Tradd cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tradd
Entrez Gene ID	71609
Full Name	TNFRSF1A-associated via death domain
Synonyms	9130005N23Rik,AA930854
General protein information	Preferred Names TNFRSF1A-associated via death domain Names tumor necrosis factor receptor type 1-associated DEATH domain protein TNF receptor 1 associated signal transducer TNFR1-associated DEATH domain protein tradd
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 D3\|8 53.04 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033161.2	NP_001028333.1	tumor necrosis factor receptor type 1-associated DEATH domain protein

Pathways from BioSystems

Homologies

	LOC698160	XP_002802576.1
Gallus gallus (chicken)	TRADD	XP_004944196.1
Homo sapiens (human)	TRADD	NP_003780.1
Pan troglodytes (chimpanzee)	TRADD	XP_511022.3
Mus musculus (house mouse)	Tradd	NP_001028333.1
Xenopus tropicalis (tropical clawed frog)	tradd	XP_004913591.1
Rattus norvegicus (Norway rat)	Tradd	NP_001093950.1
Canis lupus familiaris (dog)	TRADD	XP_853998.2
Bos taurus (cattle)	TRADD	NP_001039361.1
Danio rerio (zebrafish)	tradd	NP_571682.1

Gene Ontology
Bibliography

Related articles in PubMed

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1?-Mediated Inflammatory Disease.
Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD
Immunity46(4)635-648(2017 04)

Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice.
Wu L, Cao Z, Ji L, Mei L, Jin Q, Zeng J, Lin J, Chu M, Li L, Yang X
Biochemical and biophysical research communications483(2)810-815(2017 02)

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G
eLife5e09584(2016 Jan)

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM
Nature528(7582)370-5(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1/p38 MAPK but not AKT phosphorylation
Title: Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice.

Data indicate that ASK1 activation stimulated the activity of the transcription factor FoxO3a, which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8.
Title: Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.

data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression
Title: TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.

Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB activation.
Title: TRADD is critical for resistance to TRAIL-induced cell death through NF-?B activation.

TRADD is required for recruitment of receptor interacting protein 1 and TNFR-associated factor 2 to the DR3 signaling complex and for the ubiquitination of receptor interacting protein 1
Title: The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.

The following Tradd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tradd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16685	NM_001033161.2 Latest version!	Mus musculus TNFRSF1A-associated via death domain (Tradd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tradd ( NM_001033161.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028333.1 Mus musculus TNFRSF1A-associated via death domain (Tradd), mRNA.

Price & Availability↑

CloneID	OMu16685
Clone ID Related Accession (Same CDS sequence)	NM_001033161.2
Accession Version	NM_001033161.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor receptor type 1-associated DEATH domain protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124584.5 and AC124713.5. On Jan 12, 2007 this sequence version replaced NM_001033161.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156540.1, AK018592.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCAGCCG GTCAGAATGG CCACGAGGAG TGGGTGGGCA GTGCATACCT GTTTTTGGAG 
TCTGCGGTAG ACAAGGTGAT CCTGTCTGAA GCCTACACGG ATCCCAAGAA GAAGGTGGCA 
ATATACAAGG CTCTGCAGAC TGCACTGTCA GAGAGTGGGG ACAGCTCTGA CGTACTGCAG 
ATACTCAAGA TCCACTGCAG CGACCCTCAG CTCATCGTCC AGTTGCGGTT CTGCGGGCGC 
GTGCTGTGCG GCCGCTTCCT CCAAGCCTAC CGCGAGGGGG CGCTGCGCAC CGCGCTGCAG 
AGGTGCATGG CCCCGGCGCT TGCCCAGGAA GCGCTGCGGT TGCAGCTGGA GTTGCGTGCA 
GGTGCGGAGC AGCTGGACAG TTGGCTGACT GATGAAGAGC GCTGTTTGAA TTACATCTTA 
GCCCAGAAGC CCGACCGGCT CAGGGACGAG GAACTCGCGG AGCTGGAGGA TGAGCTCTGC 
AAACTGACGT GTGACTGCAC TGGCCAGGGT GGAGCCATAC AGGTAGCTTC TGCAGGTTCG 
AAGTTCCCGG TTTCCTCTCC GACCGAGGAG AAACCACTGC CGGCCGCCTG CCAGACTTTT 
CTGTTCCACG GGCAGCTCGT AGTGAACCGG CCACTGACTC TTCAAGACCA GCAGACGTTT 
GCGCGCTCGG TGGGTCTCAA GTGGCGCAGG GTGGGGCGCT CGCTGCAGCG TAACTGTCGG 
GCACTGAGAG ATCCTGCCCT CGACTCGCTG GCCTACGAGT ATGAGCGTGA TGGGCTATAC 
GAGCAGGCCT TCCAGCTGCT GCGCCGTTTC ATGCAAGCCG AGGGCCGCCG TGCCACACTG 
CAGCGCCTGG TGGAGGCGCT GGAGGAGAAC GAACTCACTA GTCTAGCAGA GGATCTGTTG 
GGCCAGGCGG AGCCGGATGG CGGCCTGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028333.1
CDS	43..975
Translation	MAAGQNGHEEWVGSAYLFLESAVDKVILSEAYTDPKKKVAIYKALQTALSESGDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEALRLQLELRAGAEQLDSWLTDEERCLNYILAQKPDRLRDEELAELEDELCKLTCDCTGQGGAIQVASAGSKFPVSSPTEEKPLPAACQTFLFHGQLVVNRPLTLQDQQTFARSVGLKWRRVGRSLQRNCRALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRRATLQRLVEALEENELTSLAEDLLGQAEPDGGLA

