Mypn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mypn
Entrez Gene ID	68802
Full Name	myopalladin
Synonyms	1110056A04Rik,9830112J03,AI853556,mKIAA4170
General protein information	Preferred Names myopalladin Names myopalladin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 B4

mRNA and Protein(s)

mRNA	Protein	Name
NM_182992.2	NP_892037.2	myopalladin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MYPN	XP_003312631.1
Canis lupus familiaris (dog)	MYPN	XP_546131.2
Bos taurus (cattle)	MYPN	XP_002698903.1
Gallus gallus (chicken)	MYPN	XP_004942075.1
Rattus norvegicus (Norway rat)	Mypn	NP_001101098.1
Danio rerio (zebrafish)	mypn	XP_700400.6
Xenopus tropicalis (tropical clawed frog)	mypn	XP_002936911.2
Homo sapiens (human)	MYPN	NP_001243196.1
	LOC695451	XP_002808546.1
Mus musculus (house mouse)	Mypn	NP_892037.2

Gene Ontology
Bibliography

Related articles in PubMed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Bang ML
Journal of cellular physiology232(1)38-52(2017 Jan)

Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy.
Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N
American journal of human genetics100(1)169-178(2017 Jan)

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.
Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML
Cardiovascular research107(2)216-25(2015 Jul)

Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy.
Huby AC, Mendsaikhan U, Takagi K, Martherus R, Wansapura J, Gong N, Osinska H, James JF, Kramer K, Saito K, Robbins J, Khuchua Z, Towbin JA, Purevjav E
Journal of the American College of Cardiology64(25)2765-76(2014 Dec)

Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.
Ghiasvand NM, Rudolph DD, Mashayekhi M, Brzezinski JA 4th, Goldman D, Glaser T
Nature neuroscience14(5)578-86(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mypn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mypn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08266	NM_182992.2 Latest version!	Mus musculus myopalladin (Mypn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mypn ( NM_182992.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_892037.2 Mus musculus myopalladin (Mypn), mRNA.

