Sgo2a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sgo2a
Entrez Gene ID	68549
Full Name	shugoshin 2A
Synonyms	1110007N04Rik,4932411A20Rik,5730576N04Rik,AU018846,AV008062,D1Ertd8e,Sgol2,Sgol2a,Tripin
General protein information	Preferred Names shugoshin 2A Names shugoshin 2 sgo2 shugoshin-like 2 shugoshin-like 2a
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C1.3\|1 28.86 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001177867.1	NP_001171338.1	shugoshin 2 isoform 2
NM_199007.2	NP_950172.1	shugoshin 2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SGOL2	XP_003949987.1
Canis lupus familiaris (dog)	SGOL2	XP_536023.3
Mus musculus (house mouse)	Sgol2	NP_950172.1
	SGOL2	XP_001091712.1
Mus musculus (house mouse)	Gm4975	NP_001182616.1
Rattus norvegicus (Norway rat)	Sgol2	NP_001258120.1
Homo sapiens (human)	SGOL2	NP_689737.4

Gene Ontology
Bibliography

Related articles in PubMed

Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Krishnan S, Smits AH, Vermeulen M, Reinberg D
Molecular cell67(4)579-593.e6(2017 Aug)

APC/C
Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pend?s AM, Malumbres M, Nov?k B, Herbert M, Nasmyth K
Current biology : CB27(10)1462-1476.e5(2017 May)

Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.
Faridi R, Rehman AU, Morell RJ, Friedman PL, Demain L, Zahra S, Khan AA, Tohlob D, Assir MZ, Beaman G, Khan SN, Newman WG, Riazuddin S, Friedman TB
Clinical genetics91(2)328-332(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.

In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility.
Title: Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.

Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body 'knob'.
Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
Title: Sequential assembly of centromeric proteins in male mouse meiosis.

SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres
Title: Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice.

