Nptxr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nptxr
Entrez Gene ID	73340
Full Name	neuronal pentraxin receptor
Synonyms	1200009K17Rik,1700036C17Rik,5730406O18Rik,AI452369,AI785356,D15Bwg0580e,NPR,Npcd
General protein information	Preferred Names neuronal pentraxin receptor Names neuronal pentraxin receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 E1\|15 37.85 cM
Summary	This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030689.4	NP_109614.2	neuronal pentraxin receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPTXR	NP_055108.2
Danio rerio (zebrafish)	nptxrb	NP_001037779.1
Danio rerio (zebrafish)	LOC101884706	XP_005171673.1
Bos taurus (cattle)	NPTXR	XP_003586201.1
Rattus norvegicus (Norway rat)	Nptxr	NP_110468.2
Pan troglodytes (chimpanzee)	NPTXR	XP_003317297.1
Mus musculus (house mouse)	Nptxr	NP_109614.2

Gene Ontology
Bibliography

Related articles in PubMed

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.
Lee SJ, Wei M, Zhang C, Maxeiner S, Pak C, Calado Botelho S, Trotter J, Sterky FH, S?dhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1062-1080(2017 Feb)

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ
Neuron85(6)1257-72(2015 Mar)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome biology10(10)R104(2009)

mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.
Cho RW, Park JM, Wolff SB, Xu D, Hopf C, Kim JA, Reddy RC, Petralia RS, Perin MS, Linden DJ, Worley PF
Neuron57(6)858-71(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We find that NPR is a potent inducer of both excitatory and inhibitory heterologous synapses, and that knockdown of NPR in cultured neurons decreases the density of both excitatory and inhibitory synapses
Title: Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.

Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Title: Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.

non-AUG translation initiation site. Comparison of rat determined N-terminal amino acid sequence with cDNA sequence indicates that a CUG codon is used as an initiator codon and codes for a methionine. The CTG is present in cDNAs of mouse, rat, and human.
Title: Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.

The following Nptxr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptxr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15076	NM_030689.4 Latest version!	Mus musculus neuronal pentraxin receptor (Nptxr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nptxr ( NM_030689.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_109614.2 Mus musculus neuronal pentraxin receptor (Nptxr), mRNA.

