Leprotl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Leprotl1
Entrez Gene ID	68192
Full Name	leptin receptor overlapping transcript-like 1
Synonyms	1110067H13Rik,1520402O14Rik,AI854296
General protein information	Preferred Names leptin receptor overlapping transcript-like 1 Names leptin receptor overlapping transcript-like 1 endospanin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_026609.2	NP_080885.1	leptin receptor overlapping transcript-like 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LEPROTL1	XP_528101.3
Rattus norvegicus (Norway rat)	Leprotl1	NP_001013206.1
Danio rerio (zebrafish)	zgc:92045	NP_001002390.2
Caenorhabditis elegans (roundworm)	C30B5.2	NP_495239.2
Canis lupus familiaris (dog)	LEPROTL1	XP_532817.1
Xenopus tropicalis (tropical clawed frog)	LOC100486533	XP_002936499.2
	LEPROTL1	XP_002805353.1
Bos taurus (cattle)	LEPROTL1	NP_001032539.1
Gallus gallus (chicken)	LEPROTL1	XP_420582.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008693	XP_001237600.2
Mus musculus (house mouse)	Leprotl1	NP_080885.1
Homo sapiens (human)	LEPROTL1	NP_056159.2

Gene Ontology
Bibliography

Related articles in PubMed

Glucose tolerance female-specific QTL mapped in collaborative cross mice.
Abu-Toamih Atamni HJ, Ziner Y, Mott R, Wolf L, Iraqi FA
Mammalian genome : official journal of the International Mammalian Genome Society28(1-2)20-30(2017 Feb)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.
Wu S, Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F
The Journal of biological chemistry288(38)27375-83(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
Title: Glucose tolerance female-specific QTL mapped in collaborative cross mice.

the increased expression of FGF21 during chronic undernutrition inhibits GH action on chondrocytes by activating LEPROT and LEPROTL1.
Title: Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.

both LEPROT and LEPROTL1 expression were regulated in liver by physiologic and pathologic changes in glucose homeostasis
Title: LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.

The following Leprotl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Leprotl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02665	NM_026609.2 Latest version!	Mus musculus leptin receptor overlapping transcript-like 1 (Leprotl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Leprotl1 ( NM_026609.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080885.1 Mus musculus leptin receptor overlapping transcript-like 1 (Leprotl1), mRNA.

Price & Availability↑

CloneID	OMu02665
Clone ID Related Accession (Same CDS sequence)	NM_026609.2
Accession Version	NM_026609.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	leptin receptor overlapping transcript-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC004677.1. On Jun 9, 2003 this sequence version replaced NM_026609.1. ##Evidence-Data-START## Transcript exon combination :: BC004677.1, AK150289.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849385, SAMN00849386 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGCA TCAAAGCTTT AATTAGTTTG TCCTTTGGAG GAGCGATCGG GCTGATGTTC 
CTGATGCTTG GATGTGCCCT TCCGATATAC AACCAATACT GGCCCCTCTT CGTTCTCTTC 
TTTTACATCC TCTCGCCCAT CCCGTACTGC ATAGCCAGAA GATTAGTGGA TGACACGGAC 
GCCATGAGCA ACGCGTGTAA GGAGCTTGCC ATATTCCTCA CCACAGGCAT CGTCGTCTCG 
GCTTTTGGAC TCCCTGTTGT GTTTGCCAGA GCACATCTGA TCGAGTGGGG AGCTTGCGCA 
CTTGTTCTCA CGGGAAACAC AGTCATCTTC GCGACTATTC TAGGCTTCTT CCTGGTCTTT 
GGAAGCAACG ACGACTTCAG CTGGCAGCAG TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080885.1
CDS	40..435
Translation	MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPVVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW

Target ORF information:

RefSeq Version	NM_026609.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leptin receptor overlapping transcript-like 1 (Leprotl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026609.2

ORF Insert Sequence:

ATGGCGGGCA TCAAAGCTTT AATTAGTTTG TCCTTTGGAG GAGCGATCGG GCTGATGTTC 
CTGATGCTTG GATGTGCCCT TCCGATATAC AACCAATACT GGCCCCTCTT CGTTCTCTTC 
TTTTACATCC TCTCGCCCAT CCCGTACTGC ATAGCCAGAA GATTAGTGGA TGACACGGAC 
GCCATGAGCA ACGCGTGTAA GGAGCTTGCC ATATTCCTCA CCACAGGCAT CGTCGTCTCG 
GCTTTTGGAC TCCCTGTTGT GTTTGCCAGA GCACATCTGA TCGAGTGGGG AGCTTGCGCA 
CTTGTTCTCA CGGGAAACAC AGTCATCTTC GCGACTATTC TAGGCTTCTT CCTGGTCTTT 
GGAAGCAACG ACGACTTCAG CTGGCAGCAG TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucose tolerance female-specific QTL mapped in collaborative cross mice.
Mammalian genome : official journal of the International Mammalian Genome Society28(1-2)20-30(2017 Feb)
Abu-Toamih Atamni HJ,Ziner Y,Mott R,Wolf L,Iraqi FA

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 1 (LEPROTL1) expression.
The Journal of biological chemistry288(38)27375-83(2013 Sep)
Wu S,Grunwald T,Kharitonenkov A,Dam J,Jockers R,De Luca F