The following Sgo2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sgo2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20022	NM_199007.2 Latest version!	Mus musculus shugoshin 2A (Sgo2a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
OMu20264	NM_001177867.1 Latest version!	Mus musculus shugoshin 2A (Sgo2a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sgo2a ( NM_199007.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_950172.1 Mus musculus shugoshin 2A (Sgo2a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20022
Clone ID Related Accession (Same CDS sequence)	NM_199007.2
Accession Version	NM_199007.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-16
Organism	Mus musculus(house mouse)
Product	shugoshin 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK042448.1, BC052742.1 and AK138621.1. On May 7, 2009 this sequence version replaced NM_199007.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTACC CAGGGATAAA AGTTGACACT GTTACCTCTG GAATTCAGAG ACGAGTGAAG 
GGCAGAATTG CAAAGACAAA TTTGAATGTT TCTCTTGCTT CAAAGATCAA AGCAAAAATA 
TTAAACAATT CTTCTATTTT CAAGATCTCT CTAAAGCACA ACAACAGAGC ATTAGCGCGG 
GCCCTTAGTA AAGAGAAAGA GAATTCTCGA AGAATTACTA CCGAAAAGAT GCAATTACAG 
AAAGAAGTAG AGAAACTGAA TTTTGAGAAT ACCTTTCTTC GCTTAAAGTT AAATACCTTG 
AATAAGAAGC TTGTAGAAAT AGAATCGCAT GTGAGCAATG ATTTGTTAAC TGCAATTGAA 
ATAAGCAGTC TTTCTGAGTT CCACCAAGGT TCTTTTCTCC TGTCAGCTAC CAAGAAACAA 
AGGAACAGTA AGCAGTGCAA GCCTGCGCAT CTTCCATATG CAAGAGTTCT GTTAACTTCA 
GAAAATGATG ATGATGATGG TGCTGATGAT AAATGGCAGA CAAAGTGTAA CAACAGAACT 
ATATCAAAGA CCTCACCTGA TAGTACCTCT TCAGTATCAA GACAACCTTC ATCCTTACAT 
CAGTGCAATT TGAAAGCATT CCCTCCTAAA GAAGATAATC AGAAGACATG TGGGTCAGGT 
CATTTAGAAC ATACTTCAAG TGTTGATATA CTTCCTAATG AGAGCCACTC AGATCAAAGT 
CCTAAGAGTT CTCTGAGTGA GATGAAAACT GCTCCATCTC CCAGCCTCAG AAGGGAAAAA 
TTATCACATG GTAATGTGAC TATGAGGAAG AAGTGTGTGT CTTCAACTCC AGACATTCTG 
TATGTGACAG ATTTAGATCA CCAACCAACT TCAAGTCCAG GATCAAATTG GAATAATGAG 
ATACATGGTC ATACTAATGA AACCAGCAAT AACACGCAAA GAAATGCCGA GTGTTTTCTT 
GACTTACCTT CTGAGTCTTC CAGTGAGCCT GACGCAAAGC GCATGGAGCT AGTGCAGAAG 
AACACCGATA GCTTTCACTT CCAGAAAACT GTATATGATG CCGCTGATAT GGAGTTAACT 
GCTACTGACA TAGGCAAGAT TGTAGCAGTT TCAAAAAGCA AGAAAAATCA AAATAAGAAA 
AAGGCAGACT GTAGAAAGGA GACTTTCAGA AAAGTGAAAG GTGCAAGCTC TGATAAAAAG 
AGAGAAAGCT CAAAGAGAGA ATGTAAAGAT GGTTCAGAAG TAGGTGCTGA GGAAGAGGCT 
GATGCAGCCA GAGCAGAAAG AGGCGCTGGT GTCCTGGATG GCAGAGGGGA TTCAGAAGAG 
CCAAACTGCA TTTCCAGTAC TGAGCAGCCA TCTCAGGTAA ACACGCAAAA GAAAAGAACC 
CTCCAGAACA GCTCAGATCA GGAGAACATT CAAAATACGA AGAGGAGGCA AACATATACG 
ACAGATGAGC AAGAGGAAAC AAACCCTTTC TCCAGACATT CAGTCAAATT TCTTCAAGAT 
GGTAAATTTG ATCTGTGTCA GAAAACCCTA CATCATAATT TAAGTAAGCC TTCTCGACAG 
ACATTTGTGA TTCGTAAGTC AGAAAAAGAT AACTTATTTC CAAATCAAGA AGATAAAGAC 
ACCATTTCTG AAAACCTAGA AGTTACAAAT GAATTTCATA TAGATGATCT TTCCATCGAA 
GCTAATGAAA ATGTATGTGA CCATGAGACT CAGACAATGT TGGACTTGAA AAAGTCTGTC 
AGTGCTCAAC AAAATCAAAC AAAAATAAAT AAGACTAAGC AGAAAATAAA TCGAAGGACA 
AAAATAATTT CTGTCATGAG CCAAGTATAT GAGGACAATG ATAAAGATAT TCACGTCCTA 