Price & Availability↑

CloneID	OMu15076
Clone ID Related Accession (Same CDS sequence)	NM_030689.4
Accession Version	NM_030689.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	neuronal pentraxin receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC058962.1 and AC118227.12. On Mar 22, 2007 this sequence version replaced NM_030689.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058962.1, AK147605.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGAAGTTCC TGGCCGTGCT GCTGGCCGCG GGCATGCTGG CGTTCCTCGG TGCCGTCATC 
TGCATCATCG CCAGCGTGCC CCTGGCGGCC AGCCCCGCTC GCGCGCTGCC CGGCGGCACC 
GACAACGCCT CGGCCGCCTC GGCCGCCGGT GGCTCGGGTC CGCAGCGCAG CCTGAGCGCC 
CTGCACAGCG CAGGCGGCTC GGCCGGGCCC TCGGTGTTGC CCGGGGAGCC CGCGGCCAGC 
GTCTTCCCGC CGCCGCCCGT GCCGCTGCTC AGTCGCTTCC TCTGTACGCC GCTGGCCGCC 
GCCTGCCCGT CGGGGGCCGA GCAGGGGGAC GCGGCAGGCG AGCGCGCAGA GCTGTTGCTG 
CTGCAGAGCA CCGCGGAGCA GCTGCGCCAG ACGGCGCTGC AGCAGGAGGC GCGCATCCGC 
GCAGACCGGG ACACCATCCG CGAGCTCACC GGCAAGCTGG GCCGCTGTGA GAGCGGCCTG 
CCGCGCGGCC TCCAGGACGC CGGGCCCCGC CGCGACACCA TGGCCGACGG CGCCTGGGAC 
TCACCTGCGC TGCTGCTGGA GCTGGAGGAC GCGGTGCGCG CGCTGCGAGA CCGCATCGAG 
CGCATCGAGC AGGAGCTCCC AGCCCGTGGG AACATCTCCT CGGCGCCAGC TCCAGCCATG 
CCCACCGCCC TGCACTCCAA GATGGACGAA CTAGAAGGCC AGCTGCTGGC CAAGGTGCTG 
GCGCTGGAGA AGGAGCGAGC CGCCCTCAGT CACGGGAGCC ACCAGCAACG ACAGGAAGTG 
GAGAAGGAGC TGAATGCCCT GCAGGGTCGC GTGGCCGAGC TGGAGCACGG GTCCTCGGCC 
TACAGTCCCC CTGATGCCTT CAAGGTCAGC ATCCCCATCC GCAACAACTA CATGTACGCC 
CGCGTGCGCA AGGCGCTGCC GGAACTCTAC GCCTTCACTG CCTGCATGTG GCTGCGCTCC 
AGGTCAGGTG GCTCCGGCCA GGGCACCCCC TTCTCCTACT CGGTGCCCGG GCAGGCCAAT 
GAGATCGTGC TTCTGGAGGC CGGCCTTGAG CCAATGGAGC TGCTGATCAA CGACAAGGTG 
GCCCAGCTGC CCCTGAGCCT GAAAGACAGC AACTGGCACC ATATCTGCAT CTCCTGGACT 
ACAAGGGATG GGCTGTGGTC TGCATACCAG GACGGAGAAC TGCGGGGTTC TGGCGAGAAC 
CTAGCAGCCT GGCACCCCAT CAAGCCACAC GGCATCCTTA TCCTGGGCCA AGAGCAGGAT 
ACCTTGGGAG GCCGATTTGA CGCCACACAG GCCTTCGTTG GTGACATTGC ACAGTTCAAC 
CTGTGGGACC ACGCTCTGAC ACCGGCCCAG GTGCTGGGCA TGGCCAACTG CACCGGGCCA 
CTGATGGGCA ATGTCCTCCC CTGGGAAGAT AAGCTGGTAG AGGCCTTTGG AGGTGCGAAG 
AAGGCCGCCT TTGATGTGTG CAAGGGGAGG GCAAAGGCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109614.2
CDS	127..1608
Translation	LKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGTDNASAASAAGGSGPQRSLSALHSAGGSAGPSVLPGEPAASVFPPPPVPLLSRFLCTPLAAACPSGAEQGDAAGERAELLLLQSTAEQLRQTALQQEARIRADRDTIRELTGKLGRCESGLPRGLQDAGPRRDTMADGAWDSPALLLELEDAVRALRDRIERIEQELPARGNISSAPAPAMPTALHSKMDELEGQLLAKVLALEKERAALSHGSHQQRQEVEKELNALQGRVAELEHGSSAYSPPDAFKVSIPIRNNYMYARVRKALPELYAFTACMWLRSRSGGSGQGTPFSYSVPGQANEIVLLEAGLEPMELLINDKVAQLPLSLKDSNWHHICISWTTRDGLWSAYQDGELRGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGMANCTGPLMGNVLPWEDKLVEAFGGAKKAAFDVCKGRAKA

Target ORF information:

RefSeq Version	NM_030689.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuronal pentraxin receptor (Nptxr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030689.4

ORF Insert Sequence:

CTGAAGTTCC TGGCCGTGCT GCTGGCCGCG GGCATGCTGG CGTTCCTCGG TGCCGTCATC 
TGCATCATCG CCAGCGTGCC CCTGGCGGCC AGCCCCGCTC GCGCGCTGCC CGGCGGCACC 
GACAACGCCT CGGCCGCCTC GGCCGCCGGT GGCTCGGGTC CGCAGCGCAG CCTGAGCGCC 
CTGCACAGCG CAGGCGGCTC GGCCGGGCCC TCGGTGTTGC CCGGGGAGCC CGCGGCCAGC 
GTCTTCCCGC CGCCGCCCGT GCCGCTGCTC AGTCGCTTCC TCTGTACGCC GCTGGCCGCC 
GCCTGCCCGT CGGGGGCCGA GCAGGGGGAC GCGGCAGGCG AGCGCGCAGA GCTGTTGCTG 
CTGCAGAGCA CCGCGGAGCA GCTGCGCCAG ACGGCGCTGC AGCAGGAGGC GCGCATCCGC 
GCAGACCGGG ACACCATCCG CGAGCTCACC GGCAAGCTGG GCCGCTGTGA GAGCGGCCTG 
CCGCGCGGCC TCCAGGACGC CGGGCCCCGC CGCGACACCA TGGCCGACGG CGCCTGGGAC 
TCACCTGCGC TGCTGCTGGA GCTGGAGGAC GCGGTGCGCG CGCTGCGAGA CCGCATCGAG 
CGCATCGAGC AGGAGCTCCC AGCCCGTGGG AACATCTCCT CGGCGCCAGC TCCAGCCATG 
CCCACCGCCC TGCACTCCAA GATGGACGAA CTAGAAGGCC AGCTGCTGGC CAAGGTGCTG 
GCGCTGGAGA AGGAGCGAGC CGCCCTCAGT CACGGGAGCC ACCAGCAACG ACAGGAAGTG 
GAGAAGGAGC TGAATGCCCT GCAGGGTCGC GTGGCCGAGC TGGAGCACGG GTCCTCGGCC 
TACAGTCCCC CTGATGCCTT CAAGGTCAGC ATCCCCATCC GCAACAACTA CATGTACGCC 
CGCGTGCGCA AGGCGCTGCC GGAACTCTAC GCCTTCACTG CCTGCATGTG GCTGCGCTCC 
AGGTCAGGTG GCTCCGGCCA GGGCACCCCC TTCTCCTACT CGGTGCCCGG GCAGGCCAAT 
GAGATCGTGC TTCTGGAGGC CGGCCTTGAG CCAATGGAGC TGCTGATCAA CGACAAGGTG 
GCCCAGCTGC CCCTGAGCCT GAAAGACAGC AACTGGCACC ATATCTGCAT CTCCTGGACT 
ACAAGGGATG GGCTGTGGTC TGCATACCAG GACGGAGAAC TGCGGGGTTC TGGCGAGAAC 
CTAGCAGCCT GGCACCCCAT CAAGCCACAC GGCATCCTTA TCCTGGGCCA AGAGCAGGAT 
ACCTTGGGAG GCCGATTTGA CGCCACACAG GCCTTCGTTG GTGACATTGC ACAGTTCAAC 
CTGTGGGACC ACGCTCTGAC ACCGGCCCAG GTGCTGGGCA TGGCCAACTG CACCGGGCCA 
CTGATGGGCA ATGTCCTCCC CTGGGAAGAT AAGCTGGTAG AGGCCTTTGG AGGTGCGAAG 
AAGGCCGCCT TTGATGTGTG CAAGGGGAGG GCAAAGGCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1062-1080(2017 Feb)
Lee SJ,Wei M,Zhang C,Maxeiner S,Pak C,Calado Botelho S,Trotter J,Sterky FH,S?dhof TC

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Neuron85(6)1257-72(2015 Mar)
Pelkey KA,Barksdale E,Craig MT,Yuan X,Sukumaran M,Vargish GA,Mitchell RM,Wyeth MS,Petralia RS,Chittajallu R,Karlsson RM,Cameron HA,Murata Y,Colonnese MT,Worley PF,McBain CJ

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Genome biology10(10)R104(2009)
Ling KH,Hewitt CA,Beissbarth T,Hyde L,Banerjee K,Cheah PS,Cannon PZ,Hahn CN,Thomas PQ,Smyth GK,Tan SS,Thomas T,Scott HS

mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.
Neuron57(6)858-71(2008 Mar)
Cho RW,Park JM,Wolff SB,Xu D,Hopf C,Kim JA,Reddy RC,Petralia RS,Perin MS,Linden DJ,Worley PF

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Nptxr cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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