Upf3b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Upf3b
Entrez Gene ID	68134
Full Name	UPF3 regulator of nonsense transcripts homolog B (yeast)
Synonyms	5730594O13Rik,AI317193,AW541158,RENT3B,UPF3X
General protein information	Preferred Names UPF3 regulator of nonsense transcripts homolog B (yeast) Names regulator of nonsense transcripts 3B hUPF3B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A3.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006541394.3	XP_006541457.1	regulator of nonsense transcripts 3B isoform X1
XM_006541394.4	XP_006541457.1	regulator of nonsense transcripts 3B isoform X1
XM_030251493.1	XP_030107353.1	regulator of nonsense transcripts 3B isoform X2
NM_026573.3	NP_080849.1	regulator of nonsense transcripts 3B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Upf3b	NP_080849.1
Homo sapiens (human)	UPF3B	NP_542199.1
	UPF3B	XP_001083072.1
Rattus norvegicus (Norway rat)	Upf3b	NP_001129345.1
Gallus gallus (chicken)	UPF3B	XP_003641170.1
Xenopus tropicalis (tropical clawed frog)	upf3b	XP_002940330.1
Pan troglodytes (chimpanzee)	UPF3B	XP_003954560.1
Canis lupus familiaris (dog)	UPF3B	XP_851843.1
Danio rerio (zebrafish)	upf3b	NP_957248.1

Gene Ontology
Bibliography

Related articles in PubMed

A Upf3b-mutant mouse model with behavioral and neurogenesis defects.
Huang L, Shum EY, Jones SH, Lou CH, Dumdie J, Kim H, Roberts AJ, Jolly LA, Espinoza JL, Skarbrevik DM, Phan MH, Cook-Andersen H, Swerdlow NR, Gecz J, Wilkinson MF
Molecular psychiatry(2017 Sep)

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.
Shum EY, Jones SH, Shao A, Dumdie J, Krause MD, Chan WK, Lou CH, Espinoza JL, Song HW, Phan MH, Ramaiah M, Huang L, McCarrey JR, Peterson KJ, De Rooij DG, Cook-Andersen H, Wilkinson MF
Cell165(2)382-95(2016 Apr)

The unfolded protein response is shaped by the NMD pathway.
Karam R, Lou CH, Kroeger H, Huang L, Lin JH, Wilkinson MF
EMBO reports16(5)599-609(2015 May)

Disorders with similar clinical phenotypes reveal underlying genetic interaction: SATB2 acts as an activator of the UPF3B gene.
Leoyklang P, Suphapeetiporn K, Srichomthong C, Tongkobpetch S, Fietze S, Dorward H, Cullinane AR, Gahl WA, Huizing M, Shotelersuk V
Human genetics132(12)1383-93(2013 Dec)

The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.
Jolly LA, Homan CC, Jacob R, Barry S, Gecz J
Human molecular genetics22(23)4673-87(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis revealed that UPF3A is a broadly acting nonsense-mediated RNA decay inhibitor. This discovery implies that UPF3A and UPF3B do not primarily work in a complementary or redundant manner as previously supposed; instead, they oppose each other, allowing this paralog pair to serve as a molecular rheostat to modulate the level of gene expression during development.
Title: The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.

Evidence suggests Upf3b-dependent nonsense-mediated mRNA decay is regulated at multiple levels during development including regulation of expression and sub-cellular localization of Upf3b.
Title: The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.

The following Upf3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Upf3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15708	NM_026573.3 Latest version!	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu55989	XM_006541394.4 Latest version!	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu90442	XM_030251493.1 Latest version!	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu55989	XM_006541394.3	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Upf3b ( NM_026573.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080849.1 Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), mRNA.

