Bbs10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bbs10
Entrez Gene ID	71769
Full Name	Bardet-Biedl syndrome 10 (human)
Synonyms	1300007O09Rik,AI452285
General protein information	Preferred Names Bardet-Biedl syndrome 10 (human) Names Bardet-Biedl syndrome 10 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_027914.1	NP_082190.1	Bardet-Biedl syndrome 10 protein homolog

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	BBS10	XP_003432026.2
Bos taurus (cattle)	BBS10	XP_002707864.1
Gallus gallus (chicken)	BBS10	XP_416107.4
Homo sapiens (human)	BBS10	NP_078961.3
	BBS10	XP_001081978.1
Mus musculus (house mouse)	Bbs10	NP_082190.1
Rattus norvegicus (Norway rat)	Bbs10	NP_001102756.1
Xenopus tropicalis (tropical clawed frog)	bbs10	XP_004913011.1
Pan troglodytes (chimpanzee)	BBS10	XP_001161619.1
Danio rerio (zebrafish)	bbs10	NP_001082932.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice.
Cognard N, Scerbo MJ, Obringer C, Yu X, Costa F, Haser E, Le D, Stoetzel C, Roux MJ, Moulin B, Dollfus H, Marion V
Cilia410(2015)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.
Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC, Sheffield VC
Proceedings of the National Academy of Sciences of the United States of America107(4)1488-93(2010 Jan)

Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10.
White DR, Ganesh A, Nishimura D, Rattenberry E, Ahmed S, Smith UM, Pasha S, Raeburn S, Trembath RC, Rajab A, Macdonald F, Banin E, Stone EM, Johnson CA, Sheffield VC, Maher ER
European journal of human genetics : EJHG15(2)173-8(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings confirm that FLJ23560 (BBS10) mutations are a significant cause of BBS.
Title: Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10.

report a major new BBS locus, BBS10, that encodes a previously unknown, rapidly evolving vertebrate-specific chaperonin-like protein
Title: BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus.

The following Bbs10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bbs10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04775	NM_027914.1 Latest version!	Mus musculus Bardet-Biedl syndrome 10 (human) (Bbs10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bbs10 ( NM_027914.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082190.1 Mus musculus Bardet-Biedl syndrome 10 (human) (Bbs10), mRNA.