Price & Availability↑

CloneID	OMu08266
Clone ID Related Accession (Same CDS sequence)	NM_182992.2
Accession Version	NM_182992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	myopalladin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155909.9. On or before Apr 9, 2009 this sequence version replaced XM_905765.2, XM_483911.3, NM_182992.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK220521.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCAAGAAG ACAGCATAGA GGCATCCACT TCCATCTCTC AACTCCTGAG AGAAAGTTAC 
CTGGCTGAAA CCAGACATCG TGGGGACAAC GAGCGAAGTC GAGCTGAGCC CTCCTCCAAC 
CCTTTCCATT TCAGTGGTCC TGGGGCTGCA GAGGGAGGAG GCCCAGAGGA CCTTCCGGAC 
CTTTCTGCCT TCCTGAGCCA AGAGGAGTTA GATGAAAGTG TCAATCTGGC GAGGCTGGCC 
ATCAACCACG ACCCCTTGGA GAGAGTGGAT GAAGCTCAAG CCAGGAAGCG TCTGTCTTCC 
GACCAGACGA AGCATGCATC CAAGCCAAGC TTCGAACCTG CCTTCCACCA GGACAGCTCC 
CGAGGTCCGG CCAGTCCTAA AGACAGCCCG CCAGAGACCA AGAGGCCGCA GTACAGTTCT 
GAAACCCAGT CCAAGAAAGT TTTCCTGAAC AAGGCTGCCG ATTTCATCGA AGAACTTTCC 
TCCCTTTTCA AGGCTCACAG CTCCAAGAGG ATCAGACCTC GGGCCTGCAA AAACCACAAG 
AGCAAGACGG AATCCCAAAA CAAAGTTCTG CAGGAAAACA GCCCCACTTT CTCAGATCTA 
ACAGAAAGGC GAGAGAGAGC ATCGGTCCCC ATTCCCATCC CTGCGGACAG CAGGGATAAC 
GAGCTGAACC ACGCTATTGA ACAGCGAGAA GCCAAGAGGA GGGAAGCCGA GTTGGCTGCG 
GGGGAGGCTG CGGCTGGAGA CAGCACCCCT GGCTCTTCGC CTTCATCCCT ATACTACGAA 
GAGCCTCTGG GGCAGCCTCC CCGCTTCACA CAAAAGTTAC GGAGCCGAGA AGTTCCGGAA 
GGCAGCCGAG TCCAGTTGGA TTGTATAGTG GTAGGAATTC CACCGCCCCA AGTAAGGTGG 
TATTGTGAAG GCAAGGAGCT TGAAAACTCT CCAGATATCC ACATTGTGCA GGCAGGAAAC 
CTTCACTCAC TGACCATCGC CGAGGCCTTC GAAGAGGACA CAGGACGATA CTCATGCTTT 
GCTTCCAACA TTTATGGGAC AGATTCAACT TCCGCTGAGA TTTACATAGA AGGAGTCTCT 
TCCTCTGACT CAGAAGGGGA CCCTAACAAA GAAGAGATGA ATCGAATCCA GAAGCCAAAT 
GAGGTGTCCT CACCTCCCAC CACCTCTGCA GCCATTCCTC CAGCAGCAGA AGCCCAGCCT 
TTGGCGGCCC AGCCCAGAGT GTCCACCGTC CAGCAGTGTC AGAGTCCTAC CAACTATTTG 
CAAGGCCTGA ACGGGAAGCC CATCATTGCA GCGCCAGTGT TTACGAAGAT GCTGCAGAAC 
TTGTCAGCCT CTGAGGGGCA GCTGGTTGTC TTTGAGTGCA GAGTGAAAGG GGCCCCATCT 
CCGAAAGTCG AGTGGTACAG AGAAGGGACA TTAATAGAAG ACTCTCCCGA CTTCAGGATC 