Price & Availability↑

CloneID	OMu15708
Clone ID Related Accession (Same CDS sequence)	NM_026573.3
Accession Version	NM_026573.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-17
Organism	Mus musculus(house mouse)
Product	regulator of nonsense transcripts 3B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK145431.1 and BC047049.1. On Sep 1, 2015 this sequence version replaced NM_026573.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.209501.1, AK145431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGTTG CTCAGGAAAC CGGAAAAAGG AGATGAAAAA 
GAACTTGATA AAAGAGACAA AACCAAGAGA CTGGACAAAG AAAATCTGAA TGAAGAAAGA 
GCCAGTGGGC ACAGTTATAC TCTGCCCAGG CGTTCTGATG TCGAACTGAA GGATGAAAAG 
CCAAAGAGGC TCGATGACGA GGGTGTCAGA GATTACAGAG ACAGGGACCG GGACTATGAG 
AGAGATCAGG AGCGCATGAT CCGAGAAAGA GAGAGGCTGA AGCGGCAAGA AGAAGAGCGC 
CGGCGGCAGC AGCAGAAAGA ACGCTATGAG AAAGAGAAGG CTTTTAAGCG AAAGGAAGAA 
GAAATGAAGA GAGAGAAAGA GGCACTTCGA GATAAAGGAA AGAAGAGTGA GAATACAGAA 
TCAATATGCT CATTAGAAAA AATTGAAAAA AAAGAGGAAG TGGTTAAGAG AGACCGCATA 
AGGAACAAGG ATCGTCCAGC CATGCAGCTT TACCAACCAG GAGCTCGAAG CCGAAGCCGA 
CTCTGTCCCG CCGATGACAG CATCAAGCCT GGAGATTCCC CAGTGGACAA AAAGCAGGAA 
AGTGGTATTA GCCATAGAAA AGAAGGAGGA GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080849.1
CDS	92..1510
Translation	MKEEKDHRPKEKRVTLFTPQGATGGCIGATAEGAKGDDRQDRNRDKKEALSKVVIRRLPPTLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDILLFRDRFDGYVFLDNKGQEYHAIVEFAPFQKAAKKKIKKRDTKVGTIEDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEKEKAFKRKEEEMKREKEALRDKGKKSENTESICSLEKIEKKEEVVKRDRIRNKDRPAMQLYQPGARSRSRLCPADDSIKPGDSPVDKKQESGISHRKEGGEE

Target ORF information:

RefSeq Version	NM_026573.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026573.3

ORF Insert Sequence:

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGTTG CTCAGGAAAC CGGAAAAAGG AGATGAAAAA 
GAACTTGATA AAAGAGACAA AACCAAGAGA CTGGACAAAG AAAATCTGAA TGAAGAAAGA 
GCCAGTGGGC ACAGTTATAC TCTGCCCAGG CGTTCTGATG TCGAACTGAA GGATGAAAAG 
CCAAAGAGGC TCGATGACGA GGGTGTCAGA GATTACAGAG ACAGGGACCG GGACTATGAG 
AGAGATCAGG AGCGCATGAT CCGAGAAAGA GAGAGGCTGA AGCGGCAAGA AGAAGAGCGC 
CGGCGGCAGC AGCAGAAAGA ACGCTATGAG AAAGAGAAGG CTTTTAAGCG AAAGGAAGAA 
GAAATGAAGA GAGAGAAAGA GGCACTTCGA GATAAAGGAA AGAAGAGTGA GAATACAGAA 
TCAATATGCT CATTAGAAAA AATTGAAAAA AAAGAGGAAG TGGTTAAGAG AGACCGCATA 
AGGAACAAGG ATCGTCCAGC CATGCAGCTT TACCAACCAG GAGCTCGAAG CCGAAGCCGA 
CTCTGTCCCG CCGATGACAG CATCAAGCCT GGAGATTCCC CAGTGGACAA AAAGCAGGAA 
AGTGGTATTA GCCATAGAAA AGAAGGAGGA GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Upf3b ( XM_006541394.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006541457.1 Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu55989
Clone ID Related Accession (Same CDS sequence)	XM_006541394.3 , XM_006541394.4
Accession Version	XM_006541394.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	regulator of nonsense transcripts 3B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006541394.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGGTA CACAGGTTTC TGTTACAAGC TGTGAATCAG 
AAAAATTTGC TCAGGAAACC GGAAAAAGGA GATGAAAAAG AACTTGATAA AAGAGACAAA 
ACCAAGAGAC TGGACAAAGA AAATCTGAAT GAAGAAAGAG CCAGTGGGCA CAGTTATACT 
CTGCCCAGGC GTTCTGATGT CGAACTGAAG GATGAAAAGC CAAAGAGGCT CGATGACGAG 
GGTGTCAGAG ATTACAGAGA CAGGGACCGG GACTATGAGA GAGATCAGGA GCGCATGATC 
CGAGAAAGAG AGAGGCTGAA GCGGCAAGAA GAAGAGCGCC GGCGGCAGCA GCAGAAAGAA 
CGCTATGAGA AAGAGAAGGC TTTTAAGCGA AAGGAAGAAG AAATGAAGAG AGAGAAAGAG 
GCACTTCGAG ATAAAGGAAA GAAGAGTGAG AATACAGAAT CAATATGCTC ATTAGAAAAA 
ATTGAAAAAA AAGAGGAAGT GGTTAAGAGA GACCGCATAA GGAACAAGGA TCGTCCAGCC 
ATGCAGCTTT ACCAACCAGG AGCTCGAAGC CGAAGCCGAC TCTGTCCCGC CGATGACAGC 
ATCAAGCCTG GAGATTCCCC AGTGGACAAA AAGCAGGAAA GTGGTATTAG CCATAGAAAA 
GAAGGAGGAG AGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006541457.1
CDS	167..1624
Translation	MKEEKDHRPKEKRVTLFTPQGATGGCIGATAEGAKGDDRQDRNRDKKEALSKVVIRRLPPTLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDILLFRDRFDGYVFLDNKGQEYHAIVEFAPFQKAAKKKIKKRDTKVGTIEDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKVHRFLLQAVNQKNLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEKEKAFKRKEEEMKREKEALRDKGKKSENTESICSLEKIEKKEEVVKRDRIRNKDRPAMQLYQPGARSRSRLCPADDSIKPGDSPVDKKQESGISHRKEGGEE