GAAAAAGACA ACTTTCCCTT TCATACCCAA GCAAATAAAG AAACCACCAG TGGAAACCTA 
GAAAGTTCAA AAGAATTTGA ATCACCTCTT CTTTTCACAA GAGACAACGG AAGCTTACGT 
GACTGTAAGA CCCAGAATGT TCTGGATCTG CACAAGCAAA TTCCTGATCT ATACCCTGAT 
CGGAATGAGT CCCAGATTAG CAAAATCCCT AGGCAAAAAG TAAATCGCAA GACAGAAGTA 
ATTTCTGGAG TGAAATGTTT TAGTAATGAC CAAGGTGTTC ATTGCTCAGA AAAGGATAAG 
TCTTTGTTAC TACAAAAGGA TAAAGACTTC CCAGGAACTT TAAAAGACTT AAGTGAGTTT 
GATACGCCTG CTTTTTGTAA CAAAGATAGT GCAAAGTCGT GTGATTATAA GTCTGAAATG 
CTCTTGGGGT TGAAAAAACA TGACCCTAAT ATGCAACCTG CTTGTCAAGA TGATTCAAAA 
GCAGGTAAGA AACTTAGACA AAAGGTAAAT CGAAAAACAG AAATAATTTC TAAAATCACC 
CAAATACATG AAAATGATAG AGGAAGTACA CATGACTCAT TAAATAAGAA GCTCTGTCAG 
AAGGTTAATA TATCAAAAAT CATTTCTCAA ATGAACCAAA TATATGAGAC TATTAATGAA 
GATGGAAATG GCTTTAAAAG CTCTATCAAA GATTGCGAAG ATATTAAAAG TTGTGACTTT 
GGGGAAATCA ACAGTAATAA AAAGGAAAAT TATGATCCAA TTCAAGATCC TTGCACACTG 
GTTAAAAAAA CAAAGAGAAA GGGATCATGT AAAGCAGGGA GCAGTTTGGC AGGAGCTAAG 
AACAGGTGTG GTTTGCAGTT AACAGACTCT TCCCAGGTAC AGTCTGTCCC CTTAGACTCT 
GGCTTAAGAC ACCATCCAAA CGAAGCAGAT TCTGGTCCTG GAGAGCAGAC TAACCTGCCA 
AAGATGCAGA AACAAAGCGC TGGGAGGTCA CTGGGAGATG CTTTCTCTGT GAGTCTGGGA 
AAAGAAGGAA GCCGCCCAGC CAAAGCAGTT AGTAAAATGA CACCCAAATC AAAGAAGAGA 
AAGCTCCCTC TCGGTTGTTC TCCTGAAACC CACGGGACGG TGGAGATAAC ACCCAACACT 
GACCTCGCTA AGGCTGTTGA CTCCCAACAG ACTGAGAAGG AGAACTATTT GGAGAAGGAG 
AAAATTGCCA AGAGGAAGCC AGATTTTTGT ACAAAGGTGT TGAAACCTTT ATCTGAGACA 
TGTTCATCTA ACATAAAGAA TTCTTCCTTG GACAGTATGT GTAAGAGTTC GCTACCTTTG 
AGTATTTCTT CTAGAAAAAC CCTGATGCTG GAAGAAAGTT CTTCCCTGGA GAGTACATGC 
ATCTTTCAAG TAGGTGATGC CGCTCATGAG AAGATAACGA CAGGCACACG TAATCCCCAC 
CACAGGACAC AGAAGTCGAC ACCGGGTAGC AGAACGTCCC TGGTCTTGGT GGATACCAGT 
TCTGTTTCAG ATACCAACCC TGCTAACCCC GAGAATGAGT CAGAAGGGCA GTCTTCACAC 
CCAATGAGAA GGAAAAGACA GTGCGTCCCT CTCAACCTGA CAGAGCCAAG CCTTAGAAGC 
AAGATGAGGA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_950172.1
CDS	342..3836
Translation	MEYPGIKVDTVTSGIQRRVKGRIAKTNLNVSLASKIKAKILNNSSIFKISLKHNNRALARALSKEKENSRRITTEKMQLQKEVEKLNFENTFLRLKLNTLNKKLVEIESHVSNDLLTAIEISSLSEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCGSGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSSTPDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKRMELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKVKGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQPSQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQKTLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVCDHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDNFPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRNESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEFDTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISKITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIKSCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQSVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSKMTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFCTKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAAHEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKRQCVPLNLTEPSLRSKMRR

Target ORF information:

RefSeq Version	NM_199007.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus shugoshin 2A (Sgo2a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199007.2

ORF Insert Sequence:

ATGGAGTACC CAGGGATAAA AGTTGACACT GTTACCTCTG GAATTCAGAG ACGAGTGAAG 
GGCAGAATTG CAAAGACAAA TTTGAATGTT TCTCTTGCTT CAAAGATCAA AGCAAAAATA 
TTAAACAATT CTTCTATTTT CAAGATCTCT CTAAAGCACA ACAACAGAGC ATTAGCGCGG 
GCCCTTAGTA AAGAGAAAGA GAATTCTCGA AGAATTACTA CCGAAAAGAT GCAATTACAG 
AAAGAAGTAG AGAAACTGAA TTTTGAGAAT ACCTTTCTTC GCTTAAAGTT AAATACCTTG 
AATAAGAAGC TTGTAGAAAT AGAATCGCAT GTGAGCAATG ATTTGTTAAC TGCAATTGAA 
ATAAGCAGTC TTTCTGAGTT CCACCAAGGT TCTTTTCTCC TGTCAGCTAC CAAGAAACAA 
AGGAACAGTA AGCAGTGCAA GCCTGCGCAT CTTCCATATG CAAGAGTTCT GTTAACTTCA 
GAAAATGATG ATGATGATGG TGCTGATGAT AAATGGCAGA CAAAGTGTAA CAACAGAACT 
ATATCAAAGA CCTCACCTGA TAGTACCTCT TCAGTATCAA GACAACCTTC ATCCTTACAT 
CAGTGCAATT TGAAAGCATT CCCTCCTAAA GAAGATAATC AGAAGACATG TGGGTCAGGT 
CATTTAGAAC ATACTTCAAG TGTTGATATA CTTCCTAATG AGAGCCACTC AGATCAAAGT 
CCTAAGAGTT CTCTGAGTGA GATGAAAACT GCTCCATCTC CCAGCCTCAG AAGGGAAAAA 
TTATCACATG GTAATGTGAC TATGAGGAAG AAGTGTGTGT CTTCAACTCC AGACATTCTG 
TATGTGACAG ATTTAGATCA CCAACCAACT TCAAGTCCAG GATCAAATTG GAATAATGAG 
ATACATGGTC ATACTAATGA AACCAGCAAT AACACGCAAA GAAATGCCGA GTGTTTTCTT 
GACTTACCTT CTGAGTCTTC CAGTGAGCCT GACGCAAAGC GCATGGAGCT AGTGCAGAAG 
AACACCGATA GCTTTCACTT CCAGAAAACT GTATATGATG CCGCTGATAT GGAGTTAACT 
GCTACTGACA TAGGCAAGAT TGTAGCAGTT TCAAAAAGCA AGAAAAATCA AAATAAGAAA 
AAGGCAGACT GTAGAAAGGA GACTTTCAGA AAAGTGAAAG GTGCAAGCTC TGATAAAAAG 
AGAGAAAGCT CAAAGAGAGA ATGTAAAGAT GGTTCAGAAG TAGGTGCTGA GGAAGAGGCT 
GATGCAGCCA GAGCAGAAAG AGGCGCTGGT GTCCTGGATG GCAGAGGGGA TTCAGAAGAG 
CCAAACTGCA TTTCCAGTAC TGAGCAGCCA TCTCAGGTAA ACACGCAAAA GAAAAGAACC 
CTCCAGAACA GCTCAGATCA GGAGAACATT CAAAATACGA AGAGGAGGCA AACATATACG 
ACAGATGAGC AAGAGGAAAC AAACCCTTTC TCCAGACATT CAGTCAAATT TCTTCAAGAT 
GGTAAATTTG ATCTGTGTCA GAAAACCCTA CATCATAATT TAAGTAAGCC TTCTCGACAG 
ACATTTGTGA TTCGTAAGTC AGAAAAAGAT AACTTATTTC CAAATCAAGA AGATAAAGAC 
ACCATTTCTG AAAACCTAGA AGTTACAAAT GAATTTCATA TAGATGATCT TTCCATCGAA 
GCTAATGAAA ATGTATGTGA CCATGAGACT CAGACAATGT TGGACTTGAA AAAGTCTGTC 
AGTGCTCAAC AAAATCAAAC AAAAATAAAT AAGACTAAGC AGAAAATAAA TCGAAGGACA 
AAAATAATTT CTGTCATGAG CCAAGTATAT GAGGACAATG ATAAAGATAT TCACGTCCTA 
GAAAAAGACA ACTTTCCCTT TCATACCCAA GCAAATAAAG AAACCACCAG TGGAAACCTA 
GAAAGTTCAA AAGAATTTGA ATCACCTCTT CTTTTCACAA GAGACAACGG AAGCTTACGT 
GACTGTAAGA CCCAGAATGT TCTGGATCTG CACAAGCAAA TTCCTGATCT ATACCCTGAT 
CGGAATGAGT CCCAGATTAG CAAAATCCCT AGGCAAAAAG TAAATCGCAA GACAGAAGTA 
ATTTCTGGAG TGAAATGTTT TAGTAATGAC CAAGGTGTTC ATTGCTCAGA AAAGGATAAG 
TCTTTGTTAC TACAAAAGGA TAAAGACTTC CCAGGAACTT TAAAAGACTT AAGTGAGTTT 
GATACGCCTG CTTTTTGTAA CAAAGATAGT GCAAAGTCGT GTGATTATAA GTCTGAAATG 
CTCTTGGGGT TGAAAAAACA TGACCCTAAT ATGCAACCTG CTTGTCAAGA TGATTCAAAA 
GCAGGTAAGA AACTTAGACA AAAGGTAAAT CGAAAAACAG AAATAATTTC TAAAATCACC 
CAAATACATG AAAATGATAG AGGAAGTACA CATGACTCAT TAAATAAGAA GCTCTGTCAG 
AAGGTTAATA TATCAAAAAT CATTTCTCAA ATGAACCAAA TATATGAGAC TATTAATGAA 
GATGGAAATG GCTTTAAAAG CTCTATCAAA GATTGCGAAG ATATTAAAAG TTGTGACTTT 
GGGGAAATCA ACAGTAATAA AAAGGAAAAT TATGATCCAA TTCAAGATCC TTGCACACTG 
