Glrx5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Glrx5
Entrez Gene ID	73046
Full Name	glutaredoxin 5
General protein information	Preferred Names glutaredoxin 5 Names glutaredoxin-related protein 5, mitochondrial glutaredoxin 5 homolog monothiol glutaredoxin-5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 E
Summary	This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_028419.2	NP_082695.1	glutaredoxin-related protein 5, mitochondrial
NM_028419.3	NP_082695.1	glutaredoxin-related protein 5, mitochondrial

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GLRX5	NP_001008472.1
Danio rerio (zebrafish)	glrx5	NP_998186.1
Kluyveromyces lactis	KLLA0B09636g	XP_451957.1
Rattus norvegicus (Norway rat)	Glrx5	NP_001102192.1
Drosophila melanogaster (fruit fly)	CG14407	NP_572974.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002500	XP_312440.3
	GLRX5	XP_001101070.1
Bos taurus (cattle)	GLRX5	NP_001093773.1
Caenorhabditis elegans (roundworm)	glrx-5	NP_499610.1
Saccharomyces cerevisiae (baker's yeast)	GRX5	NP_015266.1
Schizosaccharomyces pombe (fission yeast)	grx5	NP_593888.1
Homo sapiens (human)	GLRX5	NP_057501.2
Pan troglodytes (chimpanzee)	GLRX5	XP_001154482.1
Mus musculus (house mouse)	Glrx5	NP_082695.1
Eremothecium gossypii	AGOS_ADR053W	NP_984149.1
Magnaporthe oryzae (rice blast fungus)	MGG_09542	XP_003712199.1
Neurospora crassa	NCU04098	XP_960860.1
Xenopus tropicalis (tropical clawed frog)	glrx5	NP_001004919.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.
Petry SF, Sharifpanah F, Sauer H, Linn T
PloS one12(5)e0176267(2017)

Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress.
Linares GR, Xing W, Govoni KE, Chen ST, Mohan S
Bone44(5)795-804(2009 May)

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.
Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, Weber GJ, Dooley K, Davidson AJ, Schmid B, Schmidt B, Paw BH, Shaw GC, Kingsley P, Palis J, Schubert H, Chen O, Kaplan J, Zon LI,
Nature436(7053)1035-39(2005 Aug)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin secretion, increase of reactive oxygen species (ROS) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.
Title: Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.

Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS production, cardiolipin oxidation, caspase activity, Fe-S cluster formation, and MnSOD activity.
Title: Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress.

The following Glrx5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Glrx5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14862	NM_028419.3 Latest version!	Mus musculus glutaredoxin 5 (Glrx5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OMu14862	NM_028419.2	Mus musculus glutaredoxin 5 homolog (S. cerevisiae) (Glrx5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Glrx5 ( NM_028419.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082695.1 Mus musculus glutaredoxin 5 homolog (S. cerevisiae) (Glrx5), mRNA.

Price & Availability↑

CloneID	OMu14862
Clone ID Related Accession (Same CDS sequence)	NM_028419.2 , NM_028419.3
Accession Version	NM_028419.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	glutaredoxin-related protein 5, mitochondrial
Comment

ATGAGCGCGT CCCTGAGCCG GGCGGCGGCG GCTCTGCTGC GCTGGGGGCG AAGCGCTGGT 
GGCGGTGGCC TGCCCGGAGC CGGCGTGCGG GCGGCGAGCT CGGGCGGCCA GGCGGAGCAG 
CTGGACGCGC TGGTGAAGAA GGACAAGGTG GTGGTGTTCC TCAAGGGGAC GCCCGAGCAG 
CCCCAGTGCG GCTTCAGCAA CGCCGTGGTG CAGATTCTGC GGCTGCACGG TGTTCGCGAC 
TATGCGGCCT ACAACGTGCT GGACGACCCG GAGCTGAGGC AAGGTATTAA AGACTACTCC 
AACTGGCCAA CCATCCCGCA AGTGTACCTC AACGGCGAGT TTGTGGGGGG CTGTGACATC 
CTTCTGCAGA TGCATCAGAA TGGGGACCTA GTGGAAGAAC TGAAAAAGCT GGGTATCCGC 
TCTGCCCTGG TAGATGAGAA GGACCAAGAC TCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082695.1
Translation	MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK

Target ORF information:

RefSeq Version	NM_028419.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus glutaredoxin 5 homolog (S. cerevisiae) (Glrx5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028419.2

ORF Insert Sequence:

ATGAGCGCGT CCCTGAGCCG GGCGGCGGCG GCTCTGCTGC GCTGGGGGCG AAGCGCTGGT 
GGCGGTGGCC TGCCCGGAGC CGGCGTGCGG GCGGCGAGCT CGGGCGGCCA GGCGGAGCAG 
CTGGACGCGC TGGTGAAGAA GGACAAGGTG GTGGTGTTCC TCAAGGGGAC GCCCGAGCAG 
CCCCAGTGCG GCTTCAGCAA CGCCGTGGTG CAGATTCTGC GGCTGCACGG TGTTCGCGAC 
TATGCGGCCT ACAACGTGCT GGACGACCCG GAGCTGAGGC AAGGTATTAA AGACTACTCC 
AACTGGCCAA CCATCCCGCA AGTGTACCTC AACGGCGAGT TTGTGGGGGG CTGTGACATC 
CTTCTGCAGA TGCATCAGAA TGGGGACCTA GTGGAAGAAC TGAAAAAGCT GGGTATCCGC 
TCTGCCCTGG TAGATGAGAA GGACCAAGAC TCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Glrx5 ( NM_028419.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082695.1 Mus musculus glutaredoxin 5 (Glrx5), mRNA.

Price & Availability↑

CloneID	OMu14862
Clone ID Related Accession (Same CDS sequence)	NM_028419.2 , NM_028419.3
Accession Version	NM_028419.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	glutaredoxin-related protein 5, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ071975.1, CX243759.1, AK013761.1 and CJ265616.1. On Sep 18, 2015 this sequence version replaced NM_028419.2. ##Evidence-Data-START## Transcript exon combination :: AK013761.1, AK050883.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCGCGT CCCTGAGCCG GGCGGCGGCG GCTCTGCTGC GCTGGGGGCG AAGCGCTGGT 
GGCGGTGGCC TGCCCGGAGC CGGCGTGCGG GCGGCGAGCT CGGGCGGCCA GGCGGAGCAG 
CTGGACGCGC TGGTGAAGAA GGACAAGGTG GTGGTGTTCC TCAAGGGGAC GCCCGAGCAG 
CCCCAGTGCG GCTTCAGCAA CGCCGTGGTG CAGATTCTGC GGCTGCACGG TGTTCGCGAC 
TATGCGGCCT ACAACGTGCT GGACGACCCG GAGCTGAGGC AAGGTATTAA AGACTACTCC 
AACTGGCCAA CCATCCCGCA AGTGTACCTC AACGGCGAGT TTGTGGGGGG CTGTGACATC 
CTTCTGCAGA TGCATCAGAA TGGGGACCTA GTGGAAGAAC TGAAAAAGCT GGGTATCCGC 
TCTGCCCTGG TAGATGAGAA GGACCAAGAC TCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082695.1
CDS	83..541
Translation	MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK

Target ORF information:

RefSeq Version	NM_028419.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaredoxin 5 (Glrx5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028419.3

ORF Insert Sequence:

ATGAGCGCGT CCCTGAGCCG GGCGGCGGCG GCTCTGCTGC GCTGGGGGCG AAGCGCTGGT 
GGCGGTGGCC TGCCCGGAGC CGGCGTGCGG GCGGCGAGCT CGGGCGGCCA GGCGGAGCAG 
CTGGACGCGC TGGTGAAGAA GGACAAGGTG GTGGTGTTCC TCAAGGGGAC GCCCGAGCAG 
CCCCAGTGCG GCTTCAGCAA CGCCGTGGTG CAGATTCTGC GGCTGCACGG TGTTCGCGAC 
TATGCGGCCT ACAACGTGCT GGACGACCCG GAGCTGAGGC AAGGTATTAA AGACTACTCC 
AACTGGCCAA CCATCCCGCA AGTGTACCTC AACGGCGAGT TTGTGGGGGG CTGTGACATC 
CTTCTGCAGA TGCATCAGAA TGGGGACCTA GTGGAAGAAC TGAAAAAGCT GGGTATCCGC 
TCTGCCCTGG TAGATGAGAA GGACCAAGAC TCCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.
PloS one12(5)e0176267(2017)
Petry SF,Sharifpanah F,Sauer H,Linn T

Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress.
Bone44(5)795-804(2009 May)
Linares GR,Xing W,Govoni KE,Chen ST,Mohan S

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.
Nature436(7053)1035-39(2005 Aug)
Wingert RA,Galloway JL,Barut B,Foott H,Fraenkel P,Axe JL,Weber GJ,Dooley K,Davidson AJ,Schmid B,Schmidt B,Paw BH,Shaw GC,Kingsley P,Palis J,Schubert H,Chen O,Kaplan J,Zon LI,

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Glrx5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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