Target ORF information:

RefSeq Version	XM_006541394.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006541394.3

ORF Insert Sequence:

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGGTA CACAGGTTTC TGTTACAAGC TGTGAATCAG 
AAAAATTTGC TCAGGAAACC GGAAAAAGGA GATGAAAAAG AACTTGATAA AAGAGACAAA 
ACCAAGAGAC TGGACAAAGA AAATCTGAAT GAAGAAAGAG CCAGTGGGCA CAGTTATACT 
CTGCCCAGGC GTTCTGATGT CGAACTGAAG GATGAAAAGC CAAAGAGGCT CGATGACGAG 
GGTGTCAGAG ATTACAGAGA CAGGGACCGG GACTATGAGA GAGATCAGGA GCGCATGATC 
CGAGAAAGAG AGAGGCTGAA GCGGCAAGAA GAAGAGCGCC GGCGGCAGCA GCAGAAAGAA 
CGCTATGAGA AAGAGAAGGC TTTTAAGCGA AAGGAAGAAG AAATGAAGAG AGAGAAAGAG 
GCACTTCGAG ATAAAGGAAA GAAGAGTGAG AATACAGAAT CAATATGCTC ATTAGAAAAA 
ATTGAAAAAA AAGAGGAAGT GGTTAAGAGA GACCGCATAA GGAACAAGGA TCGTCCAGCC 
ATGCAGCTTT ACCAACCAGG AGCTCGAAGC CGAAGCCGAC TCTGTCCCGC CGATGACAGC 
ATCAAGCCTG GAGATTCCCC AGTGGACAAA AAGCAGGAAA GTGGTATTAG CCATAGAAAA 
GAAGGAGGAG AGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Upf3b ( XM_006541394.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006541457.1 Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu55989
Clone ID Related Accession (Same CDS sequence)	XM_006541394.3 , XM_006541394.4
Accession Version	XM_006541394.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	regulator of nonsense transcripts 3B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006541394.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGGTA CACAGGTTTC TGTTACAAGC TGTGAATCAG 
AAAAATTTGC TCAGGAAACC GGAAAAAGGA GATGAAAAAG AACTTGATAA AAGAGACAAA 
ACCAAGAGAC TGGACAAAGA AAATCTGAAT GAAGAAAGAG CCAGTGGGCA CAGTTATACT 
CTGCCCAGGC GTTCTGATGT CGAACTGAAG GATGAAAAGC CAAAGAGGCT CGATGACGAG 
GGTGTCAGAG ATTACAGAGA CAGGGACCGG GACTATGAGA GAGATCAGGA GCGCATGATC 
CGAGAAAGAG AGAGGCTGAA GCGGCAAGAA GAAGAGCGCC GGCGGCAGCA GCAGAAAGAA 
CGCTATGAGA AAGAGAAGGC TTTTAAGCGA AAGGAAGAAG AAATGAAGAG AGAGAAAGAG 
GCACTTCGAG ATAAAGGAAA GAAGAGTGAG AATACAGAAT CAATATGCTC ATTAGAAAAA 
ATTGAAAAAA AAGAGGAAGT GGTTAAGAGA GACCGCATAA GGAACAAGGA TCGTCCAGCC 
ATGCAGCTTT ACCAACCAGG AGCTCGAAGC CGAAGCCGAC TCTGTCCCGC CGATGACAGC 
ATCAAGCCTG GAGATTCCCC AGTGGACAAA AAGCAGGAAA GTGGTATTAG CCATAGAAAA 
GAAGGAGGAG AGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006541457.1
CDS	241..1698
Translation	MKEEKDHRPKEKRVTLFTPQGATGGCIGATAEGAKGDDRQDRNRDKKEALSKVVIRRLPPTLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDILLFRDRFDGYVFLDNKGQEYHAIVEFAPFQKAAKKKIKKRDTKVGTIEDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKVHRFLLQAVNQKNLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEKEKAFKRKEEEMKREKEALRDKGKKSENTESICSLEKIEKKEEVVKRDRIRNKDRPAMQLYQPGARSRSRLCPADDSIKPGDSPVDKKQESGISHRKEGGEE

