Ecscr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ecscr
Entrez Gene ID	68545
Full Name	endothelial cell surface expressed chemotaxis and apoptosis regulator
Synonyms	1110006O17Rik,ARIA
General protein information	Preferred Names endothelial cell surface expressed chemotaxis and apoptosis regulator Names endothelial cell-specific chemotaxis regulator apoptosis regulator through modulating IAP expression endothelial cell-specific molecule 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B2

mRNA and Protein(s)

mRNA	Protein	Name
XM_006526210.2	XP_006526273.2	endothelial cell-specific chemotaxis regulator isoform X1
XM_030250592.1	XP_030106452.1	endothelial cell-specific chemotaxis regulator isoform X1
NM_001033141.2	NP_001028313.1	endothelial cell-specific chemotaxis regulator isoform 3
NM_001368652.1	NP_001355581.1	endothelial cell-specific chemotaxis regulator isoform 2
NM_001033141.1	NP_001028313.1	endothelial cell-specific chemotaxis regulator
NM_001368651.1	NP_001355580.1	endothelial cell-specific chemotaxis regulator isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ECSCR	NP_001231374.1
Homo sapiens (human)	ECSCR	NP_001071161.1
	LOC100428408	XP_002804583.1
Rattus norvegicus (Norway rat)	Ecscr	XP_006254680.1
Canis lupus familiaris (dog)	ECSCR	XP_005617309.1
Mus musculus (house mouse)	Ecscr	NP_001028313.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Loss of apoptosis regulator through modulating IAP expression (ARIA) protects blood vessels from atherosclerosis.
Matsuo K, Akakabe Y, Kitamura Y, Shimoda Y, Ono K, Ueyama T, Matoba S, Yamada H, Hatakeyama K, Asada Y, Emoto N, Ikeda K
The Journal of biological chemistry290(6)3784-92(2015 Feb)

Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway.
Kilari S, Cossette S, Pooya S, Bordas M, Huang YW, Ramchandran R, Wilkinson GA
PloS one10(12)e0144185(2015)

Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
Kitamura Y, Koide M, Akakabe Y, Matsuo K, Shimoda Y, Soma Y, Ogata T, Ueyama T, Matoba S, Yamada H, Ikeda K
The Journal of biological chemistry289(5)2788-800(2014 Jan)

Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.
Akakabe Y, Koide M, Kitamura Y, Matsuo K, Ueyama T, Matoba S, Yamada H, Miyata K, Oike Y, Ikeda K
Nature communications42389(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that ECSCR plays a critical function in regulating lipolysis in white adipose tissue.
Title: Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway.

These studies, revealed a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction.
Title: Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.

Inactivation of Ecscr enhances insulin sensitivity and may represent a new therapeutic strategy for treating metabolic syndrome.
Title: Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.

two mouse ECSCR splicing variants/isoform precursors exist and are differentially expressed in a variety of tissue types and likely involved in modulation of vascular Endothelial cell migration.
Title: Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR).

ARIA was expressed in blood vessels during mouse embryogenesis, as well as in endothelial cells both in vitro and in vivo.
Title: Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2.

The following Ecscr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ecscr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17828	NM_001033141.2 Latest version!	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu70278	XM_006526210.2 Latest version!	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu84507	NM_001368651.1 Latest version!	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu84519	NM_001368652.1 Latest version!	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu87429	XM_030250592.1 Latest version!	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu17828	NM_001033141.1	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ecscr ( NM_001033141.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028313.1 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu17828
Clone ID Related Accession (Same CDS sequence)	NM_001033141.2 , NM_001033141.1
Accession Version	NM_001033141.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-13
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132837.11. On Feb 14, 2019 this sequence version replaced NM_001033141.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK157485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTCGAG ACATTTCTCT GGAAGCCCAC GGGCTGGGGT CAACACTGAC ACCCCTTCTT 
GCCCATCAAC TCCCACAGGG GAGAGTCAGA GGCTACAGCT CTCAACCTAC GACAACTCAG 
ACCTCGCAGG AAATTCTACA GAAGTCTTCT CAGGTCTCCT TGGTATCCAA TCAGCCTGTG 
ACACCAAGGT CAAGCACCAT GGATAAACAG TCCCTTTCCT TGCCTGACTT GATGTCCTTC 
CAGCCACAGA AGCACACACT GGGACCTGGC ACAGGAACCC CAGAAAGGAG CAGCAGCAGC 
AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA GCATCTCTGG ATGCTACTCC CAGTCCAGAA 
ACCACCAGCC TTCAGACAAA AAAGATGACC ATCCTGCTGA CCATCCTGCC TACCCCCACA 
TCAGAGTCAG TGCTAACTGT GGCTGCCTTT GGTGTCATCA GCTTCATTGT CATCCTGGTG 
GTTGTAGTGA TCATCCTGGT CAGTGTGGTC AGTCTAAGAT TTAAGTGTCG GAAGAACAAG 
GAGTCTGAAG ATCCACAGAA ACCAGGGAGT TCAGGGCTGT CTGAAAGCTG CTCCACAGCC 
AATGGAGAGA AAGACAGCAT CACACTCATC TCCATGAGGA ACATCAACGT GAACAACAGC 
AAAGGCAGCA TGTCAGCAGA GAAGATTCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028313.1
CDS	82..774
Translation	MLRDISLEAHGLGSTLTPLLAHQLPQGRVRGYSSQPTTTQTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERSSSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSESCSTANGEKDSITLISMRNINVNNSKGSMSAEKIL

