Kdelr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kdelr1
Entrez Gene ID	68137
Full Name	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Synonyms	8030486F04Rik,AW215843,Erd2.1
General protein information	Preferred Names KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 Names ER lumen protein-retaining receptor 1 KDEL endoplasmic reticulum protein retention receptor 1 KDEL receptor 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133950.2	NP_598711.1	ER lumen protein-retaining receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	KDELR1	NP_006792.1
	KDELR1	XP_001113600.1
Eremothecium gossypii	AGOS_AGL323C	NP_986344.1
Schizosaccharomyces pombe (fission yeast)	erd2	NP_596529.1
Magnaporthe oryzae (rice blast fungus)	MGG_16126	XP_003709210.1
Bos taurus (cattle)	KDELR1	NP_001069963.1
Mus musculus (house mouse)	Kdelr1	NP_598711.1
Kluyveromyces lactis	KLLA0E05611g	XP_454199.1
Neurospora crassa	NCU06771	XP_963612.1
Oryza sativa (rice)	Os05g0529300	NP_001056121.1
Rattus norvegicus (Norway rat)	Kdelr1	NP_001017385.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012756	XP_307101.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010224	XP_319412.2
Canis lupus familiaris (dog)	KDELR1	XP_541521.2
Saccharomyces cerevisiae (baker's yeast)	ERD2	NP_009513.1
Arabidopsis thaliana (thale cress)	ERD2	NP_564326.1
Xenopus tropicalis (tropical clawed frog)	kdelr2	NP_001011046.1
Pan troglodytes (chimpanzee)	KDELR1	XP_001170972.1
Drosophila melanogaster (fruit fly)	KdelR	NP_723587.1

Gene Ontology
Bibliography

Related articles in PubMed

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.
Kamimura D, Arima Y, Tsuruoka M, Jiang JJ, Bando H, Meng J, Sabharwal L, Stofkova A, Nishikawa N, Higuchi K, Ogura H, Atsumi T, Murakami M
International immunology28(3)117-26(2016 Mar)

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.
Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ, Beutler B
Proceedings of the National Academy of Sciences of the United States of America112(42)E5706-14(2015 Oct)

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.
Kamimura D, Katsunuma K, Arima Y, Atsumi T, Jiang JJ, Bando H, Meng J, Sabharwal L, Stofkova A, Nishikawa N, Suzuki H, Ogura H, Ueda N, Tsuruoka M, Harada M, Kobayashi J, Hasegawa T, Yoshida H, Koseki H, Miura I, Wakana S, Nishida K, Kitamura H, Fukada T, Hirano T, Murakami M
Nature communications67474(2015 Jun)

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR
Proceedings of the National Academy of Sciences of the United States of America110(47)E4456-64(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In a mouse line having nonfunctional KDELR1, polyclonal naive T cells show excessive integrated stress responses, which are rescued by strong TCR-mediated signaling
Title: Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.

present a recessive mouse missense allele of the prototypical mammalian KDEL receptor, KDEL ER protein retention receptor 1 (KDELR1). Kdelr1 homozygous mutants were mildly lymphopenic, as were mice with a CRISPR/Cas9-engineered frameshift allele
Title: Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.

regulates naive T-cell homeostasis by controlling integrated stress responses
Title: KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.

dilated cardiomyopathy found in the mutant KDEL receptor transgenic mice is associated with ER stress
Title: Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice.

The following Kdelr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdelr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23581	NM_133950.2 Latest version!	Mus musculus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (Kdelr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kdelr1 ( NM_133950.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598711.1 Mus musculus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (Kdelr1), mRNA.