Price & Availability↑

CloneID	OMu04775
Clone ID Related Accession (Same CDS sequence)	NM_027914.1
Accession Version	NM_027914.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	Bardet-Biedl syndrome 10 protein homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB855633.1, BY152247.1, BY122358.1, AK004937.1 and BE686432.1. On or before Jul 23, 2009 this sequence version replaced XM_917804.2, XM_125817.6. ##Evidence-Data-START## Transcript exon combination :: BB855633.1, BY152247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCCC AGGGGTCGGT GACGGCGGCT TTGCGGGTGG CCGAGGTGCT GGAGAGCATC 
GCGAACCGCT GCGTGGGGCC CGAGGGCGGC CAAGTGTTGT GTACGAAGCC CACCGGCGAG 
GTGCTGCTTA GCAGGGATGG AGGCTGCCTC CTGGAGGCGC TGCACTTAGA GCATCCCTTA 
GCCAGGATGA TAGTGGCGTG TGTTTCCAGT CACCTTAAAA AGACAGGAGA TGGTGCTAAG 
ACATTTATTA TTTTTCTTTG CCATTTACTC AGAGGACTTC ATGCAATCGG AGAAAAAGGA 
AAAGATTCAT TCACTTCTGA AAATATTCAG AGCCATGAAA GGCATTGGAA AAACTGTTGT 
CAGTGGAAAT CTATTTCCCA GGCTCTGCAA ACGTTTCAGA CACAAACCCT AGGTTGTATT 
GTAGACCGGA GTTTAAGCAG GCACTACCTG TCTGTCTTTT CTTCATCCAC TGAAGGAAGA 
AAACTGTGCA GGCACTCGCT AGAGTTGCTC CTGGAAGCAT ACTTTTGTGG AAGAGTGGGA 
AGAAACAATC ACAGATTCAT TTCACAGTTG ATGTGTGACT ACGTTTTCAA GTGTATGGCT 
TGTGAAAGTG GGGTTGAAGT ATTTGAGTTG TTGGATCACT GTTTTGCAGA GTTGAATGTT 
GGCGTGACAG GCCTTCCTGT TTCAGATTCT AGAATCATAG ATGGCCTTGT GCTTCCCAGG 
GACTTTTCTA TGTACTGCCC AGCAGATGGT GACATTAGGA TGGTGATAGT AACAGAAATC 
CTCCAGCCTC AGTTTTCATC GGCTGGCTCG GAGTTTGTTC TCAATTCAGA AACACAGTTT 
CAGGCATCTC AGTGCTGGAT CACGGACAGG ACAAAAACAG TAATGAACCA CTTGCGTGGT 
CAGAATGTAA AACTGCTCCT GACCAGTGTG AAGCAACCAG ACCTGGTTAT TTACTGTGCA 
AGACTTAATA GCATATCAGT GGTGGAGTGT TTATCAGCCG AAGAAGTTTC CCTTGTCCAG 
AGGATCACTG GTCTTTCTCC TTGTGTCCTA CCAGAGGTTG CTTCACAGTG TGAAATTTCT 
GATAGTACTT TGGTGAAGTT TTGCAAGCCC CTCATCCTTA GATCCAAGAG GTATGTTCAT 
CTCGGCTTGA TTAGCACATG TGCATTTATA CCTCACTCTA TGGTCCTCTG TGGACCGGTT 