Target ORF information:

RefSeq Version	NM_001033141.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033141.2

ORF Insert Sequence:

ATGCTTCGAG ACATTTCTCT GGAAGCCCAC GGGCTGGGGT CAACACTGAC ACCCCTTCTT 
GCCCATCAAC TCCCACAGGG GAGAGTCAGA GGCTACAGCT CTCAACCTAC GACAACTCAG 
ACCTCGCAGG AAATTCTACA GAAGTCTTCT CAGGTCTCCT TGGTATCCAA TCAGCCTGTG 
ACACCAAGGT CAAGCACCAT GGATAAACAG TCCCTTTCCT TGCCTGACTT GATGTCCTTC 
CAGCCACAGA AGCACACACT GGGACCTGGC ACAGGAACCC CAGAAAGGAG CAGCAGCAGC 
AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA GCATCTCTGG ATGCTACTCC CAGTCCAGAA 
ACCACCAGCC TTCAGACAAA AAAGATGACC ATCCTGCTGA CCATCCTGCC TACCCCCACA 
TCAGAGTCAG TGCTAACTGT GGCTGCCTTT GGTGTCATCA GCTTCATTGT CATCCTGGTG 
GTTGTAGTGA TCATCCTGGT CAGTGTGGTC AGTCTAAGAT TTAAGTGTCG GAAGAACAAG 
GAGTCTGAAG ATCCACAGAA ACCAGGGAGT TCAGGGCTGT CTGAAAGCTG CTCCACAGCC 
AATGGAGAGA AAGACAGCAT CACACTCATC TCCATGAGGA ACATCAACGT GAACAACAGC 
AAAGGCAGCA TGTCAGCAGA GAAGATTCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ecscr ( NM_001033141.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028313.1 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), mRNA.

Price & Availability↑

CloneID	OMu17828
Clone ID Related Accession (Same CDS sequence)	NM_001033141.2 , NM_001033141.1
Accession Version	NM_001033141.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK157485.1. On Sep 16, 2005 this sequence version replaced XM_358515.3. ##Evidence-Data-START## Transcript exon combination :: AK157485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCTTCGAG ACATTTCTCT GGAAGCCCAC GGGCTGGGGT CAACACTGAC ACCCCTTCTT 
GCCCATCAAC TCCCACAGGG GAGAGTCAGA GGCTACAGCT CTCAACCTAC GACAACTCAG 
ACCTCGCAGG AAATTCTACA GAAGTCTTCT CAGGTCTCCT TGGTATCCAA TCAGCCTGTG 
ACACCAAGGT CAAGCACCAT GGATAAACAG TCCCTTTCCT TGCCTGACTT GATGTCCTTC 
CAGCCACAGA AGCACACACT GGGACCTGGC ACAGGAACCC CAGAAAGGAG CAGCAGCAGC 
AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA GCATCTCTGG ATGCTACTCC CAGTCCAGAA 
ACCACCAGCC TTCAGACAAA AAAGATGACC ATCCTGCTGA CCATCCTGCC TACCCCCACA 
TCAGAGTCAG TGCTAACTGT GGCTGCCTTT GGTGTCATCA GCTTCATTGT CATCCTGGTG 
GTTGTAGTGA TCATCCTGGT CAGTGTGGTC AGTCTAAGAT TTAAGTGTCG GAAGAACAAG 
GAGTCTGAAG ATCCACAGAA ACCAGGGAGT TCAGGGCTGT CTGAAAGCTG CTCCACAGCC 
AATGGAGAGA AAGACAGCAT CACACTCATC TCCATGAGGA ACATCAACGT GAACAACAGC 
AAAGGCAGCA TGTCAGCAGA GAAGATTCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028313.1
CDS	82..774
Translation	MLRDISLEAHGLGSTLTPLLAHQLPQGRVRGYSSQPTTTQTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERSSSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSESCSTANGEKDSITLISMRNINVNNSKGSMSAEKIL

