Senp8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Senp8
Entrez Gene ID	71599
Full Name	SUMO/sentrin specific peptidase 8
Synonyms	9130010J17Rik,AU020827,Den1,Nedp1,Prsc2
General protein information	Preferred Names SUMO/sentrin specific peptidase 8 Names sentrin-specific protease 8 NEDD8-specific protease 1 SUMO/sentrin specific protease 8 SUMO/sentrin specific protease family member 8 deneddylase-1 protease, cysteine, 2 (NEDD8 specific) sentrin/SUMO-specific protease SENP8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_001172071.1	NP_001165542.1	sentrin-specific protease 8 isoform b
NM_001172068.1	NP_001165539.1	sentrin-specific protease 8 isoform a
NM_001172069.1	NP_001165540.1	sentrin-specific protease 8 isoform a
NM_027838.3	NP_082114.1	sentrin-specific protease 8 isoform a
NM_001172070.1	NP_001165541.1	sentrin-specific protease 8 isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	SENP8	NP_001165581.1
	SENP8	XP_001089430.1
Canis lupus familiaris (dog)	SENP8	XP_005638609.1
Gallus gallus (chicken)	SENP8	XP_413710.1
Arabidopsis thaliana (thale cress)	AT5G60190	NP_200827.1
Pan troglodytes (chimpanzee)	SENP8	XP_523114.1
Rattus norvegicus (Norway rat)	Senp8	NP_001012355.1
Danio rerio (zebrafish)	senp8	NP_001070633.1
Drosophila melanogaster (fruit fly)	Den1	NP_610763.1
Mus musculus (house mouse)	Senp8	NP_001165542.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011316	XP_309334.3
Xenopus tropicalis (tropical clawed frog)	senp8	NP_001120583.1

Gene Ontology
Bibliography

Related articles in PubMed

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.
Vogl AM, Brockmann MM, Giusti SA, Maccarrone G, Vercelli CA, Bauder CA, Richter JS, Roselli F, Hafner AS, Dedic N, Wotjak CT, Vogt-Weisenhorn DM, Choquet D, Turck CW, Stein V, Deussing JM, Refojo D
Nature neuroscience18(2)239-51(2015 Feb)

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB
Genes & development20(19)2713-27(2006 Oct)

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Hemelaar J, Borodovsky A, Kessler BM, Reverter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H
Molecular and cellular biology24(1)84-95(2004 Jan)

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, Chen A, Lee CG, Wei N, Wilkinson KD, Wang R, Pan ZQ
The Journal of biological chemistry278(31)28882-91(2003 Aug)

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.
Woolf E, Xiao C, Fainaru O, Lotem J, Rosen D, Negreanu V, Bernstein Y, Goldenberg D, Brenner O, Berke G, Levanon D, Groner Y
Proceedings of the National Academy of Sciences of the United States of America100(13)7731-6(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Senp8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Senp8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11873	NM_001172071.1 Latest version!	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu04663	NM_027838.3 Latest version!	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu04663	NM_001172068.1 Latest version!	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu04663	NM_001172070.1 Latest version!	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu04663	NM_001172069.1 Latest version!	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Senp8 ( NM_001172071.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001165542.1 Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OMu11873
Clone ID Related Accession (Same CDS sequence)	NM_001172071.1
Accession Version	NM_001172071.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sentrin-specific protease 8 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV645349.1, AK018606.1, AK029856.1 and BB522944.1. Transcript Variant: This variant (5) lacks an alternate exon and includes an uses an start codon, compared to variant 1. The resulting isoform (b) has a longer N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK018606.1, DV647294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTCTGG AATTTCTGAG AATCCCTGCT CAATACAAGA TGGACCCTGT GGTCTTGAGT 
TATATGGACA GTCTATTGCG GCAATCAGAT GTCTCACTAT TGGACCCTCC AAGCTGGCTC 
AACGACCACA TTATTGGGTT TGCCTTTGAA TACTTTGCCA ATAGTCAGTT TCATGACTGC 
TCAGACCATG TCTGTTTCAT CAGCCCTGAA GTCACCCAGT TCATTAAGTG CACCAGCAGC 
CCTGCAGAAA TTGCCATGTT CCTTGAACCC CTGGATCTTC CCCACAAAAG AGTGGTATTT 
TTAGCCATCA ATGATAATTC TAACCAGGCA GCCGGAGGTA CCCACTGGAG TTTGTTGGTT 
TATCTCCAAG ATAAAAATAG CTTCTTTCAT TATGATTCCC ATAGCAGGAG CAACTCAATC 
CATGCAAAGC AGGTAGCAGA GAAACTGAAG GCTTTCTTAG GCAGCAAAGG AGACAAACTG 
GTCTTTGTGG AAGAGAAAGC CCCAGCTCAA GAGAACAGCT ATGACTGTGG GATGTACGTG 
ATATGTAACA CCGAGGCCTT GTGTCAGAGT CTCTTTAGAC GGCAGCCAGA GTCCCCGCTG 
CAGCTACTCA CCCCGACATA CATCACAAAG AAGAGAGGAG AATGGAAAGA TCTAATTGCC 
AGACTTGCTA AAAAAAACGA AGTAGCTACT GAAGAATGCT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165542.1
CDS	180..884
Translation	MLLEFLRIPAQYKMDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQENSYDCGMYVICNTEALCQSLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNEVATEECS

Target ORF information:

RefSeq Version	NM_001172071.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172071.1

ORF Insert Sequence:

ATGCTTCTGG AATTTCTGAG AATCCCTGCT CAATACAAGA TGGACCCTGT GGTCTTGAGT 
TATATGGACA GTCTATTGCG GCAATCAGAT GTCTCACTAT TGGACCCTCC AAGCTGGCTC 
AACGACCACA TTATTGGGTT TGCCTTTGAA TACTTTGCCA ATAGTCAGTT TCATGACTGC 
TCAGACCATG TCTGTTTCAT CAGCCCTGAA GTCACCCAGT TCATTAAGTG CACCAGCAGC 
CCTGCAGAAA TTGCCATGTT CCTTGAACCC CTGGATCTTC CCCACAAAAG AGTGGTATTT 
TTAGCCATCA ATGATAATTC TAACCAGGCA GCCGGAGGTA CCCACTGGAG TTTGTTGGTT 
TATCTCCAAG ATAAAAATAG CTTCTTTCAT TATGATTCCC ATAGCAGGAG CAACTCAATC 
CATGCAAAGC AGGTAGCAGA GAAACTGAAG GCTTTCTTAG GCAGCAAAGG AGACAAACTG 
GTCTTTGTGG AAGAGAAAGC CCCAGCTCAA GAGAACAGCT ATGACTGTGG GATGTACGTG 
ATATGTAACA CCGAGGCCTT GTGTCAGAGT CTCTTTAGAC GGCAGCCAGA GTCCCCGCTG 
CAGCTACTCA CCCCGACATA CATCACAAAG AAGAGAGGAG AATGGAAAGA TCTAATTGCC 
AGACTTGCTA AAAAAAACGA AGTAGCTACT GAAGAATGCT CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Senp8 ( NM_001172068.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001165539.1 Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu04663
Clone ID Related Accession (Same CDS sequence)	NM_001172068.1 , NM_001172069.1 , NM_027838.3 , NM_001172070.1
Accession Version	NM_001172068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sentrin-specific protease 8 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV645349.1, AK049120.1, AK018606.1, AK029856.1 and BB522944.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b). ##Evidence-Data-START## Transcript exon combination :: AK049120.1, BB651645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165539.1
CDS	312..977
Translation	MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQENSYDCGMYVICNTEALCQSLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNEVATEECS

Target ORF information:

RefSeq Version	NM_001172068.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172068.1

ORF Insert Sequence:

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Senp8 ( NM_001172069.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001165540.1 Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04663
Clone ID Related Accession (Same CDS sequence)	NM_001172068.1 , NM_001172069.1 , NM_027838.3 , NM_001172070.1
Accession Version	NM_001172069.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sentrin-specific protease 8 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV645349.1, CO431667.1, AK029856.1 and BB522944.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b). ##Evidence-Data-START## Transcript exon combination :: BU703432.1, CF726322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165540.1
CDS	221..886
Translation	MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQENSYDCGMYVICNTEALCQSLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNEVATEECS

Target ORF information:

RefSeq Version	NM_001172069.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172069.1

ORF Insert Sequence:

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Senp8 ( NM_027838.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082114.1 Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu04663
Clone ID Related Accession (Same CDS sequence)	NM_001172068.1 , NM_001172069.1 , NM_027838.3 , NM_001172070.1
Accession Version	NM_027838.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sentrin-specific protease 8 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV645349.1, AK029856.1 and BB522944.1. On Feb 2, 2010 this sequence version replaced NM_027838.2. Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b). ##Evidence-Data-START## Transcript exon combination :: DV645349.1, AK029856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082114.1
CDS	109..774
Translation	MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQENSYDCGMYVICNTEALCQSLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNEVATEECS

Target ORF information:

RefSeq Version	NM_027838.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027838.3

ORF Insert Sequence:

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Senp8 ( NM_001172070.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001165541.1 Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu04663
Clone ID Related Accession (Same CDS sequence)	NM_001172068.1 , NM_001172069.1 , NM_027838.3 , NM_001172070.1
Accession Version	NM_001172070.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sentrin-specific protease 8 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV645349.1, AK136214.1, AK029856.1 and BB522944.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 all encode the same isoform (a), which is shorter than isoform (b). ##Evidence-Data-START## Transcript exon combination :: AK136214.1, CF735415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165541.1
CDS	202..867
Translation	MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVCFISPEVTQFIKCTSSPAEIAMFLEPLDLPHKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSIHAKQVAEKLKAFLGSKGDKLVFVEEKAPAQENSYDCGMYVICNTEALCQSLFRRQPESPLQLLTPTYITKKRGEWKDLIARLAKKNEVATEECS

Target ORF information:

RefSeq Version	NM_001172070.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SUMO/sentrin specific peptidase 8 (Senp8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172070.1

ORF Insert Sequence:

ATGGACCCTG TGGTCTTGAG TTATATGGAC AGTCTATTGC GGCAATCAGA TGTCTCACTA 
TTGGACCCTC CAAGCTGGCT CAACGACCAC ATTATTGGGT TTGCCTTTGA ATACTTTGCC 
AATAGTCAGT TTCATGACTG CTCAGACCAT GTCTGTTTCA TCAGCCCTGA AGTCACCCAG 
TTCATTAAGT GCACCAGCAG CCCTGCAGAA ATTGCCATGT TCCTTGAACC CCTGGATCTT 
CCCCACAAAA GAGTGGTATT TTTAGCCATC AATGATAATT CTAACCAGGC AGCCGGAGGT 
ACCCACTGGA GTTTGTTGGT TTATCTCCAA GATAAAAATA GCTTCTTTCA TTATGATTCC 
CATAGCAGGA GCAACTCAAT CCATGCAAAG CAGGTAGCAG AGAAACTGAA GGCTTTCTTA 
GGCAGCAAAG GAGACAAACT GGTCTTTGTG GAAGAGAAAG CCCCAGCTCA AGAGAACAGC 
TATGACTGTG GGATGTACGT GATATGTAAC ACCGAGGCCT TGTGTCAGAG TCTCTTTAGA 
CGGCAGCCAG AGTCCCCGCT GCAGCTACTC ACCCCGACAT ACATCACAAA GAAGAGAGGA 
GAATGGAAAG ATCTAATTGC CAGACTTGCT AAAAAAAACG AAGTAGCTAC TGAAGAATGC 
TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.
Nature neuroscience18(2)239-51(2015 Feb)
Vogl AM,Brockmann MM,Giusti SA,Maccarrone G,Vercelli CA,Bauder CA,Richter JS,Roselli F,Hafner AS,Dedic N,Wotjak CT,Vogt-Weisenhorn DM,Choquet D,Turck CW,Stein V,Deussing JM,Refojo D

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Genes & development20(19)2713-27(2006 Oct)
Evsikov AV,Graber JH,Brockman JM,Hampl A,Holbrook AE,Singh P,Eppig JJ,Solter D,Knowles BB

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.
Molecular and cellular biology24(1)84-95(2004 Jan)
Hemelaar J,Borodovsky A,Kessler BM,Reverter D,Cook J,Kolli N,Gan-Erdene T,Wilkinson KD,Gill G,Lima CD,Ploegh HL,Ovaa H

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
The Journal of biological chemistry278(31)28882-91(2003 Aug)
Wu K,Yamoah K,Dolios G,Gan-Erdene T,Tan P,Chen A,Lee CG,Wei N,Wilkinson KD,Wang R,Pan ZQ

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.
Proceedings of the National Academy of Sciences of the United States of America100(13)7731-6(2003 Jun)
Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

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Senp8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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