TTACAGAAGA AACCTCGATC CATGGCAGAA CCAGAGGAGA TCTGCACGTT AGTCATTGCT 
GAGGTGTTTT CGGAAGACTC GGGATGCTTC ACGTGCACCG CAAGCAACAA ATATGGCACC 
GTGTCTAGCA TCGCACAGTT AGACGTGAGA GGAAATGAAG ACATCAGTGA TAATGGAGCT 
CTTCACTCAG CAAATTCAAC CACCAACCCG GCTGTGGCTG AGCACCAGCC TTCCCCACTC 
AACCCACAGC CTCTTTCAGA GGAGCAGCCC CCAAAACCCA AACTTGAAGG GGTTCTGGTG 
AACCATAATG AGCCCCGGTC CAGCTCCAGG ATTGGGCTAC GGGTGCACTT CAACCTACCG 
GAAGACGACA AAGATATGGA GGCATCCTCT GGGAGCGGTG CGGCCAATAC CAGCCAGACT 
AGACCGAATT CCTTCCCCGA GAGGTTCAAT GGACAGGAAG CCAGAATCCC AGAGCCTTCC 
TCACCTATCA AGGAGCCCCC TCCGGTCCTG GCCAAACCCA AACTTGACTC CACTCAGTTA 
CAACAGCTTC ATAACCAAGT GTTACTGGAA CAGCAGCAAC TGCAAAACAC ATCTCCTTCA 
TCACCCAAGG AGTCTCTTCA CATGAGTGCC TTGAACTCGG CTCCCCCGGC AGTGACCATC 
TCCAGCAAGC AGGTGAAGGG TCCTGCGCCT CAGATGTTCA ACCTGGCCCG GCCGAAGCAC 
TTCTTCCCCG CTTCAAGCAC TTCCACAGCA ACCGTGTCCC CATCCAGCTC CCCGGTGTTC 
ACCTTGAGCA ATACTCCTCA AACAATTCAG AGGACAGTCA GCAAAGAAAG CCTCTTAATG 
GCCCACCCCT CCACACAAGG CAGATCTCCT GGCGGGCTCT CCATCCAAAA TGAGCCAGCT 
CCTCCAAGCC CAGCAGAGCC AGCAGCGCCA CCAACAGCCG CCTATTCCAT CCCTAGCGGA 
AACCAGTTTC AGCCTCACTG CGTATCCCCC ACTCCTGTCT CCCCTACCGG TCGGATTCAG 
AACCCGGTGG CTTTTCTTAG CTCTGTTCTG CCTTCTCTCC CTTCCATTCC ACCCACCAAC 
GCCATGGGGC TGCCTAAAAG CGCACCATCT GTACCATCCC AGGGTCTAAT GAAGAAAACC 
ACAAAGGCCC CTCAGGCAGT GAGTGACGAC TACATCCGAG AGACGAAGAA CTCAGTGATT 
CTAGACTTGG GGAAGAAAGT GAATTTCGGT GACGTCAGAT CACACCAGCA GGAATATAAA 
ATTTCCAGCT TTGAGCAGAG GCTGATGAAC GAGATAGAGT TCCGCCTGGA GCGGACTCCT 
GTTGACGAAT CTGATGACGA GATAGAACAC GACGAAATCC CCACGGGCAA GTGCATCGCG 
CCCATCTTTG ACAAAAGGCT CAAGCACTTC CGGGTTACCG AAGGCTCACC AGTCACCTTC 
ACCTGCAAAA TTGTTGGGAT ACCTGTTCCA AAGGTTTATT GGTTCAAAGA CGGGAAGCAG 
ATTTCTAAGA GAAATGAGCA CTGTAAAATG AGGAGAGAAG GGGATGGGAC CTGCTCACTA 
CACATTGAGT CCACCCACGG CGATGATGAC GGCAACTACA CCATCATGGC CGCCAACCCC 
CAGGGGAGAA TCAGCTGTTC TGGCCATTTG ATGGTACAGG GTTTGCCCAT TCGAAGCCGA 
CTCAGCCCTG CTCTGTCTCA CAGAGGAAGG TCCAGAATGC AGGAAAGAGA CAAAGAGCCG 
CTACAGGAAC GCTTTTTCCG ACCACATTTC CTGCAGGCCC CTGGGGATAT GGTGGCTCAC 
GAGGGCCGCC TCTGTCGGCT GGACTGTAAG GTGAGTGGCT TACCACCCCC GGAGCTGACA 