Target ORF information:

RefSeq Version	NM_001033141.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033141.1

ORF Insert Sequence:

ATGCTTCGAG ACATTTCTCT GGAAGCCCAC GGGCTGGGGT CAACACTGAC ACCCCTTCTT 
GCCCATCAAC TCCCACAGGG GAGAGTCAGA GGCTACAGCT CTCAACCTAC GACAACTCAG 
ACCTCGCAGG AAATTCTACA GAAGTCTTCT CAGGTCTCCT TGGTATCCAA TCAGCCTGTG 
ACACCAAGGT CAAGCACCAT GGATAAACAG TCCCTTTCCT TGCCTGACTT GATGTCCTTC 
CAGCCACAGA AGCACACACT GGGACCTGGC ACAGGAACCC CAGAAAGGAG CAGCAGCAGC 
AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA GCATCTCTGG ATGCTACTCC CAGTCCAGAA 
ACCACCAGCC TTCAGACAAA AAAGATGACC ATCCTGCTGA CCATCCTGCC TACCCCCACA 
TCAGAGTCAG TGCTAACTGT GGCTGCCTTT GGTGTCATCA GCTTCATTGT CATCCTGGTG 
GTTGTAGTGA TCATCCTGGT CAGTGTGGTC AGTCTAAGAT TTAAGTGTCG GAAGAACAAG 
GAGTCTGAAG ATCCACAGAA ACCAGGGAGT TCAGGGCTGT CTGAAAGCTG CTCCACAGCC 
AATGGAGAGA AAGACAGCAT CACACTCATC TCCATGAGGA ACATCAACGT GAACAACAGC 
AAAGGCAGCA TGTCAGCAGA GAAGATTCTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ecscr ( XM_006526210.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006526273.2 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu70278
Clone ID Related Accession (Same CDS sequence)	XM_006526210.2
Accession Version	XM_006526210.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006526210.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAGCT GGTGGGTAGA ACTTAGAGCT GGGTCCTTGG AGACAAGCGT CTGCAACAGT 
AGGCTTTGGG GAAACGCAGG TGCTGCAGGG AAGGACCTGA AGGGTCCCTC AGAGAGGAAG 
GAAGCTCCTG GAGAGCCAGC CCCCGCCCCT GCCCCCGCCC CATCTCACCC CAGTACTCCC 
TCTCTCTTCT CTACTATGGA CAGAGAATAC ACTGAGGAGC CTGCTACACA CCCAGCTGAT 
CTGGGGACCA GCGGAGCCAT GAGGCTGGGT TCAGCAATTC TCGGTTTACT CCTGCTCCAA 
GGCTACAGCT CTCAACCTAC GACAACTCAG ACCTCGCAGG AAATTCTACA GAAGTCTTCT 
CAGGTCTCCT TGGTATCCAA TCAGCCTGTG ACACCAAGGT CAAGCACCAT GGATAAACAG 
TCCCTTTCCT TGCCTGACTT GATGTCCTTC CAGCCACAGA AGCACACACT GGGACCTGGC 
ACAGGAACCC CAGAAAGGAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA 
GCATCTCTGG ATGCTACTCC CAGTCCAGAA ACCACCAGCC TTCAGACAAA AAAGATGACC 
ATCCTGCTGA CCATCCTGCC TACCCCCACA TCAGAGTCAG TGCTAACTGT GGCTGCCTTT 
GGTGTCATCA GCTTCATTGT CATCCTGGTG GTTGTAGTGA TCATCCTGGT CAGTGTGGTC 
AGTCTAAGAT TTAAGTGTCG GAAGAACAAG GAGTCTGAAG ATCCACAGAA ACCAGGGAGT 
TCAGGGCTGT CTGAAAGCTG CTCCACAGCC AATGGAGAGA AAGACAGCAT CACACTCATC 
TCCATGAGGA ACATCAACGT GAACAACAGC AAAGGCAGCA TGTCAGCAGA GAAGATTCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006526273.2
CDS	16..918
Translation	MGSWWVELRAGSLETSVCNSRLWGNAGAAGKDLKGPSERKEAPGEPAPAPAPAPSHPSTPSLFSTMDREYTEEPATHPADLGTSGAMRLGSAILGLLLLQGYSSQPTTTQTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERSSSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSESCSTANGEKDSITLISMRNINVNNSKGSMSAEKIL

