Klhl40 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klhl40
Entrez Gene ID	72330
Full Name	kelch-like 40
Synonyms	2310024D23Rik,Kbtbd5
General protein information	Preferred Names kelch-like 40 Names kelch-like protein 40 kelch repeat and BTB (POZ) domain containing 5 kelch repeat and BTB domain-containing protein 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F4

mRNA and Protein(s)

mRNA	Protein	Name
XM_006512296.3	XP_006512359.1	kelch-like protein 40 isoform X1
XM_006512296.4	XP_006512359.1	kelch-like protein 40 isoform X1
NM_028202.3	NP_082478.1	kelch-like protein 40

Pathways from BioSystems

Homologies

	KBTBD5	XP_002802877.1
Gallus gallus (chicken)	KBTBD5	XP_418495.2
Danio rerio (zebrafish)	klhl40a	NP_001122154.1
Xenopus tropicalis (tropical clawed frog)	klhl40	NP_001015817.1
Rattus norvegicus (Norway rat)	Klhl40	NP_001101665.1
Danio rerio (zebrafish)	klhl40b	XP_001334076.1
Homo sapiens (human)	KLHL40	NP_689606.2
Canis lupus familiaris (dog)	KLHL40	XP_542735.4
Bos taurus (cattle)	KBTBD5	NP_001015598.1
Mus musculus (house mouse)	Klhl40	NP_082478.1

Gene Ontology
Bibliography

Related articles in PubMed

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN
eLife6(2017 Aug)

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M
Development (Cambridge, England)143(23)4441-4451(2016 12)

Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X
The Journal of biological chemistry290(24)15350-61(2015 Jun)

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN
The Journal of clinical investigation124(8)3529-39(2014 Aug)

Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage.
Bowlin KM, Embree LJ, Garry MG, Garry DJ, Shi X
Differentiation; research in biological diversity86(4-5)184-91(2013 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity
Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.

NEB and LMOD3 were reduced in skeletal muscle of Klhl40-/- mice, providing a potential basis for the development of experimental nemaline myopathy.
Title: KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.

we have demonstrated that Kbtbd5 is the direct downstream target gene of the Myod family and regulates myogenic differentiation.
Title: Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage.

The following Klhl40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klhl40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05320	NM_028202.3 Latest version!	Mus musculus kelch-like 40 (Klhl40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00
OMu43561	XM_006512296.4 Latest version!	Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu43561	XM_006512296.3	Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klhl40 ( NM_028202.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082478.1 Mus musculus kelch-like 40 (Klhl40), mRNA.

Price & Availability↑

CloneID	OMu05320
Clone ID Related Accession (Same CDS sequence)	NM_028202.3
Accession Version	NM_028202.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	kelch-like protein 40
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC125576.1 and AK160799.1. On Sep 19, 2009 this sequence version replaced NM_028202.2. ##Evidence-Data-START## Transcript exon combination :: AK078669.1, AK009491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGATACAA CGAGGATGAG AAAAAGTGGG AGGGGGTCCT ACGGGAGATC 
GCCTACGCAG CTGGCGCCAC CTTCCTCCCT GTGCGCCTCA ATGTGCTTCG CCTGACCAAG 
ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082478.1
CDS	170..2035
Translation	MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLPVRLNVLRLTKM

Target ORF information:

RefSeq Version	NM_028202.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 40 (Klhl40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028202.3

ORF Insert Sequence:

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGATACAA CGAGGATGAG AAAAAGTGGG AGGGGGTCCT ACGGGAGATC 
GCCTACGCAG CTGGCGCCAC CTTCCTCCCT GTGCGCCTCA ATGTGCTTCG CCTGACCAAG 
ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klhl40 ( XM_006512296.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512359.1 Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu43561
Clone ID Related Accession (Same CDS sequence)	XM_006512296.3 , XM_006512296.4
Accession Version	XM_006512296.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	kelch-like protein 40 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512296.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGCTCTCA ATCTTGCTTC CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512359.1
CDS	644..2419
Translation	MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWSSQSCFL

Target ORF information:

RefSeq Version	XM_006512296.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512296.3

ORF Insert Sequence:

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGCTCTCA ATCTTGCTTC CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klhl40 ( XM_006512296.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512359.1 Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu43561
Clone ID Related Accession (Same CDS sequence)	XM_006512296.3 , XM_006512296.4
Accession Version	XM_006512296.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	kelch-like protein 40 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512296.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGCTCTCA ATCTTGCTTC CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512359.1
CDS	278..2053
Translation	MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWSSQSCFL

Target ORF information:

RefSeq Version	XM_006512296.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 40 (Klhl40), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512296.4

ORF Insert Sequence:

ATGACGCTGG GCTTGGAGCA GGCGGAGGAA CAGCGTCTGT ACCAGCAGAC GCTCCTGCAA 
GACGGCCTCA AGGACATGCT GGACCACGGC AAGTTCCTAG ACTGTGTAGT GCGCGTGGGT 
GAGCGCGAGT TCCCGTGCCA CCGCCTGGTG CTAGCCGCCT GTAGCCCCTA CTTCCGCGCG 
CGCTTCCTGG CTGAGCCAGA TAGCGCGGGA GAGGTACGCC TGGAGGAGGT GTCGCCAGAC 
GTAGTGTCCC AGGTGCTGCA CTACCTGTAC ACATCAGAGA TCGCGCTGGA TGAGGCAAGC 
GTGCAAGACC TGTTTGCCGC GGCGCATCGA TTCCAGATCC CGTCCATCTT CACCATCTGC 
GTGTCGTTTC TGCAGAAGCG CCTGTGCTTG GCCAATTGCC TGGCTGTCTT CCGCCTCGGC 
CTCCTGCTGG ACTGCGCGCG TCTGGCTGTG GCCGCGCGCG ACTTCATCTG CGCGCGCTTC 
CCGCTGGTGG CGCGGGACAA CGACTTCCTG GGACTCTCGG CTGACGAGCT GATCGCCATC 
ATCTCCAGCG ACGGCCTCAA CGTAGAGAAG GAGGAGGCAG TGTTTGAGGC TGTGATGCGC 
TGGGCCAGCA GCGGAGATGC TGAGGCGCAG GCGGAGCGCC AGCGCGCGCT GCCCACGGTC 
TTCGAGAGCG TTCGCTGCCG CCTGCTGCCT CGTGCTTTCC TGGAGACTCG CGTGGAGCGC 
CACCCACTTG TGCGCTCCCA GCCCGAGCTG TTGCGCAAGG TGCAGATGGT GAAGGATGCA 
CATGAGGGCC GCCTCACTAC ACTGCGCAAG AAGAAGAAGG AAAAGGGTGA GCAGACAGCT 
CGGGCCAAGG AGGCCAACCA GGGCACAGAA GACACCAAGG CTGAGGACGA TGAGGAACGA 
GTACTGCCCG GGATCCTCAA TGACACTCTG CGCTTCGGCA TGTTCCTTCA GGATCTCATC 
TTCATGATCA GCGAGGAAGG CGCCGTGGCT TACGACCCAG CCGCCAACGA GTGCTACTGT 
GCATCCCTGT CCACCCAGAT CCCCAAGAAC CATGTCAGTC TGGTGACCAA GGAGAACCAA 
GTCTTCGTGG CCGGTGGCCT CTTCTACAAT GAGGACAACA AGGAGGACCC TATGAGTGCT 
TACTTCCTGC AGTTTGACCA CTTGGACTCT GAGTGGCTGG GGATGCCGCC TCTCCCTTCA 
CCTCGCTGCC TCTTCGGCCT GGGGGAGGCT CTCAACGCCA TCTACGTGGT CGGCGGCCGG 
GAACTCAAGG ACAGCGAAGA CAGCCTGGAC TCAGTCCTGT GCTACGACAG GCTGTCATTC 
AAATGGGGTG AGTCAGACCC GCTGCCCTAC GCCGTGTACG GCCACACAGT CCTTTCCCAC 
ATGGACCTGG TCTATGTCAT TGGTGGCAAA GGCAAAGACA GGAAATGTCT GAACAAGATG 
TGTGTCTACG ACCCCAAGAA GTTTGAGTGG AAGGAGCTAG CACCCATGCA GACAGCCCGA 
TCGCTCTTTG GGGCCACGGT CCATGACGGC CGCATCTTTG TGGCCGCAGG GGTGACAGAC 
ACAGGACTTA CCAGCTCTTC AGAGGTGTAC AGCATTGCAG ACAACAAGTG GACCTCCTTT 
GAGGCCTTCC CACAGGAACG AAGCTCGCTC AGCCTGGTCA GCCTAGCTGG CACTCTTTAT 
GCCTTGGGTG GCTTTGCCAC TCTGGAGACG GAGTCTGGAG AGCTGGTCCC CACGGAGCTC 
AATGACATCT GGAGCTCTCA ATCTTGCTTC CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
eLife6(2017 Aug)
Ramirez-Martinez A,Cenik BK,Bezprozvannaya S,Chen B,Bassel-Duby R,Liu N,Olson EN

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
Development (Cambridge, England)143(23)4441-4451(2016 12)
Wang Y,Baeyens N,Corti F,Tanaka K,Fang JS,Zhang J,Jin Y,Coon B,Hirschi KK,Schwartz MA,Simons M

Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
The Journal of biological chemistry290(24)15350-61(2015 Jun)
Gong W,Gohla RM,Bowlin KM,Koyano-Nakagawa N,Garry DJ,Shi X

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
The Journal of clinical investigation124(8)3529-39(2014 Aug)
Garg A,O'Rourke J,Long C,Doering J,Ravenscroft G,Bezprozvannaya S,Nelson BR,Beetz N,Li L,Chen S,Laing NG,Grange RW,Bassel-Duby R,Olson EN

Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage.
Differentiation; research in biological diversity86(4-5)184-91(2013 Nov-Dec)
Bowlin KM,Embree LJ,Garry MG,Garry DJ,Shi X

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Klhl40 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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