Rab39b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab39b
Entrez Gene ID	67790
Full Name	RAB39B, member RAS oncogene family
Synonyms	6330580M05Rik
General protein information	Preferred Names RAB39B, member RAS oncogene family Names ras-related protein Rab-39B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X 38.26 cM\|X A7.3
Summary	This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be enriched in mouse brain, and specifically within neurons, and may play a role in synapse formation. In humans mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Jun 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_175122.6	NP_780331.1	ras-related protein Rab-39B

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rab39b	NP_001073492.1
Danio rerio (zebrafish)	tmem230	NP_001092211.1
Caenorhabditis elegans (roundworm)	rab-39	NP_495984.2
Homo sapiens (human)	RAB39B	NP_741995.1
	RAB39B	XP_001098848.1
Bos taurus (cattle)	RAB39B	NP_001069563.1
Mus musculus (house mouse)	Rab39b	NP_780331.1
Gallus gallus (chicken)	RAB39B	XP_420326.3
Drosophila melanogaster (fruit fly)	Rab39	NP_001245568.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000433	XP_310666.5
Xenopus tropicalis (tropical clawed frog)	LOC100486510	XP_002931827.2
Canis lupus familiaris (dog)	RAB39B	XP_003435654.2
Pan troglodytes (chimpanzee)	RAB39B	XP_003317848.1

Gene Ontology
Bibliography

Related articles in PubMed

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.
Mignogna ML, Giannandrea M, Gurgone A, Fanelli F, Raimondi F, Mapelli L, Bassani S, Fang H, Van Anken E, Alessio M, Passafaro M, Gatti S, Esteban JA, Huganir R, D'Adamo P
Nature communications66504(2015 Mar)

Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
Lee K, Mattiske T, Kitamura K, Gecz J, Shoubridge C
Human molecular genetics23(4)1084-94(2014 Feb)

Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Mori Y, Matsui T, Omote D, Fukuda M
Biochemical and biophysical research communications435(1)113-9(2013 May)

Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves.
Lee MP, Yutzey KE
PloS one6(12)e29758(2011)

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Giannandrea M, Bianchi V, Mignogna ML, Sirri A, Carrabino S, D'Elia E, Vecellio M, Russo S, Cogliati F, Larizza L, Ropers HH, Tzschach A, Kalscheuer V, Oehl-Jaschkowitz B, Skinner C, Schwartz CE, Gecz J, Van Esch H, Raynaud M, Chelly J, de Brouwer AP, Toniolo D, D'Adamo P
American journal of human genetics86(2)185-95(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities.
Title: Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.

The following Rab39b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab39b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23320	NM_175122.6 Latest version!	Mus musculus RAB39B, member RAS oncogene family (Rab39b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab39b ( NM_175122.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780331.1 Mus musculus RAB39B, member RAS oncogene family (Rab39b), mRNA.

Price & Availability↑

CloneID	OMu23320
Clone ID Related Accession (Same CDS sequence)	NM_175122.6
Accession Version	NM_175122.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Mus musculus(house mouse)
Product	ras-related protein Rab-39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY257784.1, BC052472.1 and AV172496.1. On Jun 8, 2013 this sequence version replaced NM_175122.5. ##Evidence-Data-START## Transcript exon combination :: BY257784.1, BC050853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGCGATTC CACGGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGCCGCTTTG CTCAGGTTTC AGATCCCACC 
GTGGGGGTAG ATTTTTTCTC CCGTTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACAGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AATTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAGACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGTTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT TGTTCATTCT 
TCAGAAGAGG TTATCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780331.1
CDS	225..866
Translation	MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVIKSERRCLC

Target ORF information:

RefSeq Version	NM_175122.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAB39B, member RAS oncogene family (Rab39b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175122.6

ORF Insert Sequence:

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGCGATTC CACGGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGCCGCTTTG CTCAGGTTTC AGATCCCACC 
GTGGGGGTAG ATTTTTTCTC CCGTTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACAGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AATTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAGACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGTTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT TGTTCATTCT 
TCAGAAGAGG TTATCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.
Nature communications66504(2015 Mar)
Mignogna ML,Giannandrea M,Gurgone A,Fanelli F,Raimondi F,Mapelli L,Bassani S,Fang H,Van Anken E,Alessio M,Passafaro M,Gatti S,Esteban JA,Huganir R,D'Adamo P

Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
Human molecular genetics23(4)1084-94(2014 Feb)
Lee K,Mattiske T,Kitamura K,Gecz J,Shoubridge C

Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Biochemical and biophysical research communications435(1)113-9(2013 May)
Mori Y,Matsui T,Omote D,Fukuda M

Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves.
PloS one6(12)e29758(2011)
Lee MP,Yutzey KE

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
American journal of human genetics86(2)185-95(2010 Feb)
Giannandrea M,Bianchi V,Mignogna ML,Sirri A,Carrabino S,D'Elia E,Vecellio M,Russo S,Cogliati F,Larizza L,Ropers HH,Tzschach A,Kalscheuer V,Oehl-Jaschkowitz B,Skinner C,Schwartz CE,Gecz J,Van Esch H,Raynaud M,Chelly J,de Brouwer AP,Toniolo D,D'Adamo P

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Rab39b cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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