Nop53 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nop53
Entrez Gene ID	68077
Full Name	NOP53 ribosome biogenesis factor
Synonyms	5330430H08Rik,9430097C02Rik,AU041936,AW536441,Gltscr2,PICT-1,R74911
General protein information	Preferred Names NOP53 ribosome biogenesis factor Names ribosome biogenesis protein NOP53 glioma tumor suppressor candidate region gene 2 glioma tumor suppressor candidate region gene 2 protein preS1-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 8.64 cM\|7 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_133831.3	NP_598592.2	ribosome biogenesis protein NOP53

Pathways from BioSystems

Homologies

	GLTSCR2	XP_001113326.1
Drosophila melanogaster (fruit fly)	CG1785	NP_572502.1
Saccharomyces cerevisiae (baker's yeast)	NOP53	NP_015179.1
Neurospora crassa	NCU05233	XP_961893.1
Xenopus tropicalis (tropical clawed frog)	gltscr2	XP_002939289.2
Homo sapiens (human)	GLTSCR2	NP_056525.2
Canis lupus familiaris (dog)	GLTSCR2	XP_005616435.1
Rattus norvegicus (Norway rat)	Gltscr2	NP_997474.1
Eremothecium gossypii	AGOS_ACR126W	NP_983528.1
Schizosaccharomyces pombe (fission yeast)	rrp16	NP_594732.1
Mus musculus (house mouse)	Gltscr2	NP_598592.2
Danio rerio (zebrafish)	gltscr2	NP_001073415.1
Magnaporthe oryzae (rice blast fungus)	MGG_04142	XP_003719688.1
Pan troglodytes (chimpanzee)	GLTSCR2	XP_001169866.2
Bos taurus (cattle)	GLTSCR2	NP_001033596.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000270	XP_310849.4
Caenorhabditis elegans (roundworm)	CELE_Y39B6A.33	NP_741664.1
Kluyveromyces lactis	KLLA0F11506g	XP_455604.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
Nature medicine17(8)944-51(2011 Jul)

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T
Molecular biology of the cell17(11)4888-95(2006 Nov)

The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.
Hong HK, Chakravarti A, Takahashi JS
Proceedings of the National Academy of Sciences of the United States of America101(6)1748-53(2004 Feb)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7.
Chae TH, Allen KM, Davisson MT, Sweet HO, Walsh CA
Mammalian genome : official journal of the International Mammalian Genome Society13(5)239-44(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that PICT-1 plays a role in phosphatidylinositol 3,4,5-trisphosphate signals through controlling PTEN protein stability.
Title: Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.

The following Nop53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nop53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10262	NM_133831.3 Latest version!	Mus musculus NOP53 ribosome biogenesis factor (Nop53), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nop53 ( NM_133831.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598592.2 Mus musculus NOP53 ribosome biogenesis factor (Nop53), mRNA.