CTGGGTCTTG TTGAACAGCA TGAGAGAGCT TTTCACGGAG CATTTAAGAT GCTTCGGCAG 
CTATTTACTG ACCTTGATCT AAATTACATC ATACAAACCA AACAGCAATG TAACCCAAGT 
CCTCTTGCTT ATGACAATAG CAGAGAGCGT AATCACTCAC CAGAAACTGA TAAGTATCAG 
GACATAGTAG CAAAGAGCAA AAATAAATTG GAAACTCAAA CACATTTAGA AGTATATTCA 
GGTTTGGGGG CTTCAGATAC AGAATTGAGA GCAGGTAAGC CGTGGTCAGC ACACAAGAAG 
ACACCAATAG CTCCATCCCA AACAGATGAA ATGCTGAAGT GCTTGCCTCC AGAAAGAAGC 
GGGATAATTG ATAACTGTGA CCTGTCAATT GAGAATCATT CCACTGGAAA TCCTACAGCA 
GAAGACACTG GAACAGAAAT TTCTTTCGAA CACTTACAGG TCTCAGATAA TGCCGGAAAG 
GGTTACACGC TGCCAGTGAT GCGCAAGTCA CTAGATACCT GTACTTGTCA GGGTTATTGT 
TCATCCACTG TGCCAGCAGG CTGTGTGCTG CCAGTGGGTG GAAGTTTTGA GATTTTGATG 
AGTTACTACC TTCTCAGCTA TGCCAAACAA TGCCGACAAT CAGATGAAAC TGTCATCAGT 
ATGTTAATAG CTGATGCTCT TCTAGGCATC CCTAAAATCC TTTATAAGCC TAAGAAGGGA 
AAGGACAGTT TCCCACACAT ATACATGCGG TCTCTCCATG CACTGCAAGC CAGTCAACCC 
ATGGTAAGTG GTCAATCAGG GTTCGAGTCA GTAGCTGGTA AGTACCAATT ACTAACTTCA 
GTTCTTCAGT GTTTGATGAA AATATTAACC ATTGATTTAA TAATCAACAT CAAGAGGCAA 
CCTCAGAAAA CTGCTGACCA AGAATCAGAA GACGAATTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082190.1
CDS	45..2186
Translation	MASQGSVTAALRVAEVLESIANRCVGPEGGQVLCTKPTGEVLLSRDGGCLLEALHLEHPLARMIVACVSSHLKKTGDGAKTFIIFLCHLLRGLHAIGEKGKDSFTSENIQSHERHWKNCCQWKSISQALQTFQTQTLGCIVDRSLSRHYLSVFSSSTEGRKLCRHSLELLLEAYFCGRVGRNNHRFISQLMCDYVFKCMACESGVEVFELLDHCFAELNVGVTGLPVSDSRIIDGLVLPRDFSMYCPADGDIRMVIVTEILQPQFSSAGSEFVLNSETQFQASQCWITDRTKTVMNHLRGQNVKLLLTSVKQPDLVIYCARLNSISVVECLSAEEVSLVQRITGLSPCVLPEVASQCEISDSTLVKFCKPLILRSKRYVHLGLISTCAFIPHSMVLCGPVLGLVEQHERAFHGAFKMLRQLFTDLDLNYIIQTKQQCNPSPLAYDNSRERNHSPETDKYQDIVAKSKNKLETQTHLEVYSGLGASDTELRAGKPWSAHKKTPIAPSQTDEMLKCLPPERSGIIDNCDLSIENHSTGNPTAEDTGTEISFEHLQVSDNAGKGYTLPVMRKSLDTCTCQGYCSSTVPAGCVLPVGGSFEILMSYYLLSYAKQCRQSDETVISMLIADALLGIPKILYKPKKGKDSFPHIYMRSLHALQASQPMVSGQSGFESVAGKYQLLTSVLQCLMKILTIDLIINIKRQPQKTADQESEDEF