Target ORF information:

RefSeq Version	XM_006541394.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006541394.4

ORF Insert Sequence:

ATGAAGGAAG AAAAAGATCA TAGGCCTAAG GAGAAACGAG TGACCCTGTT TACGCCGCAG 
GGCGCCACAG GCGGCTGTAT TGGCGCTACT GCCGAAGGCG CCAAAGGGGA CGATAGGCAG 
GATCGCAACA GGGACAAGAA AGAAGCTTTG AGCAAGGTGG TAATTCGAAG ATTACCTCCC 
ACTTTGACCA AGGAACAGCT TCAGGAACAT CTTCAACCTA TGCCTGAGCA CGATTATTTT 
GAGTTTTTTT CTAATGATAC TAGCCTTTAT CCTCATATGT ATGCCAGAGC ATATATCAAC 
TTTAAAAACC AAGAAGACAT TCTTTTATTC AGGGACCGAT TTGATGGCTA TGTATTCCTT 
GACAATAAGG GTCAAGAATA TCATGCTATA GTAGAATTTG CACCATTTCA AAAAGCTGCA 
AAAAAGAAGA TTAAGAAAAG AGATACAAAA GTTGGGACTA TCGAGGATGA TCCAGAATAC 
AGAAAATTTT TGGAGAGTTA TGCCACAGAC AATGAGAAAA TGACATCTAC TCCAGAGACA 
TTGCTGGAGG AAATTGAAGC CAAAAATCGA GAATTAATAG CTAAAAGGAC AACGCCCCTT 
TTGAGCTTCC TGAAGAACAA GCAAAGAATG AGAGAAGAAA AGAGAGAAGA AAGGAGGAGA 
CGGGAAATAG AGAGGAAAAG GCAAAGAGAA GAAGAGAGAA GAAAATGGAA AGAAGAGGAG 
AAACGAAAAA GAAAAGATAT AGAAAAACTA AAGAAGATAG AAAGAATTCC AGAAAGGGAG 
AAAATAAGGG ATGAACCAAA GATTAAGGTA CACAGGTTTC TGTTACAAGC TGTGAATCAG 
AAAAATTTGC TCAGGAAACC GGAAAAAGGA GATGAAAAAG AACTTGATAA AAGAGACAAA 
ACCAAGAGAC TGGACAAAGA AAATCTGAAT GAAGAAAGAG CCAGTGGGCA CAGTTATACT 
CTGCCCAGGC GTTCTGATGT CGAACTGAAG GATGAAAAGC CAAAGAGGCT CGATGACGAG 
GGTGTCAGAG ATTACAGAGA CAGGGACCGG GACTATGAGA GAGATCAGGA GCGCATGATC 
CGAGAAAGAG AGAGGCTGAA GCGGCAAGAA GAAGAGCGCC GGCGGCAGCA GCAGAAAGAA 
CGCTATGAGA AAGAGAAGGC TTTTAAGCGA AAGGAAGAAG AAATGAAGAG AGAGAAAGAG 
GCACTTCGAG ATAAAGGAAA GAAGAGTGAG AATACAGAAT CAATATGCTC ATTAGAAAAA 
ATTGAAAAAA AAGAGGAAGT GGTTAAGAGA GACCGCATAA GGAACAAGGA TCGTCCAGCC 
ATGCAGCTTT ACCAACCAGG AGCTCGAAGC CGAAGCCGAC TCTGTCCCGC CGATGACAGC 
ATCAAGCCTG GAGATTCCCC AGTGGACAAA AAGCAGGAAA GTGGTATTAG CCATAGAAAA 
GAAGGAGGAG AGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Upf3b ( XM_030251493.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030107353.1 Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X3, mRNA.

