Chmp2b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chmp2b
Entrez Gene ID	68942
Full Name	charged multivesicular body protein 2B
Synonyms	1190006E07Rik
General protein information	Preferred Names charged multivesicular body protein 2B Names charged multivesicular body protein 2b chromatin modifying protein 2B chromatin-modifying protein 2b
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C1.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_026879.3	NP_081155.1	charged multivesicular body protein 2b
NM_026879.2	NP_081155.1	charged multivesicular body protein 2b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CHMP2B	XP_003950194.1
Bos taurus (cattle)	CHMP2B	NP_001030549.1
Rattus norvegicus (Norway rat)	Chmp2b	XP_343996.5
Gallus gallus (chicken)	CHMP2B	NP_001025963.1
Danio rerio (zebrafish)	chmp2bb	NP_998069.1
Drosophila melanogaster (fruit fly)	CHMP2B	NP_647947.1
Arabidopsis thaliana (thale cress)	VPS2.3	NP_563696.1
Oryza sativa (rice)	Os10g0476400	NP_001064848.1
Xenopus tropicalis (tropical clawed frog)	chmp2b	NP_998866.1
Homo sapiens (human)	CHMP2B	NP_054762.2
Canis lupus familiaris (dog)	CHMP2B	XP_544799.3
Caenorhabditis elegans (roundworm)	C01A2.4	NP_493357.2
	CHMP2B	XP_001104518.1
Mus musculus (house mouse)	Chmp2b	NP_081155.1

Gene Ontology
Bibliography

Related articles in PubMed

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J, , Oliver PL, Gomez-Nicola D, Isaacs AM
Human molecular genetics26(5)873-887(2017 03)

A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
Vernay A, Therreau L, Blot B, Risson V, Dirrig-Grosch S, Waegaert R, Lequeu T, Sellal F, Schaeffer L, Sadoul R, Loeffler JP, Ren? F
Human molecular genetics25(15)3341-3360(2016 Aug)

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.
Clayton EL, Mizielinska S, Edgar JR, Nielsen TT, Marshall S, Norona FE, Robbins M, Damirji H, Holm IE, Johannsen P, Nielsen JE, Asante EA, Collinge J, , Isaacs AM
Acta neuropathologica130(4)511-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The presence of early microglial changes in our CHMP2B mutant mice indicates neuroinflammation may be a contributing factor to the neurodegeneration observed in FTD.
Title: Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.

Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course
Title: Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.

This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.
Title: Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.

Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.
Title: Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.

Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 in the embryonic mouse neural tube
Title: Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons.

The following Chmp2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chmp2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03206	NM_026879.3 Latest version!	Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu03206	NM_026879.2	Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chmp2b ( NM_026879.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081155.1 Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.

Price & Availability↑

CloneID	OMu03206
Clone ID Related Accession (Same CDS sequence)	NM_026879.3 , NM_026879.2
Accession Version	NM_026879.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Mus musculus(house mouse)
Product	charged multivesicular body protein 2b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT009578.7, AK084111.1 and BC055809.1. On Apr 20, 2018 this sequence version replaced NM_026879.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC055809.1, AK084111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG 
CTGCGTGGCA CCCAGAGGGC CATCATCAGG GACCGAGCAG CCTTAGAGAA ACAGGAGAAA 
CAGCTGGAGT TAGAAATTAA GAAGATGGCC AAGATTGGTA ATAAGGAAGC GTGCAGGGTT 
TTAGCTAAGC AGCTTGTCCA CCTACGGAAA CAGAAGACAA GAACGTTCGC TGTAAGCTCA 
AAAGTCACCT CTATGTCCAC ACAAACGAAA GTGATGAATT CCCAGATGAA GATGGCCGGT 
GCCATGTCTA CCACTGCAAA GACAATGCAA GCAGTCAACA AGAAAATGGA TCCACAGAAG 
ACACTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA 
ATGATCAATG ACACCCTGGA TGACATCTTT GATGGCTCTG ATGATGAAGA AGAAAGCCAG 
GACATCGTGA ATCAAGTTCT TGATGAAATT GGGATTGAAA TCTCTGGAAA GATGGCCAAA 
GCTCCATCGG CTGCAAGAAG CTTACCGTCT GCCTCCACTT CAAAGGCTAC AATTTCTGAT 
GAAGAGATTG AACGTCAACT CAAAGCTTTA GGGGTAGATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081155.1
CDS	255..896
Translation	MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD

Target ORF information:

RefSeq Version	NM_026879.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026879.3

ORF Insert Sequence:

ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG 
CTGCGTGGCA CCCAGAGGGC CATCATCAGG GACCGAGCAG CCTTAGAGAA ACAGGAGAAA 
CAGCTGGAGT TAGAAATTAA GAAGATGGCC AAGATTGGTA ATAAGGAAGC GTGCAGGGTT 
TTAGCTAAGC AGCTTGTCCA CCTACGGAAA CAGAAGACAA GAACGTTCGC TGTAAGCTCA 
AAAGTCACCT CTATGTCCAC ACAAACGAAA GTGATGAATT CCCAGATGAA GATGGCCGGT 
GCCATGTCTA CCACTGCAAA GACAATGCAA GCAGTCAACA AGAAAATGGA TCCACAGAAG 
ACACTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA 
ATGATCAATG ACACCCTGGA TGACATCTTT GATGGCTCTG ATGATGAAGA AGAAAGCCAG 
GACATCGTGA ATCAAGTTCT TGATGAAATT GGGATTGAAA TCTCTGGAAA GATGGCCAAA 
GCTCCATCGG CTGCAAGAAG CTTACCGTCT GCCTCCACTT CAAAGGCTAC AATTTCTGAT 
GAAGAGATTG AACGTCAACT CAAAGCTTTA GGGGTAGATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Chmp2b ( NM_026879.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081155.1 Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.

Price & Availability↑

CloneID	OMu03206
Clone ID Related Accession (Same CDS sequence)	NM_026879.3 , NM_026879.2
Accession Version	NM_026879.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Mus musculus(house mouse)
Product	charged multivesicular body protein 2b
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK084111.1. On Apr 6, 2007 this sequence version replaced NM_026879.1. ##Evidence-Data-START## Transcript exon combination :: AK084111.1, BC055809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG 
CTGCGTGGCA CCCAGAGGGC CATCATCAGG GACCGAGCAG CCTTAGAGAA ACAGGAGAAA 
CAGCTGGAGT TAGAAATTAA GAAGATGGCC AAGATTGGTA ATAAGGAAGC GTGCAGGGTT 
TTAGCTAAGC AGCTTGTCCA CCTACGGAAA CAGAAGACAA GAACGTTCGC TGTAAGCTCA 
AAAGTCACCT CTATGTCCAC ACAAACGAAA GTGATGAATT CCCAGATGAA GATGGCCGGT 
GCCATGTCTA CCACTGCAAA GACAATGCAA GCAGTCAACA AGAAAATGGA TCCACAGAAG 
ACACTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA 
ATGATCAATG ACACCCTGGA TGACATCTTT GATGGCTCTG ATGATGAAGA AGAAAGCCAG 
GACATCGTGA ATCAAGTTCT TGATGAAATT GGGATTGAAA TCTCTGGAAA GATGGCCAAA 
GCTCCATCGG CTGCAAGAAG CTTACCGTCT GCCTCCACTT CAAAGGCTAC AATTTCTGAT 
GAAGAGATTG AACGTCAACT CAAAGCTTTA GGGGTAGATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081155.1
CDS	190..831
Translation	MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD

Target ORF information:

RefSeq Version	NM_026879.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus charged multivesicular body protein 2B (Chmp2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026879.2

ORF Insert Sequence:

ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG 
CTGCGTGGCA CCCAGAGGGC CATCATCAGG GACCGAGCAG CCTTAGAGAA ACAGGAGAAA 
CAGCTGGAGT TAGAAATTAA GAAGATGGCC AAGATTGGTA ATAAGGAAGC GTGCAGGGTT 
TTAGCTAAGC AGCTTGTCCA CCTACGGAAA CAGAAGACAA GAACGTTCGC TGTAAGCTCA 
AAAGTCACCT CTATGTCCAC ACAAACGAAA GTGATGAATT CCCAGATGAA GATGGCCGGT 
GCCATGTCTA CCACTGCAAA GACAATGCAA GCAGTCAACA AGAAAATGGA TCCACAGAAG 
ACACTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA 
ATGATCAATG ACACCCTGGA TGACATCTTT GATGGCTCTG ATGATGAAGA AGAAAGCCAG 
GACATCGTGA ATCAAGTTCT TGATGAAATT GGGATTGAAA TCTCTGGAAA GATGGCCAAA 
GCTCCATCGG CTGCAAGAAG CTTACCGTCT GCCTCCACTT CAAAGGCTAC AATTTCTGAT 
GAAGAGATTG AACGTCAACT CAAAGCTTTA GGGGTAGATT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Human molecular genetics26(5)873-887(2017 03)
Clayton EL,Mancuso R,Nielsen TT,Mizielinska S,Holmes H,Powell N,Norona F,Larsen JO,Milioto C,Wilson KM,Lythgoe MF,Ourselin S,Nielsen JE,Johannsen P,Holm I,Collinge J,,Oliver PL,Gomez-Nicola D,Isaacs AM

A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
Human molecular genetics25(15)3341-3360(2016 Aug)
Vernay A,Therreau L,Blot B,Risson V,Dirrig-Grosch S,Waegaert R,Lequeu T,Sellal F,Schaeffer L,Sadoul R,Loeffler JP,Ren? F

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.
Acta neuropathologica130(4)511-23(2015 Oct)
Clayton EL,Mizielinska S,Edgar JR,Nielsen TT,Marshall S,Norona FE,Robbins M,Damirji H,Holm IE,Johannsen P,Nielsen JE,Asante EA,Collinge J,,Isaacs AM

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Chmp2b cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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