG,Vadas MA,Gamble JR

The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.
Molecular biology of the cell28(8)1066-1078(2017 Apr)
Lovelace MD,Powter EE,Coleman PR,Zhao Y,Parker A,Chang GH,Lay AJ,Hunter J,McGrath AP,Jormakka M,Bertolino P,McCaughan G,Kavallaris M,Vadas MA,Gamble JR

Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.
PloS one9(9)e107036(2014)
Yeung CY,Taylor SH,Garva R,Holmes DF,Zeef LA,Soininen R,Boot-Handford RP,Kadler KE

ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.
Small GTPases5(3)1-15(2014)
Chang GH,Lay AJ,Ting KK,Zhao Y,Coleman PR,Powter EE,Formaz-Preston A,Jolly CJ,Bower NI,Hogan BM,Rinkwitz S,Becker TS,Vadas MA,Gamble JR

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Arhgap18 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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