Target ORF information:

RefSeq Version	XM_006526210.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006526210.2

ORF Insert Sequence:

ATGGGCAGCT GGTGGGTAGA ACTTAGAGCT GGGTCCTTGG AGACAAGCGT CTGCAACAGT 
AGGCTTTGGG GAAACGCAGG TGCTGCAGGG AAGGACCTGA AGGGTCCCTC AGAGAGGAAG 
GAAGCTCCTG GAGAGCCAGC CCCCGCCCCT GCCCCCGCCC CATCTCACCC CAGTACTCCC 
TCTCTCTTCT CTACTATGGA CAGAGAATAC ACTGAGGAGC CTGCTACACA CCCAGCTGAT 
CTGGGGACCA GCGGAGCCAT GAGGCTGGGT TCAGCAATTC TCGGTTTACT CCTGCTCCAA 
GGCTACAGCT CTCAACCTAC GACAACTCAG ACCTCGCAGG AAATTCTACA GAAGTCTTCT 
CAGGTCTCCT TGGTATCCAA TCAGCCTGTG ACACCAAGGT CAAGCACCAT GGATAAACAG 
TCCCTTTCCT TGCCTGACTT GATGTCCTTC CAGCCACAGA AGCACACACT GGGACCTGGC 
ACAGGAACCC CAGAAAGGAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG GAGAGGAGAA 
GCATCTCTGG ATGCTACTCC CAGTCCAGAA ACCACCAGCC TTCAGACAAA AAAGATGACC 
ATCCTGCTGA CCATCCTGCC TACCCCCACA TCAGAGTCAG TGCTAACTGT GGCTGCCTTT 
GGTGTCATCA GCTTCATTGT CATCCTGGTG GTTGTAGTGA TCATCCTGGT CAGTGTGGTC 
AGTCTAAGAT TTAAGTGTCG GAAGAACAAG GAGTCTGAAG ATCCACAGAA ACCAGGGAGT 
TCAGGGCTGT CTGAAAGCTG CTCCACAGCC AATGGAGAGA AAGACAGCAT CACACTCATC 
TCCATGAGGA ACATCAACGT GAACAACAGC AAAGGCAGCA TGTCAGCAGA GAAGATTCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ecscr ( NM_001368651.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001355580.1 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu84507
Clone ID Related Accession (Same CDS sequence)	NM_001368651.1
Accession Version	NM_001368651.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132837.11 and CX567856.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.4123293.1, SRR7345562.2073218.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAATT CTACAGAAGT CTTCTCAGGT CTCCTTGGTA 
TCCAATCAGC CTGTGACACC AAGGTCAAGC ACCATGGATA AACAGTCCCT TTCCTTGCCT 
GACTTGATGT CCTTCCAGCC ACAGAAGCAC ACACTGGGAC CTGGCACAGG AACCCCAGAA 
AGGAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGGAGAG GAGAAGCATC TCTGGATGCT 
ACTCCCAGTC CAGAAACCAC CAGCCTTCAG ACAAAAAAGA TGACCATCCT GCTGACCATC 
CTGCCTACCC CCACATCAGA GTCAGTGCTA ACTGTGGCTG CCTTTGGTGT CATCAGCTTC 
ATTGTCATCC TGGTGGTTGT AGTGATCATC CTGGTCAGTG TGGTCAGTCT AAGATTTAAG 
TGTCGGAAGA ACAAGGAGTC TGAAGATCCA CAGAAACCAG GGAGTTCAGG GCTGTCTGAA 
AGCTGCTCCA CAGCCAATGG AGAGAAAGAC AGCATCACAC TCATCTCCAT GAGGAACATC 
AACGTGAACA ACAGCAAAGG CAGCATGTCA GCAGAGAAGA TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355580.1
CDS	25..732
Translation	MDREYTEEPATHPADLGTSGAMRLGSAILGLLLLQGYSSQPTTTQTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERSSSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSESCSTANGEKDSITLISMRNINVNNSKGSMSAEKIL

