Dusp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp3
Entrez Gene ID	72349
Full Name	dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Synonyms	2210015O03Rik,5031436O03Rik,T-DSP11,VHR
General protein information	Preferred Names dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Names dual specificity protein phosphatase 3 vaccinia H1-related phosphatase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
XM_006534306.1	XP_006534369.1	dual specificity protein phosphatase 3 isoform X2
XM_006534305.3	XP_006534368.1	dual specificity protein phosphatase 3 isoform X1
XM_006534305.2	XP_006534368.1	dual specificity protein phosphatase 3 isoform X1
XM_006534306.2	XP_006534369.1	dual specificity protein phosphatase 3 isoform X2
XM_030246364.1	XP_030102224.1	dual specificity protein phosphatase 3 isoform X3
NM_028207.3	NP_082483.1	dual specificity protein phosphatase 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DUSP3	XP_003315464.1
Canis lupus familiaris (dog)	DUSP3	XP_537624.3
Xenopus tropicalis (tropical clawed frog)	LOC100498529	XP_002937631.1
Homo sapiens (human)	DUSP3	NP_004081.1
	DUSP3	XP_001113754.1
Bos taurus (cattle)	DUSP3	NP_001069842.1
Mus musculus (house mouse)	Dusp3	NP_082483.1
Rattus norvegicus (Norway rat)	Dusp3	NP_001166847.1
Gallus gallus (chicken)	DUSP3	XP_423280.4
Danio rerio (zebrafish)	dusp3a	XP_001340818.2

Gene Ontology
Bibliography

Related articles in PubMed

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Chen YR, Chou HC, Yang CH, Chen HY, Liu YW, Lin TY, Yeh CL, Chao WT, Tsou HH, Chuang HC, Tan TH
Oncogene36(47)6509-6517(2017 Nov)

Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock.
Vandereyken MM, Singh P, Wathieu CP, Jacques S, Zurashvilli T, Dejager L, Amand M, Musumeci L, Singh M, Moutschen MP, Libert CRF, Rahmouni S
Journal of immunology (Baltimore, Md. : 1950)199(7)2515-2527(2017 Oct)

Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.
Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, Dumon S, Garc?a P, Frampton J
Leukemia31(4)957-966(2017 Apr)

Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.
Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, Singh P, Singh M, Ghuysen C, Wathieu C, Zurashvili T, Sounni NE, Moutschen M, Gilles C, Oury C, Cataldo D, Van Ginderachter JA, Rahmouni S
PloS one12(10)e0185786(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicated that regulating non-receptor tyrosine kinase FAK and cell migration is a newly revealed function of VHR/DUSP3.
Title: Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.

At the molecular level, DUSP3 deletion was associated with estrogen-dependent decreased phosphorylation of ERK1/2 and Akt in peritoneal macrophages stimulated ex vivo by LPS; results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner
Title: Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock.

DUSP3 phosphatase plays a key role in metastatic growth.
Title: Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.

Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses
Title: DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock.

Platelets from DUSP3-deficient mice displayed a selective impairment of aggregation and granule secretion.
Title: Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.

The following Dusp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05329	NM_028207.3 Latest version!	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu46989	XM_006534305.3 Latest version!	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu46990	XM_006534306.2 Latest version!	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu85920	XM_030246364.1 Latest version!	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu46989	XM_006534305.2	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu46990	XM_006534306.1	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp3 ( XM_006534305.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006534368.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46989
Clone ID Related Accession (Same CDS sequence)	XM_006534305.3 , XM_006534305.2
Accession Version	XM_006534305.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006534305.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGATGG GGTGCGGGAC AATCCGGTAT TTATATTCTC TGTGTTATGA TTCGGTCAAG 
CGCCCCGCCG CCGCCATGTC CAGCTCGTTC GAACTCTCGG TGCAAGATCT CAACGACCTG 
CTCTCGGATG GCAGCGGCTG CTACAGCCTG CCGAGCCAGC CCTGCAACGA GGTCGTCCCG 
AGGGTCTACG TGGGCAACGC GTCTGTGGCT CAGGACATCA CCCAGCTGCA GAAACTGGGC 
ATCACCCACG TCCTGAATGC TGCCGAGGGC AGGTCCTTCA TGCACGTCAA CACCAGTGCT 
AGCTTCTACG AGGATTCTGG CATCACCTAC TTGGGCATCA AGGCCAATGA TACGCAGGAG 
TTCAACCTCA GTGCTTACTT TGAAAGGGCC ACAGATTTCA TTGACCAGGC GCTGGCCCAT 
AAAAATGGCC GGGTGCTTGT CCATTGCCGC GAGGGCTACA GCCGCTCCCC AACGCTAGTT 
ATCGCCTACC TCATGATGCG GCAGAAGATG GACGTCAAGT CTGCTCTGAG TACTGTGAGG 
CAGAATCGTG AGATCGGCCC CAACGATGGC TTCCTGGCCC AACTCTGCCA GCTCAATGAC 
AGACTAGCCA AGGAGGGCAA GGATCCTGAA ACTGACTCGC TGGACAGAAA CGAGACTTGG 
CGGCACCATG AGAATGGAGA GAGAGAGAGC AAAGAAAGAA ACAGCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006534368.1
CDS	52..762
Translation	MVMGCGTIRYLYSLCYDSVKRPAAAMSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKDPETDSLDRNETWRHHENGERESKERNSL