GTTAAAAAAA CAAAGAGAAA GGGATCATGT AAAGCAGGGA GCAGTTTGGC AGGAGCTAAG 
AACAGGTGTG GTTTGCAGTT AACAGACTCT TCCCAGGTAC AGTCTGTCCC CTTAGACTCT 
GGCTTAAGAC ACCATCCAAA CGAAGCAGAT TCTGGTCCTG GAGAGCAGAC TAACCTGCCA 
AAGATGCAGA AACAAAGCGC TGGGAGGTCA CTGGGAGATG CTTTCTCTGT GAGTCTGGGA 
AAAGAAGGAA GCCGCCCAGC CAAAGCAGTT AGTAAAATGA CACCCAAATC AAAGAAGAGA 
AAGCTCCCTC TCGGTTGTTC TCCTGAAACC CACGGGACGG TGGAGATAAC ACCCAACACT 
GACCTCGCTA AGGCTGTTGA CTCCCAACAG ACTGAGAAGG AGAACTATTT GGAGAAGGAG 
AAAATTGCCA AGAGGAAGCC AGATTTTTGT ACAAAGGTGT TGAAACCTTT ATCTGAGACA 
TGTTCATCTA ACATAAAGAA TTCTTCCTTG GACAGTATGT GTAAGAGTTC GCTACCTTTG 
AGTATTTCTT CTAGAAAAAC CCTGATGCTG GAAGAAAGTT CTTCCCTGGA GAGTACATGC 
ATCTTTCAAG TAGGTGATGC CGCTCATGAG AAGATAACGA CAGGCACACG TAATCCCCAC 
CACAGGACAC AGAAGTCGAC ACCGGGTAGC AGAACGTCCC TGGTCTTGGT GGATACCAGT 
TCTGTTTCAG ATACCAACCC TGCTAACCCC GAGAATGAGT CAGAAGGGCA GTCTTCACAC 
CCAATGAGAA GGAAAAGACA GTGCGTCCCT CTCAACCTGA CAGAGCCAAG CCTTAGAAGC 
AAGATGAGGA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sgo2a ( NM_001177867.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001171338.1 Mus musculus shugoshin 2A (Sgo2a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20264
Clone ID Related Accession (Same CDS sequence)	NM_001177867.1
Accession Version	NM_001177867.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3195bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-16
Organism	Mus musculus(house mouse)
Product	shugoshin 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN716821.1 and BC052742.1. Transcript Variant: This variant (2) lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGGACAAA CACCAAAGAA AGAAGGCACA GAATGGAGCC AGACCAAAGA AAGGCTGTGG 
ATGTTGCAGG CAGCAGAGTT CCACCAAGGT TCTTTTCTCC TGTCAGCTAC CAAGAAACAA 
AGGAACAGTA AGCAGTGCAA GCCTGCGCAT CTTCCATATG CAAGAGTTCT GTTAACTTCA 
GAAAATGATG ATGATGATGG TGCTGATGAT AAATGGCAGA CAAAGTGTAA CAACAGAACT 
ATATCAAAGA CCTCACCTGA TAGTACCTCT TCAGTATCAA GACAACCTTC ATCCTTACAT 
CAGTGCAATT TGAAAGCATT CCCTCCTAAA GAAGATAATC AGAAGACATG TGGGTCAGGT 
CATTTAGAAC ATACTTCAAG TGTTGATATA CTTCCTAATG AGAGCCACTC AGATCAAAGT 
CCTAAGAGTT CTCTGAGTGA GATGAAAACT GCTCCATCTC CCAGCCTCAG AAGGGAAAAA 
TTATCACATG GTAATGTGAC TATGAGGAAG AAGTGTGTGT CTTCAACTCC AGACATTCTG 
TATGTGACAG ATTTAGATCA CCAACCAACT TCAAGTCCAG GATCAAATTG GAATAATGAG 
ATACATGGTC ATACTAATGA AACCAGCAAT AACACGCAAA GAAATGCCGA GTGTTTTCTT 
GACTTACCTT CTGAGTCTTC CAGTGAGCCT GACGCAAAGC GCATGGAGCT AGTGCAGAAG 
AACACCGATA GCTTTCACTT CCAGAAAACT GTATATGATG CCGCTGATAT GGAGTTAACT 
GCTACTGACA TAGGCAAGAT TGTAGCAGTT TCAAAAAGCA AGAAAAATCA AAATAAGAAA 
AAGGCAGACT GTAGAAAGGA GACTTTCAGA AAAGTGAAAG GTGCAAGCTC TGATAAAAAG 
AGAGAAAGCT CAAAGAGAGA ATGTAAAGAT GGTTCAGAAG TAGGTGCTGA GGAAGAGGCT 
GATGCAGCCA GAGCAGAAAG AGGCGCTGGT GTCCTGGATG GCAGAGGGGA TTCAGAAGAG 
CCAAACTGCA TTTCCAGTAC TGAGCAGCCA TCTCAGGTAA ACACGCAAAA GAAAAGAACC 
CTCCAGAACA GCTCAGATCA GGAGAACATT CAAAATACGA AGAGGAGGCA AACATATACG 
ACAGATGAGC AAGAGGAAAC AAACCCTTTC TCCAGACATT CAGTCAAATT TCTTCAAGAT 
GGTAAATTTG ATCTGTGTCA GAAAACCCTA CATCATAATT TAAGTAAGCC TTCTCGACAG 
ACATTTGTGA TTCGTAAGTC AGAAAAAGAT AACTTATTTC CAAATCAAGA AGATAAAGAC 
ACCATTTCTG AAAACCTAGA AGTTACAAAT GAATTTCATA TAGATGATCT TTCCATCGAA 