Target ORF information:

RefSeq Version	NM_001368651.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001368651.1

ORF Insert Sequence:

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAATT CTACAGAAGT CTTCTCAGGT CTCCTTGGTA 
TCCAATCAGC CTGTGACACC AAGGTCAAGC ACCATGGATA AACAGTCCCT TTCCTTGCCT 
GACTTGATGT CCTTCCAGCC ACAGAAGCAC ACACTGGGAC CTGGCACAGG AACCCCAGAA 
AGGAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGGAGAG GAGAAGCATC TCTGGATGCT 
ACTCCCAGTC CAGAAACCAC CAGCCTTCAG ACAAAAAAGA TGACCATCCT GCTGACCATC 
CTGCCTACCC CCACATCAGA GTCAGTGCTA ACTGTGGCTG CCTTTGGTGT CATCAGCTTC 
ATTGTCATCC TGGTGGTTGT AGTGATCATC CTGGTCAGTG TGGTCAGTCT AAGATTTAAG 
TGTCGGAAGA ACAAGGAGTC TGAAGATCCA CAGAAACCAG GGAGTTCAGG GCTGTCTGAA 
AGCTGCTCCA CAGCCAATGG AGAGAAAGAC AGCATCACAC TCATCTCCAT GAGGAACATC 
AACGTGAACA ACAGCAAAGG CAGCATGTCA GCAGAGAAGA TTCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ecscr ( NM_001368652.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001355581.1 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 2, mRNA.

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CloneID	OMu84519
Clone ID Related Accession (Same CDS sequence)	NM_001368652.1
Accession Version	NM_001368652.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-14
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132837.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.2381101.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAATT CTACAGAAGT CTTCTCAGGT CTCCTTGGTA 
TCCAATCAGC CTGTGACACC AAGGTCAAGC ACCATGGATA AACAGTCCCT TTCCTTGCCT 
GACTTGATGT CCTTCCAGCC ACAGAAGCAC ACACTGGGAC CTGGCACAGG AACCCCAGAA 
AGGAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGGAGAG GAGAAGCATC TCTGGATGCT 
ACTCCCAGTC CAGAAACCAC CAGCCTTCAG ACAAAAAAGA TGACCATCCT GCTGACCATC 
CTGCCTACCC CCACATCAGA GTCAGTGCTA ACTGTGGCTG CCTTTGGTGT CATCAGCTTC 
ATTGTCATCC TGGTGGTTGT AGTGATCATC CTGGTCAGTG TGGTCAGTCT AAGATTTAAG 
TGTCGGAAGA ACAAGGAGTC TGAAGATCCA CAGAAACCAG GGAGTTCAGG GCTGTCTGAA 
AGATTCTTTA AGAGTGACCT GGAGTCGCCA TGGGTCCACG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355581.1
CDS	25..669
Translation	MDREYTEEPATHPADLGTSGAMRLGSAILGLLLLQGYSSQPTTTQTSQEILQKSSQVSLVSNQPVTPRSSTMDKQSLSLPDLMSFQPQKHTLGPGTGTPERSSSSSSSSSSRRGEASLDATPSPETTSLQTKKMTILLTILPTPTSESVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSERFFKSDLESPWVHV

Target ORF information:

RefSeq Version	NM_001368652.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001368652.1

ORF Insert Sequence:

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAATT CTACAGAAGT CTTCTCAGGT CTCCTTGGTA 
TCCAATCAGC CTGTGACACC AAGGTCAAGC ACCATGGATA AACAGTCCCT TTCCTTGCCT 
GACTTGATGT CCTTCCAGCC ACAGAAGCAC ACACTGGGAC CTGGCACAGG AACCCCAGAA 
AGGAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGGAGAG GAGAAGCATC TCTGGATGCT 
ACTCCCAGTC CAGAAACCAC CAGCCTTCAG ACAAAAAAGA TGACCATCCT GCTGACCATC 
CTGCCTACCC CCACATCAGA GTCAGTGCTA ACTGTGGCTG CCTTTGGTGT CATCAGCTTC 
ATTGTCATCC TGGTGGTTGT AGTGATCATC CTGGTCAGTG TGGTCAGTCT AAGATTTAAG 
TGTCGGAAGA ACAAGGAGTC TGAAGATCCA CAGAAACCAG GGAGTTCAGG GCTGTCTGAA 
AGATTCTTTA AGAGTGACCT GGAGTCGCCA TGGGTCCACG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ecscr ( XM_030250592.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030106452.1 Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu87429
Clone ID Related Accession (Same CDS sequence)	XM_030250592.1
Accession Version	XM_030250592.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	endothelial cell-specific chemotaxis regulator isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAGAC AGATCTTCCT CAGAGCCTGG CGGCCCGGGG 
CTTTGGCTCA GCACTGTTAC CCTAGGTACT CAGCTGCTGA GACTGCTGAT AGTGGCCTGC 
AAAGGCCCCG GAGGAGCAAG ACGCAGTTTG GGCTCTGCAG GAGGATGCAG AGCCTGTGGC 
AGAAGGGACA GGCAAACAGG GCCTCACACT GGTGATTCCA GAGCAAGGGA GCAGGAACAA 
GTGTCACTGG GCCCATCTGG ATGTCAGCCT CTTCAGACGT CATCTCTGGG GCCCTTCCTA 
TGGGAACTGA GAACAGCCCA GAGACCCGAG CCAGCAAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030106452.1
CDS	65..529
Translation	MDREYTEEPATHPADLGTSGAMRLGSAILGLLLLQGYSSQPTTTQTSQEDRSSSEPGGPGLWLSTVTLGTQLLRLLIVACKGPGGARRSLGSAGGCRACGRRDRQTGPHTGDSRAREQEQVSLGPSGCQPLQTSSLGPFLWELRTAQRPEPAKE

Target ORF information:

RefSeq Version	XM_030250592.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus endothelial cell surface expressed chemotaxis and apoptosis regulator (Ecscr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030250592.1

ORF Insert Sequence:

ATGGACAGAG AATACACTGA GGAGCCTGCT ACACACCCAG CTGATCTGGG GACCAGCGGA 
GCCATGAGGC TGGGTTCAGC AATTCTCGGT TTACTCCTGC TCCAAGGCTA CAGCTCTCAA 
CCTACGACAA CTCAGACCTC GCAGGAAGAC AGATCTTCCT CAGAGCCTGG CGGCCCGGGG 
CTTTGGCTCA GCACTGTTAC CCTAGGTACT CAGCTGCTGA GACTGCTGAT AGTGGCCTGC 
AAAGGCCCCG GAGGAGCAAG ACGCAGTTTG GGCTCTGCAG GAGGATGCAG AGCCTGTGGC 
AGAAGGGACA GGCAAACAGG GCCTCACACT GGTGATTCCA GAGCAAGGGA GCAGGAACAA 
GTGTCACTGG GCCCATCTGG ATGTCAGCCT CTTCAGACGT CATCTCTGGG GCCCTTCCTA 
TGGGAACTGA GAACAGCCCA GAGACCCGAG CCAGCAAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Loss of apoptosis regulator through modulating IAP expression (ARIA) protects blood vessels from atherosclerosis.
The Journal of biological chemistry290(6)3784-92(2015 Feb)
Matsuo K,Akakabe Y,Kitamura Y,Shimoda Y,Ono K,Ueyama T,Matoba S,Yamada H,Hatakeyama K,Asada Y,Emoto N,Ikeda K

Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway.
PloS one10(12)e0144185(2015)
Kilari S,Cossette S,Pooya S,Bordas M,Huang YW,Ramchandran R,Wilkinson GA

Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
The Journal of biological chemistry289(5)2788-800(2014 Jan)
Kitamura Y,Koide M,Akakabe Y,Matsuo K,Shimoda Y,Soma Y,Ogata T,Ueyama T,Matoba S,Yamada H,Ikeda K

Ecscr regulates insulin sensitivity and predisposition to obesity by modulating endothelial cell functions.
Nature communications42389(2013)
Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

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Ecscr cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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