Target ORF information:

RefSeq Version	XM_006534305.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006534305.2

ORF Insert Sequence:

ATGGTGATGG GGTGCGGGAC AATCCGGTAT TTATATTCTC TGTGTTATGA TTCGGTCAAG 
CGCCCCGCCG CCGCCATGTC CAGCTCGTTC GAACTCTCGG TGCAAGATCT CAACGACCTG 
CTCTCGGATG GCAGCGGCTG CTACAGCCTG CCGAGCCAGC CCTGCAACGA GGTCGTCCCG 
AGGGTCTACG TGGGCAACGC GTCTGTGGCT CAGGACATCA CCCAGCTGCA GAAACTGGGC 
ATCACCCACG TCCTGAATGC TGCCGAGGGC AGGTCCTTCA TGCACGTCAA CACCAGTGCT 
AGCTTCTACG AGGATTCTGG CATCACCTAC TTGGGCATCA AGGCCAATGA TACGCAGGAG 
TTCAACCTCA GTGCTTACTT TGAAAGGGCC ACAGATTTCA TTGACCAGGC GCTGGCCCAT 
AAAAATGGCC GGGTGCTTGT CCATTGCCGC GAGGGCTACA GCCGCTCCCC AACGCTAGTT 
ATCGCCTACC TCATGATGCG GCAGAAGATG GACGTCAAGT CTGCTCTGAG TACTGTGAGG 
CAGAATCGTG AGATCGGCCC CAACGATGGC TTCCTGGCCC AACTCTGCCA GCTCAATGAC 
AGACTAGCCA AGGAGGGCAA GGATCCTGAA ACTGACTCGC TGGACAGAAA CGAGACTTGG 
CGGCACCATG AGAATGGAGA GAGAGAGAGC AAAGAAAGAA ACAGCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( XM_006534306.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006534369.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu46990
Clone ID Related Accession (Same CDS sequence)	XM_006534306.1 , XM_006534306.2
Accession Version	XM_006534306.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGATC CTGAAACTGA CTCGCTGGAC AGAAACGAGA CTTGGCGGCA CCATGAGAAT 
GGAGAGAGAG AGAGCAAAGA AAGAAACAGC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006534369.1
CDS	289..924
Translation	MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKDPETDSLDRNETWRHHENGERESKERNSL

Target ORF information:

RefSeq Version	XM_006534306.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006534306.1

ORF Insert Sequence:

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGATC CTGAAACTGA CTCGCTGGAC AGAAACGAGA CTTGGCGGCA CCATGAGAAT 
GGAGAGAGAG AGAGCAAAGA AAGAAACAGC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( NM_028207.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082483.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), mRNA.