GCTAATGAAA ATGTATGTGA CCATGAGACT CAGACAATGT TGGACTTGAA AAAGTCTGTC 
AGTGCTCAAC AAAATCAAAC AAAAATAAAT AAGACTAAGC AGAAAATAAA TCGAAGGACA 
AAAATAATTT CTGTCATGAG CCAAGTATAT GAGGACAATG ATAAAGATAT TCACGTCCTA 
GAAAAAGACA ACTTTCCCTT TCATACCCAA GCAAATAAAG AAACCACCAG TGGAAACCTA 
GAAAGTTCAA AAGAATTTGA ATCACCTCTT CTTTTCACAA GAGACAACGG AAGCTTACGT 
GACTGTAAGA CCCAGAATGT TCTGGATCTG CACAAGCAAA TTCCTGATCT ATACCCTGAT 
CGGAATGAGT CCCAGATTAG CAAAATCCCT AGGCAAAAAG TAAATCGCAA GACAGAAGTA 
ATTTCTGGAG TGAAATGTTT TAGTAATGAC CAAGGTGTTC ATTGCTCAGA AAAGGATAAG 
TCTTTGTTAC TACAAAAGGA TAAAGACTTC CCAGGAACTT TAAAAGACTT AAGTGAGTTT 
GATACGCCTG CTTTTTGTAA CAAAGATAGT GCAAAGTCGT GTGATTATAA GTCTGAAATG 
CTCTTGGGGT TGAAAAAACA TGACCCTAAT ATGCAACCTG CTTGTCAAGA TGATTCAAAA 
GCAGGTAAGA AACTTAGACA AAAGGTAAAT CGAAAAACAG AAATAATTTC TAAAATCACC 
CAAATACATG AAAATGATAG AGGAAGTACA CATGACTCAT TAAATAAGAA GCTCTGTCAG 
AAGGTTAATA TATCAAAAAT CATTTCTCAA ATGAACCAAA TATATGAGAC TATTAATGAA 
GATGGAAATG GCTTTAAAAG CTCTATCAAA GATTGCGAAG ATATTAAAAG TTGTGACTTT 
GGGGAAATCA ACAGTAATAA AAAGGAAAAT TATGATCCAA TTCAAGATCC TTGCACACTG 
GTTAAAAAAA CAAAGAGAAA GGGATCATGT AAAGCAGGGA GCAGTTTGGC AGGAGCTAAG 
AACAGGTGTG GTTTGCAGTT AACAGACTCT TCCCAGGTAC AGTCTGTCCC CTTAGACTCT 
GGCTTAAGAC ACCATCCAAA CGAAGCAGAT TCTGGTCCTG GAGAGCAGAC TAACCTGCCA 
AAGATGCAGA AACAAAGCGC TGGGAGGTCA CTGGGAGATG CTTTCTCTGT GAGTCTGGGA 
AAAGAAGGAA GCCGCCCAGC CAAAGCAGTT AGTAAAATGA CACCCAAATC AAAGAAGAGA 
AAGCTCCCTC TCGGTTGTTC TCCTGAAACC CACGGGACGG TGGAGATAAC ACCCAACACT 
GACCTCGCTA AGGCTGTTGA CTCCCAACAG ACTGAGAAGG AGAACTATTT GGAGAAGGAG 
AAAATTGCCA AGAGGAAGCC AGATTTTTGT ACAAAGGTGT TGAAACCTTT ATCTGAGACA 
TGTTCATCTA ACATAAAGAA TTCTTCCTTG GACAGTATGT GTAAGAGTTC GCTACCTTTG 
AGTATTTCTT CTAGAAAAAC CCTGATGCTG GAAGAAAGTT CTTCCCTGGA GAGTACATGC 
ATCTTTCAAG TAGGTGATGC CGCTCATGAG AAGATAACGA CAGGCACACG TAATCCCCAC 
CACAGGACAC AGAAGTCGAC ACCGGGTAGC AGAACGTCCC TGGTCTTGGT GGATACCAGT 
TCTGTTTCAG ATACCAACCC TGCTAACCCC GAGAATGAGT CAGAAGGGCA GTCTTCACAC 
CCAATGAGAA GGAAAAGACA GTGCGTCCCT CTCAACCTGA CAGAGCCAAG CCTTAGAAGC 
AAGATGAGGA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001171338.1
CDS	25..3219
Translation	MGQTPKKEGTEWSQTKERLWMLQAAEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCGSGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSSTPDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKRMELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKVKGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQPSQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQKTLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVCDHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDNFPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRNESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEFDTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISKITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIKSCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQSVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSKMTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFCTKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAAHEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKRQCVPLNLTEPSLRSKMRR

Target ORF information:

RefSeq Version	NM_001177867.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus shugoshin 2A (Sgo2a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001177867.1

ORF Insert Sequence:

ATGGGACAAA CACCAAAGAA AGAAGGCACA GAATGGAGCC AGACCAAAGA AAGGCTGTGG 
ATGTTGCAGG CAGCAGAGTT CCACCAAGGT TCTTTTCTCC TGTCAGCTAC CAAGAAACAA 
AGGAACAGTA AGCAGTGCAA GCCTGCGCAT CTTCCATATG CAAGAGTTCT GTTAACTTCA 
GAAAATGATG ATGATGATGG TGCTGATGAT AAATGGCAGA CAAAGTGTAA CAACAGAACT 
ATATCAAAGA CCTCACCTGA TAGTACCTCT TCAGTATCAA GACAACCTTC ATCCTTACAT 
CAGTGCAATT TGAAAGCATT CCCTCCTAAA GAAGATAATC AGAAGACATG TGGGTCAGGT 
CATTTAGAAC ATACTTCAAG TGTTGATATA CTTCCTAATG AGAGCCACTC AGATCAAAGT 
CCTAAGAGTT CTCTGAGTGA GATGAAAACT GCTCCATCTC CCAGCCTCAG AAGGGAAAAA 
TTATCACATG GTAATGTGAC TATGAGGAAG AAGTGTGTGT CTTCAACTCC AGACATTCTG 
TATGTGACAG ATTTAGATCA CCAACCAACT TCAAGTCCAG GATCAAATTG GAATAATGAG 
ATACATGGTC ATACTAATGA AACCAGCAAT AACACGCAAA GAAATGCCGA GTGTTTTCTT 
GACTTACCTT CTGAGTCTTC CAGTGAGCCT GACGCAAAGC GCATGGAGCT AGTGCAGAAG 
AACACCGATA GCTTTCACTT CCAGAAAACT GTATATGATG CCGCTGATAT GGAGTTAACT 
GCTACTGACA TAGGCAAGAT TGTAGCAGTT TCAAAAAGCA AGAAAAATCA AAATAAGAAA 
AAGGCAGACT GTAGAAAGGA GACTTTCAGA AAAGTGAAAG GTGCAAGCTC TGATAAAAAG 
AGAGAAAGCT CAAAGAGAGA ATGTAAAGAT GGTTCAGAAG TAGGTGCTGA GGAAGAGGCT 
GATGCAGCCA GAGCAGAAAG AGGCGCTGGT GTCCTGGATG GCAGAGGGGA TTCAGAAGAG 
CCAAACTGCA TTTCCAGTAC TGAGCAGCCA TCTCAGGTAA ACACGCAAAA GAAAAGAACC 
CTCCAGAACA GCTCAGATCA GGAGAACATT CAAAATACGA AGAGGAGGCA AACATATACG 
ACAGATGAGC AAGAGGAAAC AAACCCTTTC TCCAGACATT CAGTCAAATT TCTTCAAGAT 
GGTAAATTTG ATCTGTGTCA GAAAACCCTA CATCATAATT TAAGTAAGCC TTCTCGACAG 
ACATTTGTGA TTCGTAAGTC AGAAAAAGAT AACTTATTTC CAAATCAAGA AGATAAAGAC 
ACCATTTCTG AAAACCTAGA AGTTACAAAT GAATTTCATA TAGATGATCT TTCCATCGAA 
GCTAATGAAA ATGTATGTGA CCATGAGACT CAGACAATGT TGGACTTGAA AAAGTCTGTC 
AGTGCTCAAC AAAATCAAAC AAAAATAAAT AAGACTAAGC AGAAAATAAA TCGAAGGACA 
AAAATAATTT CTGTCATGAG CCAAGTATAT GAGGACAATG ATAAAGATAT TCACGTCCTA 
GAAAAAGACA ACTTTCCCTT TCATACCCAA GCAAATAAAG AAACCACCAG TGGAAACCTA 
GAAAGTTCAA AAGAATTTGA ATCACCTCTT CTTTTCACAA GAGACAACGG AAGCTTACGT 
GACTGTAAGA CCCAGAATGT TCTGGATCTG CACAAGCAAA TTCCTGATCT ATACCCTGAT 
CGGAATGAGT CCCAGATTAG CAAAATCCCT AGGCAAAAAG TAAATCGCAA GACAGAAGTA 
ATTTCTGGAG TGAAATGTTT TAGTAATGAC CAAGGTGTTC ATTGCTCAGA AAAGGATAAG 
