Ppp2r2b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp2r2b
Entrez Gene ID	72930
Full Name	protein phosphatase 2, regulatory subunit B, beta
Synonyms	2900026H06Rik,6330404L05Rik,E130009M08Rik,PP2A-PR55B,PR55-BETA,SCA12
General protein information	Preferred Names protein phosphatase 2, regulatory subunit B, beta Names serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform PP2A subunit B isoform B55-beta PP2A subunit B isoform PR55-beta PP2A subunit B isoform R2-beta PP2A subunit B isoform beta protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_028392.3	NP_082668.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PPP2R2B	NP_001259014.1
Xenopus tropicalis (tropical clawed frog)	ppp2r2b	NP_001016458.1
Canis lupus familiaris (dog)	PPP2R2B	XP_003433830.1
Danio rerio (zebrafish)	LOC100335012	XP_002664542.2
Homo sapiens (human)	PPP2R2B	NP_001258828.1
Pan troglodytes (chimpanzee)	PPP2R2B	XP_003310938.1
Rattus norvegicus (Norway rat)	Ppp2r2b	NP_071545.2
Mus musculus (house mouse)	Ppp2r2b	NP_082668.1
Gallus gallus (chicken)	PPP2R2B	XP_004945109.1

Gene Ontology
Bibliography

Related articles in PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M, McGillewie L, B?r S, Minocha S, Chevalier C, Po C, , Chelly J, Mandel JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, H?rault Y, Collins SC, Friant S, Godin JD, Yalcin B
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
O'Shaughnessy RF, Welti JC, Sully K, Byrne C
Development (Cambridge, England)136(20)3423-31(2009 Oct)

Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, Li DW
Molecular vision14762-73(2008 Apr)

Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.
Maeda T, Hamabe W, Gao Y, Fukazawa Y, Kumamoto K, Ozaki M, Kishioka S
Brain research1056(2)191-9(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.

The following Ppp2r2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp2r2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05573	NM_028392.3 Latest version!	Mus musculus protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp2r2b ( NM_028392.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082668.1 Mus musculus protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05573
Clone ID Related Accession (Same CDS sequence)	NM_028392.3
Accession Version	NM_028392.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK013600.1 and BB694259.1. On Jan 10, 2013 this sequence version replaced NM_028392.2. Transcript Variant: This variant (2) encodes a functional protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.92401.1, AK013600.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAAATGCT TCTCTCGTTA CCTGCCTTAT ATCTTCAGAC CTCCAAACAC CATCCTCTCT 
TCCAGCTGCC ATACTGAAGC TGACATTATC TCTACGGTAG AATTCAACCA CACGGGAGAG 
TTACTAGCGA CGGGGGACAA GGGGGGTCGG GTCGTAATAT TTCAGCGAGA ACAGGAGAGT 
AAAAACCAGG TTCATCGTAG GGGTGAATAC AATGTTTACA GCACATTCCA GAGCCATGAA 
CCCGAGTTCG ATTACCTGAA AAGTTTAGAA ATAGAAGAAA AAATCAATAA GATAAGATGG 
CTCCCTCAAC AAAACGCAGC TTACTTTCTT CTGTCTACCA ACGATAAAAC TGTGAAGCTG 
TGGAAAGTCA GTGAGCGGGA TAAGAGGCCA GAAGGCTACA ACCTGAAAGA TGAGGAGGGC 
CGGCTCCGGG ATCCTGCCAC CATCACAACC CTGCGGGTGC CTGTCCTGAG ACCCATGGAC 
CTGATGGTGG AGGCCACCCC ACGAAGAGTG TTTGCCAATG CGCACACGTA CCACATCAAC 
TCTATATCTG TCAACAGCGA CTATGAGACC TACATGTCTG CTGATGACCT GAGGATTAAT 
CTGTGGAACT TTGAGATAAC CAATCAGAGT TTTAATATCG TGGACATCAA GCCAGCCAAC 
ATGGAGGAGC TCACAGAGGT GATCACTGCA GCTGAGTTCC ACCCCCACCA CTGCAACACC 
TTCGTATACA GCAGCAGCAA GGGGACAATC CGGCTGTGTG ACATGCGTGC ATCTGCGCTG 
TGTGACAGGC ACACCAAGTT TTTTGAAGAA CCGGAAGATC CAAGCAACAG ATCGTTTTTC 
TCTGAAATCA TCTCTTCAAT TTCGGATGTG AAATTCAGCC ACAGTGGGAG GTATATCATG 
ACCAGAGACT ATCTGACCGT GAAAGTCTGG GACCTCAACA TGGAAAATCG CCCCATTGAG 
ACATACCAGG TTCATGACTA CCTCCGCAGC AAGTTGTGCT CCCTCTATGA AAACGACTGC 
ATTTTTGATA AATTTGAGTG TGTATGGAAT GGGTCAGACA GCGTCATCAT GACAGGCTCC 
TACAATAACT TCTTCAGGAT GTTCGACCGA AACACCAAGC GTGATGTGAC CCTTGAGGCC 
TCAAGGGAAA ACAGCAAACC CCGGGCTATC CTCAAACCCC GAAAAGTGTG CGTCGGGGGC 
AAGCGAAGAA AAGATGAGAT CAGTGTTGAC AGTCTGGACT TTAGCAAAAA GATCTTGCAT 
ACAGCTTGGC ATCCTTCAGA AAACATTATA GCAGTGGCGG CTACGAATAA CTTATATATA 
TTCCAAGACA AGGTTAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082668.1
CDS	232..1572
Translation	MKCFSRYLPYIFRPPNTILSSSCHTEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN

Target ORF information:

RefSeq Version	NM_028392.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028392.3

ORF Insert Sequence:

ATGAAATGCT TCTCTCGTTA CCTGCCTTAT ATCTTCAGAC CTCCAAACAC CATCCTCTCT 
TCCAGCTGCC ATACTGAAGC TGACATTATC TCTACGGTAG AATTCAACCA CACGGGAGAG 
TTACTAGCGA CGGGGGACAA GGGGGGTCGG GTCGTAATAT TTCAGCGAGA ACAGGAGAGT 
AAAAACCAGG TTCATCGTAG GGGTGAATAC AATGTTTACA GCACATTCCA GAGCCATGAA 
CCCGAGTTCG ATTACCTGAA AAGTTTAGAA ATAGAAGAAA AAATCAATAA GATAAGATGG 
CTCCCTCAAC AAAACGCAGC TTACTTTCTT CTGTCTACCA ACGATAAAAC TGTGAAGCTG 
TGGAAAGTCA GTGAGCGGGA TAAGAGGCCA GAAGGCTACA ACCTGAAAGA TGAGGAGGGC 
CGGCTCCGGG ATCCTGCCAC CATCACAACC CTGCGGGTGC CTGTCCTGAG ACCCATGGAC 
CTGATGGTGG AGGCCACCCC ACGAAGAGTG TTTGCCAATG CGCACACGTA CCACATCAAC 
TCTATATCTG TCAACAGCGA CTATGAGACC TACATGTCTG CTGATGACCT GAGGATTAAT 
CTGTGGAACT TTGAGATAAC CAATCAGAGT TTTAATATCG TGGACATCAA GCCAGCCAAC 
ATGGAGGAGC TCACAGAGGT GATCACTGCA GCTGAGTTCC ACCCCCACCA CTGCAACACC 
TTCGTATACA GCAGCAGCAA GGGGACAATC CGGCTGTGTG ACATGCGTGC ATCTGCGCTG 
TGTGACAGGC ACACCAAGTT TTTTGAAGAA CCGGAAGATC CAAGCAACAG ATCGTTTTTC 
TCTGAAATCA TCTCTTCAAT TTCGGATGTG AAATTCAGCC ACAGTGGGAG GTATATCATG 
ACCAGAGACT ATCTGACCGT GAAAGTCTGG GACCTCAACA TGGAAAATCG CCCCATTGAG 
ACATACCAGG TTCATGACTA CCTCCGCAGC AAGTTGTGCT CCCTCTATGA AAACGACTGC 
ATTTTTGATA AATTTGAGTG TGTATGGAAT GGGTCAGACA GCGTCATCAT GACAGGCTCC 
TACAATAACT TCTTCAGGAT GTTCGACCGA AACACCAAGC GTGATGTGAC CCTTGAGGCC 
TCAAGGGAAA ACAGCAAACC CCGGGCTATC CTCAAACCCC GAAAAGTGTG CGTCGGGGGC 
AAGCGAAGAA AAGATGAGAT CAGTGTTGAC AGTCTGGACT TTAGCAAAAA GATCTTGCAT 
ACAGCTTGGC ATCCTTCAGA AAACATTATA GCAGTGGCGG CTACGAATAA CTTATATATA 
TTCCAAGACA AGGTTAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Proceedings of the National Academy of Sciences of the United States of America114(44)E9308-E9317(2017 Oct)
Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,B?r S,Minocha S,Chevalier C,Po C,,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,H?rault Y,Collins SC,Friant S,Godin JD,Yalcin B

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
Development (Cambridge, England)136(20)3423-31(2009 Oct)
O'Shaughnessy RF,Welti JC,Sully K,Byrne C

Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Molecular vision14762-73(2008 Apr)
Liu WB,Li Y,Zhang L,Chen HG,Sun S,Liu JP,Liu Y,Li DW

Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.
Brain research1056(2)191-9(2005 Sep)
Maeda T,Hamabe W,Gao Y,Fukazawa Y,Kumamoto K,Ozaki M,Kishioka S

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Ppp2r2b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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