Price & Availability↑

CloneID	OMu05329
Clone ID Related Accession (Same CDS sequence)	NM_028207.3
Accession Version	NM_028207.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL591145.25 and AK008734.1. On or before Dec 17, 2010 this sequence version replaced XR_106602.1, XR_106412.1, NM_028207.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF902721.1, AK170772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGTGA AACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082483.1
CDS	56..613
Translation	MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKVKL

Target ORF information:

RefSeq Version	NM_028207.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028207.3

ORF Insert Sequence:

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGTGA AACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( XM_006534305.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006534368.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46989
Clone ID Related Accession (Same CDS sequence)	XM_006534305.3 , XM_006534305.2
Accession Version	XM_006534305.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006534305.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGATGG GGTGCGGGAC AATCCGGTAT TTATATTCTC TGTGTTATGA TTCGGTCAAG 
CGCCCCGCCG CCGCCATGTC CAGCTCGTTC GAACTCTCGG TGCAAGATCT CAACGACCTG 
CTCTCGGATG GCAGCGGCTG CTACAGCCTG CCGAGCCAGC CCTGCAACGA GGTCGTCCCG 
AGGGTCTACG TGGGCAACGC GTCTGTGGCT CAGGACATCA CCCAGCTGCA GAAACTGGGC 
ATCACCCACG TCCTGAATGC TGCCGAGGGC AGGTCCTTCA TGCACGTCAA CACCAGTGCT 
AGCTTCTACG AGGATTCTGG CATCACCTAC TTGGGCATCA AGGCCAATGA TACGCAGGAG 
TTCAACCTCA GTGCTTACTT TGAAAGGGCC ACAGATTTCA TTGACCAGGC GCTGGCCCAT 
AAAAATGGCC GGGTGCTTGT CCATTGCCGC GAGGGCTACA GCCGCTCCCC AACGCTAGTT 
ATCGCCTACC TCATGATGCG GCAGAAGATG GACGTCAAGT CTGCTCTGAG TACTGTGAGG 
CAGAATCGTG AGATCGGCCC CAACGATGGC TTCCTGGCCC AACTCTGCCA GCTCAATGAC 
AGACTAGCCA AGGAGGGCAA GGATCCTGAA ACTGACTCGC TGGACAGAAA CGAGACTTGG 
CGGCACCATG AGAATGGAGA GAGAGAGAGC AAAGAAAGAA ACAGCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006534368.1
CDS	88..798
Translation	MVMGCGTIRYLYSLCYDSVKRPAAAMSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKDPETDSLDRNETWRHHENGERESKERNSL

Target ORF information:

RefSeq Version	XM_006534305.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006534305.3

ORF Insert Sequence:

ATGGTGATGG GGTGCGGGAC AATCCGGTAT TTATATTCTC TGTGTTATGA TTCGGTCAAG 
CGCCCCGCCG CCGCCATGTC CAGCTCGTTC GAACTCTCGG TGCAAGATCT CAACGACCTG 
CTCTCGGATG GCAGCGGCTG CTACAGCCTG CCGAGCCAGC CCTGCAACGA GGTCGTCCCG 
AGGGTCTACG TGGGCAACGC GTCTGTGGCT CAGGACATCA CCCAGCTGCA GAAACTGGGC 
ATCACCCACG TCCTGAATGC TGCCGAGGGC AGGTCCTTCA TGCACGTCAA CACCAGTGCT 
AGCTTCTACG AGGATTCTGG CATCACCTAC TTGGGCATCA AGGCCAATGA TACGCAGGAG 
TTCAACCTCA GTGCTTACTT TGAAAGGGCC ACAGATTTCA TTGACCAGGC GCTGGCCCAT 
AAAAATGGCC GGGTGCTTGT CCATTGCCGC GAGGGCTACA GCCGCTCCCC AACGCTAGTT 
ATCGCCTACC TCATGATGCG GCAGAAGATG GACGTCAAGT CTGCTCTGAG TACTGTGAGG 
CAGAATCGTG AGATCGGCCC CAACGATGGC TTCCTGGCCC AACTCTGCCA GCTCAATGAC 
AGACTAGCCA AGGAGGGCAA GGATCCTGAA ACTGACTCGC TGGACAGAAA CGAGACTTGG 
CGGCACCATG AGAATGGAGA GAGAGAGAGC AAAGAAAGAA ACAGCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( XM_006534306.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006534369.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.

