Aph1c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aph1c
Entrez Gene ID	68318
Full Name	aph1 homolog C, gamma secretase subunit
Synonyms	0610008A10Rik,APH-1b,Aph1b
General protein information	Preferred Names aph1 homolog C, gamma secretase subunit Names putative gamma-secretase subunit APH-1C anterior pharynx defective 1b anterior pharynx defective 1c homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006511398.3	XP_006511461.1	putative gamma-secretase subunit APH-1C isoform X1
XM_006511398.4	XP_006511461.1	putative gamma-secretase subunit APH-1C isoform X1
NM_026674.3	NP_080950.1	putative gamma-secretase subunit APH-1C

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	RGD1559979	XP_003750580.1
Mus musculus (house mouse)	Aph1c	NP_080950.1
Rattus norvegicus (Norway rat)	Aph1b	NP_001040555.1

Gene Ontology
Bibliography

Related articles in PubMed

Inactivation of ?-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.
Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, M?ller U, Ch?vez-Guti?rrez L, De Strooper B
EMBO molecular medicine9(8)1088-1099(2017 Aug)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Deletion of the ?-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.
Biundo F, Ishiwari K, Del Prete D, D'Adamio L
Oncotarget7(11)11923-44(2016 Mar)

Antagonistic Effects of BACE1 and APH1B-?-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Bar?o S, G?rtner A, Leyva-D?az E, Demyanenko G, Munck S, Vanhoutvin T, Zhou L, Schachner M, L?pez-Bendito G, Maness PF, De Strooper B
Cell reports12(9)1367-76(2015 Sep)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of Aph1C is associated with memory deficit.
Title: Deletion of the ?-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.

the Aph1B/C-gamma-secretase complex is expressed in brain areas relevant to schizophrenia pathogenesis and that Aph1B/C deficiency causes pharmacological and behavioral abnormalities that can be reversed by antipsychotic drugs
Title: Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.

The following Aph1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aph1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02795	NM_026674.3 Latest version!	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu42946	XM_006511398.4 Latest version!	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu42946	XM_006511398.3	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aph1c ( NM_026674.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080950.1 Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), mRNA.

Price & Availability↑

CloneID	OMu02795
Clone ID Related Accession (Same CDS sequence)	NM_026674.3
Accession Version	NM_026674.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	putative gamma-secretase subunit APH-1C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC142504.2. On Nov 17, 2006 this sequence version replaced NM_026674.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050923.1, AK155147.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGACGCTGC CTGTGTTCTT CGGTTGCGCC TTCATCGCCT TCGGGCCCGC GTTCGCACTC 
TACCTCTTCA CCATCGCCAC CGACCCTTTG CGCGTCATTT TCCTCATCGC TGGTGCTTTC 
TTCTGGTTGG TGTCTCTCCT GCTTTCGTCC ATGTTTTGGT TCCTAGTGAG AGTCATTACT 
AACAACAGAG ATGAATCAGT ACAGAATTAT CTGCTCATCT TCGGAGCGTT GCTCTCTGTC 
TGTATCCAAG AGCTGTTCAG GCTCGCATAT TATAAGCTGT TAAAAAAAGC CAGTGAGGGT 
TTGAAAAGCA TAAACCCGGA GGAGGACATA GCACCCTCGA TGCGACTGTT GGCGTATGTT 
TCTGGCTTGG GCTTTGGAAT CATGAGTGGA GTGTTTTCCT TTGTGAACAC CCTGTCTAAC 
TCCTTGGGGC CAGGCACAGT GGGCATTCAT GGTGATTCTC CTCAGTTCTT CCTTAATTCA 
GCTTTCATGA CACTGGTCGT CATAATGCTG CACGTGTTCT GGGGCGTTGT GTTCTTTGAT 
GGCTGTGAGA AGAATAAGTG GTACACCCTC CTCACGGTTC TCCTGACGCA TCTGGTGGTG 
TCCACCCAGA CTTTTCTAAG TCCTTATTAT GAAGTGAATC TGGTAACAGC ATATATAATC 
ATGGTGCTCA TGGGCATCTG GGCATTTTAT GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA 
TTCTGCCTGC TCTGCCAAGA CAAGGATTTT CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080950.1
CDS	109..885
Translation	MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDIAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKDFLLYNQRSR

Target ORF information:

RefSeq Version	NM_026674.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026674.3

ORF Insert Sequence:

ATGACGCTGC CTGTGTTCTT CGGTTGCGCC TTCATCGCCT TCGGGCCCGC GTTCGCACTC 
TACCTCTTCA CCATCGCCAC CGACCCTTTG CGCGTCATTT TCCTCATCGC TGGTGCTTTC 
TTCTGGTTGG TGTCTCTCCT GCTTTCGTCC ATGTTTTGGT TCCTAGTGAG AGTCATTACT 
AACAACAGAG ATGAATCAGT ACAGAATTAT CTGCTCATCT TCGGAGCGTT GCTCTCTGTC 
TGTATCCAAG AGCTGTTCAG GCTCGCATAT TATAAGCTGT TAAAAAAAGC CAGTGAGGGT 
TTGAAAAGCA TAAACCCGGA GGAGGACATA GCACCCTCGA TGCGACTGTT GGCGTATGTT 
TCTGGCTTGG GCTTTGGAAT CATGAGTGGA GTGTTTTCCT TTGTGAACAC CCTGTCTAAC 
TCCTTGGGGC CAGGCACAGT GGGCATTCAT GGTGATTCTC CTCAGTTCTT CCTTAATTCA 
GCTTTCATGA CACTGGTCGT CATAATGCTG CACGTGTTCT GGGGCGTTGT GTTCTTTGAT 
GGCTGTGAGA AGAATAAGTG GTACACCCTC CTCACGGTTC TCCTGACGCA TCTGGTGGTG 
TCCACCCAGA CTTTTCTAAG TCCTTATTAT GAAGTGAATC TGGTAACAGC ATATATAATC 
ATGGTGCTCA TGGGCATCTG GGCATTTTAT GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA 
TTCTGCCTGC TCTGCCAAGA CAAGGATTTT CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aph1c ( XM_006511398.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006511461.1 Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu42946
Clone ID Related Accession (Same CDS sequence)	XM_006511398.3 , XM_006511398.4
Accession Version	XM_006511398.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	putative gamma-secretase subunit APH-1C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006511398.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTGGT TCCTAGTGAG AGTCATTACT AACAACAGAG ATGAATCAGT ACAGAATTAT 
CTGCTCATCT TCGGAGCGTT GCTCTCTGTC TGTATCCAAG AGCTGTTCAG GCTCGCATAT 
TATAAGCTGT TAAAAAAAGC CAGTGAGGGT TTGAAAAGCA TAAACCCGGA GGAGGACATA 
GCACCCTCGA TGCGACTGTT GGCGTATGTT TCTGGCTTGG GCTTTGGAAT CATGAGTGGA 
GTGTTTTCCT TTGTGAACAC CCTGTCTAAC TCCTTGGGGC CAGGCACAGT GGGCATTCAT 
GGTGATTCTC CTCAGTTCTT CCTTAATTCA GCTTTCATGA CACTGGTCGT CATAATGCTG 
CACGTGTTCT GGGGCGTTGT GTTCTTTGAT GGCTGTGAGA AGAATAAGTG GTACACCCTC 
CTCACGGTTC TCCTGACGCA TCTGGTGGTG TCCACCCAGA CTTTTCTAAG TCCTTATTAT 
GAAGTGAATC TGGTAACAGC ATATATAATC ATGGTGCTCA TGGGCATCTG GGCATTTTAT 
GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA TTCTGCCTGC TCTGCCAAGA CAAGGATTTT 
CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006511461.1
CDS	798..1424
Translation	MFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDIAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKDFLLYNQRSR

Target ORF information:

RefSeq Version	XM_006511398.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006511398.3

ORF Insert Sequence:

ATGTTTTGGT TCCTAGTGAG AGTCATTACT AACAACAGAG ATGAATCAGT ACAGAATTAT 
CTGCTCATCT TCGGAGCGTT GCTCTCTGTC TGTATCCAAG AGCTGTTCAG GCTCGCATAT 
TATAAGCTGT TAAAAAAAGC CAGTGAGGGT TTGAAAAGCA TAAACCCGGA GGAGGACATA 
GCACCCTCGA TGCGACTGTT GGCGTATGTT TCTGGCTTGG GCTTTGGAAT CATGAGTGGA 
GTGTTTTCCT TTGTGAACAC CCTGTCTAAC TCCTTGGGGC CAGGCACAGT GGGCATTCAT 
GGTGATTCTC CTCAGTTCTT CCTTAATTCA GCTTTCATGA CACTGGTCGT CATAATGCTG 
CACGTGTTCT GGGGCGTTGT GTTCTTTGAT GGCTGTGAGA AGAATAAGTG GTACACCCTC 
CTCACGGTTC TCCTGACGCA TCTGGTGGTG TCCACCCAGA CTTTTCTAAG TCCTTATTAT 
GAAGTGAATC TGGTAACAGC ATATATAATC ATGGTGCTCA TGGGCATCTG GGCATTTTAT 
GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA TTCTGCCTGC TCTGCCAAGA CAAGGATTTT 
CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aph1c ( XM_006511398.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006511461.1 Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu42946
Clone ID Related Accession (Same CDS sequence)	XM_006511398.3 , XM_006511398.4
Accession Version	XM_006511398.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	putative gamma-secretase subunit APH-1C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006511398.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTGGT TCCTAGTGAG AGTCATTACT AACAACAGAG ATGAATCAGT ACAGAATTAT 
CTGCTCATCT TCGGAGCGTT GCTCTCTGTC TGTATCCAAG AGCTGTTCAG GCTCGCATAT 
TATAAGCTGT TAAAAAAAGC CAGTGAGGGT TTGAAAAGCA TAAACCCGGA GGAGGACATA 
GCACCCTCGA TGCGACTGTT GGCGTATGTT TCTGGCTTGG GCTTTGGAAT CATGAGTGGA 
GTGTTTTCCT TTGTGAACAC CCTGTCTAAC TCCTTGGGGC CAGGCACAGT GGGCATTCAT 
GGTGATTCTC CTCAGTTCTT CCTTAATTCA GCTTTCATGA CACTGGTCGT CATAATGCTG 
CACGTGTTCT GGGGCGTTGT GTTCTTTGAT GGCTGTGAGA AGAATAAGTG GTACACCCTC 
CTCACGGTTC TCCTGACGCA TCTGGTGGTG TCCACCCAGA CTTTTCTAAG TCCTTATTAT 
GAAGTGAATC TGGTAACAGC ATATATAATC ATGGTGCTCA TGGGCATCTG GGCATTTTAT 
GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA TTCTGCCTGC TCTGCCAAGA CAAGGATTTT 
CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006511461.1
CDS	375..1001
Translation	MFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDIAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKDFLLYNQRSR

Target ORF information:

RefSeq Version	XM_006511398.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus aph1 homolog C, gamma secretase subunit (Aph1c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006511398.4

ORF Insert Sequence:

ATGTTTTGGT TCCTAGTGAG AGTCATTACT AACAACAGAG ATGAATCAGT ACAGAATTAT 
CTGCTCATCT TCGGAGCGTT GCTCTCTGTC TGTATCCAAG AGCTGTTCAG GCTCGCATAT 
TATAAGCTGT TAAAAAAAGC CAGTGAGGGT TTGAAAAGCA TAAACCCGGA GGAGGACATA 
GCACCCTCGA TGCGACTGTT GGCGTATGTT TCTGGCTTGG GCTTTGGAAT CATGAGTGGA 
GTGTTTTCCT TTGTGAACAC CCTGTCTAAC TCCTTGGGGC CAGGCACAGT GGGCATTCAT 
GGTGATTCTC CTCAGTTCTT CCTTAATTCA GCTTTCATGA CACTGGTCGT CATAATGCTG 
CACGTGTTCT GGGGCGTTGT GTTCTTTGAT GGCTGTGAGA AGAATAAGTG GTACACCCTC 
CTCACGGTTC TCCTGACGCA TCTGGTGGTG TCCACCCAGA CTTTTCTAAG TCCTTATTAT 
GAAGTGAATC TGGTAACAGC ATATATAATC ATGGTGCTCA TGGGCATCTG GGCATTTTAT 
GTTGCTGGAG GCAGCTGCCG AAGCCTGAAA TTCTGCCTGC TCTGCCAAGA CAAGGATTTT 
CTTCTTTACA ACCAACGCTC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inactivation of ?-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.
EMBO molecular medicine9(8)1088-1099(2017 Aug)
Acx H,Serneels L,Radaelli E,Muyldermans S,Vincke C,Pepermans E,M?ller U,Ch?vez-Guti?rrez L,De Strooper B

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Deletion of the ?-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.
Oncotarget7(11)11923-44(2016 Mar)
Biundo F,Ishiwari K,Del Prete D,D'Adamio L

Antagonistic Effects of BACE1 and APH1B-?-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Cell reports12(9)1367-76(2015 Sep)
Bar?o S,G?rtner A,Leyva-D?az E,Demyanenko G,Munck S,Vanhoutvin T,Zhou L,Schachner M,L?pez-Bendito G,Maness PF,De Strooper B

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Aph1c cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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