TGGCTACTCA ATGGGCAACC TGTGCTACCC GACGCCTCCC ACAAGATGCT GGTCAGAGAG 
ACGGGAGTCC ACTCTCTGCT CATCGACCCG CTCACCCAAC GAGACGCAGG GACCTACACG 
TGCGTGGCTA CCAACAAAAC CGGGCAGAAT TCCTTTAGTC TGGAGCTCAC TGTGGTAGCC 
AAAGAGGTAA AGAAGGCGCC AGTGATCCTG GAGAAACTCC AGAACAGCGG CGTCCCTGAG 
GGCCACCCGG TGCGACTGGA GGGCCGGGTC ATAGGCATGC CCCCGCCTGT GTTCTACTGG 
AAGAAAGACA ACGAGACCAT CCCGTTCACT AGAGAGAGGA TCAGCATGCA CCAGGATACA 
ACAGGCTATG TCTGCCTCCT CATCCAGCCA GCCAAGAAGT CCGACGCTGG GTGGTACACA 
CTGTCAGCCA AGAACGAAGC CGGCATCGTA TCGTGCACAG CTAGGTTGGA TATATATGCT 
CAGTGGCACC AGCAAATCCC AACACCCATA TCTATCCGGC CCAGCGGCAG CCGCTACGGG 
TCTCTCACCA GCAAAGGCCT CGACATCTTT TCTGCCTTCT CCTCCGTGGA AAGCACGATG 
CTGTATTCCT GTACTTCTCG GAGTGTAGTG GAGAGCGATG AACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_892037.2
CDS	237..4184
Translation	MQEDSIEASTSISQLLRESYLAETRHRGDNERSRAEPSSNPFHFSGPGAAEGGGPEDLPDLSAFLSQEELDESVNLARLAINHDPLERVDEAQARKRLSSDQTKHASKPSFEPAFHQDSSRGPASPKDSPPETKRPQYSSETQSKKVFLNKAADFIEELSSLFKAHSSKRIRPRACKNHKSKTESQNKVLQENSPTFSDLTERRERASVPIPIPADSRDNELNHAIEQREAKRREAELAAGEAAAGDSTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGSRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAAIPPAAEAQPLAAQPRVSTVQQCQSPTNYLQGLNGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGCFTCTASNKYGTVSSIAQLDVRGNEDISDNGALHSANSTTNPAVAEHQPSPLNPQPLSEEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKDMEASSGSGAANTSQTRPNSFPERFNGQEARIPEPSSPIKEPPPVLAKPKLDSTQLQQLHNQVLLEQQQLQNTSPSSPKESLHMSALNSAPPAVTISSKQVKGPAPQMFNLARPKHFFPASSTSTATVSPSSSPVFTLSNTPQTIQRTVSKESLLMAHPSTQGRSPGGLSIQNEPAPPSPAEPAAPPTAAYSIPSGNQFQPHCVSPTPVSPTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSVPSQGLMKKTTKAPQAVSDDYIRETKNSVILDLGKKVNFGDVRSHQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIEHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQGLPIRSRLSPALSHRGRSRMQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYTCVATNKTGQNSFSLELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLEGRVIGMPPPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHQQIPTPISIRPSGSRYGSLTSKGLDIFSAFSSVESTMLYSCTSRSVVESDEL