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CloneID	OMu46990
Clone ID Related Accession (Same CDS sequence)	XM_006534306.1 , XM_006534306.2
Accession Version	XM_006534306.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006534306.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGATC CTGAAACTGA CTCGCTGGAC AGAAACGAGA CTTGGCGGCA CCATGAGAAT 
GGAGAGAGAG AGAGCAAAGA AAGAAACAGC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006534369.1
CDS	294..929
Translation	MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKDPETDSLDRNETWRHHENGERESKERNSL

Target ORF information:

RefSeq Version	XM_006534306.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006534306.2

ORF Insert Sequence:

ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 
GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 
AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 
AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 
TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 
TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 
CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 
ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 
GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 
GGCAAGGATC CTGAAACTGA CTCGCTGGAC AGAAACGAGA CTTGGCGGCA CCATGAGAAT 
GGAGAGAGAG AGAGCAAAGA AAGAAACAGC CTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp3 ( XM_030246364.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030102224.1 Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu85920
Clone ID Related Accession (Same CDS sequence)	XM_030246364.1
Accession Version	XM_030246364.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 3 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTCGGT CAAGCGCCCC GCCGCCGCCA TGTCCAGCTC GTTCGAACTC TCGGTGCAAG 
ATCTCAACGA CCTGCTCTCG GATGGCAGCG GCTGCTACAG CCTGCCGAGC CAGCCCTGCA 
ACGAGGTCGT CCCGAGGGTC TACGTGGGCA ACGCGCCGGG TGCTTGTCCA TTGCCGCGAG 
GGCTACAGCC GCTCCCCAAC GCTAGTTATC GCCTACCTCA TGATGCGGCA GAAGATGGAC 
GTCAAGTCTG CTCTGAGTAC TGTGAGGCAG AATCGTGAGA TCGGCCCCAA CGATGGCTTC 
CTGGCCCAAC TCTGCCAGCT CAATGACAGA CTAGCCAAGG AGGGCAAGGA TCCTGAAACT 
GACTCGCTGG ACAGAAACGA GACTTGGCGG CACCATGAGA ATGGAGAGAG AGAGAGCAAA 
GAAAGAAACA GCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030102224.1
CDS	108..545
Translation	MIRSSAPPPPCPARSNSRCKISTTCSRMAAAATACRASPATRSSRGSTWATRRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKDPETDSLDRNETWRHHENGERESKERNSL

Target ORF information:

RefSeq Version	XM_030246364.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030246364.1

ORF Insert Sequence:

ATGATTCGGT CAAGCGCCCC GCCGCCGCCA TGTCCAGCTC GTTCGAACTC TCGGTGCAAG 
ATCTCAACGA CCTGCTCTCG GATGGCAGCG GCTGCTACAG CCTGCCGAGC CAGCCCTGCA 
ACGAGGTCGT CCCGAGGGTC TACGTGGGCA ACGCGCCGGG TGCTTGTCCA TTGCCGCGAG 
GGCTACAGCC GCTCCCCAAC GCTAGTTATC GCCTACCTCA TGATGCGGCA GAAGATGGAC 
GTCAAGTCTG CTCTGAGTAC TGTGAGGCAG AATCGTGAGA TCGGCCCCAA CGATGGCTTC 
CTGGCCCAAC TCTGCCAGCT CAATGACAGA CTAGCCAAGG AGGGCAAGGA TCCTGAAACT 
GACTCGCTGG ACAGAAACGA GACTTGGCGG CACCATGAGA ATGGAGAGAG AGAGAGCAAA 
GAAAGAAACA GCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.
Oncogene36(47)6509-6517(2017 Nov)
Chen YR,Chou HC,Yang CH,Chen HY,Liu YW,Lin TY,Yeh CL,Chao WT,Tsou HH,Chuang HC,Tan TH

Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock.
Journal of immunology (Baltimore, Md. : 1950)199(7)2515-2527(2017 Oct)
Vandereyken MM,Singh P,Wathieu CP,Jacques S,Zurashvilli T,Dejager L,Amand M,Musumeci L,Singh M,Moutschen MP,Libert CRF,Rahmouni S

Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.
Leukemia31(4)957-966(2017 Apr)
Clarke M,Volpe G,Sheriff L,Walton D,Ward C,Wei W,Dumon S,Garc?a P,Frampton J

Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.
PloS one12(10)e0185786(2017)
Vandereyken M,Jacques S,Van Overmeire E,Amand M,Rocks N,Delierneux C,Singh P,Singh M,Ghuysen C,Wathieu C,Zurashvili T,Sounni NE,Moutschen M,Gilles C,Oury C,Cataldo D,Van Ginderachter JA,Rahmouni S

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Dusp3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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