Target ORF information:

RefSeq Version	NM_001033161.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus TNFRSF1A-associated via death domain (Tradd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033161.2

ORF Insert Sequence:

ATGGCAGCCG GTCAGAATGG CCACGAGGAG TGGGTGGGCA GTGCATACCT GTTTTTGGAG 
TCTGCGGTAG ACAAGGTGAT CCTGTCTGAA GCCTACACGG ATCCCAAGAA GAAGGTGGCA 
ATATACAAGG CTCTGCAGAC TGCACTGTCA GAGAGTGGGG ACAGCTCTGA CGTACTGCAG 
ATACTCAAGA TCCACTGCAG CGACCCTCAG CTCATCGTCC AGTTGCGGTT CTGCGGGCGC 
GTGCTGTGCG GCCGCTTCCT CCAAGCCTAC CGCGAGGGGG CGCTGCGCAC CGCGCTGCAG 
AGGTGCATGG CCCCGGCGCT TGCCCAGGAA GCGCTGCGGT TGCAGCTGGA GTTGCGTGCA 
GGTGCGGAGC AGCTGGACAG TTGGCTGACT GATGAAGAGC GCTGTTTGAA TTACATCTTA 
GCCCAGAAGC CCGACCGGCT CAGGGACGAG GAACTCGCGG AGCTGGAGGA TGAGCTCTGC 
AAACTGACGT GTGACTGCAC TGGCCAGGGT GGAGCCATAC AGGTAGCTTC TGCAGGTTCG 
AAGTTCCCGG TTTCCTCTCC GACCGAGGAG AAACCACTGC CGGCCGCCTG CCAGACTTTT 
CTGTTCCACG GGCAGCTCGT AGTGAACCGG CCACTGACTC TTCAAGACCA GCAGACGTTT 
GCGCGCTCGG TGGGTCTCAA GTGGCGCAGG GTGGGGCGCT CGCTGCAGCG TAACTGTCGG 
GCACTGAGAG ATCCTGCCCT CGACTCGCTG GCCTACGAGT ATGAGCGTGA TGGGCTATAC 
GAGCAGGCCT TCCAGCTGCT GCGCCGTTTC ATGCAAGCCG AGGGCCGCCG TGCCACACTG 
CAGCGCCTGG TGGAGGCGCT GGAGGAGAAC GAACTCACTA GTCTAGCAGA GGATCTGTTG 
GGCCAGGCGG AGCCGGATGG CGGCCTGGCC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1?-Mediated Inflammatory Disease.
Immunity46(4)635-648(2017 04)
Gurung P,Fan G,Lukens JR,Vogel P,Tonks NK,Kanneganti TD

Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice.
Biochemical and biophysical research communications483(2)810-815(2017 02)
Wu L,Cao Z,Ji L,Mei L,Jin Q,Zeng J,Lin J,Chu M,Li L,Yang X

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
eLife5e09584(2016 Jan)
Nechiporuk T,McGann J,Mullendorff K,Hsieh J,Wurst W,Floss T,Mandel G

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Nature528(7582)370-5(2015 Dec)
Wertz IE,Newton K,Seshasayee D,Kusam S,Lam C,Zhang J,Popovych N,Helgason E,Schoeffler A,Jeet S,Ramamoorthi N,Kategaya L,Newman RJ,Horikawa K,Dugger D,Sandoval W,Mukund S,Zindal A,Martin F,Quan C,Tom J,Fairbrother WJ,Townsend M,Warming S,DeVoss J,Liu J,Dueber E,Caplazi P,Lee WP,Goodnow CC,Balazs M,Yu K,Kolumam G,Dixit VM

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Tradd cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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