Ddit4l cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ddit4l
Entrez Gene ID	73284
Full Name	DNA-damage-inducible transcript 4-like
Synonyms	1700037B15Rik,1700108M02Rik,REDD2,RTP801L,Smhs1
General protein information	Preferred Names DNA-damage-inducible transcript 4-like Names DNA damage-inducible transcript 4-like protein HIF-1 responsive protein RTP801-like skeletal muscle hindlimb suspension 1 soleus muscle atrophied after hindlimb suspension protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 G3

mRNA and Protein(s)

mRNA	Protein	Name
NM_030143.4	NP_084419.2	DNA damage-inducible transcript 4-like protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DDIT4L	XP_544999.2
Bos taurus (cattle)	DDIT4L	NP_001074988.1
Pan troglodytes (chimpanzee)	DDIT4L	XP_001167944.1
Mus musculus (house mouse)	Ddit4l	NP_084419.2
Xenopus tropicalis (tropical clawed frog)	ddit4l	XP_004911505.1
Homo sapiens (human)	DDIT4L	NP_660287.1
	DDIT4L	XP_001108176.1
Rattus norvegicus (Norway rat)	LOC100363484	XP_002729167.1

Gene Ontology
Bibliography

Related articles in PubMed

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development.
Bohnenpoll T, Wittern AB, Mamo TM, Weiss AC, Rudat C, Kleppa MJ, Schuster-Gossler K, Wojahn I, L?dtke TH, Trowe MO, Kispert A
PLoS genetics13(8)e1006951(2017 Aug)

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.
Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S
Science signaling10(468)(2017 Feb)

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P
Skeletal muscle6(1)30(2016)

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.
Morquette B, Morquette P, Agostinone J, Feinstein E, McKinney RA, Kolta A, Di Polo A
Cell death and differentiation22(4)612-25(2015 Apr)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data showed that DDiT4L may be an important transducer of pathological stress to autophagy through mTOR signaling in the heart.
Title: DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.

Axonal injury-induced upregulation of the stress-responsive REDD2 leads to mTOR inhibition triggering early dendritic arbor retraction, neuronal dysfunction and subsequent death of adult retinal neurons.
Title: REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.

IRF-1 physically interacts with REDD2 in the large cytoplasmic protein complex
Title: Interferon regulatory factor-1 (IRF-1) interacts with regulated in development and DNA damage response 2 (REDD2) in the cytoplasm of mouse bone marrow cells.

REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
Title: REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.

RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions
Title: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.

The following Ddit4l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddit4l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07978	NM_030143.4 Latest version!	Mus musculus DNA-damage-inducible transcript 4-like (Ddit4l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ddit4l ( NM_030143.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084419.2 Mus musculus DNA-damage-inducible transcript 4-like (Ddit4l), mRNA.

Price & Availability↑

CloneID	OMu07978
Clone ID Related Accession (Same CDS sequence)	NM_030143.4
Accession Version	NM_030143.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	DNA damage-inducible transcript 4-like protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK018944.1 and AC140486.4. On Jun 18, 2009 this sequence version replaced NM_030143.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK053333.1, SRR1660813.247798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGTTGCAA CGGGCAGTTT GAGCAGTAAG AACCCGGCCA GCATTTCAGA GTTGTTGGAC 
GGTGGCTATC ACCCTGGGAG TCTGCTAAGT GATTTCGACT ACTGGGATTA TGTTGTCCCT 
GAGCCCAACC TCAACGAGGT GGTATTTGAA GAGACAACAT GCCAGAATTT GGTTAAAATG 
TTGGAGAACT GTCTGTCCAG ATCAAAGCAA ACCAAACTTG GTTGCTCTAA GGTCTTGGTC 
CCTGAGAAAC TGACCCAGAG AATTGCTCAA GATGTCCTGC GGCTCTCGTC CACGGAGCCC 
TGCGGCCTTC GGGGTTGTGT TATGCACGTG AACTTGGAGA TTGAAAATGT ATGTAAAAAG 
CTGGATAGGA TCGTGTGTGA TGCTAGCGTG GTGCCGACCT TTGAGCTCAC GCTTGTGTTT 
AAGCAGGAGA GCTGCCCGTG GACCAGCCTC AAGGACTTCT TCTTTAGCAG AGGTCGCTTC 
TCCTCAGGCC TTAAGCGAAC TCTGATTCTC AGCTCAGGAT TTCGACTTGT GAAGAAAAAA 
CTGTACTCCC TGATTGGAAC GACAGTCATT GAAGAGTGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084419.2
CDS	264..845
Translation	MVATGSLSSKNPASISELLDGGYHPGSLLSDFDYWDYVVPEPNLNEVVFEETTCQNLVKMLENCLSRSKQTKLGCSKVLVPEKLTQRIAQDVLRLSSTEPCGLRGCVMHVNLEIENVCKKLDRIVCDASVVPTFELTLVFKQESCPWTSLKDFFFSRGRFSSGLKRTLILSSGFRLVKKKLYSLIGTTVIEEC

Target ORF information:

RefSeq Version	NM_030143.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus DNA-damage-inducible transcript 4-like (Ddit4l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030143.4

ORF Insert Sequence:

ATGGTTGCAA CGGGCAGTTT GAGCAGTAAG AACCCGGCCA GCATTTCAGA GTTGTTGGAC 
GGTGGCTATC ACCCTGGGAG TCTGCTAAGT GATTTCGACT ACTGGGATTA TGTTGTCCCT 
GAGCCCAACC TCAACGAGGT GGTATTTGAA GAGACAACAT GCCAGAATTT GGTTAAAATG 
TTGGAGAACT GTCTGTCCAG ATCAAAGCAA ACCAAACTTG GTTGCTCTAA GGTCTTGGTC 
CCTGAGAAAC TGACCCAGAG AATTGCTCAA GATGTCCTGC GGCTCTCGTC CACGGAGCCC 
TGCGGCCTTC GGGGTTGTGT TATGCACGTG AACTTGGAGA TTGAAAATGT ATGTAAAAAG 
CTGGATAGGA TCGTGTGTGA TGCTAGCGTG GTGCCGACCT TTGAGCTCAC GCTTGTGTTT 
AAGCAGGAGA GCTGCCCGTG GACCAGCCTC AAGGACTTCT TCTTTAGCAG AGGTCGCTTC 
TCCTCAGGCC TTAAGCGAAC TCTGATTCTC AGCTCAGGAT TTCGACTTGT GAAGAAAAAA 
CTGTACTCCC TGATTGGAAC GACAGTCATT GAAGAGTGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development.
PLoS genetics13(8)e1006951(2017 Aug)
Bohnenpoll T,Wittern AB,Mamo TM,Weiss AC,Rudat C,Kleppa MJ,Schuster-Gossler K,Wojahn I,L?dtke TH,Trowe MO,Kispert A

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.
Science signaling10(468)(2017 Feb)
Simonson B,Subramanya V,Chan MC,Zhang A,Franchino H,Ottaviano F,Mishra MK,Knight AC,Hunt D,Ghiran I,Khurana TS,Kontaridis MI,Rosenzweig A,Das S

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Skeletal muscle6(1)30(2016)
Sakakibara I,Wurmser M,Dos Santos M,Santolini M,Ducommun S,Davaze R,Guernec A,Sakamoto K,Maire P

REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.
Cell death and differentiation22(4)612-25(2015 Apr)
Morquette B,Morquette P,Agostinone J,Feinstein E,McKinney RA,Kolta A,Di Polo A

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Ddit4l cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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