Target ORF information:

RefSeq Version	NM_182992.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus myopalladin (Mypn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182992.2

ORF Insert Sequence:

ATGCAAGAAG ACAGCATAGA GGCATCCACT TCCATCTCTC AACTCCTGAG AGAAAGTTAC 
CTGGCTGAAA CCAGACATCG TGGGGACAAC GAGCGAAGTC GAGCTGAGCC CTCCTCCAAC 
CCTTTCCATT TCAGTGGTCC TGGGGCTGCA GAGGGAGGAG GCCCAGAGGA CCTTCCGGAC 
CTTTCTGCCT TCCTGAGCCA AGAGGAGTTA GATGAAAGTG TCAATCTGGC GAGGCTGGCC 
ATCAACCACG ACCCCTTGGA GAGAGTGGAT GAAGCTCAAG CCAGGAAGCG TCTGTCTTCC 
GACCAGACGA AGCATGCATC CAAGCCAAGC TTCGAACCTG CCTTCCACCA GGACAGCTCC 
CGAGGTCCGG CCAGTCCTAA AGACAGCCCG CCAGAGACCA AGAGGCCGCA GTACAGTTCT 
GAAACCCAGT CCAAGAAAGT TTTCCTGAAC AAGGCTGCCG ATTTCATCGA AGAACTTTCC 
TCCCTTTTCA AGGCTCACAG CTCCAAGAGG ATCAGACCTC GGGCCTGCAA AAACCACAAG 
AGCAAGACGG AATCCCAAAA CAAAGTTCTG CAGGAAAACA GCCCCACTTT CTCAGATCTA 
ACAGAAAGGC GAGAGAGAGC ATCGGTCCCC ATTCCCATCC CTGCGGACAG CAGGGATAAC 
GAGCTGAACC ACGCTATTGA ACAGCGAGAA GCCAAGAGGA GGGAAGCCGA GTTGGCTGCG 
GGGGAGGCTG CGGCTGGAGA CAGCACCCCT GGCTCTTCGC CTTCATCCCT ATACTACGAA 
GAGCCTCTGG GGCAGCCTCC CCGCTTCACA CAAAAGTTAC GGAGCCGAGA AGTTCCGGAA 
GGCAGCCGAG TCCAGTTGGA TTGTATAGTG GTAGGAATTC CACCGCCCCA AGTAAGGTGG 
TATTGTGAAG GCAAGGAGCT TGAAAACTCT CCAGATATCC ACATTGTGCA GGCAGGAAAC 
CTTCACTCAC TGACCATCGC CGAGGCCTTC GAAGAGGACA CAGGACGATA CTCATGCTTT 
GCTTCCAACA TTTATGGGAC AGATTCAACT TCCGCTGAGA TTTACATAGA AGGAGTCTCT 
TCCTCTGACT CAGAAGGGGA CCCTAACAAA GAAGAGATGA ATCGAATCCA GAAGCCAAAT 
GAGGTGTCCT CACCTCCCAC CACCTCTGCA GCCATTCCTC CAGCAGCAGA AGCCCAGCCT 
TTGGCGGCCC AGCCCAGAGT GTCCACCGTC CAGCAGTGTC AGAGTCCTAC CAACTATTTG 
CAAGGCCTGA ACGGGAAGCC CATCATTGCA GCGCCAGTGT TTACGAAGAT GCTGCAGAAC 
TTGTCAGCCT CTGAGGGGCA GCTGGTTGTC TTTGAGTGCA GAGTGAAAGG GGCCCCATCT 
CCGAAAGTCG AGTGGTACAG AGAAGGGACA TTAATAGAAG ACTCTCCCGA CTTCAGGATC 
TTACAGAAGA AACCTCGATC CATGGCAGAA CCAGAGGAGA TCTGCACGTT AGTCATTGCT 
GAGGTGTTTT CGGAAGACTC GGGATGCTTC ACGTGCACCG CAAGCAACAA ATATGGCACC 
GTGTCTAGCA TCGCACAGTT AGACGTGAGA GGAAATGAAG ACATCAGTGA TAATGGAGCT 
CTTCACTCAG CAAATTCAAC CACCAACCCG GCTGTGGCTG AGCACCAGCC TTCCCCACTC 
AACCCACAGC CTCTTTCAGA GGAGCAGCCC CCAAAACCCA AACTTGAAGG GGTTCTGGTG 
AACCATAATG AGCCCCGGTC CAGCTCCAGG ATTGGGCTAC GGGTGCACTT CAACCTACCG 
GAAGACGACA AAGATATGGA GGCATCCTCT GGGAGCGGTG CGGCCAATAC CAGCCAGACT 
AGACCGAATT CCTTCCCCGA GAGGTTCAAT GGACAGGAAG CCAGAATCCC AGAGCCTTCC 
TCACCTATCA AGGAGCCCCC TCCGGTCCTG GCCAAACCCA AACTTGACTC CACTCAGTTA 
CAACAGCTTC ATAACCAAGT GTTACTGGAA CAGCAGCAAC TGCAAAACAC ATCTCCTTCA 
TCACCCAAGG AGTCTCTTCA CATGAGTGCC TTGAACTCGG CTCCCCCGGC AGTGACCATC 
TCCAGCAAGC AGGTGAAGGG TCCTGCGCCT CAGATGTTCA ACCTGGCCCG GCCGAAGCAC 
TTCTTCCCCG CTTCAAGCAC TTCCACAGCA ACCGTGTCCC CATCCAGCTC CCCGGTGTTC 
ACCTTGAGCA ATACTCCTCA AACAATTCAG AGGACAGTCA GCAAAGAAAG CCTCTTAATG 
GCCCACCCCT CCACACAAGG CAGATCTCCT GGCGGGCTCT CCATCCAAAA TGAGCCAGCT 
CCTCCAAGCC CAGCAGAGCC AGCAGCGCCA CCAACAGCCG CCTATTCCAT CCCTAGCGGA 
AACCAGTTTC AGCCTCACTG CGTATCCCCC ACTCCTGTCT CCCCTACCGG TCGGATTCAG 