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CloneID	OMu90442
Clone ID Related Accession (Same CDS sequence)	XM_030251493.1
Accession Version	XM_030251493.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	regulator of nonsense transcripts 3B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACATCTA CTCCAGAGAC ATTGCTGGAG GAAATTGAAG CCAAAAATCG AGAATTAATA 
GCTAAAAGGA CAACGCCCCT TTTGAGCTTC CTGAAGAACA AGCAAAGAAT GAGAGAAGAA 
AAGAGAGAAG AAAGGAGGAG ACGGGAAATA GAGAGGAAAA GGCAAAGAGA AGAAGAGAGA 
AGAAAATGGA AAGAAGAGGA GAAACGAAAA AGAAAAGATA TAGAAAAACT AAAGAAGATA 
GAAAGAATTC CAGAAAGGGA GAAAATAAGG GATGAACCAA AGATTAAGGT ACACAGGTTT 
CTGTTACAAG CTGTGAATCA GAAAAATTTG CTCAGGAAAC CGGAAAAAGG AGATGAAAAA 
GAACTTGATA AAAGAGACAA AACCAAGAGA CTGGACAAAG AAAATCTGAA TGAAGAAAGA 
GCCAGTGGGC ACAGTTATAC TCTGCCCAGG CGTTCTGATG TCGAACTGAA GGATGAAAAG 
CCAAAGAGGC TCGATGACGA GGGTGTCAGA GATTACAGAG ACAGGGACCG GGACTATGAG 
AGAGATCAGG AGCGCATGAT CCGAGAAAGA GAGAGGCTGA AGCGGCAAGA AGAAGAGCGC 
CGGCGGCAGC AGCAGAAAGA ACGCTATGAG AAAGAGAAGG CTTTTAAGCG AAAGGAAGAA 
GAAATGAAGA GAGAGAAAGA GGCACTTCGA GATAAAGGAA AGAAGAGTGA GAATACAGAA 
TCAATATGCT CATTAGAAAA AATTGAAAAA AAAGAGGAAG TGGTTAAGAG AGACCGCATA 
AGGAACAAGG ATCGTCCAGC CATGCAGCTT TACCAACCAG GAGCTCGAAG CCGAAGCCGA 
CTCTGTCCCG CCGATGACAG CATCAAGCCT GGAGATTCCC CAGTGGACAA AAAGCAGGAA 
AGTGGTATTA GCCATAGAAA AGAAGGAGGA GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030107353.1
CDS	1332..2270
Translation	MTSTPETLLEEIEAKNRELIAKRTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIERIPEREKIRDEPKIKVHRFLLQAVNQKNLLRKPEKGDEKELDKRDKTKRLDKENLNEERASGHSYTLPRRSDVELKDEKPKRLDDEGVRDYRDRDRDYERDQERMIRERERLKRQEEERRRQQQKERYEKEKAFKRKEEEMKREKEALRDKGKKSENTESICSLEKIEKKEEVVKRDRIRNKDRPAMQLYQPGARSRSRLCPADDSIKPGDSPVDKKQESGISHRKEGGEE