Price & Availability↑

CloneID	OMu23581
Clone ID Related Accession (Same CDS sequence)	NM_133950.2
Accession Version	NM_133950.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	ER lumen protein-retaining receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC149053.3. On Nov 17, 2006 this sequence version replaced NM_133950.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AJ278132.1, AK078785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAACCTCT TCCGATTCCT GGGAGACCTC TCCCACCTCC TAGCTATCAT CTTGTTACTG 
CTCAAAATCT GGAAGTCCCG ATCGTGTGCG GGCATTTCAG GGAAGAGCCA AGTCCTGTTT 
GCTGTGGTGT TCACTGCCCG ATATCTGGAC CTGTTCACCA ACTACATTTC ACTCTACAAC 
ACCTGCATGA AGGTGGTCTA CATAGCTTGT TCCTTTACCA CGGTGTGGAT GATCTACAGC 
AAGTTCAAAG CTACTTATGA TGGCAACCAC GACACTTTCC GGGTGGAGTT CCTCGTCGTT 
CCTACTGCTA TTTTGGCTTT CCTGGTCAAC CATGACTTCA CCCCTCTGGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCAGTGGCT ATCTTGCCAC AGTTGTTCAT GGTGAGCAAG 
ACGGGTGAGG CGGAGACCAT CACCAGCCAT TACCTGTTTG CACTGGGTGT CTACCGTACA 
CTCTATCTCT TCAATTGGAT CTGGCGCTAC CACTTCGAGG GCTTTTTTGA CCTCATCGCC 
ATCGTTGCTG GCCTGGTCCA GACAGTCCTC TACTGCGATT TCTTCTACCT CTATATCACC 
AAAGTCCTGA AGGGGAAGAA GCTGAGCTTG CCGGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598711.1
CDS	172..810
Translation	MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWMIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA

Target ORF information:

RefSeq Version	NM_133950.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (Kdelr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133950.2

ORF Insert Sequence:

ATGAACCTCT TCCGATTCCT GGGAGACCTC TCCCACCTCC TAGCTATCAT CTTGTTACTG 
CTCAAAATCT GGAAGTCCCG ATCGTGTGCG GGCATTTCAG GGAAGAGCCA AGTCCTGTTT 
GCTGTGGTGT TCACTGCCCG ATATCTGGAC CTGTTCACCA ACTACATTTC ACTCTACAAC 
ACCTGCATGA AGGTGGTCTA CATAGCTTGT TCCTTTACCA CGGTGTGGAT GATCTACAGC 
AAGTTCAAAG CTACTTATGA TGGCAACCAC GACACTTTCC GGGTGGAGTT CCTCGTCGTT 
CCTACTGCTA TTTTGGCTTT CCTGGTCAAC CATGACTTCA CCCCTCTGGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCAGTGGCT ATCTTGCCAC AGTTGTTCAT GGTGAGCAAG 
ACGGGTGAGG CGGAGACCAT CACCAGCCAT TACCTGTTTG CACTGGGTGT CTACCGTACA 
CTCTATCTCT TCAATTGGAT CTGGCGCTAC CACTTCGAGG GCTTTTTTGA CCTCATCGCC 
ATCGTTGCTG GCCTGGTCCA GACAGTCCTC TACTGCGATT TCTTCTACCT CTATATCACC 
AAAGTCCTGA AGGGGAAGAA GCTGAGCTTG CCGGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.
International immunology28(3)117-26(2016 Mar)
Kamimura D,Arima Y,Tsuruoka M,Jiang JJ,Bando H,Meng J,Sabharwal L,Stofkova A,Nishikawa N,Higuchi K,Ogura H,Atsumi T,Murakami M

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America112(42)E5706-14(2015 Oct)
Siggs OM,Popkin DL,Krebs P,Li X,Tang M,Zhan X,Zeng M,Lin P,Xia Y,Oldstone MB,Cornall RJ,Beutler B

KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.
Nature communications67474(2015 Jun)
Kamimura D,Katsunuma K,Arima Y,Atsumi T,Jiang JJ,Bando H,Meng J,Sabharwal L,Stofkova A,Nishikawa N,Suzuki H,Ogura H,Ueda N,Tsuruoka M,Harada M,Kobayashi J,Hasegawa T,Yoshida H,Koseki H,Miura I,Wakana S,Nishida K,Kitamura H,Fukada T,Hirano T,Murakami M

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America110(47)E4456-64(2013 Nov)
Rockich BE,Hrycaj SM,Shih HP,Nagy MS,Ferguson MA,Kopp JL,Sander M,Wellik DM,Spence JR

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Kdelr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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