Lancl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lancl2
Entrez Gene ID	71835
Full Name	LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms	1700003F10Rik
General protein information	Preferred Names LanC (bacterial lantibiotic synthetase component C)-like 2 Names lanC-like protein 2 testis-specific adriamycin sensitivity protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133737.2	NP_598498.1	lanC-like protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	LANCL2	NP_061167.1
Danio rerio (zebrafish)	lancl2	NP_001076472.1
Neurospora crassa	NCU08190	XP_959280.1
Arabidopsis thaliana (thale cress)	GPCR	NP_175700.2
Xenopus tropicalis (tropical clawed frog)	lancl2	NP_001039268.1
Canis lupus familiaris (dog)	LANCL2	XP_005631064.1
Bos taurus (cattle)	LANCL2	NP_001095726.1
Mus musculus (house mouse)	Lancl2	NP_598498.1
Gallus gallus (chicken)	LANCL2	XP_418874.2
Pan troglodytes (chimpanzee)	LANCL2	XP_003318497.1
Rattus norvegicus (Norway rat)	Lancl2	NP_001014209.1
Arabidopsis thaliana (thale cress)	GCL2	NP_850003.1
Oryza sativa (rice)	Os10g0497900	NP_001064963.1
	LANCL2	XP_001090911.1
Oryza sativa (rice)	Os04g0529600	NP_001174024.1

Gene Ontology
Bibliography

Related articles in PubMed

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.
He C, Zeng M, Dutta D, Koh TH, Chen J, van der Donk WA
Scientific reports740980(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.
Leber A, Bassaganya-Riera J, Tubau-Juni N, Zoccoli-Rodriguez V, Viladomiu M, Abedi V, Lu P, Hontecillas R
PloS one11(12)e0167440(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The predicted impairment of regulatory macrophage differentiation by the loss of LANCL2 was simulated based on multiscale linkages between the tissue-level gastric mucosa and the intracellular models. The simulated deletion of LANCL2 resulted in a greater clearance of H. pylori, but also greater IFNgamma responses and damage to the epithelium.
Title: Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.

Data show that LANCL2 silencing resulted in a 70% inhibition of the plasma membrane lipid peroxidation induced by abscisic acid (ABA).
Title: Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.

The following Lancl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lancl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10152	NM_133737.2 Latest version!	Mus musculus LanC (bacterial lantibiotic synthetase component C)-like 2 (Lancl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lancl2 ( NM_133737.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598498.1 Mus musculus LanC (bacterial lantibiotic synthetase component C)-like 2 (Lancl2), mRNA.

Price & Availability↑

CloneID	OMu10152
Clone ID Related Accession (Same CDS sequence)	NM_133737.2
Accession Version	NM_133737.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Mus musculus(house mouse)
Product	lanC-like protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127307.3 and BC016072.1. On Dec 9, 2009 this sequence version replaced NM_133737.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.141988.1, SRR1660813.243062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGAGA CCATGTCAAA GAGACTCAAG TTCCACCTAG GAGAGGCGGA GATGGAGGAG 
CGGTCGTTCC CCAATCCCTT CCCAGACTAT GAAGCCGCCG CCTCCGCCGC AGGGCTCGCC 
GCTGGAAGTG CGGAGGAAAC CGGCCGTGTC TGCCCTCTCC CCACCACGGA AGACCCGGGC 
CTCCCTTTCC ACCCTAACGG GAAGATTGTT CCCAACTTCA TAAAGCGTAT CCAGACCAAA 
ATCAAAGATC TTCTGCAGCA GATGGAGGAA GGACTGAAGA CAGCGGACCC TCATGACTGC 
TCTGCATATA CTGGTTGGAC AGGCATAGCA CTTTTGTACC TGCAGCTGTA CCGGGTCACT 
GGTGACCAGA CCTACCTGCT TCGATCCCTG GATTACGTGA AGAGAACACT CCGAAATTTG 
AGTGGTCGCA GAGTCACTTT CCTTTGTGGA GATGCTGGGC CCCTTGCTGT GGGAGCTGTG 
ATATATCATA AACTCAAAAG TGAATGTGAG TCCCAGGAAT GCATCACAAA ACTTCTACAG 
ATGCATAGAA CTATTGTCTG TCAAGAGTCA GAGCTTCCTG ATGAACTGCT GTATGGACGA 
GCAGGATACC TGTATGCCTT ACTGTACCTG AACACAGAGA TTGGCCCTGG CACTGTTGGT 
GAGACAGCTA TTAAAGAGGT AGTCAGTGCT ATTATTGAGT CGGGAAAGAG TCTATCAAGG 
GAAGAAAGGA AATCTGAGCG CTGCCCCCTG CTCTATCAGT GGCACAGAAA ACAATATGTT 
GGAGCAGCCC ATGGTATGGC TGGCATCTAC TACATGCTAA TGCAGCCAGA AGCAAAAGTG 
GACCAAGAAA CCTTAACCGA AATGGTGAAA CCCAGCATTG ATTATGTGCG CCATAAAAAA 
TTCCGATCTG GAAATTATCC ATCATCATTA AGCAATGAAA CAGATCGATT GGTCCACTGG 
TGCCATGGTG CTCCAGGAGT CATCCACGTG CTCTTACAGG CATACCAGGT TTTTAAGGAG 
GAAAAATACT TGAAAGAGGC CATGGAGTGT AGCGATGTGA TTTGGCAGCG AGGTCTGCTC 
CGGAAAGGTT ATGGAATCTG CCATGGAACC TCTGGCAATG GCTATTCCTT TTTGTCCCTT 
TATCGCCTGA CGCAGGATAA GAAGTATCTC TATCGAGCTT GTAAGTTTGC AGAGTGGTGT 
CTAGATTACG GAGCACATGG ATGCCGCATT CCTGACAGAC CTTATTCCCT CTTTGAAGGT 
ATGGCTGGTG CTGTTCACTT CCTTTCTGAC ATCTTGGTAC CAGAGACAGC ACGGTTTCCA 
GCATTTGAAC TTGGCTTTTT GCAGAAGGAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598498.1
CDS	606..1958
Translation	MGETMSKRLKFHLGEAEMEERSFPNPFPDYEAAASAAGLAAGSAEETGRVCPLPTTEDPGLPFHPNGKIVPNFIKRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAVIYHKLKSECESQECITKLLQMHRTIVCQESELPDELLYGRAGYLYALLYLNTEIGPGTVGETAIKEVVSAIIESGKSLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPEAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHVLLQAYQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTSGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDILVPETARFPAFELGFLQKD

Target ORF information:

RefSeq Version	NM_133737.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus LanC (bacterial lantibiotic synthetase component C)-like 2 (Lancl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133737.2

ORF Insert Sequence:

ATGGGCGAGA CCATGTCAAA GAGACTCAAG TTCCACCTAG GAGAGGCGGA GATGGAGGAG 
CGGTCGTTCC CCAATCCCTT CCCAGACTAT GAAGCCGCCG CCTCCGCCGC AGGGCTCGCC 
GCTGGAAGTG CGGAGGAAAC CGGCCGTGTC TGCCCTCTCC CCACCACGGA AGACCCGGGC 
CTCCCTTTCC ACCCTAACGG GAAGATTGTT CCCAACTTCA TAAAGCGTAT CCAGACCAAA 
ATCAAAGATC TTCTGCAGCA GATGGAGGAA GGACTGAAGA CAGCGGACCC TCATGACTGC 
TCTGCATATA CTGGTTGGAC AGGCATAGCA CTTTTGTACC TGCAGCTGTA CCGGGTCACT 
GGTGACCAGA CCTACCTGCT TCGATCCCTG GATTACGTGA AGAGAACACT CCGAAATTTG 
AGTGGTCGCA GAGTCACTTT CCTTTGTGGA GATGCTGGGC CCCTTGCTGT GGGAGCTGTG 
ATATATCATA AACTCAAAAG TGAATGTGAG TCCCAGGAAT GCATCACAAA ACTTCTACAG 
ATGCATAGAA CTATTGTCTG TCAAGAGTCA GAGCTTCCTG ATGAACTGCT GTATGGACGA 
GCAGGATACC TGTATGCCTT ACTGTACCTG AACACAGAGA TTGGCCCTGG CACTGTTGGT 
GAGACAGCTA TTAAAGAGGT AGTCAGTGCT ATTATTGAGT CGGGAAAGAG TCTATCAAGG 
GAAGAAAGGA AATCTGAGCG CTGCCCCCTG CTCTATCAGT GGCACAGAAA ACAATATGTT 
GGAGCAGCCC ATGGTATGGC TGGCATCTAC TACATGCTAA TGCAGCCAGA AGCAAAAGTG 
GACCAAGAAA CCTTAACCGA AATGGTGAAA CCCAGCATTG ATTATGTGCG CCATAAAAAA 
TTCCGATCTG GAAATTATCC ATCATCATTA AGCAATGAAA CAGATCGATT GGTCCACTGG 
TGCCATGGTG CTCCAGGAGT CATCCACGTG CTCTTACAGG CATACCAGGT TTTTAAGGAG 
GAAAAATACT TGAAAGAGGC CATGGAGTGT AGCGATGTGA TTTGGCAGCG AGGTCTGCTC 
CGGAAAGGTT ATGGAATCTG CCATGGAACC TCTGGCAATG GCTATTCCTT TTTGTCCCTT 
TATCGCCTGA CGCAGGATAA GAAGTATCTC TATCGAGCTT GTAAGTTTGC AGAGTGGTGT 
CTAGATTACG GAGCACATGG ATGCCGCATT CCTGACAGAC CTTATTCCCT CTTTGAAGGT 
ATGGCTGGTG CTGTTCACTT CCTTTCTGAC ATCTTGGTAC CAGAGACAGC ACGGTTTCCA 
GCATTTGAAC TTGGCTTTTT GCAGAAGGAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.
Scientific reports740980(2017 Jan)
He C,Zeng M,Dutta D,Koh TH,Chen J,van der Donk WA

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS genetics12(2)e1005691(2016 Feb)
West DB,Engelhard EK,Adkisson M,Nava AJ,Kirov JV,Cipollone A,Willis B,Rapp J,de Jong PJ,Lloyd KC

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.
PloS one11(12)e0167440(2016)
Leber A,Bassaganya-Riera J,Tubau-Juni N,Zoccoli-Rodriguez V,Viladomiu M,Abedi V,Lu P,Hontecillas R

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Lancl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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