Srsf6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srsf6
Entrez Gene ID	67996
Full Name	serine/arginine-rich splicing factor 6
Synonyms	1210001E11Rik,AI314910,AW146126,Sfrs6
General protein information	Preferred Names serine/arginine-rich splicing factor 6 Names serine/arginine-rich splicing factor 6 pre-mRNA-splicing factor SRP55 splicing factor, arginine/serine-rich 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H2\|2 83.87 cM
Summary	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_026499.4	NP_080775.3	serine/arginine-rich splicing factor 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SRSF6	XP_003639908.1
Bos taurus (cattle)	SRSF6	NP_001030349.1
Gallus gallus (chicken)	SRSF6	NP_001026014.1
Mus musculus (house mouse)	Srsf6	NP_080775.3
Homo sapiens (human)	SRSF6	NP_006266.2
Pan troglodytes (chimpanzee)	SRSF6	XP_003317036.1
Rattus norvegicus (Norway rat)	Srsf6	NP_001014207.2

Gene Ontology
Bibliography

Related articles in PubMed

Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Zhou J, Wang R, Zhang J, Zhu L, Liu W, Lu S, Chen P, Li H, Yin B, Yuan J, Qiang B, Shu P, Peng X
Biochimica et biophysica acta1860(12)1159-1168(2017 Dec)

Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
Choo HJ, Cutler A, Rother F, Bader M, Pavlath GK
Stem cells (Dayton, Ohio)34(11)2784-2797(2016 Nov)

RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
Lin JC, Chi YL, Peng HY, Lu YH
Biochimica et biophysica acta1859(11)1368-1379(2016 11)

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC
Journal of virology90(3)1397-413(2015 Nov)

Splicing factor TRA2B is required for neural progenitor survival.
Roberts JM, Ennajdaoui H, Edmondson C, Wirth B, Sanford JR, Chen B
The Journal of comparative neurology522(2)372-92(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nova1 isoforms exhibited differential effects on repressing the development of BAs. Moreover, overexpression of Nova1 proteins reduced the serine/arginine splicing factor 6 (SRSF6) level by enhancing the generation of intron 2-included (SRSF6(+intron 2)) transcripts
Title: RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.

The following Srsf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srsf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18057	NM_026499.4 Latest version!	Mus musculus serine and arginine-rich splicing factor 6 (Srsf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srsf6 ( NM_026499.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080775.3 Mus musculus serine and arginine-rich splicing factor 6 (Srsf6), mRNA.

Price & Availability↑

CloneID	OMu18057
Clone ID Related Accession (Same CDS sequence)	NM_026499.4
Accession Version	NM_026499.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Mus musculus(house mouse)
Product	serine/arginine-rich splicing factor 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY783855.1, AK133872.1, AL590418.16 and AL606473.6. On Mar 13, 2009 this sequence version replaced NM_026499.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133872.1, AK159519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GCGAGAAGGA CATCCAGCGC 
TTTTTCAGCG GCTACGGCCG CCTCCTCGAG ATCGACCTCA AAAATGGGTA CGGTTTCGTG 
GAGTTCGAGG ACTCCCGGGA TGCCGACGAT GCCGTGTACG AGCTCAACAG CAAGGAGCTG 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GCCGCGACCG CGATGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACTTC TGGCAGAGAC 
AAATATGGAC CACCTGTTCG TACAGAGTAC AGGCTTATTG TAGAAAATCT GTCTAGTCGT 
TGCAGTTGGC AAGACTTAAA GGATTTCATG CGGCAAGCAG GAGAAGTGAC TTATGCAGAT 
GCTCACAAAG AACGAACAAA TGAGGGTGTG ATTGAATTTA GATCCTACTC CGACATGAAG 
CGTGCTTTGG ATAAACTGGA TGGTACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAA GAACAAGCCA TAGGCGCTCC TACTCTGGCA GTAGATCCAG ATCACGGTCT 
AGAAGAAGGT CTCGGAGTAG GAGTCGCAGA AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGATCTAG GTCTCGGAGC AAAGGTCGAT CCCGATCCCG CTCAAAAGGC 
AGGAAATCCA GATCAAAGAG CAAATCGAAG CCCAAGTCTG ACCGGGGCTC CCATTCCCAC 
TCAAGAAGCA GGTCTAAGGA TAAGTATGGG AAGTCACGTA GTAGGTCACG GTCTCGGTCC 
CCCAAAGAGA ACGGCAAAGG AGACATAAAG TCAAAGTCCA GATCCCGGAG CCAGTCTCGG 
TCCCACTCGC CTCTACCTGC TCCACCCTCA AAGGCTCGGT CCATGTCCCC TCCGCCAAAA 
AGAGCTTCAA GGTCCCGTTC TAGATCTCGT TCAAGGTCCA GATCAAGTTC CAGAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080775.3
CDS	164..1183
Translation	MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFEDSRDADDAVYELNSKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDKYGKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSHSPLPAPPSKARSMSPPPKRASRSRSRSRSRSRSSSRD