Target ORF information:

RefSeq Version	NM_027914.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Bardet-Biedl syndrome 10 (human) (Bbs10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027914.1

ORF Insert Sequence:

ATGGCGTCCC AGGGGTCGGT GACGGCGGCT TTGCGGGTGG CCGAGGTGCT GGAGAGCATC 
GCGAACCGCT GCGTGGGGCC CGAGGGCGGC CAAGTGTTGT GTACGAAGCC CACCGGCGAG 
GTGCTGCTTA GCAGGGATGG AGGCTGCCTC CTGGAGGCGC TGCACTTAGA GCATCCCTTA 
GCCAGGATGA TAGTGGCGTG TGTTTCCAGT CACCTTAAAA AGACAGGAGA TGGTGCTAAG 
ACATTTATTA TTTTTCTTTG CCATTTACTC AGAGGACTTC ATGCAATCGG AGAAAAAGGA 
AAAGATTCAT TCACTTCTGA AAATATTCAG AGCCATGAAA GGCATTGGAA AAACTGTTGT 
CAGTGGAAAT CTATTTCCCA GGCTCTGCAA ACGTTTCAGA CACAAACCCT AGGTTGTATT 
GTAGACCGGA GTTTAAGCAG GCACTACCTG TCTGTCTTTT CTTCATCCAC TGAAGGAAGA 
AAACTGTGCA GGCACTCGCT AGAGTTGCTC CTGGAAGCAT ACTTTTGTGG AAGAGTGGGA 
AGAAACAATC ACAGATTCAT TTCACAGTTG ATGTGTGACT ACGTTTTCAA GTGTATGGCT 
TGTGAAAGTG GGGTTGAAGT ATTTGAGTTG TTGGATCACT GTTTTGCAGA GTTGAATGTT 
GGCGTGACAG GCCTTCCTGT TTCAGATTCT AGAATCATAG ATGGCCTTGT GCTTCCCAGG 
GACTTTTCTA TGTACTGCCC AGCAGATGGT GACATTAGGA TGGTGATAGT AACAGAAATC 
CTCCAGCCTC AGTTTTCATC GGCTGGCTCG GAGTTTGTTC TCAATTCAGA AACACAGTTT 
CAGGCATCTC AGTGCTGGAT CACGGACAGG ACAAAAACAG TAATGAACCA CTTGCGTGGT 
CAGAATGTAA AACTGCTCCT GACCAGTGTG AAGCAACCAG ACCTGGTTAT TTACTGTGCA 
AGACTTAATA GCATATCAGT GGTGGAGTGT TTATCAGCCG AAGAAGTTTC CCTTGTCCAG 
AGGATCACTG GTCTTTCTCC TTGTGTCCTA CCAGAGGTTG CTTCACAGTG TGAAATTTCT 
GATAGTACTT TGGTGAAGTT TTGCAAGCCC CTCATCCTTA GATCCAAGAG GTATGTTCAT 
CTCGGCTTGA TTAGCACATG TGCATTTATA CCTCACTCTA TGGTCCTCTG TGGACCGGTT 
CTGGGTCTTG TTGAACAGCA TGAGAGAGCT TTTCACGGAG CATTTAAGAT GCTTCGGCAG 
CTATTTACTG ACCTTGATCT AAATTACATC ATACAAACCA AACAGCAATG TAACCCAAGT 
CCTCTTGCTT ATGACAATAG CAGAGAGCGT AATCACTCAC CAGAAACTGA TAAGTATCAG 
GACATAGTAG CAAAGAGCAA AAATAAATTG GAAACTCAAA CACATTTAGA AGTATATTCA 
GGTTTGGGGG CTTCAGATAC AGAATTGAGA GCAGGTAAGC CGTGGTCAGC ACACAAGAAG 
ACACCAATAG CTCCATCCCA AACAGATGAA ATGCTGAAGT GCTTGCCTCC AGAAAGAAGC 
GGGATAATTG ATAACTGTGA CCTGTCAATT GAGAATCATT CCACTGGAAA TCCTACAGCA 
GAAGACACTG GAACAGAAAT TTCTTTCGAA CACTTACAGG TCTCAGATAA TGCCGGAAAG 
GGTTACACGC TGCCAGTGAT GCGCAAGTCA CTAGATACCT GTACTTGTCA GGGTTATTGT 
TCATCCACTG TGCCAGCAGG CTGTGTGCTG CCAGTGGGTG GAAGTTTTGA GATTTTGATG 
AGTTACTACC TTCTCAGCTA TGCCAAACAA TGCCGACAAT CAGATGAAAC TGTCATCAGT 
ATGTTAATAG CTGATGCTCT TCTAGGCATC CCTAAAATCC TTTATAAGCC TAAGAAGGGA 
AAGGACAGTT TCCCACACAT ATACATGCGG TCTCTCCATG CACTGCAAGC CAGTCAACCC 
ATGGTAAGTG GTCAATCAGG GTTCGAGTCA GTAGCTGGTA AGTACCAATT ACTAACTTCA 
GTTCTTCAGT GTTTGATGAA AATATTAACC ATTGATTTAA TAATCAACAT CAAGAGGCAA 
CCTCAGAAAA CTGCTGACCA AGAATCAGAA GACGAATTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice.
Cilia410(2015)
Cognard N,Scerbo MJ,Obringer C,Yu X,Costa F,Haser E,Le D,Stoetzel C,Roux MJ,Moulin B,Dollfus H,Marion V

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.
Proceedings of the National Academy of Sciences of the United States of America107(4)1488-93(2010 Jan)
Seo S,Baye LM,Schulz NP,Beck JS,Zhang Q,Slusarski DC,Sheffield VC

Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10.
European journal of human genetics : EJHG15(2)173-8(2007 Feb)
White DR,Ganesh A,Nishimura D,Rattenberry E,Ahmed S,Smith UM,Pasha S,Raeburn S,Trembath RC,Rajab A,Macdonald F,Banin E,Stone EM,Johnson CA,Sheffield VC,Maher ER

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Bbs10 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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