TCTTTGTTAC TACAAAAGGA TAAAGACTTC CCAGGAACTT TAAAAGACTT AAGTGAGTTT 
GATACGCCTG CTTTTTGTAA CAAAGATAGT GCAAAGTCGT GTGATTATAA GTCTGAAATG 
CTCTTGGGGT TGAAAAAACA TGACCCTAAT ATGCAACCTG CTTGTCAAGA TGATTCAAAA 
GCAGGTAAGA AACTTAGACA AAAGGTAAAT CGAAAAACAG AAATAATTTC TAAAATCACC 
CAAATACATG AAAATGATAG AGGAAGTACA CATGACTCAT TAAATAAGAA GCTCTGTCAG 
AAGGTTAATA TATCAAAAAT CATTTCTCAA ATGAACCAAA TATATGAGAC TATTAATGAA 
GATGGAAATG GCTTTAAAAG CTCTATCAAA GATTGCGAAG ATATTAAAAG TTGTGACTTT 
GGGGAAATCA ACAGTAATAA AAAGGAAAAT TATGATCCAA TTCAAGATCC TTGCACACTG 
GTTAAAAAAA CAAAGAGAAA GGGATCATGT AAAGCAGGGA GCAGTTTGGC AGGAGCTAAG 
AACAGGTGTG GTTTGCAGTT AACAGACTCT TCCCAGGTAC AGTCTGTCCC CTTAGACTCT 
GGCTTAAGAC ACCATCCAAA CGAAGCAGAT TCTGGTCCTG GAGAGCAGAC TAACCTGCCA 
AAGATGCAGA AACAAAGCGC TGGGAGGTCA CTGGGAGATG CTTTCTCTGT GAGTCTGGGA 
AAAGAAGGAA GCCGCCCAGC CAAAGCAGTT AGTAAAATGA CACCCAAATC AAAGAAGAGA 
AAGCTCCCTC TCGGTTGTTC TCCTGAAACC CACGGGACGG TGGAGATAAC ACCCAACACT 
GACCTCGCTA AGGCTGTTGA CTCCCAACAG ACTGAGAAGG AGAACTATTT GGAGAAGGAG 
AAAATTGCCA AGAGGAAGCC AGATTTTTGT ACAAAGGTGT TGAAACCTTT ATCTGAGACA 
TGTTCATCTA ACATAAAGAA TTCTTCCTTG GACAGTATGT GTAAGAGTTC GCTACCTTTG 
AGTATTTCTT CTAGAAAAAC CCTGATGCTG GAAGAAAGTT CTTCCCTGGA GAGTACATGC 
ATCTTTCAAG TAGGTGATGC CGCTCATGAG AAGATAACGA CAGGCACACG TAATCCCCAC 
CACAGGACAC AGAAGTCGAC ACCGGGTAGC AGAACGTCCC TGGTCTTGGT GGATACCAGT 
TCTGTTTCAG ATACCAACCC TGCTAACCCC GAGAATGAGT CAGAAGGGCA GTCTTCACAC 
CCAATGAGAA GGAAAAGACA GTGCGTCCCT CTCAACCTGA CAGAGCCAAG CCTTAGAAGC 
AAGATGAGGA GATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Molecular cell67(4)579-593.e6(2017 Aug)
Krishnan S,Smits AH,Vermeulen M,Reinberg D

APC/C
Current biology : CB27(10)1462-1476.e5(2017 May)
Rattani A,Ballesteros Mejia R,Roberts K,Roig MB,Godwin J,Hopkins M,Eguren M,Sanchez-Pulido L,Okaz E,Ogushi S,Wolna M,Metson J,Pend?s AM,Malumbres M,Nov?k B,Herbert M,Nasmyth K

Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.
Clinical genetics91(2)328-332(2017 Feb)
Faridi R,Rehman AU,Morell RJ,Friedman PL,Demain L,Zahra S,Khan AA,Tohlob D,Assir MZ,Beaman G,Khan SN,Newman WG,Riazuddin S,Friedman TB

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Sgo2a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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