Target ORF information:

RefSeq Version	NM_026499.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine and arginine-rich splicing factor 6 (Srsf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026499.4

ORF Insert Sequence:

ATGCCGCGCG TCTACATAGG ACGCCTGAGC TACAACGTCC GCGAGAAGGA CATCCAGCGC 
TTTTTCAGCG GCTACGGCCG CCTCCTCGAG ATCGACCTCA AAAATGGGTA CGGTTTCGTG 
GAGTTCGAGG ACTCCCGGGA TGCCGACGAT GCCGTGTACG AGCTCAACAG CAAGGAGCTG 
TGCGGCGAGC GCGTGATCGT AGAGCACGCC CGGGGCCCGC GCCGCGACCG CGATGGCTAC 
AGCTACGGAA GCCGCAGTGG TGGAGGTGGA TACAGCAGTC GGAGAACTTC TGGCAGAGAC 
AAATATGGAC CACCTGTTCG TACAGAGTAC AGGCTTATTG TAGAAAATCT GTCTAGTCGT 
TGCAGTTGGC AAGACTTAAA GGATTTCATG CGGCAAGCAG GAGAAGTGAC TTATGCAGAT 
GCTCACAAAG AACGAACAAA TGAGGGTGTG ATTGAATTTA GATCCTACTC CGACATGAAG 
CGTGCTTTGG ATAAACTGGA TGGTACAGAA ATAAATGGCA GAAATATTAG GCTTATTGAA 
GATAAGCCAA GAACAAGCCA TAGGCGCTCC TACTCTGGCA GTAGATCCAG ATCACGGTCT 
AGAAGAAGGT CTCGGAGTAG GAGTCGCAGA AGCAGCCGCA GTAGATCTCG AAGTATCTCA 
AAAAGTCGCT CCCGATCTAG GTCTCGGAGC AAAGGTCGAT CCCGATCCCG CTCAAAAGGC 
AGGAAATCCA GATCAAAGAG CAAATCGAAG CCCAAGTCTG ACCGGGGCTC CCATTCCCAC 
TCAAGAAGCA GGTCTAAGGA TAAGTATGGG AAGTCACGTA GTAGGTCACG GTCTCGGTCC 
CCCAAAGAGA ACGGCAAAGG AGACATAAAG TCAAAGTCCA GATCCCGGAG CCAGTCTCGG 
TCCCACTCGC CTCTACCTGC TCCACCCTCA AAGGCTCGGT CCATGTCCCC TCCGCCAAAA 
AGAGCTTCAA GGTCCCGTTC TAGATCTCGT TCAAGGTCCA GATCAAGTTC CAGAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Biochimica et biophysica acta1860(12)1159-1168(2017 Dec)
Zhou J,Wang R,Zhang J,Zhu L,Liu W,Lu S,Chen P,Li H,Yin B,Yuan J,Qiang B,Shu P,Peng X

Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.
Stem cells (Dayton, Ohio)34(11)2784-2797(2016 Nov)
Choo HJ,Cutler A,Rother F,Bader M,Pavlath GK

RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
Biochimica et biophysica acta1859(11)1368-1379(2016 11)
Lin JC,Chi YL,Peng HY,Lu YH

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Journal of virology90(3)1397-413(2015 Nov)
Salinas E,Byrum SD,Moreland LE,Mackintosh SG,Tackett AJ,Forrest JC

Splicing factor TRA2B is required for neural progenitor survival.
The Journal of comparative neurology522(2)372-92(2014 Feb)
Roberts JM,Ennajdaoui H,Edmondson C,Wirth B,Sanford JR,Chen B

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Srsf6 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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