Price & Availability↑

CloneID	OMu10262
Clone ID Related Accession (Same CDS sequence)	NM_133831.3
Accession Version	NM_133831.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1455bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	ribosome biogenesis protein NOP53
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY283382.1, AK169290.1 and AI850210.1. On Apr 30, 2009 this sequence version replaced NM_133831.2. ##Evidence-Data-START## Transcript exon combination :: BC025810.1, AK146916.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGG GTGGTAACAG GGACGGTGAG AAGCGCGGCT CGAGAAGCCA GGCGGACTCT 
GGCTTCCTGG GGCTGCGGCC GACCTCGGTG GATCCCGCTC TGAGGCGGCG GCGGCGGGGC 
CCCAGAAACA AGAAGCGCGG CTGGAGGAGG CTCGCCGAGG AGCCGCTGGG GTTAGAGGTC 
GACCAGTTCC TGGAAGACGT CCGGCTACAG GAGCGCACGA CCGGTGGCTT GTTGGCAGAG 
GCCCCAAACG AAAAGCTCTT CTTCGTGGAC ACAGGATTCA AGAGAAAAGA ACCAAGAAAG 
AAGAGGACCT TGGTCCAGAA GAAGTCACAG CGTCTCCAGA AACCCTTACG GGTTGACCTT 
GCCCTTGAGA ATCATTCTAA GATCCCTGCT CCCAAAGACA TCCTCGCACA TCAGGTCCCT 
AATGCCAAGA AGCTCAGGCG AAAGGAGGAG TTATGGGAGA AACTGGCAAA GCAGGGCGAA 
CTGCCCAGGG ATGTGCGCAA GGCACAGGCC CGACTCCTTA GCCCTCCCAC ACCAAAGGCC 
AAACCTGGGC CCCAGGACAT CATTGAGCGA CCCTTCTATG ACCTCTGGAA CCCAGACAAC 
CCTCTGGACA CGCCTTTGAT TGGTCAGGAT GCATTTTTTC TGGAACAGAC CAAGAAGAAA 
GGCGTGAGGC GGCCACAACG CCTCCACATC AAGCCTTCCC AGGTGCCTGC AGTGGAGGTG 
ATTCCTGCAG GAGCCTCCTA CAACCCAACC TTTGAAGATC ACCAGGCCCT GCTTCGAGAG 
GCCCATGAGG TGGAGCTGCA GCGTGAGAAA GAGGCAGAAA AGCTGGAGCG ACAGCTGGCC 
CTGCCCACCT CAGAGCAAGC TGCCACCCAG GAGTCCGTGT TTCGGGAGAT GTGTGAGGGC 
CTGCTGGAGG AGTCTGATGG TGAGGATGAG CATGAGGCAG GCCGTGCCGG GCAGCCAGAG 
GCTGGTGATG GGACCACCGA GATCTCACCC ACTGGTGCTG CTGGTCCTGA GAAGAGGATG 
GAGAAGAAGA CGGAGCAGCA GCGGCGGCGG GAGAAAGCTG CTCGCAAGCT GCGGGTGCAG 
CAGGCTGCAC TGAGGGCAGC CCGGCTTCAG CACCAAGAAC TTTTCAGGCT GCGTGGGATC 
AAGGCCCAGG TGGCCCGAAG GCTGGCAGAA CTGGCACGCC GGAGGGAGCA GCGGCGCATA 
CGGCGACTGG CAGAGGCTGA CAAGCCCCGA AGGCTGGGAC GGCTCAAGTA CCAGGCTCCT 
GACATTGATG TGCAGCTCAG CTCTGAGTTG TCTGGCTCAC TCAGGACACT GAAGCCAGAA 
GGTCACATTC TCCGAGACAG GTTCAAGAGC TTCCAGAAGA GAAATATGAT TGAGCCCCGA 
GAACGAGCCA AGTTCAAGCG CAAATACAAA GTGAAGCTGG TGGAGAAGCG GGCCTACCGT 
GAGATTCAGT TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598592.2
CDS	56..1510
Translation	MAAGGNRDGEKRGSRSQADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEKLFFVDTGFKRKEPRKKRTLVQKKSQRLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLSPPTPKAKPGPQDIIERPFYDLWNPDNPLDTPLIGQDAFFLEQTKKKGVRRPQRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLREAHEVELQREKEAEKLERQLALPTSEQAATQESVFREMCEGLLEESDGEDEHEAGRAGQPEAGDGTTEISPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARRREQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSGSLRTLKPEGHILRDRFKSFQKRNMIEPRERAKFKRKYKVKLVEKRAYREIQL

Target ORF information:

RefSeq Version	NM_133831.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus NOP53 ribosome biogenesis factor (Nop53), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133831.3

ORF Insert Sequence:

ATGGCTGCGG GTGGTAACAG GGACGGTGAG AAGCGCGGCT CGAGAAGCCA GGCGGACTCT 
GGCTTCCTGG GGCTGCGGCC GACCTCGGTG GATCCCGCTC TGAGGCGGCG GCGGCGGGGC 
CCCAGAAACA AGAAGCGCGG CTGGAGGAGG CTCGCCGAGG AGCCGCTGGG GTTAGAGGTC 
GACCAGTTCC TGGAAGACGT CCGGCTACAG GAGCGCACGA CCGGTGGCTT GTTGGCAGAG 
GCCCCAAACG AAAAGCTCTT CTTCGTGGAC ACAGGATTCA AGAGAAAAGA ACCAAGAAAG 
AAGAGGACCT TGGTCCAGAA GAAGTCACAG CGTCTCCAGA AACCCTTACG GGTTGACCTT 
GCCCTTGAGA ATCATTCTAA GATCCCTGCT CCCAAAGACA TCCTCGCACA TCAGGTCCCT 
AATGCCAAGA AGCTCAGGCG AAAGGAGGAG TTATGGGAGA AACTGGCAAA GCAGGGCGAA 
CTGCCCAGGG ATGTGCGCAA GGCACAGGCC CGACTCCTTA GCCCTCCCAC ACCAAAGGCC 
AAACCTGGGC CCCAGGACAT CATTGAGCGA CCCTTCTATG ACCTCTGGAA CCCAGACAAC 
CCTCTGGACA CGCCTTTGAT TGGTCAGGAT GCATTTTTTC TGGAACAGAC CAAGAAGAAA 
GGCGTGAGGC GGCCACAACG CCTCCACATC AAGCCTTCCC AGGTGCCTGC AGTGGAGGTG 
ATTCCTGCAG GAGCCTCCTA CAACCCAACC TTTGAAGATC ACCAGGCCCT GCTTCGAGAG 
GCCCATGAGG TGGAGCTGCA GCGTGAGAAA GAGGCAGAAA AGCTGGAGCG ACAGCTGGCC 
CTGCCCACCT CAGAGCAAGC TGCCACCCAG GAGTCCGTGT TTCGGGAGAT GTGTGAGGGC 
CTGCTGGAGG AGTCTGATGG TGAGGATGAG CATGAGGCAG GCCGTGCCGG GCAGCCAGAG 
GCTGGTGATG GGACCACCGA GATCTCACCC ACTGGTGCTG CTGGTCCTGA GAAGAGGATG 
GAGAAGAAGA CGGAGCAGCA GCGGCGGCGG GAGAAAGCTG CTCGCAAGCT GCGGGTGCAG 
CAGGCTGCAC TGAGGGCAGC CCGGCTTCAG CACCAAGAAC TTTTCAGGCT GCGTGGGATC 
AAGGCCCAGG TGGCCCGAAG GCTGGCAGAA CTGGCACGCC GGAGGGAGCA GCGGCGCATA 
CGGCGACTGG CAGAGGCTGA CAAGCCCCGA AGGCTGGGAC GGCTCAAGTA CCAGGCTCCT 
GACATTGATG TGCAGCTCAG CTCTGAGTTG TCTGGCTCAC TCAGGACACT GAAGCCAGAA 
GGTCACATTC TCCGAGACAG GTTCAAGAGC TTCCAGAAGA GAAATATGAT TGAGCCCCGA 
GAACGAGCCA AGTTCAAGCG CAAATACAAA GTGAAGCTGG TGGAGAAGCG GGCCTACCGT 
GAGATTCAGT TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Nature medicine17(8)944-51(2011 Jul)
Sasaki M,Kawahara K,Nishio M,Mimori K,Kogo R,Hamada K,Itoh B,Wang J,Komatsu Y,Yang YR,Hikasa H,Horie Y,Yamashita T,Kamijo T,Zhang Y,Zhu Y,Prives C,Nakano T,Mak TW,Sasaki T,Maehama T,Mori M,Suzuki A

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Molecular biology of the cell17(11)4888-95(2006 Nov)
Okahara F,Itoh K,Nakagawara A,Murakami M,Kanaho Y,Maehama T

The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.
Proceedings of the National Academy of Sciences of the United States of America101(6)1748-53(2004 Feb)
Hong HK,Chakravarti A,Takahashi JS

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7.
Mammalian genome : official journal of the International Mammalian Genome Society13(5)239-44(2002 May)
Chae TH,Allen KM,Davisson MT,Sweet HO,Walsh CA

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Nop53 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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