Target ORF information:

RefSeq Version	XM_030251493.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030251493.1

ORF Insert Sequence:

ATGACATCTA CTCCAGAGAC ATTGCTGGAG GAAATTGAAG CCAAAAATCG AGAATTAATA 
GCTAAAAGGA CAACGCCCCT TTTGAGCTTC CTGAAGAACA AGCAAAGAAT GAGAGAAGAA 
AAGAGAGAAG AAAGGAGGAG ACGGGAAATA GAGAGGAAAA GGCAAAGAGA AGAAGAGAGA 
AGAAAATGGA AAGAAGAGGA GAAACGAAAA AGAAAAGATA TAGAAAAACT AAAGAAGATA 
GAAAGAATTC CAGAAAGGGA GAAAATAAGG GATGAACCAA AGATTAAGGT ACACAGGTTT 
CTGTTACAAG CTGTGAATCA GAAAAATTTG CTCAGGAAAC CGGAAAAAGG AGATGAAAAA 
GAACTTGATA AAAGAGACAA AACCAAGAGA CTGGACAAAG AAAATCTGAA TGAAGAAAGA 
GCCAGTGGGC ACAGTTATAC TCTGCCCAGG CGTTCTGATG TCGAACTGAA GGATGAAAAG 
CCAAAGAGGC TCGATGACGA GGGTGTCAGA GATTACAGAG ACAGGGACCG GGACTATGAG 
AGAGATCAGG AGCGCATGAT CCGAGAAAGA GAGAGGCTGA AGCGGCAAGA AGAAGAGCGC 
CGGCGGCAGC AGCAGAAAGA ACGCTATGAG AAAGAGAAGG CTTTTAAGCG AAAGGAAGAA 
GAAATGAAGA GAGAGAAAGA GGCACTTCGA GATAAAGGAA AGAAGAGTGA GAATACAGAA 
TCAATATGCT CATTAGAAAA AATTGAAAAA AAAGAGGAAG TGGTTAAGAG AGACCGCATA 
AGGAACAAGG ATCGTCCAGC CATGCAGCTT TACCAACCAG GAGCTCGAAG CCGAAGCCGA 
CTCTGTCCCG CCGATGACAG CATCAAGCCT GGAGATTCCC CAGTGGACAA AAAGCAGGAA 
AGTGGTATTA GCCATAGAAA AGAAGGAGGA GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Upf3b-mutant mouse model with behavioral and neurogenesis defects.
Molecular psychiatry(2017 Sep)
Huang L,Shum EY,Jones SH,Lou CH,Dumdie J,Kim H,Roberts AJ,Jolly LA,Espinoza JL,Skarbrevik DM,Phan MH,Cook-Andersen H,Swerdlow NR,Gecz J,Wilkinson MF

The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.
Cell165(2)382-95(2016 Apr)
Shum EY,Jones SH,Shao A,Dumdie J,Krause MD,Chan WK,Lou CH,Espinoza JL,Song HW,Phan MH,Ramaiah M,Huang L,McCarrey JR,Peterson KJ,De Rooij DG,Cook-Andersen H,Wilkinson MF

The unfolded protein response is shaped by the NMD pathway.
EMBO reports16(5)599-609(2015 May)
Karam R,Lou CH,Kroeger H,Huang L,Lin JH,Wilkinson MF

Disorders with similar clinical phenotypes reveal underlying genetic interaction: SATB2 acts as an activator of the UPF3B gene.
Human genetics132(12)1383-93(2013 Dec)
Leoyklang P,Suphapeetiporn K,Srichomthong C,Tongkobpetch S,Fietze S,Dorward H,Cullinane AR,Gahl WA,Huizing M,Shotelersuk V

The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.
Human molecular genetics22(23)4673-87(2013 Dec)
Jolly LA,Homan CC,Jacob R,Barry S,Gecz J

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Upf3b cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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