AACCCGGTGG CTTTTCTTAG CTCTGTTCTG CCTTCTCTCC CTTCCATTCC ACCCACCAAC 
GCCATGGGGC TGCCTAAAAG CGCACCATCT GTACCATCCC AGGGTCTAAT GAAGAAAACC 
ACAAAGGCCC CTCAGGCAGT GAGTGACGAC TACATCCGAG AGACGAAGAA CTCAGTGATT 
CTAGACTTGG GGAAGAAAGT GAATTTCGGT GACGTCAGAT CACACCAGCA GGAATATAAA 
ATTTCCAGCT TTGAGCAGAG GCTGATGAAC GAGATAGAGT TCCGCCTGGA GCGGACTCCT 
GTTGACGAAT CTGATGACGA GATAGAACAC GACGAAATCC CCACGGGCAA GTGCATCGCG 
CCCATCTTTG ACAAAAGGCT CAAGCACTTC CGGGTTACCG AAGGCTCACC AGTCACCTTC 
ACCTGCAAAA TTGTTGGGAT ACCTGTTCCA AAGGTTTATT GGTTCAAAGA CGGGAAGCAG 
ATTTCTAAGA GAAATGAGCA CTGTAAAATG AGGAGAGAAG GGGATGGGAC CTGCTCACTA 
CACATTGAGT CCACCCACGG CGATGATGAC GGCAACTACA CCATCATGGC CGCCAACCCC 
CAGGGGAGAA TCAGCTGTTC TGGCCATTTG ATGGTACAGG GTTTGCCCAT TCGAAGCCGA 
CTCAGCCCTG CTCTGTCTCA CAGAGGAAGG TCCAGAATGC AGGAAAGAGA CAAAGAGCCG 
CTACAGGAAC GCTTTTTCCG ACCACATTTC CTGCAGGCCC CTGGGGATAT GGTGGCTCAC 
GAGGGCCGCC TCTGTCGGCT GGACTGTAAG GTGAGTGGCT TACCACCCCC GGAGCTGACA 
TGGCTACTCA ATGGGCAACC TGTGCTACCC GACGCCTCCC ACAAGATGCT GGTCAGAGAG 
ACGGGAGTCC ACTCTCTGCT CATCGACCCG CTCACCCAAC GAGACGCAGG GACCTACACG 
TGCGTGGCTA CCAACAAAAC CGGGCAGAAT TCCTTTAGTC TGGAGCTCAC TGTGGTAGCC 
AAAGAGGTAA AGAAGGCGCC AGTGATCCTG GAGAAACTCC AGAACAGCGG CGTCCCTGAG 
GGCCACCCGG TGCGACTGGA GGGCCGGGTC ATAGGCATGC CCCCGCCTGT GTTCTACTGG 
AAGAAAGACA ACGAGACCAT CCCGTTCACT AGAGAGAGGA TCAGCATGCA CCAGGATACA 
ACAGGCTATG TCTGCCTCCT CATCCAGCCA GCCAAGAAGT CCGACGCTGG GTGGTACACA 
CTGTCAGCCA AGAACGAAGC CGGCATCGTA TCGTGCACAG CTAGGTTGGA TATATATGCT 
CAGTGGCACC AGCAAATCCC AACACCCATA TCTATCCGGC CCAGCGGCAG CCGCTACGGG 
TCTCTCACCA GCAAAGGCCT CGACATCTTT TCTGCCTTCT CCTCCGTGGA AAGCACGATG 
CTGTATTCCT GTACTTCTCG GAGTGTAGTG GAGAGCGATG AACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Journal of cellular physiology232(1)38-52(2017 Jan)
Bang ML

Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy.
American journal of human genetics100(1)169-178(2017 Jan)
Miyatake S,Mitsuhashi S,Hayashi YK,Purevjav E,Nishikawa A,Koshimizu E,Suzuki M,Yatabe K,Tanaka Y,Ogata K,Kuru S,Shiina M,Tsurusaki Y,Nakashima M,Mizuguchi T,Miyake N,Saitsu H,Ogata K,Kawai M,Towbin J,Nonaka I,Nishino I,Matsumoto N

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.
Cardiovascular research107(2)216-25(2015 Jul)
Mastrototaro G,Liang X,Li X,Carullo P,Piroddi N,Tesi C,Gu Y,Dalton ND,Peterson KL,Poggesi C,Sheikh F,Chen J,Bang ML

Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy.
Journal of the American College of Cardiology64(25)2765-76(2014 Dec)
Huby AC,Mendsaikhan U,Takagi K,Martherus R,Wansapura J,Gong N,Osinska H,James JF,Kramer K,Saito K,Robbins J,Khuchua Z,Towbin JA,Purevjav E

Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.
Nature neuroscience14(5)578-86(2011 May)
Ghiasvand NM,Rudolph DD,Mashayekhi M,Brzezinski JA 4th,Goldman D,Glaser T

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Mypn cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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